Articles tagged with Neural Stem Cells
Researchers create progerin-induced aging in stem cells, accelerating disease modeling by weeks, not years. This breakthrough opens avenues for preventing and treating late-onset disorders.
Researchers found that potassium current density increased sharply after 2 weeks of neural stem cell differentiation, indicating functional neurons. Neural stem cells from newborn rat hippocampus can be cultured and induced to differentiate into mature neurons in vitro.
Researchers from Bonn University discovered that immature nerve cells secrete chemical attractants that prevent mature brain cells from migrating into the brain. Inactivating these attractants improves nerve cell migration in animal models, offering a promising universal approach to treat Parkinson's and Huntington's diseases.
Scientists have found a critical mechanism to keep newborn neurons alive, which may help understand underlying causes of diseases like Alzheimer's and mental illness. The discovery suggests that parvalbumin-expressing interneurons release GABA, a chemical signal that promotes the survival of new brain cells.
A traditional Chinese medicine, Buyang Huanwu Decoction, has been shown to improve neurological function in patients with stroke. The decoction increases the number of cells positive for markers of neuronal differentiation and synaptic plasticity in ischemic rat cerebral regions.
Researchers discovered that doxycycline-induced neural stem cells exhibit increased proliferative activity and inhibitory differentiation similar to tumor stem cells. This suggests a possible link between neural stem cells and the origin of brain tumor stem cells.
Researchers at Lund University have made a breakthrough in stem cell-based treatment for stroke by developing induced pluripotent stem cells that mature into functional nerve cells. These cells, transplanted into the cerebral cortex of rats with stroke, improve mobility and demonstrate promising results.
SMEK1 promotes neural stem cell differentiation and suppresses uncontrolled proliferation, while collaborating with Protein Phosphatase 4 to regulate PAR3 activity. This discovery offers new hope for patients with Alzheimer's, Parkinson's, and other neurodegenerative diseases.
Researchers have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from human stem cells. Using a discovery platform combining yeast cells with human stem cells, scientists found that the compound reversed alpha-synuclein toxicity in yeast cells and partially rescued neurons in anima...
Researchers at Clemson University found that increasing mTOR pathway activity in neural stem cells leads to neuron generation and may offer a new treatment for neurodevelopmental disorders. The study, published in Cell Reports, points to the potential benefits of targeting 4E-BP2, a specific mTOR target.
Researchers found that transplanted stem cells guide neural stem cells to the injured brain site via a neurovascular matrix, promoting functional recovery. The study presents evidence for a new concept of stem-cell mediated brain repair, offering a potential treatment for traumatic brain injury.
Researchers used cynomolgus monkeys to compare autologous and allogeneic transplantation of iPS cell-derived neural cells. Autologous transplantation produced almost no immune reaction, while allogeneic transplantation provoked an immune response.
Researchers used iPSCs from nonhuman primates to develop neural cells depleted by Parkinson's disease, eliciting only a minimal immune response. This breakthrough suggests autologous transplantation could be a viable option for humans, offering promise as a treatment for the disease.
Researchers found that Noggin accelerates and increases the differentiation of neural precursors, outperforming basic fibroblast growth factor (bFGF). Noggin's greater effect was observed in inducing neural precursor differentiation from human embryonic stem cells.
Defective stem cell regulation throughout the body may contribute to learning and physical disabilities in people with Down syndrome. Reducing the expression of the Usp16 gene on chromosome 21 alleviates these defects and raises the possibility of an eventual therapy.
Researchers transplanted fetal stem cells into lab animals with radiation-induced cognitive impairments, showing improved hippocampal spatial memory and fear-conditioning performance. The study suggests fetal stem cell transplantation may provide a potential treatment for cranially irradiated patients.
Transplantation of neural stem cells into tumor-bearing rats inhibits abnormal Ras/Raf/Mek/Erk signaling, promoting apoptosis and potentially treating glioma. This study provides insights into the therapeutic effects of neural stem cell transplantation on glioma in mice.
Researchers at Johns Hopkins Medicine have discovered that neural stem cells can resist radiation and regenerate after damage, potentially restoring lost function in brain cancer patients and individuals with conditions like MS and PD. The findings may lead to new treatments for brain trauma and strokes.
Researchers at Karolinska Institutet found that CHD5 is essential for stem cells to mature into neurons. In the absence of CHD5, stem cells are unable to silence certain genes and switch on those necessary for neuronal maturation. The study suggests restoring CHD5 in aggressive tumor cells could make them more treatable.
A study found that the loss of CHD5 gene in stem cells underlies severe forms of neuroblastoma, a potentially curable tumor. CHD5 is required for cellular transition from a stem cell to a mature neuron, and its reactivation may increase responsiveness to treatment.
A protein involved in nerve-cell migration is implicated in the spread of brain cancer, according to new research from the University of Illinois at Chicago. The study found that cadherin11 promotes cancer cell migration and invasion by regulating cell adhesion and movement.
Researchers at the University of Luxembourg's LCSB have developed a computational model that accurately predicts cell reprogramming, eliminating the need for stem cells. The breakthrough could lead to treatments for diseases like Parkinson's by repurposing healthy skin cells into functional nerve cells.
Researchers have discovered that novel nanofiber scaffolds can enhance the proliferation of spinal cord-derived neural stem cells while inhibiting apoptosis. The study found that these scaffolds regulate gene expression, promoting cell growth without inducing differentiation.
Researchers found that ginkgo biloba extract EGb761 promoted and prolonged the proliferation of neural stem cells in rats with vascular dementia. The treatment significantly improved learning and memory in these animals.
Researchers at Helmholtz Association discovered that exercise can fully rescue the phenotype of CHD7-deficient neural stem cells, allowing them to differentiate into mature neurons. This breakthrough provides new insights into the molecular mechanisms underlying CHARGE syndrome and may lead to potential treatments.
A team of NYU biologists found that a series of genes expressed in brain stem cells control the generation of neural diversity in the visual system of fruit flies. This process, known as a temporal cascade, ensures the sequential generation of different neural types.
A study by researchers at the University of Oregon reveals a novel stem cell mechanism in fruit flies that may help explain how neurons form in humans. The research shows how a select group of stem cells can create progenitors that generate numerous subtypes of cells, increasing neural diversity.
Researchers successfully mobilize brain's native stem cells to replenish neurons lost in Huntington's disease. The study demonstrates the feasibility of a completely new concept to treat the disease by recruiting endogenous neural stem cells to regenerate cells, significantly extending survival of treated mice.
Scientists have developed a method to derive mature human neurons from reprogrammed skin cells, enabling direct disease modeling and customized treatments. The new approach uses astrocytes to guide the growth of neurons, leading to more effective cell differentiation and improved neural function.
Researchers at the University of Wisconsin-Madison have made an engineered stem cell advance that points toward a treatment for ALS. The study, published in Molecular Therapy, found that using adult stem cells to deliver growth factors improved survival and delayed disease progression in rat models with symptoms resembling ALS.
A single injection of human neural stem cells produced therapeutic benefits in rats with acute spinal cord injury, including improved function and mobility. The grafted stem cells stimulated host neuron regeneration and partially replaced the function of lost neurons, reducing muscle spasticity.
Researchers at the University of California - San Francisco have developed a type of human brain cell called medial ganglionic eminence (MGE) cell that grows seamlessly when transplanted into mice. These cells have the potential to treat several types of neurodevelopmental and neurodegenerative disorders, including Parkinson's disease,...
Researchers have developed a method to convert skin cells into neural progenitor cells without passing through the pluripotent stem cell stage. This breakthrough allows for the production of specific types of neural cells, enabling rapid drug screening and modeling of neurological diseases such as ALS and spinal muscular atrophy.
Scientists have created a model cell system that allows them to investigate normal brain development and identify specific disruptions in biological signals contributing to neurodevelopmental disorders. The new model uses human embryonic stem cells to produce cortical interneurons, which control electrical firing in brain circuits.
Researchers at University of Wisconsin-Madison successfully transplanted human embryonic stem cells into mouse brains to repair damaged neural circuits. The study demonstrates the potential for stem cell therapy to treat neurological disorders such as Alzheimer's and depression.
Researchers discovered a novel compound that promotes motor neuron survival, offering a new approach to treating ALS. The study used stem-cell-derived motor neurons and screened over 5,000 compounds, finding kenpaullone to be more effective than existing treatments.
A new stem-cell based drug screening technology has identified a compound that prolongs the life of motor neurons in both normal and ALS-affected cells. The study found kenpaullone, which inhibits HGK, an enzyme associated with motor neuron death, to be more effective than two failed drugs in human clinical trials.
Researchers at Stanford University School of Medicine have successfully transformed skin cells directly into oligodendrocyte precursor cells, which can insulate neurons. This breakthrough could lead to cell therapies for diseases like multiple sclerosis and spinal cord injuries.
Autophagy, a type of internal 'spring cleaning', helps maintain neural stem cells' readiness to become new brain and nerve cells. Without this process, these crucial stem cells suffer damage from waste products and their ability to differentiate diminishes.
New technique allows for direct reprogramming of human cells into nerve cells, opening possibilities for treating Parkinson's disease and other conditions. Researchers at Lund University have made a breakthrough in the field of cell therapy by successfully reprogramming skin cells and support cells into nerve cells.
Researchers at Caltech have found that neural-crest stem cells differentiate into microvillous neurons, which sense pheromones, and are distinct from ciliated neurons that detect volatile scents. The discovery sheds light on how olfactory neurons form and may lead to new treatments for conditions like anosmia.
The study demonstrates that when transplanted into mice, human glial cells can influence communication within the brain, allowing animals to learn more rapidly. Human astrocytes are found to have unique functional advantages and play a significant role in integrating and coordinating neural activity.
A molecule called Dickkopf-1 accumulates with age and inhibits the formation of new neurons in the brain. Researchers found that blocking production of Dkk1 can restore youthful levels of neurogenesis and improve memory performance.
Researchers successfully created human brain cells from skin cells, which are highly effective in treating myelin disorders such as multiple sclerosis. The study opens the door to potential new treatments using these cells for neurological diseases characterized by the loss of myelin.
Scientists at the University of Melbourne have successfully transplanted neural stem cells into mice, which then migrated to the gut and developed into functional neurons. This breakthrough could lead to new treatments for intestinal motility disorders such as Hirschsprung's disease.
Researchers have found that transplanted neural stem cells can migrate to the gut and develop into functional neurons, providing a promising new treatment for gastrointestinal motility disorders. Additionally, a protein called MFGE8 has been identified as an important regulator of inflammation, blocking inflammasome activity and limiti...
Scientists have successfully reprogrammed one type of neuron into another within the brain, challenging the long-held notion that neurons are immutable. This breakthrough has significant implications for treating neurodegenerative diseases such as ALS.
A new study reveals that leprosy bacteria reprogram adult Schwann cells into stem cell-like cells and convert them to muscle-like cells, spreading infection. This finding could lead to the development of new therapeutic strategies and regenerative medicine tools.
Researchers at North Carolina State University found that the lack of Sp2 protein disrupts neural stem cell division and leads to a decline in neurons in the developing and postnatal brain. This discovery could have implications for understanding neurodevelopmental diseases and regenerative medicine.
Scientists at University of California, San Diego, discovered that repressing a single protein in fibroblasts is enough to convert them into functional neurons. This finding has far-reaching implications for developing new treatments for neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers found that stem cell transplantation significantly extended the lifespan of mice with ALS by 20 days and improved their neuromuscular function by 15 percent. This breakthrough study suggests that stem cells may represent a promising avenue for effective cell-based treatment for ALS and other neurodegenerative diseases.
Researchers found that bacterial imbalance contributes to intestinal inflammation and carcinogenesis, with treatment reducing disease risk. Dysbiosis was shown to enhance intestinal inflammation and increase the risk for inflammation-associated colon cancer.
Researchers investigated five cell types in CNS transplantation, finding none showed significant repair benefits. Despite differences in immune responses, only a few cells survived, highlighting the need for further research to better understand cell graft induced tissue damage.
Researchers have shown that transplanted neural stem cells slow ALS onset and progression, improving motor function and survival time. The study also found that these cells promote the production of protective molecules and reduce inflammation.
In a groundbreaking study, researchers found that transplanted neural stem cells slow ALS disease onset and progression by producing protective molecules and reducing inflammation. The treatment improves motor function and prolongs survival in ALS mice, offering new hope for treating this devastating disease.
Researchers found that transplanting neural stem cells into mice with familial ALS slowed disease onset and progression, improved motor function, and extended survival. The study suggests targeting detrimental roles played by non-neuronal cells to develop more effective therapeutics.
Researchers developed a way to derive dopaminergic neurons from adult bone marrow stem cells in monkeys. The new neurons were then transplanted into the same monkeys with induced Parkinson's disease, showing significant improvement in motor function.
A new study published in PLOS ONE reveals that human stem cells are resistant to human cytomegalovirus (HCMV), a leading cause of congenital intellectual disability and deafness. The research findings suggest that HCMV infection distorts cell differentiation, leading to impaired brain maturation and intellectual ability.
Researchers have identified a cell growth pathway that is unusually active in pediatric brain tumors, known as gliomas. The study suggests that tools developed to diagnose and treat NF1 may also be helpful for sporadic brain tumors.
Sanford-Burnham researchers found that different brain tumor cell types respond to distinct treatments due to varying growth factor regulation. This discovery offers potential for more effective and less harmful treatments tailored to individual tumors.