Articles tagged with Neural Stem Cells
New UCL research reveals that blood vessels play a vital role in telling neural stem cells when and how to reproduce. The study found that preventing blood vessel growth interferes with normal neuron production, causing stem cells to disappear from the brainstem.
Researchers have discovered that schizophrenia-linked gene deletions alter the brain's ability of stem cells to differentiate into neurons and astrocytes. HiPSCs from patients with schizophrenia exhibit reduced neurogenesis and increased glial cell production compared to healthy controls.
Researchers at Lund University have made a significant breakthrough in producing high-quality dopamine neurons using stem cells. The study has identified key markers that correlate with successful transplantation and graft function, enabling a more accurate methods for producing dopamine cells for clinical use.
A recent study suggests that manipulating the immune response in adult zebrafish brains could lead to the activation of neural stem cells and the proliferation of new neurons. This finding has significant implications for the potential development of novel therapies against Alzheimer's disease.
Researchers at SNPRC have developed an operational technique for delivering neural stem cells to the brain with low invasiveness and high accuracy, targeting the basal ganglia to treat Parkinson's disease. The technique revealed a pulsatile dispersion of injected cells, which could enhance cell survival and efficacy.
Researchers used Real-time intraoperative magnetic resonance imaging (RT-IMRI) to guide the transplantation of induced pluripotent stem cell (iPSC)-derived neurons into brains modeled with Parkinson's disease. The study found that RT-IMRI guidance enhances cell survival and improves procedure efficacy and safety.
Researchers have confirmed that mutation-caused dysfunction in a process cells use to transport molecules within the cell plays a previously suspected but underappreciated role in promoting Alzheimer's disease. The study found that treating mutated neurons with a beta-secretase inhibitor rescued endocytosis and transcytosis functions.
Researchers found that induced neural stem cells promoted survival and functional recovery in mice modeled with ischemic stroke. The study also discovered that early administration of iNSCs protected the brain from ischemia-related damage, reducing infarct volume and enhancing sensorimotor function.
Researchers used human embryonic stem cells to treat spinal cord injuries in mice, finding that the cells produced GABA, reduced neuropathic pain and bladder dysfunction, and improved voiding ability. The study suggests a new approach for treating chronic pain and bladder issues in spinal cord injury patients.
Researchers generated induced pluripotent stem cells from Nijmegen breakage syndrome patients and found that the P53 gene plays a crucial role in neural development, leading to cancer and neurological impairments. The study provides a powerful tool for understanding the disease and may lead to new treatments.
Researchers have identified a potential molecular mechanism through which lead exposure can harm neural stem cells and neurodevelopment in children. Lead exposure was found to induce oxidative stress response in these cells, with two proteins involved in the process: SPP1 and NRF2.
A Yale team discovered that Zika virus diverts a key protein necessary for neural cell division, causing microcephaly. Researchers found an FDA-approved drug, Sofosbuvir, may prevent Zika virus infection of neural stem cells and keep phospho-TBK1 involved in cell division.
A new study found that a human protein combined with stem cell therapy can repair brain damage caused by stroke. The treatment, known as 3K3A-APC, was tested in mice and showed promising results, including the growth of functional neurons and improved motor function. Researchers believe this could pave the way for a potential breakthro...
A new study found that a combination of stem cell grafts and a compound called 3K3A-APC significantly improves motor and sensory functions in mice with stroke-induced brain damage. The therapy increases the production of nerve cells, forming functional connections with the host's nervous system.
Researchers discover Zika virus kills off neural stem cells in adult mice, raising concerns about its impact on the adult brain. The study found a 4- to 10-fold drop in adult stem cell proliferation, which could have implications for learning and memory.
Researchers found that neural stem cells in the hippocampus use the Drosha protein to regulate their differentiation into specific cell types. The discovery challenges the long-held view that stem cell differentiation is controlled solely by the local environment.
Researchers have identified two Zika proteins responsible for thousands of microcephaly cases in Brazil and elsewhere. These proteins stunt brain development and promote autophagy, leading to reduced neural stem cell differentiation and growth.
Researchers identify citron kinase as key to building a normally sized human brain, finding mutations associated with severe microcephaly and lissencephaly. Studying stem cells and human brain tissue provides clues to the condition's origins, paving the way for further research into its causes.
A microfluidic device has been developed to replicate the neuromuscular junction, enabling precise stimulation of nerve cells and observation of muscle interactions. This innovation may help identify effective treatments for ALS and other neuromuscular disorders.
Researchers at the University of Basel discovered that the choroid plexus produces key signaling factors that regulate adult neural stem cells. As people age, these signals change, affecting stem cell behavior and leading to a decrease in new neuron formation.
Researchers at Cedars-Sinai Medical Center have discovered that current engineered stem cells are too immature to accurately model ALS. To improve this, they suggest 'aging' the motor neurons in a laboratory dish to better represent the disease's progression.
The National Stem Cell Foundation has funded a grant to study how astrocytes can be manipulated to halt or prevent neurodegeneration in diseases like MS and Parkinson's. The researchers aim to advance understanding of cell cross-talk in the central nervous system.
A new study co-led by Salk Institute scientists found that some people with autism spectrum disorder have brains that grow faster than usual, often before diagnosis. The researchers used stem cell reprogramming technologies to model the earliest stages of complex disorders and evaluate potential therapeutic drugs.
Scientists at Hokkaido University developed a new CRISPR/Cas9 technique to unleash silenced genes, changing cell fates. They used DNA repair mechanism MMEJ with CRISPR/Cas9 to replace off-switches with on-switches, enabling efficient gene expression in cultured cells.
A new study shows that post-transplant gamma-ray irradiation can prevent immature cells from forming tumors in rat brains after human iPS cell transplantation. This approach aims to improve the safety of cell replacement therapy using human iPS cells for Parkinson's disease treatment.
Researchers at Johns Hopkins Medicine have successfully grown lab-grown human nerve cells that can partner with heart muscle cells to stimulate contractions. The nerve cells, derived from pluripotent stem cells, were found to connect with and control heart muscle cells, similar to their natural counterparts.
Human parthenogenetic stem cells derived from unfertilized oocytes can be used to generate unlimited supply of neural stem cells for transplantation. The study found that grafting these cells into non-human primates with Parkinson's disease promoted behavioral recovery and increased dopamine concentrations.
By transplanting healthy human glia cells into mice with Huntington's disease, researchers were able to reduce symptoms and slow disease progression. The transplanted cells restored normal neuronal activity and rescued nerve cells at risk of death.
Researchers at UC Santa Barbara have pinpointed a specific long non-coding RNA that regulates neural development and drives human brain expansion. The lncRNA, called lncND, binds to microRNAs and regulates the expression of Notch proteins, which are critical for cell differentiation and development.
A study published in Acta Neuropathologica shows that abnormal protein from Huntington's disease (HD) can spread to the brain of normal animals, leading to behavioral abnormalities. The findings provide new insights into how HD develops and may lead to novel therapies for neurodegenerative diseases.
The Brazilian Zika virus strain causes significant damage to mouse fetuses, leading to cell death and impaired growth. In vitro experiments confirm the virus's lethal effects on human nervous system cells, mirroring the development of congenital malformations like microcephaly.
Researchers found that Zika virus activates the innate immune receptor TLR3, which leads to cell death in neural stem cells. However, inhibiting TLR3 helps infected cells survive and function normally.
Researchers have discovered how Zika virus blunts brain development by hijacking the human immune system. The study found that activating a specific protein called TLR3 triggers genes that block stem cell differentiation and lead to increased cell suicide.
A recent study tracked developing cells in an adult mouse brain, finding that the brain prunes back excess dendrite branches to achieve optimal design. This pruning process may hold implications for understanding neurological disorders such as autism, intellectual disabilities, and schizophrenia.
A University of Wisconsin-Madison neuroscientist has successfully inserted a genetic switch into nerve cells to regulate dopamine production with designer drugs. This breakthrough could lead to the development of a new Parkinson's disease treatment and expand its application to other conditions.
Researchers at Gladstone Institutes successfully reprogrammed human skin cells into beating heart cells and neural stem cells using chemical cocktails. This breakthrough could lead to new treatments for heart failure and neurodegenerative diseases.
A cancer drug has improved learning and memory in mice with fragile X syndrome by coaxes neural stem cells to generate neurons critical for cognitive function. The treatment targets the MDM2 enzyme, which is overactive in FMRP-deficient cells, leading to enhanced proliferation but reduced differentiation.
Brain-region-specific organoids were used to model Zika virus exposure, showing the virus prefers to infect neural stem cells and causing cell death. The technology has potential as a preclinical testing ground for therapies against Zika.
Researchers found that neural stem cell transplantation increased M2 microglial proteins, contributing to anti-inflammatory effects and reducing axonal injury. The study suggests a potential therapeutic strategy for treating traumatic brain injury.
Human cytomegalovirus (HCMV) infection can cause abnormal brain development in the fetus by activating a key signaling pathway. Studies have found that HCMV substantially reduces the rate of neurons generated by neural stem cells.
Researchers tested Zika virus in human neural stem cells to understand its effects on developing brains. The study found that the virus preferentially killed brain cells, reducing growth by 40% in a brain organoid model.
Researchers have developed a new method for gene transfer using an array of carbon nanotubes, overcoming limitations of existing technologies. The device successfully delivers DNA into tens of thousands of cells simultaneously with minimal toxicity and no restrictions on genetic payload.
A study of seven cases with severe myasthenia gravis found that autologous hematopoietic stem cell transplantation resulted in long-term symptom-free remission. The treatment was previously used for other autoimmune conditions, suggesting its potential as a therapy for MG.
The study found that the AXL surface receptor is highly abundant on human neural stem cells, but not on neurons in the developing brain. This discovery suggests that the Zika virus may be able to hijack this receptor to infect vulnerable cells, leading to devastating cases of microcephaly and eye lesions.
Researchers have deciphered an early step in the process of stem cells transforming into neurons, revealing a fundamental understanding of stem cell differentiation. The discovery identifies a new pathway, known as the PAN axis, which plays a crucial role in determining a stem cell's final form.
Scientists have developed a novel approach to track neural stem cells using microscopic iron beads and magnetic resonance imaging, allowing for non-invasive tracking without harming the cell. The findings focus mainly on neural stem cells but also show potential for use with mesenchymal stem cells.
Researchers developed a 3D micro-scaffold technology that promotes reprogramming of stem cells into neurons and supports growth of neuronal connections. The system improved cell-survival rates by nearly 40-fold compared to individual cell injections, enabling the potential treatment for human neurodegenerative disorders.
A $6.3 million CIRM grant will fund stem cell trials to rescue and restore neurons devastated by ALS. The goal is to extend motor neuron survival, adding years to fulfilling life for patients.
University of Wisconsin-Madison neuroscientist Xinyu Zhao has identified the genetic machinery that causes maturation in a young nerve cell, revealing four stages of gene activation. The study found hints about the origin of Alzheimer's, Parkinson's diseases and autism, suggesting a link between stem cell impairment and complex disorders.
Researchers found that the Zika virus directly targets human embryonic cortical neural progenitors, leading to cell death and stunted growth. The discovery provides critical insight into the link between the virus and birth defects like microcephaly.
A Johns Hopkins Medicine research team found that Zika virus selectively infects and kills cells in the brain's cortex, leading to disruptions in cell division and growth. This discovery using lab-grown stem cells may lead to identifying potential therapies for protecting these susceptible cells.
Researchers have found that Zika virus infects a type of neural stem cell responsible for brain development, leading to cell death and disruption of growth. The study provides new insights into the potential effects of Zika on neural tissue and may lead to the development of therapeutics.
Researchers at TSRI successfully sequenced individual neuron genomes and produced live mice carrying neuronal genomes in all of their cells. They found that each neuron contained an average of more than 100 mutations and accumulated more mutations in genes used frequently.
A stem cell study published in Stem Cell Reports has discovered that the GBA1 mutation creates problems with protein processing and recycling in cells, leading to an accumulation of alpha-synuclein. This excess protein is released into the brain, contributing to Parkinson's spread and symptoms.
Harvard researchers have identified a disrupted signaling pathway that, when corrected, can ameliorate symptoms of Rett syndrome in mice. The findings may lead to the discovery of compounds or drugs that can benefit children affected by the disease.
Researchers have found that carnitine deficiency can interfere with neural stem cell development, increasing autism risk. Supplementing carnitine may help offset this effect, particularly in cases involving genetic mutations associated with TMLHE gene variants.
Researchers at Dresden University Hospital have discovered a molecular signal pathway that allows stem cells and pancreatic islet cells to interpret signals in a similar manner. This finding could lead to new approaches for regenerating damaged tissue and treating metabolic diseases such as diabetes.
A new study using mouse embryonic stem cells found that gene mutations leading to Complex I deficiency cause significant differences in early patterns of cellular gene expression. The mutations also disrupted energy-producing processes, affecting neuronal development and the initiation of a heartbeat.
Researchers at Duke University found that delayed neural stem cells can cause premature differentiation into neurons and increased cell death, leading to smaller brain development. This study provides new insights into the mechanisms of microcephaly and its potential links to other neurodevelopmental disorders.
Researchers have successfully created human stem cell-derived serotonin neurons, a breakthrough that could lead to more effective drug treatments for depression and anxiety. The cells were generated using induced pluripotent stem cells from patients' skin cells.