Articles tagged with Neural Stem Cells
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Researchers at Hebrew University develop theoretical model and conduct experiments to understand how stem cells differentiate based on their surroundings' rigidity. The study reveals elongated, muscle-like fibers in cells on rigid supports, differing from brain and bone cell structures on softer or harder substrates.
A team of researchers at the University of Oregon has made a groundbreaking discovery about stem cell division, finding that cortical proteins help position a cleavage furrow in the right location. This new mechanism has important implications for understanding how stem cells divide to produce unique cell types.
The new journal aims to evaluate the safety and effectiveness of cell medicine in treating debilitating and fatal disorders. The journal features a diverse global editorial board and publishes papers on cell therapy with direct clinical relevance.
Researchers found that human umbilical cord blood cells stabilized the brain cell environment and aided astrocyte survival after oxygen deprivation. However, the cells also had an impact on cytokine expression, sometimes suppressing inflammation and other times enhancing it.
A UC Irvine study shows that human neural stem cells can reverse long-term hind-limb paralysis in mice with chronic spinal cord injuries. The therapy demonstrates potential for treating a broader population of patients with spinal cord injuries.
Researchers discovered that the Prox1 gene plays a crucial role in developing and maintaining cells vital for making new memories throughout life. The study revealed a novel feedback mechanism regulating differentiation of adult neural stem cells.
A team of researchers has developed an approach to repairing spinal cord injuries using manipulated neural stem cells. In a mouse model, the cells were combined with valproic acid and resulted in impressive restoration of hind limb function. Further work is needed to determine if this approach can be used in human patients.
Researchers have successfully reprogrammed adult mouse fat cells and neural cells to become induced pluripotent stem cells (iPS) that can differentiate into various cell types. The study demonstrates that adipose tissue-derived cells are the most amenable to reprogramming, making them a promising source for clinical applications.
A study found that high-dose radiation targeting the neural stem cell niche in brain cancer patients doubles their progression-free survival time. Patients who received higher doses experienced 15 months of progression-free survival, while those with lower or no doses had 7.2 months.
Dr. Anthony-Samuel LaMantia's research identifies stem cells responsible for generating nerve cells involved in eating, reproduction, and social behavior. These cells are essential for understanding neurological and mental disabilities, such as autism, schizophrenia, and Alzheimer's disease.
Researchers at USF found that combining nutrients called NT-020 increased adult neural stem cell proliferation and boosted learning and memory performance in aged rats. The study suggests aging may be linked to reduced neurogenesis due to inflammation.
Researchers identify a protein released by neural stem cells that induces signaling in glioblastoma cells, causing them to differentiate. This discovery could lead to new therapy concepts targeting tumor stem cells and potentially destroying the aggressive brain tumors.
Researchers have successfully reprogrammed human blood cells to an embryonic stem-cell-like state, opening up new possibilities for studying genetic and molecular mechanisms of blood disorders and other diseases. This breakthrough uses frozen blood samples from blood banks, providing a readily available source of pluripotent stem cells.
Researchers have identified Pax6 as a critical genetic factor in human brain development, governing the differentiation of stem cells into various brain cell types. This discovery may lead to the creation of customized brain cells for therapeutic purposes.
Researchers have identified a key molecular guard that prevents brain stem cells from proliferating, protecting the brain against excessive cell division. This study highlights the importance of bone morphogenetic factor protein (BMP) signaling for maintaining neural stem cells throughout adulthood.
The 2009 Journal Citation Reports reveals a surge in Impact Factors for Cell Press journals, with Cell Stem Cell and Cell Host and Microbe leading the charge. Cancer Cell also continues to grow, while Molecular Cell sees an impressive 13% increase, demonstrating the growing importance of these publications in the scientific community.
A UCI study identifies the body's immune system as a key player in navigating transplanted stem cells to injured areas in the central nervous system. Adult neural stem cells were shown to be guided by CXCR-4 receptors and chemokine proteins to specific sites, where they differentiated into oligodendrocytes to repair damaged tissue.
Researchers have discovered a new stem cell in the developing human brain that produces nerve cells forming the neocortex, the site of higher cognitive function. The study sheds light on developmental diseases such as autism, schizophrenia, and Alzheimer's disease, and could lead to novel therapies.
A new £800,000 research programme aims to unlock the secrets of motor neuron disease by studying human motor neurons and support cells from donors. The programme will investigate whether support cells are injurious or protective to motor neurons, and may lead to promising new treatment strategies.
Researchers at Linköping University discovered a new function that regulates stem cell production of different types of cells in various parts of the nervous system. The study found that Hox genes, similar to a GPS system, guide stem cells to produce specific nerve cells in certain regions.
Researchers successfully transplanted endometrial stem cells into the brains of mice with a Parkinson-like condition, restoring partially dopamine levels. This finding raises the possibility of women serving as their own stem cell donors and banks being established for men and women with Parkinson's disease.
Researchers discovered that neuronal stem cells exist in the human brain, even in adulthood, and can form new neurons. Physical activity and pathological stimuli like epileptic seizures reactivate dormant stem cells, promoting the formation of new neurons.
The American Society for Neural Therapy and Repair (ASNTR) has awarded Dr. Shinn-Zong Lin with the 2010 Bernard Sanberg Memorial Award for Brain Repair in recognition of his significant research contributions in neuroscience. Dr. Lin's work focuses on neural and stem cell transplantation therapy for stroke and Parkinson's disease.
Scientists at the German Cancer Research Center discovered that brain stem cells in the subventricular zone are characterized by Protein Tlx, which stimulates gene activity. When Tlx is increased, tissue stem cells turn into cancer stem cells, leading to glioblastoma formation.
Researchers at University of California - Berkeley found an insulin-like signal necessary to keep stem cells alive in the adult brain. Blocking apoptosis genes alone is not enough, as neural stem cells also require an insulin-type signal to persist. The study suggests that manipulating the insulin pathway may be essential for re-growin...
Scientists at UCSF have developed a novel cell-based strategy to treat Parkinson's disease by transplanting embryonic neurons into the striatum, improving motor function and balance in rats. The approach may offer a more precise effect than traditional strategies and has implications for other neurodegenerative diseases.
A study published in the Journal of Cerebral Blood Flow & Metabolism found that repeated anesthesia can cause a significant decrease in stem cells in the hippocampus, leading to impaired memory and learning in young animals. The researchers believe this effect may be age-related, with younger animals being more susceptible.
Clive Svendsen's team develops specifically-engineered stem cells that stall nerve cell degeneration in ALS patients. The award will fund novel ex vivo gene therapy approaches to treat the disease.
A new study finds that induced pluripotent stem cells differentiate less efficiently and faithfully than embryonic stem cells, which are considered the 'gold standard' for all pluripotent stem cells. Despite their limitations, induced stem cells can still be used for certain applications, such as testing potential new drugs.
Researchers demonstrate that transplanted stem cells can rescue diseased neurons from death by sending signals through gap junctions, a newly recognized way of cell communication. This mechanism may play a role in both normal development and many diseases, including Huntington's disease and spinal cord injuries.
Researchers at Karolinska Institutet have discovered that stem cells can connect with and rescue threatened neurons through direct contact via gap junctions. The findings suggest a new possible treatment approach for brain damage and neurodegenerative diseases.
Scientists at Queen Mary University of London have discovered that medulloblastomas, the most common type of children's brain cancer, can arise from a specific type of stem cell. This breakthrough finding may lead to new ways to tackle the disease and improve treatment outcomes for patients.
Researchers developed a self-assembling nanofiber scaffold to regulate cell activity, delaying growth and differentiation. The innovation enhances the survival rate of implanted stem cells, allowing them to maintain their youthful state and promote neural circuit regeneration.
Researchers have created human stem cell-derived neurons to model Alzheimer's disease and Niemann-Pick Type C, revealing early transport defects as a key factor in severe neuronal dysfunction. The study aims to understand how genetic differences affect cellular transport and behavior in these diseases.
Scientists have discovered a new type of stem cell in the skin that acts like embryonic stem cells, generating various cell types and aiding in hair growth and wound healing. The dermal stem cells may hold the key to treating baldness and other neurological disorders.
Researchers discovered that the peptide C3a regulates nerve cell maturation and migration in mice, which could lead to treating stroke, Parkinson's disease, and other neurological disorders. The study found that molecules similar to C3a can boost nerve cell formation and replace damaged cells.
A Stanford study reveals that a gene linked to human longevity impacts the brain's ability to generate new neurons. Researchers found that mice without this gene had fewer neural stem cells and more rapidly churned out nerve cell precursors, leading to brain weight increases.
Researchers genetically engineered adult neural stem cells to express anti-inflammatory molecule IL-10, improving functional and pathological recovery from multiple sclerosis. These modified cells induced immunomodulation, nerve cell repair, and production of the nerve cell protective sheath.
Researchers have identified a molecular mechanism underlying DES-induced male infertility in mice, which may be linked to increased incidence of human reproductive disorders. The study found that neonatal exposure to DES disrupts the protein NR0B2, leading to reduced fertility and protected males against negative effects.
The Gladstone Institute of Neurological Disease and partners will use induced pluripotent stem (iPS) cell technology to develop human neurons with Huntington's disease characteristics, offering hope for new treatments. The goal is to understand the molecular differences between mice and humans that lead to ineffective therapies.
Case Western Reserve University researchers are using pluripotent stem cells to study schizophrenia and gain a better understanding of the complex disease. The study aims to characterize brain cell function in adolescent patients with schizophrenia, with the goal of deciphering the underlying cause of the condition.
Researchers at Salk Institute discover critical period during which Lhx2 decides progenitors' regional identity, determining the development of distinct cortical regions. This knowledge may help understand neurodegenerative disorders and specify stem cells to repair brain damage.
A UNC study found that the GSK-3 gene plays a crucial role in regulating the balance between neural stem cell proliferation and differentiation. Deleting this gene led to an overabundance of proliferating stem cells, resulting in fewer mature neurons. This discovery has implications for treating neuropsychiatric disorders.
A new study resolves the mystery of Merkel cell development, finding that they originate from the embryonic epidermis. Adult skin stem cells also replenish the Merkel cell population as they die off over time.
The Canadian Stem Cell Foundation has released a charter that unifies supporters of stem cell research, outlining five principles for advancing the field. The charter aims to promote responsible science, protect citizens, and empower the public to speak out on behalf of stem cell research.
Scientists create induced pluripotent stem cells from human neural stem cells using a footprint-free methodology, retaining some gene expression of the original donor cells. The study reveals that these cells maintain a 'transcriptional signature' similar to human embryonic stem cells.
A study finds substantial improvement in a mouse model of a rare neurodegenerative disease after transplantation of normal human neural stem cells. The transplanted cells provided a critical enzyme missing in the brains of experimental mice, showing promise for a potential therapeutic approach.
Researchers found that HPRT gene plays crucial role in regulating transcription factors' expression and development of neurons, supporting a possible link to Lesch Nyhan disease. The study provides first direct experimental support for HPRT's involvement in neurological disorders.
Researchers have developed a new technique to efficiently edit genes in human embryonic stem cells, enabling the creation of specific cell types for modeling genetic diseases. The method uses zinc finger nucleases to cut out one gene and substitute it with another, allowing precise control over gene expression.
The study reveals that alpha-synuclein aggregates can pass to new, healthy cells, contributing to the progression of Parkinson's disease. The researchers found that cell-to-cell transmission of alpha-synuclein occurs through endocytosis and is linked to impaired quality-control systems in recipient cells.
Researchers at UC Irvine have found that neural stem cells can rescue memory in mice with advanced Alzheimer's disease by secreting a protein called BDNF, which creates new neural connections. This study provides hope for a potential treatment for the leading cause of elderly dementia.
A recent study found that transplanted neurons develop disease-like pathology in Huntington's patients, raising concerns about the therapeutic potential of cell transplantation therapy. The research suggests new mechanisms involved in the development of the disease and offers a new direction for developing novel therapeutic strategies.
Researchers at the Salk Institute found that Fgf10 plays a critical role in regulating brain development by controlling the timing of cellular transitions. This process, known as corticogenesis, allows for the expansion of specific brain areas, such as the frontal lobe in humans.
Researchers at Goethe University Frankfurt identified a soluble Notch inhibitor, EGFL7, which blocks neural stem cell self-renewal and promotes differentiation into neurons. The findings offer potential medical applications in tissue development and neurodegenerative diseases.
Researchers have identified a fruit fly tumor suppressor gene, PP2A, that can prevent brain tumors from forming. The study suggests that the protein's counterpart in mammals may also play a crucial role in regulating neural stem cell divisions and controlling tumor development.
A study conducted by Michigan Medicine scientists found that a deficiency in the p53 gene in the brain leads to glioblastoma, a type of adult brain cancer. The researchers discovered that neural stem cells in the subventricular zone may be the origin of this aggressive cancer, suggesting a new target for treatment and early screening.
Researchers found that a deficiency in tumor suppressor gene p53 leads to glioblastoma, a highly aggressive type of brain cancer. The study suggests that targeting the subventricular zone, where neural stem cells reside, may improve treatment outcomes and enable early detection.
The American Society for Neural Therapy and Repair (ASNTR) endorses the new NIH Guidelines, enabling research on human embryonic stem cells derived from IVF embryos. This move aims to facilitate the development of stem cell therapies for central nervous system diseases by reducing restrictions on cell line acquisition.
Scientists at the University of Edinburgh have discovered that zebrafish can produce motor neurones after spinal cord damage, offering a potential stem cell treatment for humans. Researchers are now screening small molecules to find drugs that could kick-start motor neurone regeneration.
Researchers at the Burnham Institute developed a protocol to differentiate human embryonic stem cells into committed neural precursor cells, which can be used for transplantation. The C-NPCs were transplanted into mice and became active neurons without generating tumor outgrowth.