Articles tagged with Expression Cloning
Researchers have developed fresh tomatoes with improved stress tolerance and elongated fruit shapes, suitable for mechanized harvesting. The study identified the FS8.1 gene responsible for this trait, which promotes cell proliferation in the ovary wall, resulting in longer fruit shapes.
A team of researchers at IISc has designed a small molecular fluorogenic probe that can sense Acetylcholinesterase (AChE), an enzyme linked to the progression of Alzheimer's disease. The probe is designed to detect AChE levels in the early stages of the disease, which become imbalanced.
Researchers found that Merkel cell carcinoma (MCC) Glypican-3 (GPC3) is expressed in nearly 70% of MCC tumors and up to 90% of MCPyV-negative cases. GPC3 expression is associated with worse prognosis, including increased risk of death from MCC. This makes GPC3 a promising target for chimeric antigen receptor T cell therapy.
The study found that API-5 is overexpressed in chemoresistant TNBC, associated with increased micro-vessel density and enhanced cell survival. A peptide targeting API-5 shows promise as an innovative treatment option for this aggressive cancer type.
Researchers found that API-5 was overexpressed in endothelial cells of patients with chemoresistant TNBC, associated with increased micro-vessel density. API-5 promotes cell survival and cancer growth by inhibiting apoptosis.
A Korean research team at KAIST has developed a powerful strategy for developing high-performance microbial cell factories by employing synthetic small RNAs. This approach allows for rapid identification of multiple genes to be attenuated in multiple strains simultaneously, making it easier to find the best platform strain.
Researchers at Penn's School of Veterinary Medicine found that a specific gene, Oct4, plays a crucial role in the viability of cloned embryos. Only 34% of embryonic cells correctly reprogrammed to express Oct4, and just 10% showed levels of expression conducive to further development.
Gene expression is found to be highly variable in cloned mice, with imprinted genes showing widespread aberrant regulation. This variability may contribute to the large offspring and respiratory problems commonly seen in clones.