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Probiotic Lactobacillus acidophilus shows promise for treating inflammatory bowel disease and other intestinal inflammation disorders

Researchers found that probiotic Lactobacillus acidophilus strain LA1 generates a rapid and sustained enhancement of the intestinal barrier, effectively treating intestinal inflammation. The study also showed that LA1 can prevent colonic inflammation formation and promote healing in mice with induced colitis.

SourceElsevier·JournalAmerican Journal Of Pathology·DateApr 20, 2021

Probiotics keep calves healthy, too!

Scientists at Hokkaido University developed a novel probiotic formulation to control severe diarrhea in calves, reducing mortality and economic loss. The probiotic supplement was tested on newborn calves and found to be effective in preventing bovine diarrhea caused by BRV and cryptosporidiosis.

SourceHokkaido University·JournalVeterinary Microbiology·DateApr 1, 2021

Experts agree on new global definition of 'fermented foods'

Experts have agreed on a new global definition of fermented foods, specifying the differences between them and probiotics. The definition covers thousands of different types of fermented foods from around the world and provides a starting point for further research into their effects on human health.

SourceInternational Scientific Association for Probiotics and Prebiotics·JournalNature Reviews Gastroenterology & Hepatology·DateJan 5, 2021

Can we improve our health with doses of safe, live microbes on a daily basis?

A group of seven interdisciplinary scientists published a review paper highlighting specific gaps in the research on live microbes and health outcomes. They argue that there is only weak evidence to date confirming the link between live microbes and better human health, and propose a plan for quantifying this relationship.

Gut bacteria in multiple sclerosis: Probiotic or commensal, good or bad?

A study published in Proceedings of the National Academy of Sciences found that Lactobacillus reuteri, a commonly used probiotic, can exacerbate multiple sclerosis in mouse models. The research suggests that gut microbiome balance is crucial in chronic diseases and that a one-size-fits-all approach to treatment may not be effective.

SourceUniversity of Vermont·JournalProceedings of the National Academy of Sciences·DateOct 19, 2020

Group of international scientists align on a definition for 'synbiotic'

A group of international scientists has developed a new definition for synbiotics, outlining a mixture of live microorganisms and selectively utilized substrates that confer a health benefit on the host. The definition aims to clarify scientific ambiguity and provide a foundation for science-based claims about synbiotic health benefits.

SourceInternational Scientific Association for Probiotics and Prebiotics·JournalNature Reviews Gastroenterology & Hepatology·DateAug 21, 2020

Insights on the gut microbiome could shape more powerful, precise treatment

Researchers from Brigham and Women's Hospital have identified key factors influencing the success of fecal microbiota transplantation (FMT) in treating C. difficile infection. They developed an algorithm to design personalized probiotic cocktails, which contain species effective inhibitors of C. difficile and can be administered to pat...

SourceBrigham and Women's Hospital·JournalNature Communications·DateJul 31, 2020

AGA does not recommend the use of probiotics for most digestive conditions

The American Gastroenterological Association recommends against using probiotics to treat most digestive diseases due to a lack of strong evidence supporting their efficacy. However, certain probiotic formulations may benefit patients in specific situations, such as preventing Clostridioides difficile infection or managing pouchitis.

SourceAmerican Gastroenterological Association·JournalGASTROENTEROLOGY·DateJun 9, 2020

Probiotics may help treat acne

A recent analysis published in Dermatologic Therapy suggests that probiotics may be an effective alternative to traditional treatments for acne. The study found that probiotics can reduce inflammation and help the skin's natural defenses against acne, but further research is needed to confirm these findings.

SourceWiley·JournalDermatologic Therapy·DateApr 8, 2020

The Lancet Gasteroenterology & Hepatology: First clinical trial finds probiotic treatment with dead bacteria is better than placebo at alleviating symptoms of irritable bowel syndrome

A new 12-week clinical trial found that heat-inactivated Bifidobacterium bifidum MIMBb75 improved IBS symptoms by at least 30% in 34% of patients compared to 19% on placebo. The treatment was also associated with a strong placebo effect, but the dead bacterial cells were still significantly better than placebo.

SourceThe Lancet·JournalThe Lancet Gastroenterology & Hepatology·DateApr 8, 2020

Designer probiotic treatment for cancer immunotherapy

Researchers have designed a novel probiotic strain that can seek out solid tumors and safely deliver immune checkpoint inhibitors, leading to tumor regression. The probiotic platform can also be used to deliver multiple immunotherapies simultaneously, enabling effective therapeutic combinations for difficult-to-treat cancers.

SourceColumbia University School of Engineering and Applied Science·JournalScience Translational Medicine·DateFeb 12, 2020

Be wary of online probiotic health-benefit claims

A recent study highlights the unreliable sources of probiotic information online and how health-benefit claims are often not supported by robust scientific evidence. Most websites providing probiotic info are from commercial sources or news outlets, which provide incomplete information on potential side effects and regulatory issues.

SourceFrontiers·JournalFrontiers in Medicine·DateJan 15, 2020

Beware probiotics in ICU patients

A study found that probiotics can cause bloodstream infections in ICU patients, with 1.1% of cases linked to Lactobacillus bacteria. Genetic analysis revealed a mutation that made the bacteria resistant to antibiotics, highlighting the need for caution when using probiotics in critically ill patients.

SourceBoston Children's Hospital·JournalNature Medicine·DateNov 12, 2019

Scientists discover new antibiotic in tropical forest

Researchers have discovered a new antibiotic, phazolicin, produced by a soil bacterium from a Mexican tropical forest that can prevent harmful bacteria from growing in plant roots. The findings suggest the potential for using this bacterium as a 'plant probiotic' to improve crop health and resistance to disease.

SourceRutgers University·JournalNature Communications·DateOct 8, 2019

Anxiety might be alleviated by regulating gut bacteria

A recent review of studies found that regulating intestinal microbiota through probiotics and non-probiotic interventions can effectively reduce anxiety symptoms in people. Probiotic supplements were only effective in about half of the studies, while non-probiotic interventions showed a 86% rate of effectiveness.

SourceBMJ Group·JournalGeneral Psychiatry·DateMay 20, 2019

Probiotic bacteria evolve inside mice's GI tracts

A new study found that probiotic bacteria can evolve and change inside the mouse's gut, making them less effective and sometimes harmful. The researchers discovered that the bacteria's DNA changes and they develop new capabilities after living in the mice's intestines for a few weeks.

SourceWashU Medicine·JournalCell Host & Microbe·DateMar 26, 2019