Articles tagged with Viruses
Researchers from the University of Michigan have discovered how polyomaviruses hijack cellular molecular motors to build a portal for itself, allowing it to reach the nucleus and cause problems. The findings could aid in the development of new treatments or preventive strategies against polyomavirus diseases such as Merkel cell carcinoma.
Researchers used genome sequencing to track Zika virus spread across Brazil, discovering it was present a year before first confirmed cases. The study's findings have significant public health implications and could improve responses to future outbreaks.
A recent study led by Colorado State University researchers found that Aedes aegypti mosquitoes can transmit multiple viruses simultaneously, including Zika, chikungunya, and dengue. The findings contradict existing research on coinfections and suggest that these simultaneous transmissions may be more common than previously thought.
A recent $540,000 NASA grant will fund a team of researchers at Portland State University to study the nature of a hybrid virus discovered by Ken Stedman in a hot spring. The study aims to shed light on the evolutionary history of viruses and their ability to adapt and infect hosts.
Researchers developed custom-engineered protein destroying MERS virus in cultured human cells within 24 hours. Synthetic ubiquitin variants also target Crimean-Congo hemorrhagic fever virus, showing promise for future anti-viral medicine.
A novel compound called AV-C triggers a cell's innate antiviral system, inhibiting replication of Zika, Chikungunya, and Dengue viruses. Researchers discovered the compound through high-throughput screening, which shows potential as an antiviral immunotherapy.
Researchers analyzed rooster testes to uncover how piRNA shields germ cells from viral invaders. The study reveals a unique defense mechanism that could be adapted to combat human diseases related to viruses like avian leukosis virus, which can lead to cancer in chickens and is related to similar viruses in humans.
Researchers identified cyclic GMP-AMP synthase (cGAS) as the protein responsible for detecting viral infection, but dengue virus counteracts this by degrading cGAS. This study sheds light on a novel mechanism by which viruses evade immune detection and may inform techniques to dampen pro-inflammatory responses.
A group of giant viruses, called Klosneuviruses, were identified as acquiring components from many other viruses and proteins in an evolutionarily recent timeframe. The analysis suggests that these whopper viruses did not evolve from a cellular ancestor but rather are derived from a much smaller virus through extensive gene gain.
Researchers discovered that viral infections can break oral tolerance to dietary antigens, leading to celiac disease. The study highlights the previously unexplored connection between viral infection and immune responses in mice.
Scientists have discovered novel viruses in oceanic basement fluids, infecting microorganisms and influencing the chemical balance of oceans. The study provides insights into the origins of life and the role of viruses in shaping life on Earth.
Researchers aim to learn how to provide healthier aquatic environments for animals and plants by studying viruses in controlled aquariums. The study will explore unique relationships between fish, animals, and plants with microbes.
Researchers have discovered how viruses disable CRISPR-Cas systems, a sophisticated defense mechanism against bacterial infections. Anti-CRISPR proteins lock down the system's ability to identify and attack viral DNA, making them 'exceptionally clever' evolutionary tools.
Research finds that dengue virus transmissions are often centered in and around homes, with a high percentage of cases related to individuals living within a short distance. The study's findings could aid in developing targeted mosquito control programs and reducing severe illness.
Researchers found that most dengue virus infections occur within neighborhoods and are transmitted by the same family of mosquitoes. The study suggests that large urban centers can spread dengue diversity, which can be dispersed to other areas.
Researchers have developed a rapid-testing prototype that weighs under a pound, costs as little as $100 and can detect mosquito-borne illnesses within 30 minutes. The device uses loop-mediated isothermal amplification (LAMP) diagnostic method to test for Zika, dengue and chikungunya viruses.
A molecule naturally produced by the immune system protects mice and monkeys against Zika virus infection, reducing fetal brain damage and microcephaly. Administering 25-hydroxycholesterol to pregnant mice also protected them from Zika-induced developmental defects.
A new strain of ranivirus is causing mass mortality in amphibian populations in Serra da Estrela Natural Park, Portugal. The virus also affects fish and reptiles, complicating the situation and requiring urgent optimization of conservation strategies.
Researchers studied 19 virus families and found that cross-species transmission has played a central role in their evolution. Co-divergence is relatively rare compared to cross-species jumps.
Researchers at Penn State are investigating the collection of viruses, known as the virome, in white-footed mice and black-legged ticks to better predict infectious disease outbreaks in humans. The team aims to identify new infectious viruses in these animals before they spill over into humans.
Researchers have found a common protein involved in both sexual reproduction and viral infections, which could lead to breakthroughs in controlling parasites like malaria. The discovery reveals that the protein acts as a biochemical 'key' enabling cell fusion, and its structure is similar to that of viruses.
Researchers have successfully protected mice against Zika by injecting synthetic messenger RNA that encodes for virus proteins into the animals. The vaccine triggers an immune response and prevents viral replication in 95% of the mice.
Researchers say viral charity campaigns like the ALS Ice Bucket Challenge have a shallow 'half-life' and require a shift from extrinsic to intrinsic motivation. Dr. Sander van der Linden's SMART formula outlines social influences, moral imperatives, affective reactions, and translational impact as key psychological levers.
The journal focuses on virus evolution and publishes work that benefits science, technology, and medicine. It offers fast decision times, timely publication, and high-quality peer review with an international editorial board.
A recent study published in Alimentary Pharmacology & Therapeutics found that the 10-year incidence of liver cancer in UK patients with cirrhosis is as low as 4%. Patients with cirrhosis due to chronic viral hepatitis have the highest risk, but even then, it's lower than expected.
A recent study has provided the first details of how enteroviruses, which cause millions of infections worldwide annually, may enter the body through the intestine. The researchers used a mini-gut model to demonstrate that echovirus 11 induced significant damage to intestinal cells, facilitating passage into the bloodstream.
A small group of children with autism and moderate to severe gastrointestinal problems showed significant improvements in behavioral and gastrointestinal symptoms after receiving a fecal transplant. Parents reported positive changes that lasted at least eight weeks after treatment, while doctor-reported symptoms decreased by 22-24%.
Researchers discovered flaviviruses like Dengue and Zika use an unexpected mechanism to hijack human cell machinery, suppressing translation initiation while promoting viral protein synthesis. This finding may reveal new targets for designing antiviral therapies.
A Penn study identifies specific biological properties of HIV-1 strains that facilitate infection, including increased infectivity and resistance to interferons. This research may aid in the development of vaccines against HIV-1 by targeting these key characteristics.
A new study published in Diabetologia suggests that enterovirus infections are associated with the onset of autoimmunity in children who develop type 1 diabetes. The study found a higher incidence of enterovirus infections in children with T1D compared to control children, particularly those who developed islet autoantibodies.
Researchers analyzed genetic sequences of the virus and found specific mutations that occurred as it crossed the Pacific Ocean, suggesting new hypotheses for its association with microcephaly and GBS. The analysis also revealed potential relationships between viral infection and severe symptoms in adults and infants.
Researchers discovered a 17th-century variola virus in a child mummy, providing a more accurate timeline for the evolution of smallpox. The study suggests that smallpox may have appeared in humans more recently than previously thought, and its evolutionary history was influenced by human migration and colonization.
Biologists observed the emergence of two distinct virus species within a month-long experiment, leveraging a harmless human virus and two types of bacteria with varying receptors. This rapid process, known as speciation, was previously challenging to study due to its slow pace.
VirusDetect is a free, open-source bioinformatics pipeline that analyzes small RNA datasets to identify both known and novel viruses. Researchers can predict the presence of RNA viruses, DNA viruses, and viroids using an antiviral defense system called RNA interference (RNAi).
Highly pathogenic avian influenza A(H5N8) viruses have been reported in Europe via wild bird migration, primarily affecting poultry and wild birds. The risk of transmission to the general public is considered very low, but people handling infected birds may be at risk.
Researchers at UTMB have created a Zika virus replicon system that strips the virus of its infectious genes, reducing safety risks. This tool will aid in vaccine development and understanding viral replication and mutations.
Scientists have found that mosquitoes can carry both Zika and chikungunya viruses simultaneously, potentially infecting humans with both diseases in a single bite. The study suggests that co-infection with chikungunya may inhibit infection of Zika virus in mosquitoes, impacting the epidemiology of two mosquito-borne viruses.
Researchers developed a new laboratory system to study the deformed wing virus, showing viral antigens in all body areas, particularly in gland tissue. The discovery could lead to targeted strategies against disease-causing viruses and improve bee colony survival.
A new study reveals that an individual's birth year plays a crucial role in determining their susceptibility to specific flu strains. The research found that people born before and after 1968 have reduced risk of severe disease from novel strains within the same group.
Scientists have found that the Zika virus uses a complex molecular process to produce disease-causing small RNAs. The researchers used x-ray crystallography to understand the structure of these RNA segments, which interact with and block cellular enzymes.
A lab at Southern Methodist University is searching for a biological mechanism to intervene in the growth of virus-induced cancers. The researchers discovered that certain viruses, including human T-cell leukemia virus and high-risk human papillomaviruses, share a common mechanism to evade the immune system.
Researchers at Binghamton University are using a National Science Foundation grant to study the potential of hardware in detecting malware. By modifying a computer's central processing unit (CPU) chip, the team aims to improve malware detection and provide continuous protection without requiring significant software investment.
The discovery of the Moku virus highlights a new threat to bees worldwide, particularly honey bees that pollinate vital crops. The novel pathogen has the potential to spread globally and cause widespread harm to honey bee colonies.
Scientists created a coarse-grained model of the Cowpea Chlorotic Mottle Virus (CCMV) capsid and applied forces to it. This allowed them to see how the capsid broke apart, providing clues about its assembly process. The study reveals that weaker protein-protein contacts assemble first, followed by stronger ones.
A recent study reveals that archaic and modern humans co-diverged with a common HPV16 strain, which was then transmitted through sexual contact with Neanderthals. This ancient 'hanky panky' may have influenced the spread of STIs, explaining regional diversity in HPV16 strains.
A new study reveals that household wastewater can release disease-causing pathogens into the air during irrigation, contaminating crops. On moderately windy days, up to 89% of these pathogens were released within half an hour of soil irrigation.
Researchers used existing compounds to target the critical CHIKV protease enzyme, showing potent activity against the virus. Several compounds proved to be effective inhibitors of RNA synthesis and virus replication.
Researchers have discovered that a yeast gene called XRN1 rapidly evolves to recognize and destroy attacking viruses. This finding suggests that non-immunity proteins can play a role in viral defense. The study's results provide new insights into the genetic arms race between hosts and viruses.
Researchers have engineered a novel, virus-like shell that can self-assemble and carry therapeutic DNA or RNA into human cells. This breakthrough could advance gene therapy treatments for rare genetic diseases and common conditions like diabetes.
Researchers have cataloged 15,222 genetically distinct viruses and grouped them into 867 clusters, revealing their role in nature. The study could lead to ways to fine-tune viruses to sink carbon into the deep ocean, a potential strategy for managing climate change.
Researchers Tim Stasevich and Brian Munsky are using sensitive microscopes and computational analysis to quantify protein expression in single cells. They aim to illuminate the hijacking of host cells by viruses, a process never before seen.
Researchers found that female Aedes aegypti mosquitoes can pass the Zika virus to their eggs and offspring. This discovery highlights the importance of using larvicides to curb the spread of the virus. The study suggests that controlling adult mosquitoes may not be enough to eliminate the virus.
Scientists have identified a new multicomponent virus called Guaico Culex virus (GCXV) that can infect animals but not mammals. The discovery highlights the diversity of host ranges among viruses and underscores the need for continued research to better prepare for emerging diseases.
A new study suggests that cancer in sub-Saharan Africa is linked to malaria and Epstein-Barr virus, particularly in children born to mothers with malaria during pregnancy. This increased risk of infection may lead to early exposure and a weakened immune system, making it harder for the body to manage the virus.
Researchers at OIST Graduate University have developed an efficient approach to study ribozyme mutants, revealing key findings about the structure and properties of these RNA molecules. The study found that ribozymes are highly robust against mutations, potentially explaining their widespread presence across different forms of life.
Researchers at Australian National University predict that a warmer climate could lead to a decrease in dengue transmission in certain regions, such as northeast Australia. This finding is relevant to other mosquito-borne viruses like Zika, and highlights the need for continued monitoring of global health impacts.
A new virus, largemouth bass reovirus, has been discovered in association with a 2015 fish kill in Pine Lake, Wisconsin. The virus is a distant relative of known pathogens and makes the species a key suspect in fish mortality.
A research group at Osaka University has clarified the molecular mechanism behind inducing germinal-center B cells to differentiate into memory B cells, a crucial step in creating effective vaccines. This breakthrough reveals that lower-affinity maturation of antigens is key to memory B cell differentiation.
A study reveals that viruses have driven protein adaptation in humans and other mammals, with 30% of all protein adaptations since humans' divergence from chimpanzees being influenced by viruses. This discovery sheds light on the impact of viruses on cellular machinery and could lead to new therapeutic leads against viral threats.
Scientists discover that chewed plants by mountain gorillas can be used to test for viruses, providing a simple way to monitor the health of endangered apes. The new non-invasive method is effective for detecting both RNA and DNA viruses and has implications for conservation management.