Articles tagged with Probiotics
Researchers have discovered a compound that can combat multidrug-resistant bacteria within one hour, including the ESKAPE group of pathogens. The compound, Pln149-PEP20, is a synthetic peptide inspired by molecules secreted by Lactobacillus plantarum and has been found to be highly active against MDR bacteria.
A study of 307,000 neonates with very low birth weight found that increased use of probiotics in hospitals was associated with reduced risk of necrotizing enterocolitis, but not sepsis or mortality rates. The adoption of routine probiotic use increased slowly from 2012 to 2019.
A comprehensive review by experts confirms probiotics are generally safe for healthy individuals, but require careful evaluation for vulnerable populations. The review provides guidance on assessing probiotic safety, including genetic makeup analysis to identify potential risks.
A genetically engineered probiotic has been shown to blunt the ill effects of alcohol in mice by reducing alcohol absorption and prolonging tolerance. The treatment also shortened recovery time after alcohol exposure and reduced liver damage. Further research is needed to confirm its effectiveness in humans.
Researchers found that probiotic bacteria Lactobacillus reuteri stimulates cancer-killing T cells by secreting indole-3-aldehyde, which activates a receptor in CD8 cells. A diet rich in tryptophan enhances the effect of immunotherapy on shrinking tumors and prolonging survival.
Researchers have identified a probiotic that can protect Caribbean corals from stony coral tissue loss disease (SCTLD), a deadly and rapidly spreading affliction. The probiotic treatment has been shown to stop or slow the progression of the disease in infected coral fragments, offering an antibiotic-free alternative.
A new case series study found that an 8-week methylation-supportive diet and lifestyle program reduced biological age by 4.60 years, with five of six participants exhibiting significant age reversal. The study suggests that this intervention may favorably influence biological age in both sexes.
Researchers successfully add purified curcumin to probiotic yogurt, preserving its dissolved form and enhancing its health properties. The study shows that the curcumin inhibits yeast, fungi, and bacteria growth while maintaining the recommended levels of beneficial lactic acid bacteria.
A UCalgary study found that a healthy gut microbiome can prevent deadly hospital infections in critically ill patients. The research showed that the gut microbiota and immune system work together to fight infection, with abnormal gut bacteria increasing the risk of severe infections.
Scientists have engineered a unique strain of probiotic bacteria to over-express a metal transporter that binds and concentrates copper, facilitating the delivery of radionuclide therapy to cancer cells. This approach targets tumors without relying on specific receptors, making it potentially effective against treatment-resistant cancers.
Researchers found that certain enzymes within a class known as bile salt hydrolases (BSHs) can restrict Clostridioides difficile (C. diff.) colonization by altering existing bile acids and creating a new class of bile acids within the gut's microbial environment. Selecting the right suite of BSH-producing bacteria is critical, as inter...
A new study found that increased consumption of live dietary microbes is linked to better health outcomes, including lower waist circumference and body mass index. The research suggests that a higher intake of fermented foods, raw fruits, and vegetables may support immune function and increase the diversity of microbes in the gut.
A Brazilian study found that a strain of brewer's yeast can act as a preventive against asthma in male mice. Daily administration of the probiotic at a dose of 10 billion CFU/mL significantly reduced bronchial hypersensitivity and inflammation. However, airway and lung inflammation was not significantly reduced by lower doses.
Researchers demonstrate a model for developing probiotic therapies to modulate the microbiome by targeting intestinal biofilms and identifying beneficial microbial strains. The study showed positive effects in reducing GI symptoms and improving overall well-being in healthy individuals.
A Phase 2 clinical trial found that a probiotic reduced S. aureus colonization by 96.8% in the stool and 65.4% in the nose. The probiotic Bacillus subtilis was administered orally, surviving passage through the stomach, and did not harm gut microbiota.
A pooled data analysis of 7 clinical trials found that probiotics, including Lactobacillus salivarius and Streptococcus salivarius, reduced OLP scores and volatile sulphuric compound levels in the mouth. However, the effects were relatively short-lived and more high-quality research is needed to verify these findings.
A Rutgers study found that COVID-19 patients, especially those treated with antibiotics, experience significant disruptions in their gut microbiome balance. This imbalance may lead to the development of targeted probiotic supplements to improve treatment outcomes.
A systematic review of 29 studies found that combining probiotics with antibiotics can prevent or lessen some changes to the gut microbiome composition. Probiotics can also help protect species diversity and restore friendly bacteria populations, such as Faecalibacterium prausnitzii.
Researchers at the University of Wisconsin-Madison develop nanoparticles to neutralize molecules implicated in IBD, significantly improving treatment outcomes. The probiotic bacteria are equipped with nano-backpacks that target reactive oxygen species, reducing inflammation and promoting weight gain and colon length restoration.
Researchers developed a 'clean-label' method to minimize spoilage problems in fresh pasta, adding 30 days to its shelf life. The technique uses modified atmosphere packaging and bioprotective probiotic cultures to control microbial growth.
Tagbo Niepa's research aims to capture and store a person's healthy gut microbiome, then restore balance when ill. The technology has the potential to revolutionize illness treatment, especially for diseases like C. diff infection.
The event will cover various topics including microbiota dysbiosis, oral and vaginal microbiota, and their impact on diseases like depression, cancer, and respiratory infections. The meeting aims to accelerate Microbiota medicine applications through strategic discussions.
Researchers at the University of Toledo found that consumption of highly refined fiber may increase liver cancer risk in some individuals, particularly those with a silent vascular deformity. The study discovered that high concentrations of bile acids caused by a portosystemic shunt led to the development of liver cancer.
Researchers found that transplanted gut bacteria from mice with obstructive sleep apnea caused increased blood pressure and impaired coronary function in recipient mice. Probiotics improved symptoms for the recipients but not the donor mice, highlighting a potential therapeutic strategy to mitigate cardiovascular disease.
Researchers from NUS Medicine developed a probiotic that detects antibiotic-induced microbiome imbalance and regulates bile salt metabolism to prevent Clostridioides difficile infection. The probiotic significantly reduced CDI in laboratory models, demonstrating a 100% survival rate and improved clinical outcomes.
A newly published framework outlines steps for administering probiotics to wildlife, prioritizing native species, effective dosages, and delivery systems. The goal is to restore beneficial bacteria and protect key symbiotic relationships, while considering potential risks and side effects.
NC State researchers discovered a new way to make the difficult-to-characterize gut bacterium Bifidobacterium more responsive to antibiotics. They also found tiny changes in different strains that reflect large differences in their characteristics, highlighting the need for individualized CRISPR-based genome engineering approaches.
The 9th World Congress on Targeting Microbiota will discuss recent advances in microbiome research, including the potential of naked mole rat's gut microbiome to extend human lifespan. The congress also explores gene editing and microbiome therapy for depression and cancer immunotherapy.
A new study found that probiotics did not improve vaginal health in women with an imbalance in their microbiota. However, 34% of women showed spontaneous improvement over a period of one to three months. The study suggests that postponing fertility treatment until a normal balance is achieved may be beneficial.
A recent study published in Cellular and Molecular Life Sciences found that a specific type of gut bacteria, Bifidobacterium breve, plays a crucial role in regulating fetal growth and metabolism during pregnancy. The researchers discovered that the maternal microbiome promotes development of the placenta and healthy growth of the baby ...
Researchers at Leibniz-HKI found that lactic acid bacteria nourish intestinal cells, promoting bacterial growth and adapting Candida's metabolism to make it less infectious. This balance restores a healthy state and prevents fungal infections.
A new study published in iScience found that the co-development of the gut microbiome, immune system, and respiratory system is correlated with a baby's respiratory health. Disruption of any of these systems resulted in greater respiratory morbidity for infants, highlighting the importance of timing in intervening with therapies.
A new study suggests that probiotic bacteria, particularly Lactobacillus, may enhance the effectiveness of tamoxifen and other endocrine-targeted therapies in reducing ER+ breast cancer risk. The researchers found elevated levels of Lactobacillus in breast tissue of mice treated with tamoxifen, leading to decreased breast tumor formation.
A study by researchers from the University of Basel found that probiotics can improve depressive symptoms in patients taking antidepressants. The probiotic group showed a greater improvement in symptoms than the placebo group, with changes in intestinal flora composition and brain activity when viewing emotional stimuli.
Australian researchers have discovered specific gene networks rewired to drive peanut allergy remission through a combination treatment of probiotic and oral immunotherapy. This network reprogramming shuts down the allergic immune response responsible for causing food allergies.
A randomized clinical trial found that a specific probiotic supplement accelerated the maturation of the microbiome in extremely preterm infants, leading to reduced intestinal inflammation and improved feeding tolerance. The study also showed potential benefits for reducing the risk of food allergies in these vulnerable infants.
Scientists estimate 20% of children and 26% of adults in the US consume high levels of live microorganisms daily. These findings suggest a link between dietary microbes and health outcomes, highlighting the importance of quantifying live microbes consumed through food and supplements.
A new study published in Cell Host & Microbe finds that friendly bacteria in the gut, such as Escherichia coli Nissle 1917, can compete with harmful bacteria like Salmonella for energy resources like nitrate. This competition allows the probiotic to occupy both niches and protect against infection.
Researchers at Vanderbilt University Medical Center discovered a mechanism Acinetobacter baumannii uses to survive in a dried state: producing hydrophilin proteins that protect against water loss. This finding could lead to new strategies for eliminating the pathogen from hospital surfaces.
Researchers have engineered probiotic bacteria to produce the dopamine precursor L-DOPA, a potential treatment for Parkinson's disease. The new approach eliminates side effects and reduces treatment complications, offering a promising alternative to existing treatments.
The Experimental Biology (EB) 2022 meeting features live presentations and a moderated Q&A session on groundbreaking studies. The virtual press conference reveals potential treatments for Parkinson's disease, COVID-19 vaccine-associated side effects, and alleviating food allergies.
Bar-Ilan University researchers develop a two-step recovery process to revive failed networks by restructuring damaged links and reigniting the entire system through controlled node activation. This approach has shown promise in steering a failed microbiome back to functionality, particularly with probiotic interventions.
A recent review highlights the effects of different intestinal bacteria on colorectal cancer, exploring new therapies for disease prevention and treatment. Beneficial probiotics, such as Akkermansia muciniphila and Lactobacillus rhamnosus GG, exhibit anticancer properties and reduce CRC cell proliferation.
Researchers developed Inducible Directed Evolution (IDE), a new technique for controlling directed evolution in bacteria, allowing up to 30 gene modifications at a time. This approach enables finely tuned changes to bacteria, making it suitable for biopharmaceutical and chemical manufacturing industries.
A team of researchers discovered that chance plays a significant role in the formation of individual gut microbiomes, with genetic, diet, and environmental factors influencing the odds of colonization. The study's findings have major implications for treatments like fecal transplants and probiotics.
Researchers at Oregon Health & Science University have made a groundbreaking connection between the gut microbiome and cognitive decline in an animal model of Alzheimer's disease. Fecal implants induced significant behavioral and cognitive changes in mice, offering new avenues for treating or forestalling dementia.
A Toronto study found that certain probiotic bacteria can alter the function of immune cells and spur cancer growth in pancreatic cancer. Deletion or inhibition of a key protein enabled better treatment sensitivity and more inflammatory T cells, while activation thwarted these effects.
Two new treatments have been found to induce peanut allergy remission in children, with about half achieving remission and experiencing significant improvements in quality of life. The combination treatment and oral immunotherapy alone were both highly effective, providing substantial benefits for children's health and well-being.
Patients with sufficient fiber intake had improved progression-free survival and response to immunotherapy in melanoma. A high-fiber diet was associated with slower tumor growth and increased CD4+ T cells in pre-clinical models, supporting the potential benefits of dietary interventions on cancer treatment outcomes.
A high-fiber diet has been shown to improve the response of melanoma patients to immunotherapy by influencing the gut microbiome. Patients who consumed at least 20 grams of dietary fiber per day lived longer without their cancer progressing, compared to those who consumed less fiber.
A new study published in the journal Nutrients found that probiotics can reduce nausea and vomiting during pregnancy by up to 33% and improve quality of life symptoms. The study also identified specific gut microbes associated with higher levels of nausea, suggesting potential biomarkers for future research.
Researchers have discovered that certain microbes can prevent Clostridioides difficile infection by consuming nutrients essential for its growth. This new understanding challenges existing approaches to probiotic treatment options, which focus on restoring secondary bile acids.
Researchers engineered a probiotic designed to target and break down cancer cell defenses, allowing therapies to kill tumors more effectively. The new probiotic was tested in animal models of breast and colon cancer, showing promising results with improved survival rates.
Researchers developed a quick test to identify beneficial bacteria species known to benefit coral, allowing for non-invasive assessment of coral health. The method enables rapid detection of specific bacterial species in seawater and coral samples, suggesting that the bacteria may be concentrated in coral.
Researchers from Kaunas University of Technology and the University of Helsinki have developed a nutritious meat analogue using fermented okara, which can help alleviate digestive problems due to its probiotics. The product contains less salt and saturated fats than real meat while maintaining protein levels.
Researchers at Tel Aviv University have created a system that enables the production of 'good' bacteria capable of eliminating 'bad' bacteria. This breakthrough technology uses a toxin injection system to target specific types and amounts of toxins, offering an alternative to antibiotics.
A randomized clinical trial found that yogurt containing Bifidobacterium lactis BB-12 protected against harmful changes in the gut microbiome after antibiotic administration. The study also showed that levels of beneficial short-chain fatty acid acetate returned to baseline within 30 days.
A study by Kazan Federal University found that probiotics administered to antibiotic-treated mice improved behavior, reduced oxidative stress, and restored gut microbiota diversity. The researchers demonstrated a strong link between the gut microbiota and brain functioning, with potential therapeutic benefits for treating dysbiosis-rel...
A recent study suggests that the gut microbiome plays a significant role in mental health, with disruptions in beneficial microorganisms linked to depressive disorders. The researchers propose a multifaceted approach to manage depression through rebalancing and maintaining the gut microbiome using diet, probiotics, and lifestyle changes.
Researchers found that a probiotic cocktail of beneficial bacteria increases coral survival after a bleaching event. The approach could be administered in advance to help corals recover from high sea temperatures. Probiotic treatment improved coral response and recovery, boosting survival from 60% to 100%.