Articles tagged with Neural Stem Cells
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Researchers identified a new pathway of stem cell activity in the subventricular zone of the human brain, which targets the prefrontal cortex in newborns. This discovery challenges previous reports that suggested neural stem cells remain active into adulthood.
Researchers successfully grafted deciduous canine teeth and dental pulp stem cells into parent canines, demonstrating bone regeneration after four weeks. The study found increased immunosuppressive activity of these stem cells, paving the way for potential clinical applications in allogenic in vivo stem cell transplantation.
Researchers at Case Western Reserve University have successfully guided mouse stem cells into oligodendrocyte progenitor cells, which can restore myelin on nerves. This breakthrough opens up new avenues for basic research and potential therapies for multiple sclerosis and other demyelinating diseases.
Deep brain stimulation (DBS) stimulates specific brain regions to produce new cells that enhance memory. In a mouse study, DBS led to a two-fold increase in new cells in the hippocampus, which improved spatial learning and memory.
Researchers at Tel Aviv University have developed a patented technology that uses bone marrow stem cells to produce neuroprotectors, proteins that shield the brain from neurodegenerative disorders. The treatment has shown efficacy in animal models and is now being tested in human clinical trials.
A new class of stem cell-like radial glial cells has been identified in the spinal cord, which may offer a fresh avenue for therapies to treat spinal cord injury and disease. These cells were discovered using the Allen Spinal Cord Atlas and display a unique progenitor phenotype.
Researchers at University of British Columbia have discovered radial glial cells in the spinal cord that can function as stem cells and regenerate portions of the central nervous system. These cells share unique genes with other neural stem cells and could be targeted for potential gene therapy treatments.
Researchers have identified a key gene that enables the brain to continue growing while other organs shut down in fetal development. This genetic link may hold clues for understanding intra-uterine growth restriction and its potential links to metabolic disease later in life.
A signaling pathway plays a key role in determining the type of new neurons generated from postnatal neural stem cells. The study found that sonic hedgehog signaling, which is active in specific locations within the subventricular zone, influences neuron production and can redirect adult stem cell fate.
Researchers at Duke University Medical Center discovered that neighboring ependymal cells maintain a structure that keeps neural stem cells
Researchers found that transplanted stem cells restored learning and memory abilities in rats, with as few as 100,000 cells sufficient to improve cognition. The study provides hope for future stem cell therapies to alleviate side effects of radiotherapy for brain tumors.
Researchers from Stanford University School of Medicine successfully converted skin cells into fully functional neurons using two specific gene snippets, known as microRNAs. This breakthrough finding opens up new avenues for studying neuronal development, modeling disease processes, and testing treatments.
Human stem cells can be directed to specific cell types through molecular cues, enabling more efficient tissue regeneration. Researchers found that pluripotent stem cells have unique 'suitcases' for different destinations, increasing specialized cell production.
Researchers at Salk Institute use genetically embedded tools to study neural stem cell differentiation and protein activity in brain cells. The technique, described in a recent study, may aid in the development of regenerative medicine and help scientists understand the mysteries of stem cells.
Researchers at University of Florida have developed a technique to separate neural wheat from chaff in brain cell generation, enabling precise doses of therapeutic neurons. This technology holds promise for treating disorders like Huntington's disease, spinal cord injuries, and Parkinson's disease.
A Johns Hopkins team discovered that a single brain stem cell can replace itself and generate specialized neurons and glia. They also found that these cells can amplify, producing two new stem cells like themselves.
A team of researchers has discovered a gene connected to the production of new brain cells in adults, which acts as an 'off switch' before neurons are formed. However, further experiments revealed that Foxj1-expressing cells functioned as stem cells until adulthood, producing fewer neurons than expected.
Researchers have found that adult stem cells from the human olfactory system can provide a new source of cells to treat brain disorders. These cells, known as OE-MSCs, have been shown to migrate to damaged areas and stimulate nerve cell growth, improving learning and memory in mice.
Researchers found that neural stem cells can adapt to stressful environments by producing more neurons when conditions become favorable. The study suggests a novel form of brain plasticity and potential treatment for neurodegenerative diseases.
Ependymoma, a devastating brain tumor in children, is chemo-resistant and incurable in up to 40 percent of cases. Researchers will investigate the role of the Ephb2 gene in ependymoma development.
The latest issue of Cell journal features QR codes connecting readers to author-narrated figure walks and hidden treasures of animated figures, videos, podcasts, and more. This innovative approach improves the reader's experience and conceptualization of scientific content.
Researchers at Stanford University School of Medicine successfully converted human skin cells into functional neurons in a period of four to five weeks. Adding a fourth transcription factor called NeuroD proved crucial for the transformation, generating electrical activity and integrating with mouse neurons.
A new article discusses the current status of neural stem cell research and its translation into clinical therapeutics. The authors highlight the need for a comprehensive and collaborative team effort to overcome hurdles in the process, including funding levels and regulatory approval.
Astrocytes, the most common cell in the human nervous system, have been cultivated in a lab dish using embryonic and induced human stem cells. This breakthrough allows researchers to better understand their functions and develop new therapies for neurological disorders such as dementia and Parkinson's disease.
A new antibody called 5750 has been developed by researchers at Ruhr-University Bochum to label specific stem cells in the nervous system. The antibody targets a sugar residue on the cell surface called LewisX, which is found on different types of neural stem cells.
A study from Cold Spring Harbor Laboratory suggests that adult stem cells in the brain are 'disposable' and lose their ability to produce neurons with age, leading to a decline in new neuron production. This decline may contribute to age-related cognitive decline.
A study by Dr. Alexey Terskikh and colleagues found that the SOX2 gene maintains the potential for neural crest stem cells to become neurons in the peripheral nervous system. This discovery could help inform therapies for neurocristopathies, diseases caused by defects in the neural crest or neurons.
Researchers at University of California - San Diego School of Medicine and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing neural precursor cells from human embryonic stem cells that can be directed to become many types of neuron. The new process promises to have broad applicatio...
A Gladstone scientist has made two significant stem-cell discoveries, creating powerful new approaches for using stem cells and stem-cell-like technology. Dr. Sheng Ding reveals novel and safer methods for transforming embryonic stem cells into large numbers of brain cells and adult skin cells into neural stem cells.
Researchers have developed a method to recreate schizophrenic brain cells from skin cells, enabling safe and effective studies. This approach offers a step towards personalized medicine for patients with schizophrenia and potentially other diseases.
Nine patients with amyotrophic lateral sclerosis (ALS) were treated with Neuralstem's spinal cord stem cells, showing no unresolved serious adverse reactions or death. The trial indicates the feasibility of transplanting stem cells directly into the spinal cord, paving the way for future treatments.
Researchers at Karolinska Institutet discovered that dopamine controls the formation of new neurons in the adult brain by acting as a switch for stem cells. The study used salamanders, which can recover from Parkinson's-like conditions, to understand how dopamine regulates neural regeneration.
The phase I safety trial of Neuralstem's human spinal cord stem cells in amyotrophic lateral sclerosis (ALS) will be presented at the American Academy of Neurology Annual Meeting, featuring interim safety data on nine patients. The trial is designed to evaluate the safety of the cells and surgery procedure for ALS treatment.
Researchers have discovered that a gene called Sox10 coordinates the balance of cell types in healthy development. This means that it's difficult to get 100% of cells to become one type, even in lab conditions. The study suggests that understanding these balancing mechanisms is crucial for harnessing stem cells in medical applications.
A team of researchers at Marshall University has identified and analyzed unique adult animal stem cells that can transform into neurons, which could pave the way for novel therapies for slowly progressing diseases like Parkinson's and multiple sclerosis. The discovery is especially interesting as it involves using readily available and...
Researchers create induced pluripotent stem cells from adult siblings with schizophrenia and DISC1 gene mutation, providing a potential tool for screening treatments and understanding the disease. The stem cells can be coaxed to become brain cells like neurons, offering new insights into the causes of major mental illnesses.
Scientists found that a protein called Igf2 in the cerebrospinal fluid signals brain cells to multiply during embryonic development. This discovery could lead to new treatments for neurological diseases and cancer by targeting specific areas of the brain, eliminating the need for localized drug delivery.
Deanna Thompson is utilizing NYSTEM funding to study adult neural stem cells for developing new stem cell therapies and research tools. Her research aims to understand how these stem cells proliferate and differentiate into new nerve cells, with potential applications in treating brain injuries, illnesses, and cancers.
Research suggests that cerebrospinal fluid contains a complex mix of proteins that change with age, supporting or hindering neural stem cell growth. The protein Insulin-like growth factor 2 (Igf2) strongly correlates with cell division levels.
Researchers have found that stem cells derived from umbilical cord blood cells and menstrual blood may offer therapeutic benefits for disorders such as stroke, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). These cells can differentiate into various types of cells and have anti-inflammatory properties.
Researchers at Northwestern University have successfully reprogrammed human embryonic stem cells to produce critical neurons lost in Alzheimer's disease. This breakthrough allows for rapid drug testing and the possibility of transplanting these new neurons into people with Alzheimer's, which could help preserve memory function.
Researchers have discovered that specific human astrocytes derived from stem cells can repair damaged nervous systems and promote locomotor function in spinal cord injured rats. The study reveals the importance of creating beneficial cell types through tissue culture before transplantation, providing a potential new avenue for treating...
Cell Press won the PROSE Award for Excellence in Biological & Life Sciences for its 'Article of the Future' format, which offers a personalized reading experience. This award reflects Elsevier's and Cell Press' commitment to evolving scientific publications with new technologies.
Cell Alerts offers free, instant access to high-impact research articles from top journals like Cell, Neuron, and Current Biology. The app also features upcoming conference listings, enabling easy browsing on-the-go.
Researchers found that nestin recruits cdk5 to the muscle membrane, initiating dispersion and regulating neuromuscular junction formation. The study sheds light on signaling mechanisms connecting brain to muscle and may aid future treatments for neuromuscular diseases.
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research found that neural stem cells maintain high levels of reactive oxygen species (ROS) to help regulate normal self-renewal and differentiation. The findings may have significant implications for brain repair and abnormal brain development.
A new study found that deep brain stimulation (DBS) targets the same class of neuronal cells known to respond to exercise and Prozac, leading to an increase in new neurons in the hippocampus. The targeted area, anterior thalamic nucleus, may provide a guide for designing better treatments.
Researchers at UCSF have identified that oligodendroglioma brain tumors arise from progenitor cells rather than neural stem cells. This distinction explains why these tumors are more responsive to therapy, unlike other brain tumors such as glioblastoma multiforme.
USF researchers discovered that human umbilical cord blood cells (HUCB) promote the growth and differentiation of hippocampal neurons in both young and old laboratory animals. HUCBs have been found to enhance survival, maturation, and arborization of key brain cells, potentially benefiting treating brain injury and degenerative disease...
Researchers at the University of Rochester Medical Center have created a way to isolate pure preparations of neural stem cells directly from human brain tissue. This breakthrough technique saves months of time and labor in the laboratory, allowing scientists to study stem cells in unprecedented detail. The findings suggest that human n...
Scientists at Scripps Research Institute have made a significant leap forward in finding chemicals needed to reprogram mature human cells and turn them into stem cells. The discovery represents a fundamentally different approach from previous methods and offers a new method for generating induced pluripotent stem cells with defined sma...
A study by Thomas Jefferson University found that bone marrow stromal stem cells can significantly recover motor behavior in laboratory rats after a simulated stroke. Early administration of the stem cells was more effective than late administration, with profound changes in brain structure and long-lasting motor function improvement.
Researchers at Johns Hopkins discovered that NG2+ cells undergo dramatic changes in ALS, growing rapidly and forming abnormal oligodendrocytes that quickly die. This overgrowth suggests a new player in the disease's progression.
Researchers have identified the origin of olfactory ensheathing cells (OECs), which promote nerve repair in the central nervous system. OECs are derived from neural crest cells, which can be grown in large quantities from adult stem cells.
Researchers at Duke University Medical Center discovered a novel feedback mechanism controlled by the Zif protein that regulates the balance of brain stem cells. This discovery has implications for understanding neural stem cell self-renewal and may lead to new therapies against brain tumors and diseases.
A team of researchers has developed a human cell-based model of Rett syndrome, overcoming the main limitation of accessing live neurons from patients. The study provides evidence of functional rescue using human cells and opens up new avenues for drug development and high-throughput screening.
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Researchers found that nerve cell activity regulates balance between stem cells and mature nerve cells in the developing brain. The study suggests that abnormal brain activity may have long-lasting effects on brain development and could lead to new therapies for neurodegenerative diseases.
The discovery of the interaction between two cellular signaling pathways may lead to therapies that aid brain growth and repair in children and adults. Researchers have found a critical step toward understanding the molecular networks regulating neural stem cells.
Neuralstem's spinal cord stem cells survive and differentiate into neurons in rat brains affected by stroke, leading to improved motor skill and strength measurements. The study shows significant promise for treating post-stroke symptoms and paralysis.