Articles tagged with Multiple Sclerosis
The Consortium of Multiple Sclerosis Centers released a new 2025 Best Practices Update to help healthcare providers stay up-to-date with the latest advances in MS care. The document addresses evolving disease classification, additional disease-modifying therapies, and newer biomarkers to detect changes in disease progression.
University of Cincinnati researchers, in collaboration with end users, develop a user-centered, easy-to-use assistive device to help restore hand grasping motions. The team aims to combine an exoskeleton device with functional electrical stimulation (FES) technology to create a hybrid system.
A phase 3 trial demonstrated a 31% delay in confirmed disability progression in patients with non-relapsing secondary progressive multiple sclerosis. Tolebrutinib, an oral Bruton's tyrosine kinase inhibitor, showed promise as a potential treatment option for this form of the disease.
Neuro-immunologist Stephen Hauser has won the 2025 Breakthrough Prize in Life Sciences for his role in identifying the immune system's primary driver of damage to nerve cells in multiple sclerosis. His B-cell theory has led to the development of therapies that have transformed treatment, reducing relapses and improving prognosis.
A new AI tool called MindGlide can extract key information from brain images to measure damaged areas and highlight subtle changes in MS patients. The tool performed better than other AI tools and expert clinical analysis, enabling researchers to unlock valuable insights into multiple sclerosis.
Scientists have long believed that cells respond to stress in a linear chain of events, but a new study reveals a more complex 'split-integrated stress response' that can be fine-tuned depending on the type and intensity of stress. This flexibility could lead to new targets for treating cancer and neurodegenerative diseases.
Dr. Amit Bar-Or is awarded the 2025 John Dystel Prize for his contributions to neuroimmunology and precision medicine in multiple sclerosis research. His work has led to significant advancements in disease mechanisms, treatment approaches, and biomarker studies.
A new gamified mobile health app, More Stamina, has been shown to effectively manage MS-related fatigue by helping users track their daily activities and energy expenditure. The study found that the app facilitated conversations between MS patients and their families, improving understanding and support.
Scientists at the University of South Australia have developed a phospholipid complex to improve cannabidiol's effectiveness in treating epilepsy, multiple sclerosis, and other neurodegenerative diseases. The new formula increases cannabidiol's solubility by up to six times and improves its absorption in the gastrointestinal tract.
A new study published in Multiple Sclerosis and Related Disorders highlights the potential of a gamified mobile health app to help people with Multiple Sclerosis (MS) manage fatigue. The app, More Stamina, uses a gamified approach to visualize energy use and facilitate discussions with family members and healthcare providers.
Research finds that certain viral antibodies and genetic risk factors can increase MS risk, with elevated antibody levels combined with a specific gene variant associated with strong increased risk. The study also identifies potential biomarkers for early diagnosis.
A preliminary study found that a simple algorithm can rapidly increase the use of newer, more effective treatments for MS among all three groups, greatly improving health. The algorithm matches people to treatments based on clinical factors like weakness and bladder dysfunction, as well as social factors.
Researchers at the National Institutes of Health (NIH) have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. The findings provide insight into early disease state changes and could help identify potential targets for MS treatments and brain tissue repair.
A high dietary intake of lean and oily fish may slow the progression of disability in people with MS, according to a comparative population-based study. The anti-inflammatory and neuroprotective properties of nutrients found in fish may be key to managing the disease.
The CMSC Annual Meeting brings together experts to share cutting-edge research and innovative treatment approaches. Healthcare professionals can earn continuing education credits while expanding their expertise in MS care.
In Finland, MS treatment has undergone significant changes over the past decade, with diagnoses now made within five months of symptoms onset. New, highly effective treatments have become the standard first-line treatment, improving patient outcomes and quality of life.
A new sponge-like implant helps guide a treatment that slows or stops a degenerative condition similar to multiple sclerosis. The implant attracted diseased immune cells, enabling researchers to study and target them with a nanoparticle-based treatment, which prevented mice from developing symptoms such as paralysis if administered early.
A comprehensive review published in Brain Medicine maps out the extensive influence of reproductive hormones on neurological health and disease. The study examines how sex hormones affect a broad spectrum of neurological conditions, including vascular disorders, movement disorders, epilepsy, multiple sclerosis, and Alzheimer's disease.
Researchers at UCF aim to create mobile robotic assistants that offer easier control and a better robot-human interface. The project, supported by a $600,000 grant, will focus on testing and user feedback, with initial trials conducted with students and adults with upper body paralysis.
A rare case report highlights the association between systemic mastocytosis and severe osteoporosis in a young adult patient, emphasizing the importance of early diagnosis and consideration of SM as an underlying cause. The study aims to raise awareness about this underrecognized condition and its potential impact on bone health.
A study published by the American Academy of Neurology found that children with multiple sclerosis who had at least 30 minutes of daily summer sun in their first year of life were less likely to experience relapses. The study also showed that maternal sun exposure during pregnancy was associated with a lower risk of MS relapse for offs...
Dr. Mikael Simons is being recognized for his pioneering research on myelin biology, glial cell biology, and neuroinflammation that continues to inform MS research. His work has helped identify a promising therapeutic target with potential to benefit people with MS.
Researchers found that pregnant people with multiple sclerosis (MS) have a higher chance of experiencing mental illness during their pregnancy and in the first years after giving birth. Mental illnesses included anxiety, depression, bipolar disorder, psychosis, suicide attempts and substance abuse.
A new study found that people with multiple sclerosis experience a significantly higher risk of perinatal mental illness compared to those with other chronic conditions. Depression and anxiety were the most common conditions reported, with half of people with MS living with a mental illness in the first year postpartum.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
A new study by UCSF found that menopause increases the rate of MS progression in women, particularly in walking speed and fine motor skills. The study also suggests that hormone therapy may be beneficial in slowing disease progression, with some participants showing a lower rate of relapse during pregnancy.
A study by the American Academy of Neurology found no association between COVID-19 infections and worsening multiple sclerosis (MS) symptoms or disability. Researchers followed 2,132 adults with MS over 18 months and found similar increases in symptom severity for those with and without COVID-19 infection.
Researchers found that neuroinflammation in the hippocampus significantly alters motivation and behaviour in mice, particularly in females. This study suggests that treatments targeting hippocampal neuroinflammation could help reduce cognitive and behavioural symptoms in diseases such as Alzheimer's and Depression.
Pregnant women with MS receiving disease-modifying therapies show increased risk of low birth weight and serious infections. Exposure to S1P modulators, natalizumab, and anti-CD20 antibodies is particularly concerning.
EBViously aims to prevent infectious mononucleosis and secondary diseases such as ME/CFS, while also protecting against certain types of cancer. The company's innovative vaccine candidate uses virus-like particles derived from EBV to trigger a targeted immune response.
Research published online in Journal of Neurology Neurosurgery & Psychiatry found that cutting early life exposure to parental smoking may lower the risk of developing MS in those who are genetically predisposed. The study also showed an interplay between genetic and environmental risk factors for MS, associated with certain aspects of...
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
Scientists have created a living cell therapy that can navigate to specific organs using a
A study published in Neurology found that children with multiple sclerosis from disadvantaged neighborhoods had greater brain inflammation and tissue loss. Social factors such as public health insurance, race, and parental education level were associated with worse MS outcomes.
A new study found that fampridine can improve working memory in individuals with reduced cognitive function, particularly those with low baseline working memory levels. The drug increased brain excitability and enabled faster processing of stimuli.
Dr. Yael Goverover joins an elite group of professionals at Kessler Foundation who have earned the Fellow of ACRM designation for their nationally significant contributions to cognitive rehabilitation research for individuals with multiple sclerosis and acquired brain injury. Her work has led to innovative assessments and interventions...
Healthy mice swing their tails actively to counterbalance tilts, producing significant angular momentum. This study provides a new experimental setup for assessing mouse balance and improves understanding of neurological mechanisms behind balance issues.
Researchers at Case Western Reserve University are studying a new approach to treat multiple sclerosis, focusing on toxic astrocytes that contribute to nerve-cell damage. They aim to develop medicines that prevent the formation of these cells and promote brain repair.
Silvana Lopes Costa, PhD, of Kessler Foundation has received the Women in Neurodegenerative Disease Rehabilitation Science Award for her groundbreaking research on multiple sclerosis and cognitive assessment. Her work aims to improve quality of life among individuals with neurological conditions through innovative rehabilitation science.
A new study suggests that a keto diet rich in ketone bodies may help alleviate symptoms of multiple sclerosis and other autoimmune disorders. The diet promotes the production of indole lactic acid, which blocks the activation of immune cells responsible for these conditions.
Researchers found that specific enzymes in neurons mediate the toxicity of diets rich in palm oil, leading to mitochondrial damage and neurodegeneration. Inactivating these enzymes provides neuroprotection, suggesting a potential pathway for slowing diet-induced symptom severity in MS patients.
Scientists discovered that fragments of immune-stimulating proteins, called guardian peptides, are produced by the brain and spinal cord to maintain a healthy balance between defending against injury and infection and guarding healthy tissue. These peptides activate regulatory T cells to dampen abnormal immune reactions.
Researchers have unveiled a complex interplay between liver X and thyroid hormone receptors that regulates critical brain functions and protects against neurodegeneration. LXRs play a crucial role in regulating thyroid hormone function in the brain, while both receptors are essential for normal brain development and maintenance.
Scientists have discovered a natural compound called sulfuretin that can halt the progression of certain forms of cancer and demyelinating conditions like multiple sclerosis. The study found that sulfuretin blocks the activity of an enzyme involved in these diseases, suggesting its potential as a treatment.
Researchers have identified specific human endogenous retrovirus sequences associated with increased risk of neurodegenerative diseases, including multiple sclerosis and amyotrophic lateral sclerosis. The study suggests that these viral elements contribute to disease susceptibility by influencing brain function.
Scientists have identified a key driver of brain inflammation in neurological diseases, proposing a new treatment approach by neutralizing fibrin. This protein, involved in blood coagulation, triggers neurologic diseases by hijacking the immune system, resulting in damaged neurons.
A University of Michigan-led study found that treatment with either modafinil or cognitive behavioral therapy alone was associated with significant reductions in fatigue over 12 weeks. A combination of both treatments worked as well as each individual treatment but did not result in better fatigue scores.
A new study found an association between some types of cancer and multiple sclerosis (MS), with people with MS having a 6% increased risk of developing any type of cancer. The study identified higher risks for bladder, brain, and cervical cancers, but lower risks for prostate, colorectal, and breast cancers.
A study of identical twins found that CD8-positive T cells play a key role in the early stages of multiple sclerosis. The researchers discovered that these cells exhibit increased migration ability, promote inflammation and show activation markers, suggesting they are already embarking on their journey to the central nervous system. Th...
A new study explores a promising combined therapy for multiple sclerosis, using tolerogenic dendritic cells modified with myelin antigens. Researchers found that these cells from patients have a persistent pro-inflammatory signature, making them less effective compared to those derived from healthy individuals.
Researchers developed a new combined therapy for multiple sclerosis, combining tolerogenic dendritic cells with Dimethyl Fumarate to restore immune balance. The treatment showed promise in preclinical studies, reducing symptoms in mice and potentially offering hope for patients worldwide.
A new study found that people taking certain medications for primary progressive multiple sclerosis (MS) do not experience a slower rate of disability progression compared to those not receiving treatment. The study, published in Neurology, suggests that anti-CD20 therapies may not be effective in slowing disability progression.
A pioneering study identified critical biomarkers that can predict disability worsening in MS. Elevated serum neurofilament light chain and serum glial fibrillary acidic protein levels correlate with progression independent of relapse activity, guiding personalized treatment approaches.
Researchers at the Plasticity and Remodeling of Neural Circuits laboratory aim to stimulate myelin plasticity to regenerate affected nerve fibers in MS patients. The team will explore gene therapy, pharmacological approaches, and rehabilitation strategies to enhance myelin repair.
A study by Amber Salter found that people with multiple sclerosis (MS) who have comorbidities experience worsened disease activity. The research highlights the importance of addressing comorbidities in MS treatment.
A recent study found significant therapeutic inertia in the treatment of women with multiple sclerosis (MS), leading to delayed or reduced use of disease-modifying treatments. The research highlights gender disparities that could impact long-term health outcomes for women of childbearing age, particularly due to concerns about pregnanc...
A landmark study has identified novel ancestry-specific genetic variants linked to multiple sclerosis (MS) risk, offering new insights for treatment approaches. The research highlights the potential of ancestry-informed genetic studies to uncover previously unidentified risk factors for MS.
A new study presented at ECTRIMS 2024 reveals that initiating monoclonal antibody therapy during childhood can lead to improved long-term outcomes for children with MS. The research showed a substantially lower risk of progressing to higher disability levels in the early treatment group, particularly in moderate disability range.
A new study published in The FEBS Journal found that protein C1QL1 plays a crucial role in promoting the replacement of specialized cells responsible for producing myelin. This discovery could lead to novel therapies for demyelinating diseases like multiple sclerosis.
Researchers at Kessler Foundation develop a new clinical protocol to improve learning and memory in individuals with multiple sclerosis who have mobility disability. The study combines aerobic exercise with virtual reality and cognitive rehabilitation, showing potential synergistic effects on cognitive improvements.