Articles tagged with Multiple Sclerosis
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A phase 3 trial found that an internet-delivered cognitive behavioral therapy program significantly reduced depressive symptoms in patients with multiple sclerosis. The online program, modified for MS, led to a large drop in depressive symptoms compared to a control group.
The study found that premorbid income and education levels correlated with disability and symptom severity in multiple sclerosis, regardless of treatment. Socioeconomic status may reflect both structural and individual determinants of health in MS.
A new study from the University of British Columbia suggests that people with multiple sclerosis are nearly twice as likely to experience mental illness before symptoms appear. The research found higher rates of psychiatric conditions in patients with MS compared to the general population.
Researchers launch EU-funded initiative to uncover EBV's role in MS, aiming to find underlying mechanism and develop antiviral treatments. The project seeks to improve disease course or stop progression, with potential for preventive strategies like vaccination.
A study published by UCI researchers found that N-acetylglucosamine reduced multiple inflammation and neurodegeneration markers in patients with Multiple Sclerosis. The dietary supplement also improved neurological function in 30% of patients, suggesting a potential new treatment for the condition.
A study published by the American Academy of Neurology found that nearly one in five people on Medicare travel 50 or more miles to see a neurologist, indicating significant access barriers for individuals with chronic neurologic conditions. The research also revealed that people living in areas with fewer neurologists and rural residen...
A three-year grant from the National Multiple Sclerosis Society will fund Dr. Carly Wender's study on maximizing learning and memory function in individuals with MS. The COMBINE intervention combines cognitive rehabilitation technique KF-mSMT with innovative exercise training to improve new learning and memory.
Researchers at Pritzker Molecular Engineering have developed an 'inverse vaccine' that can eliminate autoimmune reactions associated with multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. The vaccine works by removing the immune system's memory of a molecule, allowing it to tolerate healthy tissues.
A novel mouse model confirms HERV-W's role in MS, showing damage to white matter and weakening of regeneration capacity. Antibody Temelimab neutralizes HERV-W, reducing neurodegeneration and activating microglial cells.
Scientists at CeMM and Max Perutz Labs have reclassified approximately 200 rare immune system disorders using a network-based approach. The study reveals strong similarities between rare diseases and autoimmune conditions, enabling the prediction of treatment efficacy and personalized approaches for diagnosis and treatment.
Researchers at Brigham and Women's Hospital linked MS brain lesions to memory problems by mapping white matter lesion locations in people with MS. The study found that lesions intersecting with a previously derived memory circuit centered on the hippocampus were associated with memory issues.
Scientists discover unique immune cells in skull's bone marrow, facilitating movement of immune cells between brain and skull, offering new possibilities for diagnosing and treating neurological diseases. Non-invasive skull imaging may enable early detection and monitoring of conditions like Alzheimer's and stroke.
Researchers at Brigham and Women's Hospital have designed a probiotic to suppress autoimmunity in the brain, which is at the core of several diseases including MS. The treatment offers a more precise way to target brain inflammation with reduced negative side effects compared to standard therapies.
A recent study published in Multiple Sclerosis and Related Disorders found that higher daily physical activity is associated with lower levels of fatigue in patients with relapsing-remitting multiple sclerosis. The study also suggests that maintaining functional capacity through suitable exercise can help reduce fatigue, improving the ...
A study of 1,300 patients has identified a specific antibody, MOG-IgA, which may differentiate another MS-like illness from others. This discovery could lead to better understanding of the causes and treatment of these autoimmune diseases.
Researchers developed a blood test to detect nerve injury in MS and found it works for children, even when symptom-free. The test measures neurofilament light chain levels, which reflect nerve cell injury.
A recent study published in Neurology suggests that starting treatment for multiple sclerosis (MS) soon after the first signs of the disease may lead to a lower risk of disability later. Researchers found that patients who received treatment within six months of symptom onset had a significantly lower risk of developing severe disabili...
A study published in JAMA Neurology found that oral medications surpassed injectable therapies as the preferred treatment for multiple sclerosis patients in the US. Oral therapies rose sharply after their introduction in 2010 and became the predominant treatment by 2020.
A mouse model of multiple sclerosis reveals evidence of inflammatory gene expression spilling over from the brain's barrier to grey matter. The study uses spatial transcriptomics to show a gradient of immune genes and inflammatory markers from meninges to surrounding brain tissue.
Researchers have confirmed that measuring retinal layer thickness can significantly improve MS diagnosis and predict progression. The study found a strong correlation between retinal damage and brain damage, paving the way for earlier treatment and better patient outcomes.
An international consortium, led by Charité – Universitätsmedizin Berlin, is developing an AI-supported online platform to predict the course of multiple sclerosis (MS) on an individual basis. The project aims to make treatment more tailored and effective for specific patients.
New research suggests that myelin can harm axons in people with multiple sclerosis, even when it's intact. Oligodendrocytes support the energy metabolism of axons, which rely on undamaged myelin for nutrients.
Scientists have discovered a genetic variant associated with faster MS progression, which can rob patients of mobility and independence. The breakthrough finding could pave the way for treatments that prevent disease accumulation and improve resilience in the nervous system.
A study of over 22,000 people with MS discovered the first genetic variant associated with faster disease progression, which can rob patients of mobility and independence. Understanding this variant will hopefully pave the way for new treatments that can prevent disease progression.
A large international collaboration has identified a genetic variant associated with faster disease progression in multiple sclerosis, highlighting the need to focus on nervous system resilience and repair. The study found that individuals with two copies of the gene variant experience accelerated disability due to MS.
Researchers discovered a genetic variant associated with faster disease progression in multiple sclerosis, linked to years of disability. The study provides new leads on addressing the nervous system component of MS and developing effective treatments.
A new study investigates the safety of discontinuing disease-modifying therapies for multiple sclerosis patients over 55, finding low risk of new clinical activity but unclear benefits. The study suggests that some older patients may consider a personal trial of discontinuation due to the low risk of recurrence.
Researchers at UCLA Health have discovered that estriol, a pregnancy hormone, can repair damaged myelin in the brain's cortex of mice with multiple sclerosis. This finding offers hope for developing new treatments to address the disease's progression.
Research identifies beneficial changes in immune system during pregnancy, which can lead to new treatment strategies for MS. Women with MS experience a 70% decrease in relapses during the last third of pregnancy, possibly due to epigenetic changes and hormone regulation.
Researchers have developed a technique to measure the effectiveness of clemastine in repairing myelin, allowing for future therapies to be assessed. Patients with MS treated with clemastine experienced modest increases in myelin water, indicating myelin repair.
Researchers at Gladstone Institutes discovered that blood leaking into the brain triggers toxic genes in microglia, turning them into harmful cells that destroy neurons. Fibrin, a blood protein, is responsible for this process, which can lead to cognitive dysfunction and motor impairment.
Scientists at University of Virginia Health System discovered a gene that acts as a master controller for immune tolerance, shedding light on how our immune systems are calibrated to prevent MS. The new understanding could lead to better, more targeted treatments.
Researchers developed a method to 'tip the balance' of immune cells from bad to good, reversing MS-like symptoms in 100% of mice and achieving full recovery in 38%. The therapy uses biodegradable microparticles to deliver three key therapeutic agents, including rapamycin and a myelin peptide.
A new study published in JAMA Neurology suggests that multiple sclerosis is more prevalent in Black Americans than once thought, with the disease also affecting Northern regions of the US. The study's findings have significant implications for public policy and resource allocation towards historically under-represented populations.
Researchers at Brown University have developed a new imaging technique to track changes in blood vessels in the brains of mice, which could lead to early detection of neurodegenerative diseases. The method uses advanced imaging techniques and AI algorithms to identify biomarkers that may predict disease onset.
A Michigan Medicine-led study reveals that life stressors across the lifespan, including childhood trauma and adult abuse, contribute significantly to worsening health and functional outcomes for people with multiple sclerosis. The findings highlight the importance of analyzing the impact of life stressors on MS patients.
A new study published in Science Advances has found that certain antibodies against the Epstein-Barr virus can mistakenly target the brain and spinal cord, causing damage in multiple sclerosis patients. The research reveals a potential link between EBV infection and MS, with implications for personalized therapies.
A national cohort study found that multiple sclerosis (MS) distribution has become more diverse, with white individuals having the highest prevalence, followed by Black and Hispanic populations. The study's results highlight the need for tailored healthcare approaches for diverse patient groups.
Researchers at Mount Sinai have discovered a previously unknown way in which the brain and immune system interact in multiple sclerosis. They found that the inflammatory protein interleukin-3 (IL-3) coordinates this communication, inciting the recruitment of immune cells to the brain and exacerbating brain inflammation.
A pilot study found that remote aerobic walking exercise training improved cognitive processing speed in fully ambulatory persons with MS. The study, which showed high adherence rates, supports the design of a large-scale randomized controlled trial.
Researchers developed a novel tool to monitor recovery after CNS demyelination, enabling early testing of pro-remyelinating strategies. This new approach shows promising results in reducing clinical failure and advancing therapeutic success for multiple sclerosis.
A cell therapy using myeloid cells bound to drug delivery microparticles reduces disease burden in a preclinical multiple sclerosis model. The therapy partially reverses hind limb paralysis and improves motor functions.
Researchers found a novel biomarker, Sphingosine 1-Phosphate, linked to neuroinflammation in MS. A synergistic treatment combining Bezafibrate and Fingolimod reversed pathologies in animal models, offering potential improved therapy for patients.
A drug called teriflunomide has been found to delay the first symptoms of multiple sclerosis in people with radiologically isolated syndrome. In a preliminary study, researchers found that those taking teriflunomide had a 72% lower risk of experiencing first symptoms than those taking a placebo.
Dr. Roland Martin is honored for his work on immune mechanisms underlying multiple sclerosis, identifying key genes and nerve-insulating components targeted by immune attacks. His experimental therapy aims to make the immune system ignore those targets while preserving protective immunity.
Researchers found that women with multiple sclerosis were more likely to report sleep disorders, including obstructive sleep apnea, insomnia, and sleepiness. Insomnia mediated more than 10% of the cognitive problems reported by women with MS, while sleep apnea accounted for 34%.
Researchers have created wearable microscopes to produce high-definition, real-time images of mouse spinal cord activity across previously inaccessible regions. This technology enables unprecedented insight into the neural basis of sensations and movement in healthy and disease contexts.
A Rutgers study found that criteria used to diagnose multiple sclerosis in adults may not be sufficient for pediatric patients, who often go undetected in early stages. The study suggests that diagnostic tools used for adults may need to be re-evaluated for children with abnormal MRI findings.
Experts advocate for genetic testing to identify MS patients at high risk of developing progressive multifocal leukoencephalopathy (PML), a devastating side effect from medications. The availability of such testing could allow physicians to use alternative therapies, reducing the risk of PML.
A new study has found that female participants with MS were no more likely to experience a disease flare-up after receiving fertility treatments than before. The study also discovered a link between the use of MS medications and a lack of increase in relapses during fertility treatments.
A new platform allows researchers to study cell-cell interactions in inflammatory neurological diseases like multiple sclerosis (MS). By identifying genes that control biologic processes, the team hopes to develop therapeutics to change disease-promoting cell behavior.
Researchers at Brigham and Women's Hospital tested a new nasal monoclonal antibody treatment, Foralumab, which decreased inflammatory markers and lung inflammation in patients with COVID-19. The treatment also showed similar effects in multiple sclerosis patients, suggesting its potential use for treating other diseases.
A preliminary study found that people with multiple sclerosis who follow a Mediterranean diet have a lower risk for problems with memory and thinking skills. The study involved 563 participants and found that those who more closely followed the diet had a 20% lower risk for cognitive impairment.
A study led by the University at Buffalo found that cortical, deep gray matter, and spinal cord damage are key factors in severe MS disability, rather than lesions. Patients with severe disabilities showed more pronounced loss of neurons and atrophy of the medulla oblongata compared to their less-disabled counterparts.
Researchers at the University of Virginia Health System have identified a vital contributor to hyperactive immune responses and neuroinflammation in multiple sclerosis. Blocking this regulator alleviated harmful inflammation in lab mice, suggesting a potential therapeutic target for new treatments.
A study published in the Journal of Biological Chemistry found that a fish oil derivative called DHEA can reduce inflammation and disease severity in mice with multiple sclerosis. By supplementing the diet of mice with DHEA, researchers noticed a decrease in MS-like disease symptoms and an improvement in the immune system's response.
A new biomarker, GFAP, has been identified that can predict both current and future progression of multiple sclerosis. Elevated blood levels of GFAP indicate chronic disease processes involving astrocytes, which contribute to gradual progressive disability.
A University of Alberta researcher has found that fractalkine triggers the repair of brain damage caused by multiple sclerosis, leading to increased production of vital brain cells. This discovery could potentially halt or reverse MS symptoms by replacing damaged cells with new ones.
Dr. Ruth Ann Marrie has made significant contributions to multiple sclerosis research, including the discovery of comorbidities' impact on MS evolution and development of personalized medicine strategies. Her work aims to improve quality of life by stopping and preventing MS through early intervention and targeted treatments.
Researchers at Kessler Foundation are conducting a double-blind randomized clinical trial to evaluate the impact of their strategy-based cognitive training program on new learning and memory in individuals with multiple sclerosis. The study aims to assess the efficacy of this protocol, which is based on the KF-STEM protocol.