Articles tagged with Neural Stem Cells
Researchers discovered Ryk's chaperone, Smek, which regulates key genes transforming stem cells into brain cells. The study sheds light on the mechanisms of brain development and may lead to new therapies for neurological diseases and brain cancer.
Scientists at the University of Edinburgh have identified two molecules, SMAD2 and SMAD3, that enhance cellular reprogramming efficiency. This breakthrough could accelerate production of induced pluripotent stem cells for studying diseases like multiple sclerosis and Parkinson's disease.
A study published in Stem Cell Reports reveals that DNA-encoded factors influence the vulnerability of brain cells to Alzheimer's disease. Brain regions with higher Aβ protein levels are more susceptible to damage, while protected areas have a less toxic response.
Frequent alcohol consumption can lead to the death of stem cells responsible for creating new nerve cells in adult brains. Females are particularly susceptible to this damage, which may help develop new approaches to treating alcoholism.
Researchers from UW-Madison detail a defined process to make an exact mimic of the human blood-brain barrier in a laboratory dish. This breakthrough allows for more robust exploration of cells and their properties, paving the way for new therapeutic strategies.
A Rutgers-led study has shown promise in using inner ear stem cells to reverse deafness, but also poses a risk of increased cell division, which could lead to cancer. The researchers discovered that controlling the chromatin state can reduce unwanted stem cell proliferation.
Researchers have discovered a long-distance brain circuit that controls the production of new neurons in the hippocampus, a critical area for learning and memory. The circuit, involving the medial septum and PV interneurons, regulates stem cell activity and maintains healthy neurogenesis.
A new technique has been developed to accelerate the maturation of stem cells into neurons, enabling faster brain tissue regeneration. The method uses a hydrogel scaffold that mimics the elasticity and adhesive properties of the human brain, promoting neurogenesis and neural cell differentiation.
The New York Stem Cell Foundation (NYSCF) has selected six promising researchers and neuroscientists to join the NYSCF - Robertson Investigators program, providing critical seed funding of $1.5 million over five years. The program supports high-risk/high-reward research that aims to accelerate treatments and cures for various diseases.
Researchers review the effectiveness of stem cells and emerging agents in preventing and treating neurodegenerative pathologies. They discuss potential advantages and obstacles of using different types of stem cells and present evidence for further study of certain compounds.
Dr. Paul Tesar receives the 2017 NYSCF Robertson Stem Cell Prize for his pioneering work on pluripotent epiblast stem cells, which holds promise for treating neurological disorders like multiple sclerosis and pediatric leukodystrophies.
Researchers have found that interaction between mesenchymal and adult neural stem cells can strongly promote oligodendrogenesis, potentially leading to improved treatment options for Multiple Sclerosis. The study's results demonstrate conservation across species, offering hope for clinical translation.
Researchers have developed a new, simplified technique to produce homogeneous human brain cells in the lab, accelerating drug screening and disease study. This breakthrough allows for cost-effective production of large quantities of brain cells within weeks, enabling wider adoption in basic science and industry.
Researchers developed improved mini brain organoids from stem cells, closely mimicking human brain structure. They found critical similarities between the organoids and real brain tissue and identified effective drugs to block Zika's entry into the brain, offering new avenues for studying neurological disorders
Researchers at Karolinska Institutet create cell models of human brain using skin cells from patients with lissencephaly, a rare congenital developmental disease. The study reveals that diseased cells matured slower and were less mobile compared to healthy controls.
Researchers found that the success of transplanting stem cells into the brain to regenerate tissue damaged by stroke depends on the maturity of the neuronal precursor cells used. Mid-differentiated cells were most likely to mature and become neurons, according to the study published in Tissue Engineering.
Researchers at WashU Medicine convert skin cells from healthy adults into motor neurons, retaining their age and potential for studying neurodegenerative diseases. The technique eliminates ethical concerns and allows for the study of human motor neurons in the lab.
Researchers have found that Zika virus preferentially infects and kills glioblastoma stem cells compared to other cell types. A mutant strain of the virus shows promise in slowing tumor growth and extending lifespan when combined with chemotherapy, offering a new potential treatment for brain cancer.
Researchers found that Zika virus can kill glioblastoma stem cells, which are resistant to standard treatments. The virus targets these cells without harming noncancerous brain cells, making it a promising potential treatment option.
Scientists have successfully transplanted human stem cells into monkeys with Parkinson's disease, showing long-term benefits. The quality of donor cells, particularly the Dlk1 gene, played a crucial role in determining cell survival. This study brings iPS cell-based therapy closer to clinical trials.
A new study in mice found that transplantation of donor stem cells from human brain tissue can help repair an injured spinal cord. However, the effectiveness of these stem cells is hindered by the body's immune response to injury. Immune cell depletion can improve the recovery outcome for animals receiving transplanted stem cells.
Researchers found that human neural stem cells retained an intrinsic human rate of maturation despite being placed in a traumatic rodent environment. The study's findings suggest that clinical outcome measures for future trials need to focus on long time points after grafting, as success may take time.
A new study published in Neuron confirms that lab-grown astrocytes mature at the same rate as human brains, providing a valuable technique to investigate their role in brain development and disease. The findings have significant implications for understanding the roots of neurological disorders such as schizophrenia and autism.
Scientists coaxed early stage stem cells to create two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons. This imbalance has been implicated in neurodevelopmental disorders such as autism and schizophrenia.
Scientists at the University of California - Davis have discovered a way to steer neural stem cells transplanted into the rat brain towards specific locations using electric fields. This breakthrough opens up new possibilities for effectively guiding stem cells to repair brain damage and treat diseases such as stroke and injuries.
Researchers at Lund University have developed a method to produce diseased, aging brain cells on a large scale in a cell culture dish. This enables experiments that were previously not possible, opening up research areas linked to new drug testing, accurate disease models, and earlier diagnostics.
Researchers have discovered that specialized gut cells called enterochromaffin (EC) cells sense potentially noxious chemicals and trigger electrical impulses in nearby nerve fibers. This finding could lead to new approaches for treating gastrointestinal disorders like irritable bowel syndrome (IBS).
Researchers have found that brain regions can target specific pools of stem cells in the subventricular zone, stimulating them to divide and produce particular types of olfactory bulb neurons. This allows for the on-demand generation of specific neuron subtypes in the adult brain.
Researchers discovered a novel epigenetic signaling axis involving PRC1, microRNA, and PRC2 that regulates the self-renewal and proliferation of neural stem/progenitor cells. The study found that Ezh2 represses miR-203 expression, which negatively regulates self-renewal and proliferation but promotes neuronal differentiation.
Researchers found that Zika virus hijacks Musashi-1 protein to replicate in and kill neural stem cells, leading to microcephaly. The study suggests that MSI1 is essential for normal brain development and its presence increases the vulnerability of these cells to Zika infection.
Scientists have discovered how certain forms of motor neuron disease begin and progress, revealing potential new ways to slow down or even stop the process. Healthy astrocyte-supporting cells may play a role in combating neurodegenerative diseases.
Researchers at Massachusetts General Hospital discovered how a potential treatment for Huntington disease produces its effects, but found impaired NRF2-mediated activity in neural stem cells from HD patients. This limits the therapeutic potential of NRF2 signaling.
Scientists at the University of Seville have found that adult carotid body mother cells can transform into both blood vessels and neurons. This breakthrough could lead to new treatments for pediatric tumors and Parkinson's disease, as these stem cells may contribute to tumor growth.
Researchers developed a lab-based model of the blood-brain barrier defect that causes Allan-Herndon-Dudley Syndrome, a rare congenital disorder. The study may hold promise for treating this syndrome and analyzing other neurological conditions.
Researchers at USF Health used bone marrow stem cells to repair damage to the blood-spinal cord barrier in mice with ALS, improving motor functions and nervous system conditions. The study demonstrates an early step towards pursuing stem cell therapy for potential ALS treatment.
A steroid hormone called ecdysone has been identified as a crucial trigger for brain development in fruit flies. The hormone is similar to human thyroid hormone and its activity timing may hold clues to maternal hypothyroidism, a condition that can cause severe neurological defects and fetal brain damage.
UC Berkeley scientists have developed a new technique to track individual stem cells in the nose, uncovering clues that could help restore smell to those who have lost it. The team used single-cell RNA sequencing and statistical analysis to identify the molecules that trigger stem cell differentiation into specific cell types.
Researchers have identified multipotent stem cells in the human brain following a stroke, which can differentiate into neurons and help repair damage. These cells, called iSCs, express multiple stem cell markers and demonstrate high proliferative potential.
Researchers find Lgl1 controls neural stem cell proliferation, producing neurons and glia cells in the developing cortex. The study reveals two mechanisms of Lgl1 function: one for embryonic development and another for postnatal brain growth.
Li-Ru Zhao, PhD, MD, receives the 2017 Bernard Sanberg Memorial Award for her research contributions in acute and chronic stroke, vascular dementia, traumatic brain injury, and Alzheimer's disease. Her work has significantly advanced our understanding of SCF and G-CSF in slowing Alzheimer's progression.
Researchers created a new tool that analyzes RNA sequencing data using topology, providing insights into cellular differentiation and development. The approach identifies connections between cellular states and genes active during development, offering potential discoveries in understanding cell identity and guiding cellular development.
Researchers discovered a birth-and-death cycle of neurons in the adult mouse gut, with about five percent of nerve cells regenerating daily or a third every week. This finding has profound implications for understanding and treating digestive system disorders and diseases.
Researchers have discovered a key peptide called DBI that promotes the production of new neurons in the hippocampus, a region critical for learning and memory. DBI binds to GABA receptors, suppressing its inhibitory effect and allowing neural stem cells to proliferate.
Researchers developed organoids that resemble human brain structure, investigating rare congenital brain defect Miller-Dieker syndrome. The study reveals disrupted stem cell division leading to poor organization and early differentiation of nerve cells.
A team of scientists from Caltech has found that lamprey gut neurons originate from cells called Schwann cell precursors, challenging the long-held theory that these cells give rise to vagal neural crest cells. This discovery offers insights into the evolutionary origins of vertebrates and their digestive systems.
Researchers at Indiana University School of Medicine found that electroacupuncture triggers the release of reparative mesenchymal stem cells, which promote tendon repair and anti-inflammatory cell activity. The study's findings suggest a new approach to treating pain and injuries by harnessing the healing properties of stem cells.
A University at Buffalo research team has successfully reprogrammed adult skin cells into neural crest cells, a type of stem cell, without adding foreign genetic material. These cells can differentiate into various cell types found in the spinal cord and brain, holding promise for studying genetic diseases and generating regenerative t...
A team of scientists at the University of California San Diego has created a cellular model of anorexia nervosa using induced pluripotent stem cells, revealing a potential genetic link to the disease. The study identified a novel gene, TACR1, that may contribute to the development of eating disorders.
A recent study published in Developmental Biology reveals that stem cells adhere strictly to their unique species' developmental clocks. The research paves the way for accelerated stem cell differentiation and faster cell growth, potentially solving various diseases such as Parkinson's, Multiple Sclerosis, and Alzheimer's.
Research reveals that individual neurons or specific types of neurons can silence genes from one parent or the other, particularly during brain development. As the brain matures, these differences tend to decrease, but some genes continue to exhibit differential expression in adult brains.
Researchers at UTMB have discovered that the Asian lineage of the Zika virus halts brain stem cell proliferation and hinders their ability to develop into brain nerve cells. This finding provides insight into the mechanisms behind Zika-induced microcephaly, a serious birth defect characterized by small brain and head development.
Researchers have shed light on the relationship between misfolded alpha-synuclein protein and Parkinson's disease, identifying key genes and cellular processes involved. The study provides new insights into the underlying mechanisms of synucleinopathies, paving the way for developing patient-specific treatments.
Researchers at Lund University successfully incorporated transplanted neurons into a stroke-injured rat brain, showing they formed normal connections with the host brain. The study used human skin cells reprogrammed to become healthy neurons and demonstrated functionality in response to touch.
Scientists have discovered neural stem cells in epileptic brain tissue outside normal regions, suggesting greater plasticity in damaged brain areas. The study provides new knowledge about molecular characteristics of these cells and may lead to improved treatments for epilepsy.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have discovered that sorting nexin 27 (SNX27) is required for the formation of cells that maintain normal flow of fluid out of the brain. The study found that deleting SNX27 causes hydrocephalus, and gave hope for potential non-surgical treatments.
Researchers found a dynamic, multi-step process in which multiple independent changes converge to transform stem cells into motor neurons. The study outlines challenges facing current cell-replacement technology but also highlights potential pathways for enhanced gene-therapy methods.
Researchers have discovered that TET proteins, which modify methyl groups attached to cytosine, influence gene expression and facilitate the removal of these marks. This dynamic modulation is critical for driving developmental gene expression programs in early embryos, particularly in neural tissue formation.
Researchers have identified the functions of two sibling RNA-binding proteins in neural stem cells and neurons. PTBP1 and PTBP2 serve both redundant and unique roles in brain development, contributing to neuronal differentiation. This discovery has implications for fine-tuning stem cell therapeutic strategies for neurologic disorders.
Researchers discovered that neural stem cells serve as RNA highways, transporting proteins and messenger RNAs to the endfeet. FMRP was found to be responsible for controlling mRNA movement and is linked to autism-related disorders.
Researchers have discovered unexpected cells in the protective membranes covering the brain that produce new neurons after birth. This finding challenges current ideas about the brain's ability to heal and regenerate, and opens up new possibilities for developing new therapies for brain damage or neurodegeneration.