A review of probiotics for restoring antibiotic-disturbed gut microbiota found limited conclusive evidence. While certain probiotics can reduce clinical symptoms like diarrhea and C. difficile colitis, the lack of standardization in measuring microbiota disruption and recovery hinders conclusions.
A UC Riverside study found that probiotic supplementation can reduce the negative impacts of PBDEs on neurodevelopment, behavior, and metabolism in mouse offspring. The researchers discovered that LR treatment helped normalize body weight gain and tooth eruption timing, as well as improved glucose metabolism and insulin levels.
Researchers at WashU Medicine engineered a probiotic that delivers immunotherapy directly to the gut, shrinking tumors in mice. The probiotic uses a yeast-based system to produce immune checkpoint inhibitors, potentially treating hard-to-reach cancers.
The winners of the Applied Microbiology International Horizon Awards 2024 have been named, including the One Health Microbiome Center at Penn State and researchers Dr. François Thomas and Dr. Helen Onyeaka.
Researchers have found that specific E. coli bacteria in the gut promote colon cancer by binding to intestinal cells and releasing a DNA-damaging toxin called colibactin. This binding is made possible by bacterial pili and adhesins, which can be targeted to prevent tumor development.
A new perspective paper emphasizes the critical role of diet in shaping the efficacy of prebiotics and probiotics. The authors found that diet significantly affects gut microbiome composition and function, potentially impacting the success of these interventions. Researchers are urged to collect data on participants' background diets a...
Researchers at University College Cork found that wild birds' gut microbiome impacts their growth, weight, and survival. The study manipulated the birds' microbiome by feeding them beneficial bacteria Lactobacillus kimchicus.
A new framework outlines essential criteria for establishing prebiotic status, emphasizing selective utilization, measurable health benefits, and safe use. The proposed guidelines aim to promote clarity and informed decision-making around prebiotic products.
A research team developed an RNA-based sensor platform that can regulate gene expression in bacteria, mimicking natural biological interactions. The START platform enables tunable control over sensor response and detection of various molecules, including drugs and proteins.
A new study has found a natural probiotic in the microbiomes of UK newborns, which could be used to develop personalized infant therapeutic probiotics. The researchers analyzed stool samples from 1,288 healthy infants and found that one of the pioneer bacteria was genetically adapted to utilize breast milk nutrients and block pathogens.
Researchers at Tecnolat have identified three Lactobacillus strains with probiotic properties, safe for consumption, and beneficial to human health. These strains can also enhance the sensory diversity and microbiological quality of traditional Brazilian cheeses.
Researchers discovered a unique probiotic strain, Bifidobacterium bifidum BB1, that strengthens intestinal barrier function and protects against harmful bacteria. This strain may lead to the development of novel therapies for patients with inflammatory bowel disease and other inflammatory conditions.
A study in mice found that the bacteria Bifidobacterium breve supports healthy brain development in fetuses, improving nutrient transport and cell processes. This discovery suggests using probiotics during pregnancy may support fetal brain health and future treatments for growth restriction could focus on maternal gut health.
A new study by Ohio State University Wexner Medical Center found that probiotics can improve the immune system and behavior of both mothers and their offspring during pregnancy. Probiotics may also help counteract negative effects of prenatal stress, such as changes in brain inflammation and amino acid metabolism.
Researchers from Poland developed an ice cream made from mare's milk blended with cow's cream, which may have beneficial probiotic qualities. The study found that this unique combination could lead to the creation of synbiotic ice cream production, potentially offering a new approach to probiotic supplements.
New studies from the University of Illinois found that adding honey to yogurt supports the survival of probiotic bacteria in the gut. The research suggests that pairing honey with yogurt is a delicious and healthy way to support digestive health and gut microbiome, with potential benefits for mood and cognition.
Beneficial bacteria like Bacillus subtilis possess memory and express genes associated with colonization and symbiosis for generations after being detached from their host. This multigenerational inheritance stabilizes interactions with their host, enabling efficient recolonization.
The team created stable microbial therapeutics using synthetic extremophiles, maintaining potency and function over time despite extreme temperatures and harsh manufacturing processes. These formulations have potential applications in healthcare, agriculture, and space exploration.
Researchers at MIT have developed a new way to make microbes hardy enough to withstand industrial processing, high temperatures, radiation, and long-term storage. The method involves mixing bacteria with food and drug additives, resulting in stable formulations that can be used in various applications.
Scientists identified Roseomonas mucosa as a beneficial bacterium that relieves eczema symptoms in adults and children. The probiotic is available over-the-counter and has shown significant improvement in eczema severity, skin barrier function, and quality of life.
A probiotic spray method has been developed to improve hatchability and health in chicks without using antibiotics. The patented method has shown an approximately 5% increase in hatchability and healthier chick quality.
Researchers in Brazil have developed bread with probiotic yeast that may help combat asthma by reducing airway inflammation and hyperresponsiveness. The bread's probiotic properties were shown to attenuate asthma symptoms in mice, suggesting potential for a new treatment approach.
Researchers at UC Davis Health discovered that mesalamine can replace good bacteria's work in fighting Candida albicans in the gut. The study found that mesalamine maintains a low oxygen environment that prevents fungal growth, reducing the risk of invasive candidiasis.
A pilot study found that targeted gut-microbiota therapy improved symptoms in almost all patients with post-infection IBS, with 38.5% achieving total remission. The treatment involved a personalised blend of antibiotics, probiotics, and prebiotics tailored to each patient's unique microbiome.
A randomized controlled trial found that co-administration of probiotic and vitamin D supplements improved MoCA scores and increased the percentage of patients with normal cognition in individuals with schizophrenia. The study suggests that probiotics may be a novel way to treat mental disorders by regulating gut microbiota.
Researchers found that probiotics in kombucha tea alter fat metabolism in worms, leading to reduced fat stores and lower triglyceride levels. This study suggests possible health benefits of kombucha for humans and informs potential use in complementary healthcare approaches.
Researchers found that synbiotics, a combination of prebiotics and paraprobiotics, improved the gut microbiome of Magellanic penguins, reducing inflammation and enhancing overall health. The study also revealed that parasynbiotics can modulate inflammatory responses in penguins.
Researchers at RIKEN found that gut bacteria, particularly Bifidobacterium, are associated with higher chances of successful milk-allergy treatment. However, only 7 out of 28 children who underwent oral immunotherapy passed the food challenge after a two-week milk avoidance period.
Researchers identified two probiotic strains that promote weight loss in obese dogs. The strains, Enterococcus faecium IDCC 2102 and Bifidobacterium lactis IDCC 4301, reduced body fat percentage and improved intestinal microflora balance in dogs fed a high-fat diet.
A new perspective paper addresses common questions and misconceptions about the postbiotic definition, which excludes microbially-produced metabolites. The authors provide further justification for the concept, clarifying its scope and implications for commercial products.
A recent study found that alterations in the human microbiome, including those in the gut, urinary, and salivary tracts, are linked to kidney stone formation. The research team discovered changes in these microbiomes were common among patients with kidney stones.
The AGA releases its first comprehensive evidence-based guideline for managing pouchitis, a complication of ulcerative colitis surgery. The guideline recommends treatment with antibiotics and multi-strain probiotics to prevent recurrent pouchitis.
Recent progress in CRISPR-Cas editing enables tailored probiotic organisms to promote gut health, support immune systems, and enhance metabolism. Genetically modified probiotics have shown potential in preventing or mitigating diseases, such as antibiotic-resistant bacteria and inflammatory bowel disease.
Scientists in Brazil have developed a method to obtain a substance similar to estrogen from soy isoflavones, which may help alleviate menopause symptoms. The researchers extracted equol from soybean oil production residue and found it to be more bioavailable than glycosylated forms.
Researchers found that probiotics can limit CRC-promoting bacteria, rebalance the microbial profile, and induce targeted cancer cell death. Postbiotics derived from probiotic bacteria have also been shown to prevent CRC by limiting tumor proliferation and modulating the balance of anti-apoptotic and pro-apoptotic factors.
A UConn researcher has patented a novel approach of spraying eggs with probiotics before they hatch, showing promise as a sustainable growth promoter for chickens. The method resulted in increased embryo weight, breast and leg muscle mass, and improved feed efficiency.
Researchers at the University of Virginia Health System have discovered how Lactobacillus, a bacterium found in fermented foods and yogurt, influences mood disorders. The findings suggest that maintaining a healthy level of Lactobacillus may help prevent depression and anxiety by regulating immune response to stress.
Scientists have identified a key genetic factor, abfA cluster, responsible for improving gut motility and alleviating constipation. The study found that Bifidobacteria longum strains with the abfA cluster can enhance arabinan utilization, leading to improved gastrointestinal transit time.
A systematic review published in the journal Virulence reveals that introducing more diverse gut bacteria can improve outcomes for people and animals infected with cryptosporidium. This may be achieved through diet, probiotics, or faecal transplant therapy.
Researchers identified two fungus strains, Cyberlindnera jadinii and Kluyveromyces lactis, with potential probiotic effects on gut inflammation. These strains may offer a new way to develop probiotics and treat inflammatory bowel diseases like Crohn's disease and ulcerative colitis.
Researchers at The University of Toledo discovered that engineered Lactobacillus paracasei can lower blood pressure in female rats by introducing human ACE2. The study provides a paradigm shift in harnessing the body's microbiome to regulate blood pressure and offers new hope for treating chronic conditions.
Recent studies suggest that probiotics may offer a protective effect against hypertension, but the exact mechanisms are unclear. A new study identifies two probiotic strains, Bifidobacterium lactis and Lactobacillus rhamnosus, as promising treatments for high blood pressure.
Researchers at Oregon State University discovered a novel strain of Paenibacillus bacteria with probiotic qualities that could help alleviate canine inflammatory bowel disease. The bacteria can digest complex carbohydrates and has antimicrobial properties, promoting anti-inflammatory immune responses in the gut.
A study found that specific proteins in breast milk correlate with the abundance of certain gut microbes in infants, potentially playing a role in early immune and metabolic development. The research suggests a regulatory function of these proteins on the immune function of the gut microbiome in humans.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
Researchers developed a platform that allows engineered biosensor bacteria to safely pass through the gastrointestinal tract in animal models. The platform enables real-time monitoring of gut health and can be used to diagnose and monitor various diseases, including inflammatory bowel disease. It has the potential to revolutionize pati...
Researchers at Brigham and Women's Hospital have designed a probiotic to suppress autoimmunity in the brain, which is at the core of several diseases including MS. The treatment offers a more precise way to target brain inflammation with reduced negative side effects compared to standard therapies.
Researchers at the University of Gothenburg have developed a new strategy for producing oxygen-tolerant probiotics, including Faecalibacterium prausnitzii, which can improve glucose control. The combination of bacteria increased biomass and butyrate production, making it safe for human consumption.
A new study estimates that dandelion greens, Jerusalem artichokes, garlic, leeks, and onions are the top five foods rich in prebiotics. These foods support gut microbes and contain high amounts of fiber, which can benefit health.
A combination of Lactobacillus acidophilus and Lacticaseibacillus rhamnosus strains successfully inhibited the production of superantigens causing toxic shock syndrome. Probiotics may also prevent growth of Staphylococcus aureus, a virulent strain that produces proteins triggering the disease.
Researchers identify genes that directly influence what we eat and find foods that can boost brain health and protect the planet. New insights into genetic basis for food preferences could help improve personalized nutrition.
A new study calls for collaborative efforts to improve probiotic manufacturing standards for preterm infants. The authors propose five action areas to optimize the safety of probiotic products, including collaboration between clinicians, pharmacies, and manufacturers.
Researchers have developed a microgel delivery system that keeps beneficial bacteria safe while actively clearing out harmful ones in the gut. In mice, this system treated intestinal inflammation without side effects and showed promise as a viable treatment strategy for intestinal diseases.
Researchers found that probiotics help preterm babies achieve a balanced gut microbiome and eradicate harmful bacteria. The study also shows that probiotic-supplemented preterm newborns have lower risk of carrying antimicrobial resistant bugs despite frequent antibiotic treatment.
A new study by researchers at Baylor College of Medicine found that an orally administered probiotic bacterial strain improved dry eye disease in an animal model. The probiotic, Limosilactobacillus reuteri DSM17938, enhanced corneal health and increased goblet cell production in the eyes, suggesting potential treatment benefits.
Researchers discovered a probiotic that can convert toxic mercury into less harmful forms, reducing neurological damage and improving iron absorption. The probiotic uses genes from a resistant bacteria to detoxify methylmercury, a neurotoxin found in fish-based diets.
A new pilot study published in JAMA Psychiatry demonstrates the potential role of probiotic supplementation in supporting mood and mental health in adults with Major Depressive Disorder. The study found significant improvements in depression and anxiety scores over an eight-week period, with notable benefits seen from week four onwards.
A new SCIVVS approach accelerates probiotics quality assessment by rapidly counting live bacteria, identifying species, and testing viability in just five hours. The method also tracks the source of individual cells in a sample, promising to transform current practice in quality control and intellectual-property protection.
A new study found that a vaccine against the deadly chytrid fungus in frogs can shift the composition of the microbiome, making frogs more resilient to future exposure. The researchers applied a non-lethal dosage of a metabolic product created by the chytrid fungus to tadpoles and observed a protective shift in the microbiome.
SourcePenn State·JournalPhilosophical Transactions of the Royal Society B Biological Sciences·TypeExperimental study·DateJun 11, 2023
The NEC Society has released a neonatal probiotics toolkit to guide clinicians in deciding whether to implement probiotics to prevent NEC. The toolkit encourages multidisciplinary teams, including NICU family advisors, to foster informed dialogue and inclusive conversations about patient-families' health.