Articles tagged with Multiple Sclerosis
A study published by the American Academy of Neurology found that children with multiple sclerosis who had at least 30 minutes of daily summer sun in their first year of life were less likely to experience relapses. The study also showed that maternal sun exposure during pregnancy was associated with a lower risk of MS relapse for offs...
Dr. Mikael Simons is being recognized for his pioneering research on myelin biology, glial cell biology, and neuroinflammation that continues to inform MS research. His work has helped identify a promising therapeutic target with potential to benefit people with MS.
A new study found that people with multiple sclerosis experience a significantly higher risk of perinatal mental illness compared to those with other chronic conditions. Depression and anxiety were the most common conditions reported, with half of people with MS living with a mental illness in the first year postpartum.
Researchers found that pregnant people with multiple sclerosis (MS) have a higher chance of experiencing mental illness during their pregnancy and in the first years after giving birth. Mental illnesses included anxiety, depression, bipolar disorder, psychosis, suicide attempts and substance abuse.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
A new study by UCSF found that menopause increases the rate of MS progression in women, particularly in walking speed and fine motor skills. The study also suggests that hormone therapy may be beneficial in slowing disease progression, with some participants showing a lower rate of relapse during pregnancy.
A study by the American Academy of Neurology found no association between COVID-19 infections and worsening multiple sclerosis (MS) symptoms or disability. Researchers followed 2,132 adults with MS over 18 months and found similar increases in symptom severity for those with and without COVID-19 infection.
Researchers found that neuroinflammation in the hippocampus significantly alters motivation and behaviour in mice, particularly in females. This study suggests that treatments targeting hippocampal neuroinflammation could help reduce cognitive and behavioural symptoms in diseases such as Alzheimer's and Depression.
Pregnant women with MS receiving disease-modifying therapies show increased risk of low birth weight and serious infections. Exposure to S1P modulators, natalizumab, and anti-CD20 antibodies is particularly concerning.
EBViously aims to prevent infectious mononucleosis and secondary diseases such as ME/CFS, while also protecting against certain types of cancer. The company's innovative vaccine candidate uses virus-like particles derived from EBV to trigger a targeted immune response.
Research published online in Journal of Neurology Neurosurgery & Psychiatry found that cutting early life exposure to parental smoking may lower the risk of developing MS in those who are genetically predisposed. The study also showed an interplay between genetic and environmental risk factors for MS, associated with certain aspects of...
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
Scientists have created a living cell therapy that can navigate to specific organs using a
A study published in Neurology found that children with multiple sclerosis from disadvantaged neighborhoods had greater brain inflammation and tissue loss. Social factors such as public health insurance, race, and parental education level were associated with worse MS outcomes.
A new study found that fampridine can improve working memory in individuals with reduced cognitive function, particularly those with low baseline working memory levels. The drug increased brain excitability and enabled faster processing of stimuli.
Dr. Yael Goverover joins an elite group of professionals at Kessler Foundation who have earned the Fellow of ACRM designation for their nationally significant contributions to cognitive rehabilitation research for individuals with multiple sclerosis and acquired brain injury. Her work has led to innovative assessments and interventions...
Healthy mice swing their tails actively to counterbalance tilts, producing significant angular momentum. This study provides a new experimental setup for assessing mouse balance and improves understanding of neurological mechanisms behind balance issues.
Researchers at Case Western Reserve University are studying a new approach to treat multiple sclerosis, focusing on toxic astrocytes that contribute to nerve-cell damage. They aim to develop medicines that prevent the formation of these cells and promote brain repair.
Silvana Lopes Costa, PhD, of Kessler Foundation has received the Women in Neurodegenerative Disease Rehabilitation Science Award for her groundbreaking research on multiple sclerosis and cognitive assessment. Her work aims to improve quality of life among individuals with neurological conditions through innovative rehabilitation science.
A new study suggests that a keto diet rich in ketone bodies may help alleviate symptoms of multiple sclerosis and other autoimmune disorders. The diet promotes the production of indole lactic acid, which blocks the activation of immune cells responsible for these conditions.
Researchers found that specific enzymes in neurons mediate the toxicity of diets rich in palm oil, leading to mitochondrial damage and neurodegeneration. Inactivating these enzymes provides neuroprotection, suggesting a potential pathway for slowing diet-induced symptom severity in MS patients.
Scientists discovered that fragments of immune-stimulating proteins, called guardian peptides, are produced by the brain and spinal cord to maintain a healthy balance between defending against injury and infection and guarding healthy tissue. These peptides activate regulatory T cells to dampen abnormal immune reactions.
Researchers have unveiled a complex interplay between liver X and thyroid hormone receptors that regulates critical brain functions and protects against neurodegeneration. LXRs play a crucial role in regulating thyroid hormone function in the brain, while both receptors are essential for normal brain development and maintenance.
Scientists have discovered a natural compound called sulfuretin that can halt the progression of certain forms of cancer and demyelinating conditions like multiple sclerosis. The study found that sulfuretin blocks the activity of an enzyme involved in these diseases, suggesting its potential as a treatment.
Researchers have identified specific human endogenous retrovirus sequences associated with increased risk of neurodegenerative diseases, including multiple sclerosis and amyotrophic lateral sclerosis. The study suggests that these viral elements contribute to disease susceptibility by influencing brain function.
Scientists have identified a key driver of brain inflammation in neurological diseases, proposing a new treatment approach by neutralizing fibrin. This protein, involved in blood coagulation, triggers neurologic diseases by hijacking the immune system, resulting in damaged neurons.
A University of Michigan-led study found that treatment with either modafinil or cognitive behavioral therapy alone was associated with significant reductions in fatigue over 12 weeks. A combination of both treatments worked as well as each individual treatment but did not result in better fatigue scores.
A new study found an association between some types of cancer and multiple sclerosis (MS), with people with MS having a 6% increased risk of developing any type of cancer. The study identified higher risks for bladder, brain, and cervical cancers, but lower risks for prostate, colorectal, and breast cancers.
A study of identical twins found that CD8-positive T cells play a key role in the early stages of multiple sclerosis. The researchers discovered that these cells exhibit increased migration ability, promote inflammation and show activation markers, suggesting they are already embarking on their journey to the central nervous system. Th...
A new study explores a promising combined therapy for multiple sclerosis, using tolerogenic dendritic cells modified with myelin antigens. Researchers found that these cells from patients have a persistent pro-inflammatory signature, making them less effective compared to those derived from healthy individuals.
Researchers developed a new combined therapy for multiple sclerosis, combining tolerogenic dendritic cells with Dimethyl Fumarate to restore immune balance. The treatment showed promise in preclinical studies, reducing symptoms in mice and potentially offering hope for patients worldwide.
A new study found that people taking certain medications for primary progressive multiple sclerosis (MS) do not experience a slower rate of disability progression compared to those not receiving treatment. The study, published in Neurology, suggests that anti-CD20 therapies may not be effective in slowing disability progression.
A pioneering study identified critical biomarkers that can predict disability worsening in MS. Elevated serum neurofilament light chain and serum glial fibrillary acidic protein levels correlate with progression independent of relapse activity, guiding personalized treatment approaches.
Researchers at the Plasticity and Remodeling of Neural Circuits laboratory aim to stimulate myelin plasticity to regenerate affected nerve fibers in MS patients. The team will explore gene therapy, pharmacological approaches, and rehabilitation strategies to enhance myelin repair.
A study by Amber Salter found that people with multiple sclerosis (MS) who have comorbidities experience worsened disease activity. The research highlights the importance of addressing comorbidities in MS treatment.
A recent study found significant therapeutic inertia in the treatment of women with multiple sclerosis (MS), leading to delayed or reduced use of disease-modifying treatments. The research highlights gender disparities that could impact long-term health outcomes for women of childbearing age, particularly due to concerns about pregnanc...
A new study presented at ECTRIMS 2024 reveals that initiating monoclonal antibody therapy during childhood can lead to improved long-term outcomes for children with MS. The research showed a substantially lower risk of progressing to higher disability levels in the early treatment group, particularly in moderate disability range.
A landmark study has identified novel ancestry-specific genetic variants linked to multiple sclerosis (MS) risk, offering new insights for treatment approaches. The research highlights the potential of ancestry-informed genetic studies to uncover previously unidentified risk factors for MS.
A new study published in The FEBS Journal found that protein C1QL1 plays a crucial role in promoting the replacement of specialized cells responsible for producing myelin. This discovery could lead to novel therapies for demyelinating diseases like multiple sclerosis.
Researchers at Kessler Foundation develop a new clinical protocol to improve learning and memory in individuals with multiple sclerosis who have mobility disability. The study combines aerobic exercise with virtual reality and cognitive rehabilitation, showing potential synergistic effects on cognitive improvements.
Researchers have created the largest collection of patient stem cell models of multiple sclerosis, identifying unique ways in which glia contribute to the disease. The study suggests that glial cells from MS patients have intrinsic hallmarks of disease, independent of immune system influences.
A new study from Washington University School of Medicine found that people with multiple sclerosis are less likely to develop the molecular hallmarks of Alzheimer's disease. The discovery suggests a potential new avenue for treating Alzheimer's and could inform therapeutic strategies.
A new study published in Neurology found that COVID-19 vaccination does not increase the risk of relapse in people with multiple sclerosis. However, participants with high MS activity and those who received booster doses did show a small increased risk, especially if they were not taking disease-modifying treatments.
A Wayne State University research team led by Taylor Takla is studying the neural, motor, cognitive and psychological factors underlying fear of falling in multiple sclerosis patients. The goal is to break the cycle of falls, reduced physical activity and social isolation, ultimately improving quality of life for MS patients.
Fatigue affects up to 90% of individuals with MS, significantly impacting their daily lives. The study proposes that disruptions in the cortico-striato-thalamo-cortical loop contribute to central fatigue.
Researchers have developed a new therapy called PIPE-307 that targets an elusive receptor on certain cells in the brain, prompting them to mature into myelin-producing oligodendrocytes. This could potentially reverse damage caused by multiple sclerosis, leading to improved movement, balance, and vision.
A recent study published in Scientific Reports found that blocking connexin 43 (Cx43) channels with the compound INI-0602 improved MS symptoms in an animal model by regulating immune processes and reducing inflammation. The findings suggest a potential therapeutic strategy for chronic MS treatment.
A new study published in PLOS Digital Health found that machine learning models can reliably predict the disability progression of multiple sclerosis. The models were trained on data from 15,240 adults with at least three years of MS history and had an average accuracy of 0.71 ± 0.01.
Researchers study T cells and monocytes interaction in the meninges before they attack the brain and spinal cord, potentially leading to new disease progression targets. The findings could provide a pathway to treating other neurological diseases like Alzheimer's and Parkinson's.
Researchers at Durham University have developed a groundbreaking method to diagnose Multiple Sclerosis using advanced eye imaging techniques. The innovative approach integrates optical coherence tomography and infrared scanning laser ophthalmoscopy, achieving an impressive 92% accuracy in initial tests.
A new study published in Neurology found that ofatumumab is more effective than teriflunomide at helping people with relapsing-remitting MS reach a period of no disease activity across racial and ethnic groups. The medication showed consistent results among diverse populations, including Black, Hispanic, and Asian individuals.
The WISDOM project aims to integrate healthcare and research data to combat CIMDs through AI-driven models. The initiative hopes to improve disease diagnosis, treatment, and patient outcomes by sharing data securely across borders.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
A pilot study found that remote cognitive rehabilitation using TELE-Self-GEN improved memory performance and daily life functionality in individuals with MS. The virtual intervention demonstrated high levels of participant satisfaction and effectiveness.
A pilot study found that methylphenidate enhances oculomotor function in individuals with multiple sclerosis, improving visual processing speed. The treatment also showed promise for mitigating cognitive symptoms associated with MS.
A new methodology, backward walking speed reserve, measures an individual's capacity to increase their walking speed on demand in the backward direction. This assessment is linked to disease severity, falls risk, and cognitive decline in multiple sclerosis patients.
Researchers at University of Cambridge uncover unified healer army of regulatory T cells that constantly move and repair damaged tissue. This discovery has implications for treating various diseases, including autoimmune disorders and infectious diseases.
Researchers investigate Epstein-Barr Virus and Multiple Sclerosis connection, discovering cross-reactivity between viral proteins and brain proteins. The study suggests that differences in immune cell function may explain why some people develop MS after EBV infection.
Researchers discovered how Epstein-Barr virus (EBV)-infected B cells contribute to multiple sclerosis (MS) inflammation and disease. A new treatment strategy targeting these problematic cells may offer a selectively cytotoxic approach to MS therapy.
Researchers found that abnormally active B cell metabolism causes an inflammatory immune response in individuals with Multiple Sclerosis (MS), leading to nerve damage and symptoms. Emerging BTK inhibitors alter this abnormal B cell respiration, stopping the signaling that leads to MS flare-ups.