Articles tagged with Multiple Sclerosis
FutureNeuro, a leading SFI Research Centre, is expanding its research programme with a focus on diagnostics, therapeutics, and digital health. The centre aims to develop precision diagnostics, future treatments, and systems using real-time health data.
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
Researchers have discovered a small molecule compound called ESI1 that can regenerate vital myelin coatings, potentially treating multiple sclerosis and age-related cognitive deficits. The treatment promotes healing by clearing a roadblock in the repair process, allowing oligodendrocytes to produce myelin sheaths.
Alexander Gow is studying the disease's effects on oligodendrocytes to provide new insight into the development and origins of MS. He aims to develop improved treatments by identifying a protein called Trb3 that may be a good drug target for the disease.
A study published by the American Academy of Neurology found that immigrants to Canada who spend a greater proportion of their lives in the country have a higher risk of developing multiple sclerosis. The study involved 1.5 million immigrants and found that those who spent 70% of their lives in Canada were 38% more likely to develop MS.
Researchers found that older adults tend to conserve energy by modifying their movements under certain circumstances. The findings suggest that the effort costs of reaching are a determining factor in slowing movement with age. This research may lead to new tools for diagnosing diseases, including Parkinson's and multiple sclerosis.
A new study from Brigham and Women's Hospital suggests that PET brain scans can detect hidden inflammation in MS patients who are being treated with highly-effective treatments. The findings indicate that smoldering inflammation may linger in patients, driving disease progression and symptoms.
Researchers have identified CAR-T cell therapy as a potential treatment for autoimmune diseases such as rheumatoid arthritis, SLE, and type 1 Diabetes Mellitus. Early studies have shown promising results in reducing disease activity and improving patients' quality of life, but long-term data on safety and efficacy is limited.
Researchers identified a unique autoantibody signature in approximately 10% of patients with MS, appearing years before symptom onset. This finding could revolutionize patient care and treatment strategies for multiple sclerosis.
Scientists have identified a consistent signature of multiple sclerosis in the blood of patients years before they develop symptoms. The discovery, published in Nature Medicine, could lead to earlier diagnosis and treatment of the disease, affecting nearly 1 million people in the US.
Researchers used fitness trackers and smartphone data from 55 MS patients and 24 controls to identify clinically useful information. Data on physical activity, heart rate variability, and phone usage revealed relationships between disease severity, fatigue levels, and motor function.
A new study by Kessler Foundation scientist Glenn Wylie will independently investigate brain networks associated with 'state' fatigue in MS. The research aims to validate 'state' measures of fatigue and offer a more accurate assessment of primary fatigue, potentially improving the quality of life for individuals living with MS.
A team of researchers at Trinity College Dublin has developed a new blood test that measures the immune response to Epstein Barr Virus (EBV), which is the leading risk factor for multiple sclerosis (MS). The study found that people with MS have a higher immune response to EBNA-1, a part of the EBV, compared to those without MS.
Researchers have identified three distinct immunological endophenotypes of multiple sclerosis, defined by specific blood immune signatures. These findings could lead to more effective and tailored treatment strategies for patients with the disease.
Dr. Rhonda Voskuhl's groundbreaking research has shed light on the mechanisms underlying sex differences in MS, highlighting a gene on female sex chromosomes that promotes inflammation and brain-protective effects of estrogen. Her work may lead to new treatment approaches for MS.
Researchers discovered that mature oligodendrocytes, critical for brain function, can survive for up to 45 days after a fatal trauma, defying the classical programmed cell-death pathway. This finding opens new avenues for understanding and potentially preventing damage caused by aging and neurodegenerative diseases.
A UK study found that individuals with multiple sclerosis had a seven times greater risk of hospitalization and a four-fold increased risk of dying from COVID-19, even after repeated doses of vaccines. Vaccination alone may not adequately protect this vulnerable population, highlighting the need for additional preventive measures.
A study found that children and adolescents with obesity are at a significantly higher risk of developing multiple sclerosis, with the risk being more than two-fold. The study also suggests that the persistent low-grade inflammatory state associated with obesity may be mediating this association.
A team of researchers has developed the world's first 3D-printed brain phantom, which can be imaged using dMRI. The brain model is made up of microchannels that mimic nerve cells in the brain, allowing for more accurate analysis and research into neurodegenerative diseases.
Scientists at Karolinska Institutet and Stockholm University have mapped the cellular architecture of MS lesions using advanced methodology. This reveals how immune cells and glial cells interact in the disease.
Researchers found that ageing reduces the ability of regulatory T cells to enhance myelin regeneration, which can have profound consequences for neurological functions. The study suggests that the loss of function may be reversible, and two new molecules, ITGA2 and MCAM, have been identified as potential therapeutic targets.
Researchers at Brigham and Women's Hospital discovered that astrocytes, non-immune cells, can develop aspects of immune memory. This epigenetic memory promotes CNS pathology in autoimmune inflammation, including chronic neurologic disorders like multiple sclerosis.
A new study found that infants exposed to monoclonal antibodies for multiple sclerosis through breastfeeding experienced no negative effects on health or development within the first three years of life. The research used data from 183 infants born to mothers taking these medications while breastfeeding, and compared them to another gr...
Researchers have developed a genetic risk tool that combines genetic factors with demographic information to improve MS risk prediction in young people presenting with optic neuritis. The study shows that this approach can help identify patients at high risk of MS, potentially enabling earlier treatment and improving long-term health.
Scientists studied clusters of immune cells called microglia in normal-appearing white matter to understand their role in Multiple Sclerosis. They found that these nodules are associated with worsened pathology, more lesions, and inflammation, and may be activated by oxidized lipids.
Researchers have discovered a previously unknown mechanism behind immune tolerance, where B cells teach T cells to ignore the body's own proteins. This failure can lead to autoimmune diseases such as Multiple Sclerosis-like Neuromyelitis optica.
Researchers at ETH Zurich have developed a new magnetic resonance imaging (MRI) procedure that maps the condition of myelin sheaths in the central nervous system more accurately. This breakthrough technology has the potential to facilitate early MS diagnosis and monitoring, as well as the development of new drugs for the disease.
A new computational biology tool has analyzed the complex biological networks of multiple sclerosis patients, revealing relationships between genes, proteins, cells, brain function, and behavior. The study identified correlations between protein MK03 and immune system cell counts, retinal nerve fiber thickness, and gait test results.
A study published in Lancet eClinical Health found pregnancy outcomes for pregnant individuals with autoimmune disease vary greatly depending on the specific condition and individual factors. Research highlights the importance of considering comorbidities when discussing autoimmune disease and pregnancy.
A team of neuroscientists has discovered that oligodendrocytes, myelin-forming cells, accelerate glucose consumption to deliver energy-rich molecules to rapidly firing axons. This communication is mediated by potassium signals and maintains axonal health.
A new study published in Neurology found that young Black and Hispanic women with multiple sclerosis face greater challenges in pregnancy, have more advanced disease, and experience higher inflammation levels, which may signal MS progression. The researchers also noted disparities in healthcare access and treatment.
A new study will compare the effects of a single bout of cycling alone to two different cycling experiences enhanced with VR technology. The goal is to uncover the relationship between sensory demand and acute improvements in processing speed, informing future research on exercise training for long-term benefits.
A Kessler Foundation researcher will examine the impact of social determinants on brain health and MS outcomes in Latinos. The study aims to improve healthcare access and quality for this minoritized group.
Researchers discovered that a little-understood synapse in the brain plays a pivotal role in producing myelin, the protective sheath around nerve cells. This finding could lead to new therapies for multiple sclerosis, neurodegenerative conditions and brain cancer.
A large-scale ancient human gene bank analysis revealed that genetic variants increasing MS risk were introduced by sheep and cattle herders 5,000 years ago. This finding explains the North-South Gradient of MS prevalence in Europe.
Research from Michigan Medicine found that widespread pain with nociplastic features can make physical activity challenging for patients with multiple sclerosis. The study suggests tailoring exercise plans to individual needs by considering underlying pain mechanisms, aiming to maintain functional independence and reduce pain intensity.
A combination of 11 proteins can predict long-term disability outcomes in multiple sclerosis, making it possible to tailor treatments to individual patients. The study identified a specific protein, neurofilament light chain, as a reliable biomarker for disease activity.
Researchers from UTHealth Houston discovered that Epstein-Barr virus (EBV)-specific T-cells are present in high numbers in the cerebrospinal fluid of people with multiple sclerosis at its earliest stages. The study suggests that these cells may be contributing to the disease's pathogenesis.
Women with autoimmune disease are 30% more likely to experience perinatal depression, while those with perinatal depression have a 30% higher risk of developing an autoimmune disease. The strongest association is seen with multiple sclerosis.
Researchers investigated cognitive fatigue across multiple sclerosis, traumatic brain injury, and controls using two tasks, finding that fatigue was consistent across participants regardless of task. Cognitive fatigue correlated with longer response times and activation in the caudate nucleus and thalamus.
A study by researchers at the Medical University of Vienna found that natural killer cells may play a crucial role in protecting against multiple sclerosis (MS) disease. The investigation revealed that strong EBV-specific and autoreactive immune responses combined with poor autoimmunity control increase MS risk.
Researchers at Sanford Burnham Prebys identified a molecular signaling pathway that could enhance current MS treatments by linking vitamin B12 deficiency to MS. The study found that supplementing with brain-targeted B12 formulations may improve drug efficacy for this class of medicines.
A small molecule drug compound has shown promise in treating multiple sclerosis by targeting the glutamate system, reducing MS-like symptoms and repairing damaged myelin. The results come from a CAMH-led pre-clinical study published in Science Advances.
Multiple sclerosis affects over 2.8 million worldwide, and EU funding will investigate viral infections like EBV as potential causes and co-factors. The BEHIND-MS consortium aims to develop new cell models to test hypotheses on the disease's development.
A new study found that people with multiple sclerosis (MS) are more likely to have depression, constipation, and urinary tract infections five years before their diagnosis. These conditions were also more common in those with other autoimmune diseases like lupus and Crohn's disease.
A clinical trial of stem cell therapy in patients with secondary progressive multiple sclerosis has shown a long-lasting effect that appears to protect the brain from further damage. The study found no signs of disease progression and a substantial stability of the disease without worsening of symptoms.
A novel robotic system developed by USC researchers can help clinicians accurately assess a patient's rehabilitation progress. The method generates an 'arm nonuse' metric using machine learning and a socially assistive robot to track how much a patient is using their weaker arm spontaneously.
Researchers at Oregon Health & Science University found that a low-fat diet significantly improved fatigue levels in patients with MS. The study, published in the Multiple Sclerosis Journal, suggests that diet alone can improve concentration and quality of life for patients with MS.
The PhRMA Foundation awarded two $500,000 Frontier Awards to researchers William Padula and Surachat Ngorsuraches for their patient-centered value assessment models. Their studies will advance the field of value assessment by applying theoretical models in a real-world context and engaging with patients to ensure their voices are inclu...
Researchers found that patients with elevated NfL levels had a 91% higher risk of worsening disability with relapse within a year, and a 49% higher risk without relapse nearly two years later. The study suggests that interventions may prevent worsening symptoms by targeting nerve cell death.
A phase 3 trial found that an internet-delivered cognitive behavioral therapy program significantly reduced depressive symptoms in patients with multiple sclerosis. The online program, modified for MS, led to a large drop in depressive symptoms compared to a control group.
The study found that premorbid income and education levels correlated with disability and symptom severity in multiple sclerosis, regardless of treatment. Socioeconomic status may reflect both structural and individual determinants of health in MS.
A new study from the University of British Columbia suggests that people with multiple sclerosis are nearly twice as likely to experience mental illness before symptoms appear. The research found higher rates of psychiatric conditions in patients with MS compared to the general population.
Researchers launch EU-funded initiative to uncover EBV's role in MS, aiming to find underlying mechanism and develop antiviral treatments. The project seeks to improve disease course or stop progression, with potential for preventive strategies like vaccination.
A study published by UCI researchers found that N-acetylglucosamine reduced multiple inflammation and neurodegeneration markers in patients with Multiple Sclerosis. The dietary supplement also improved neurological function in 30% of patients, suggesting a potential new treatment for the condition.
A study published by the American Academy of Neurology found that nearly one in five people on Medicare travel 50 or more miles to see a neurologist, indicating significant access barriers for individuals with chronic neurologic conditions. The research also revealed that people living in areas with fewer neurologists and rural residen...
A three-year grant from the National Multiple Sclerosis Society will fund Dr. Carly Wender's study on maximizing learning and memory function in individuals with MS. The COMBINE intervention combines cognitive rehabilitation technique KF-mSMT with innovative exercise training to improve new learning and memory.
Researchers at Pritzker Molecular Engineering have developed an 'inverse vaccine' that can eliminate autoimmune reactions associated with multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. The vaccine works by removing the immune system's memory of a molecule, allowing it to tolerate healthy tissues.
A novel mouse model confirms HERV-W's role in MS, showing damage to white matter and weakening of regeneration capacity. Antibody Temelimab neutralizes HERV-W, reducing neurodegeneration and activating microglial cells.
Scientists at CeMM and Max Perutz Labs have reclassified approximately 200 rare immune system disorders using a network-based approach. The study reveals strong similarities between rare diseases and autoimmune conditions, enabling the prediction of treatment efficacy and personalized approaches for diagnosis and treatment.