Articles tagged with Neural Stem Cells
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have found that transplanted human umbilical cord blood cells migrate to brain tissue and remain active for up to 30 days, without promoting tumor growth. The study suggests that these cells may confer therapeutic effects through modulation of the inflammatory response associated with Alzheimer's disease.
Researchers discovered that bipolar patients' brain cells are more sensitive to stimuli, leading to differing responses to lithium. The study suggests a starting point for probing cellular differences and developing new treatments.
A University of California, Irvine study found that neural stem cells can improve both motor and cognitive impairments associated with dementia with Lewy bodies. The treatment involves the production of brain-derived neurotrophic factor, which enhances dopamine- and glutamate-producing neurons.
Researchers have successfully generated aged neurons using stem cell technology, allowing for the study of age-related changes in the brain. The newly created neurons exhibit defects in protein transport and gene expression patterns similar to those found in older brains.
The researchers created mini-brains using living tissue from a single rodent, which can form complex neural connections and produce electrical signals within two weeks. The approach is expected to reduce animal use in neuroscience research and make it more accessible to labs without advanced equipment.
Researchers at NYU Langone Health found that GANT61 increases myelin production by 50% and recruits neural stem cells to repair damaged areas of the brain. The treatment also improves symptoms in mice with multiple sclerosis, including paralysis and leg weakness.
Researchers have identified a unique group of stem cells in the human brain that generate most neurons, expanding the cortex by 1,000-fold. These stem cells, called outer radial glia (oRGs), exhibit remarkable generative capacity and self-renewal properties.
Scientists at the University of Zurich discovered a novel mechanism that helps neural stem cells resist aging-induced damage. A diffusion barrier in the endoplasmic reticulum regulates the sorting of damaged proteins, allowing for rejuvenation and longer lifespan.
Justin Ichida's lab will use cellular reprogramming to transform blood cells of ALS patients into motor nerve cells in a Petri dish. The goal is to rescue the cells by exposing them to normal levels of C9ORF72 protein and reveal its protective mechanism against ALS.
Researchers from Drexel University used image-tracking technology to study the development of neural stem cells in mice, finding intrinsic differences between anterior and posterior stem cells that could explain how areas of the cortex develop into specialized structures. The discovery was made possible by powerful biological tracking ...
Researchers at the University of Newcastle have developed a method to generate large and pure populations of human Schwann cells using small molecules, which support nerves and play a crucial role in nerve repair. These cells exhibit characteristics similar to those found in the body and can interact with nerves in vitro.
Researchers have identified a protein, NFIX, that promotes the differentiation of neural stem cells into oligodendrocytes, a type of glial cell crucial for protecting neurons. This finding has implications for the development of stem cell-based therapies for brain injury and demyelinating diseases.
Researchers in China have independently transformed skin cells from humans and mice into neurons using chemical cocktails. The studies show that the reprogrammed cells exhibit similar gene expression and neuronal activity as those generated through traditional methods.
Researchers found that dental pulp stem cells can regenerate myelinated axons in laboratory rats with sciatic nerve defects, outperforming autologous nerve grafts. The study suggests that MDPSCs contribute to peripheral nerve regeneration through the secretion of neurotrophic and angiogenic factors.
Researchers at LCSB have successfully grown dopaminergic neurons in a three-dimensional cell culture system. The system models the natural conditions of the brain and is significantly cheaper than existing methods, allowing for the automation of drug testing.
A study published in Cell suggests that adult neural stem cells are pre-programmed to make specific neurons before birth, contradicting the long-held assumption of their potential for neural repair. The researchers found that the precise type of neuron each stem cell can develop into is determined by its location on the ventricle wall.
Researchers successfully grow multiple brain structures and form connections between them in vitro for the first time. The new method uses human pluripotent stem cells to produce connections between neurons from different brain regions.
Scientists have discovered two distinct types of stem cells in the hippocampus, a region critical for learning and memory. The discovery may lead to new treatments for learning- and mood-related disorders.
Researchers have developed mini cultured 3-D structures that grow and function like the outer mantle of the brain, allowing for modeling and understanding of mental illnesses. The new 'human cortical spheroids' buzz with neuronal network activity, providing a potential breakthrough in personalized medicine.
Researchers created a human embryonic stem cell model that allows real-time tracking of cellular behavior during early human development. The study discovered critical molecular cues required for the formation of the neurovascular unit, comprising endothelial cells, smooth muscle cells, and autonomic neurons.
Researchers have developed high-throughput techniques to quickly and easily give every cell in a sample a unique genetic barcode, enabling scientists to analyze complex tissues at the single-cell level. This breakthrough allows for deeper understanding of cell diversity and gene expression.
Researchers at McMaster University have developed a technology to convert adult human blood cells into functional neurons, providing insights into pain perception and potential new treatments. This breakthrough could lead to the development of personalized pain medications that target specific neural pathways.
Researchers have found that epilepsy reduces the generation of new neurons in the hippocampus, a brain region crucial for learning and stress response. The study's findings suggest that preserving neural stem cells could prevent or mitigate epilepsy symptoms.
Researchers have made significant progress in cell transplantation therapy, demonstrating improved outcomes for patients with complete spinal cord injury and potential treatments for Parkinson's disease. Studies also show that human pluripotent stem cells hold promise for treating the disease.
A new study suggests that injecting stem cells into the eye may preserve vision in people with early-stage age-related macular degeneration. The treatment, which uses adult-derived human cells, has shown promise in laboratory rats and could potentially be used to slow or reverse the effects of the disease.
Johns Hopkins researchers have developed a new tool for understanding ALS by transforming skin cells into brain cells affected by the disease. The resulting cell library, now publicly available, will enable scientists to study the disease in greater detail and potentially discover new treatments.
Researchers have developed new 3D designs for reconstructing damaged neural tissue using stem cells grown on nanofiber scaffolding within a supportive hydrogel. The approach guides neural connections, acting like a roadmap for cell growth and function.
A research team at UCSF has discovered a noncoding RNA molecule called Pnky that can be manipulated to increase the production of neurons from neural stem cells. The study suggests that Pnky may have broad applications in regenerative medicine, including treatments for Alzheimer's disease and Parkinson's disease.
Researchers at UC San Diego have identified a gene variant in the SORL1 gene that may be used to predict people most likely to respond to an investigational therapy for Alzheimer's disease. The study found that variants of the gene confer some protection from AD and are associated with reduced beta amyloid peptide production in neurons.
The generation of neurons in humans is limited to development, and this process declines with age due to the limited self-renewal of neural stem cells. Therapeutic approaches must focus on maintaining stem cell supply by promoting their self-renewal rate.
Columbia University researchers successfully converted human skin cells into hypothalamic neurons, a type that regulates appetite. These neurons provide a patient-specific model for studying the neurophysiology of weight control and testing potential therapies.
Researchers found that fruit flies can remember and crave sweeter, energy-rich foods. A growth factor controlling brain vessel formation also stimulates mouse and human neural stem cells to produce new brain cells.
Researchers at UCI found that transplanted human neural stem cells can restore cognitive functions in rats with chemotherapy-induced damage. The study suggests that stem cell therapies may one day provide relief to patients suffering from cognitive impairments incurred as a result of their cancer treatments.
Researchers are using novel methods to understand how nerve cells form new connections after spinal cord injury, with the goal of restoring function and movement. A five-year NIH grant will allow them to isolate specific cell types and study their growth and interactions.
Human stem cells have been shown to repair damage caused by radiation therapy for brain cancer in rats, regaining cognitive and motor functions lost after treatment. The study uses human embryonic stem cells or induced pluripotent stem cells to replace damaged oligodendrocyte progenitor cells.
Scientists at RIKEN have successfully induced human embryonic stem cells to self-organize into a three-dimensional structure resembling the cerebellum. The resulting neurons demonstrated proper responses to currents and inhibition, indicating functional development. This breakthrough could lead to modeling of cerebellar diseases like s...
A recent review article suggests that stem cell therapy may be less effective in older patients with chronic diseases, such as diabetes and cardiovascular disease. The study proposes strategies to enhance the regenerative properties of autologous stem cells and improve their therapeutic potential.
Researchers at Harvard University successfully converted mouse and human skin cells into pain sensing neurons that respond to various stimuli, including acute and inflammatory pain. The 'disease in a dish' model may lead to improved drug development for chronic pain treatment.
A study in mice reveals that Sox2 protein can convert NG2 glia, a type of support cell, into neurons in the injured cerebral cortex. This finding supports the notion that cellular reprogramming may become a way to replace degenerated neurons in the adult brain.
Scientists at Karolinska Institutet have discovered a key role for the signal molecule TGF-beta in regulating brain stem cells' development potential. By understanding this mechanism, researchers hope to develop new treatments for neurodegenerative diseases.
Researchers at McLean Hospital have successfully transplanted human stem cell-derived neurons into the brains of mice with epilepsy, reducing seizures in half of the recipients. The treatment showed promise, with improved electrical activity and reversal of seizure symptoms.
Researchers successfully generate neural stem cells that can self-renew and differentiate into neurons, opening the door to transplantation therapies. The breakthrough allows cells to divide repeatedly without ongoing expression of reprogramming factors, making them suitable for therapeutic use.
Transplantation of stem-cell-derived dopamine neurons restores motor function in a rat model of Parkinson's disease, suggesting a viable alternative to existing treatments. The therapy demonstrates efficacy and potency similar to fetal neurons, paving the way for human clinical trials.
Scientists have found that ganglioside GD3 is crucial for maintaining neural stem cells in the brain. Removing GD3 from mice resulted in reduced stem cell populations and impaired function, highlighting its importance in brain health.
Researchers found that newly formed brain cells in the olfactory system maintain proper connections and are essential for recovery from disrupted states. The discovery challenges previous assumptions about neuronal development and suggests a constant supply of new neurons is necessary to stabilize the mature structure.
A team of scientists received funding to investigate how neural stem cells vary, which could lead to better treatments for neurological conditions. The study aims to identify molecular differences between types of neural stem cells, shedding light on their behavior and potential therapies.
A new study by UCLA researchers demonstrates how maternal inflammation can trigger excessive division of neural stem cells, leading to brain overgrowth and autism-like behavior in offspring. The findings suggest a potential environmental factor contributing to the complex disorder.
The University of California, Irvine is leading an $8 million National Institutes of Health effort to develop a comprehensive database of human brain cell activity. The project will focus on understanding the underlying mechanisms of motor neuron disorders like ALS and other neurodegenerative diseases.
Researchers found that the protein BRD4 plays a crucial role in regulating stem cell identity, holding promise for regenerating tissues and organs. The study suggests that inhibiting BRD4 could be used to reprogram stem cells into specific cell types, such as neurons.
A study on Gambel's white-crowned sparrows reveals how dying brain cells trigger the growth of new neurons each spring. The researchers hope to apply this knowledge to develop treatments for neurodegenerative diseases like Alzheimer's and depression.
The UW-Madison team is creating a human tissue chip technology to classify compounds as dangerous or not dangerous. The technology has shown 100% accuracy in predicting toxic responses with early results on a 2-D system with 45 known toxins.
Researchers at the University of Cambridge discovered that stem cells 'communicate' with damaged cells by transferring molecules via fluid-filled bags called vesicles, helping other cells modify the damaging immune response. This novel mechanism enables stem-cell-based therapies to work more efficiently.
Using human induced pluripotent stem cells (hiPSCs), researchers discovered that schizophrenia patients' hiPSC-derived neurons release more neurotransmitters, including dopamine. This finding could lead to a better understanding of brain disorders and the development of new therapeutic strategies.
Researchers at University of Wisconsin-Madison found that the stiffness of surfaces on which stem cells are grown influences cell fate. A soft, brain tissue-like surface directed cells to become neurons, while stiffer surfaces favored the stem cell state.
Researchers explore adipose-derived stem cells as a tool for improving nerve regeneration through bioengineered nerve grafts, aiming to revolutionize peripheral nerve repair. Adipose-derived stem cells have shown potential to stimulate improved nerve regeneration and could replace current clinical approaches.
A thermosensitive collagen hydrogel was used as an extracellular matrix to construct tissue-engineered peripheral nerve composites in vitro. The results showed that seeded cells maintained larger numbers and were well-distributed throughout the material, improving the construction of tissue-engineered peripheral nerves.
Researchers have developed a method to isolate stem cells from skeletal muscle that can regenerate nerves after severe damage. These cells, called Sk-MSCs, have been shown to facilitate the growth of responsible nerve and vascular cells, making them a potential tool for treating large resection surgery.
Research highlights the importance of glial cells in CNS regeneration. Glial cells provide support and protection for neurons, but also influence the survival and fates of transplanted neural stem cells. Regulating their behavior can create a permissive microenvironment for neuronal regeneration.
Researchers have found that blood cells in crayfish can differentiate into neurons, challenging our understanding of neural development and regeneration. This discovery has significant implications for the treatment of neurological diseases such as clinical depression and neurodegenerative disorders.
Researchers at University of California, San Diego School of Medicine and Veteran's Affairs San Diego Healthcare System report that neurons derived from human induced pluripotent stem cells (iPSC) extended tens of thousands of axons across the rats' central nervous system. The study suggests a promising approach for treating spinal cor...