Articles tagged with Neural Stem Cells
The CIRM grant will enable pre-investigational new drug studies for neural stem cells as a potential treatment for perinatal hypoxic-ischemic brain injury, which can cause cerebral palsy and other neurological disorders. The project aims to protect at-risk brain cells and potentially restore balance to the injured region.
Researchers at UCSF and NIH create a new CRISPR technique that allows them to systematically alter gene activity in human neurons, enabling the study of neurological diseases. They discovered that housekeeping genes behave differently in neurons and stem cells, suggesting that these differences may play important roles in disease.
Researchers at the University of Cambridge discovered that increasing brain stiffness as we age causes brain stem cell dysfunction. They developed new materials to study this effect, showing that older stem cells can be rejuvenated into younger, healthier states.
Rutgers University-developed nanotechnology boosts stem cell transplantation research, enabling accurate characterization of human stem cell fates and biomarkers without destruction. This allows further analyses and biomedical applications, addressing a major hurdle in current cell-based therapies.
Researchers found that chronic stress leads to autophagic death of adult hippocampal NSCs, causing decline in adult neurogenesis. Deleting Atg7 or SGK3 gene prevents cell death and maintains normal brain functions.
Boundary cells in zebrafish hindbrain sense mechanical forces to regulate progenitor stem cells and differentiated neurons. The activity of Yap/Taz-TEAD proteins is essential for maintaining boundary cells as proliferating progenitors.
Scientists at UC Davis have traced the fate of hydra's cells, revealing how three lines of stem cells become nerves, muscles or other tissues. This high-resolution map will help researchers understand regulatory gene networks in place early in evolution.
Researchers uncover a molecular mechanism controlling neural stem cell development, enabling precise differentiation into neurons. The discovery sheds light on brain developmental processes and has implications for stem cell biology and cancer research.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago discovered a previously unknown regulatory mechanism controlling stem cell differentiation into neurons in fragile X syndrome. This breakthrough offers novel targets for potential treatments for the condition.
The new microrobots can load, transport and deliver cellular material with greater speed and less damage than traditional methods, opening up a wide range of applications in life sciences and beyond. They also enable precise control over cell behavior, which is crucial for regenerative medicine and neural repair.
A Stanford University School of Medicine study found that immune cells called killer T cells infiltrate neurogenic niches in the aging brain, secreting a substance that chokes off new nerve cell production. This breakthrough could lead to progress in treating age-related brain deterioration and finding treatments to reverse it.
Researchers used stem cells and optochemogenetics to treat mice after a stroke, showing improved recovery. The combination of stem cell injection and stimulation increased successful recovery rates.
A UC Riverside study found that electronic cigarettes produce a stress response in neural stem cells, leading to cell death or disease. The research identifies a protective response mechanism called SIMH, which can accelerate aging and lead to neurodegenerative diseases.
Researchers at Emory University School of Medicine have developed an 'optochemogenetics' approach that modifies a widely used neuroscience tool to stimulate brain cells. The approach uses light to promote functional recovery in mouse models of stroke, with promising results for treating stroke patients.
Researchers developed a strategy to expand enteroendocrine cells in the gut, allowing for better study of gut-body communication. The new system enables detection of serotonin and other hormonal mediators, opening doors to research on gut health and disease.
Scientists have created functional neural networks derived from cerebral organoids, which can mimic the development of the human brain. The study provides a new tool for understanding brain function and may lead to breakthroughs in drug discovery, modeling neuropsychiatric disorders, and regenerative medicine.
Researchers found that seizures associated with Alzheimer's disease accelerate neurogenesis in adult brains, but administering anti-seizure medication restored normal dynamics and improved cognitive function. The findings suggest a possible explanation for the controversy surrounding neurogenesis in Alzheimer's patients.
Research at Kanazawa University reveals that FGF signaling pathway determines the fate of neural stem cells in cerebral cortex, enabling proper numbers of neurons and astrocytes to be generated. The study sheds light on the mechanisms behind brain disorders caused by unbalanced cell numbers.
Researchers at Duke-NUS Medical School discovered that a protein complex called CRL4 is essential for reactivating dormant neural stem cells in fruit flies, which can then generate new neurons. This finding could lead to therapeutic treatment of neurodevelopmental and neurodegenerative diseases such as Parkinson's or Alzheimer's.
Researchers developed a scaffold microrobot that precisely delivers cells to target tissues, increasing treatment safety and efficiency. The technology minimizes cell loss in the body and can be controlled wirelessly using an external magnetic field.
Researchers from Harvard Medical School and others have discovered that undifferentiated cells face multiple competing choices before committing to their ultimate destiny. By analyzing single-cell sequencing data, they found that genetic programs regulate various cellular functions and influence cell specialization.
A new study published in Cell Reports sheds light on the mechanisms used by neural stem cells to reactivate, with key findings indicating that STRIPAK molecules play a crucial role in enabling reactivation. The research holds promise for future therapies to replace lost brain cells and facilitate brain damage repair.
Researchers have created a method to track gene expression in cells during development, providing unprecedented detail. This technique could be used to develop future regenerative treatments for diseases like macular degeneration and other neurological disorders.
Scientists at the University of Bonn and Amsterdam created a novel human nerve cell model consisting of a single nerve cell from pluripotent stem cells, providing highly standardized conditions for investigating nerve cell functions. The model was tested with various stimulation experiments and demonstrated highly reproducible data.
Scientists at Kyoto University have found a 'wake-up' signal that can unlock brain cells' regenerative potential. The discovery, published in Genes & Development, reveals the ebb and flow of gene expression that activates dormant neural stem cells.
Swiss and Belgian researchers decipher the genetic programmes of neurons in the cerebral cortex to understand how specific cell types are generated. They found temporal patterns of gene expression that control the developmental scenario, which may contribute to neurodevelopmental disorders.
Researchers at Karolinska Institutet developed a stem cell-based model to study neuron resilience in ALS. The model identified genes contributing to the resilience of oculomotor neurons, which can withstand the disease.
Researchers at IST Austria identified PRC2 as a key protein regulating temporal maturation of stem cells, leading to correct neuron type production. Eliminating PRC2 activity resulted in incorrect neuronal cell type composition and reduced neuron numbers.
Researchers at the University of Maryland School of Medicine have discovered pigment-producing stem cells that can regenerate myelin sheaths in mice, potentially treating neurodegenerative diseases like multiple sclerosis. The discovery could offer a less invasive and simpler alternative to embryonic stem cells.
Researchers found that Integrator complex proteins regulate Earmuff, a transcription factor that prevents dedifferentiation. This process is critical for healthy brain development. Mutations in human Integrator genes are associated with neurodevelopmental syndrome.
Researchers have identified stem cells in hair follicles that can regenerate the myelin sheath coating neurons, potentially treating nerve injuries and demyelinating diseases like multiple sclerosis. The study found that these cells can enhance functional recovery from neuronal injury.
A new study by University of Notre Dame scientists reveals microglia can cross from the central nervous system (CNS) into the peripheral nervous system (PNS) in response to injury. This finding has broad implications for nervous system diseases and opens up new questions about the function and capabilities of these cells.
A team of researchers has shown that a single population of stem cells in mice generates new neurons throughout their lifetime, contributing to embryonic, early postnatal, and adult neurogenesis in the hippocampus. This finding suggests that the brain has the capacity for continuous improvement and adaptation.
Researchers from the University of Pennsylvania have found that a single population of stem cells generates new neurons throughout life in the hippocampus. This process is crucial for healthy learning, memory, and mood adjustment.
Researchers discovered that stem cells in the neural retina act as 'bosses' during growth, telling cells in the retinal pigment epithelium when to create more cells. The study reveals an unappreciated mechanism for growth coordination, where one tissue gives cues to synchronise the growth of nearby tissues.
Researchers found that brain stem cells from primary progressive MS patients act and look older than normal cells, affecting myelin production. Blocking a specific protein may improve oligodendrocyte growth and offer new treatment options.
Researchers at D'Or Institute improve human brain organoid cultivation protocol to display regionalized brain structures and retinal pigmented cells. The team's advancements aim to mimic later stages of brain development, enabling studies on neurological diseases and drug effects.
Researchers at LCSB and DKFZ successfully rejuvenated stem cells in the aging brain of mice, improving regeneration of injured areas. The study identified a molecule called sFRP5 that keeps neuronal stem cells inactive, but neutralizing it allowed them to proliferate again.
Scientists have identified a key role for protein Akna in regulating neural stem cells via microtubule organization, promoting differentiation and detachment from the niche. This mechanism also plays a crucial role in epithelial-to-mesenchymal transition.
Researchers at German Cancer Research Center discovered that stem cell genes remain active, allowing for reversible decision-making in becoming a neuron or reverting back to stem cell. Uncontrolled TOR activity can cause brain cancer, highlighting the importance of controlling this signal for future stem cell therapy developments
Researchers at Harvard Medical School have created a new model of sporadic Alzheimer's disease, which points to molecular causes and potential treatments. The model, reported in Cell Reports, removes a major obstacle for scientists seeking to understand the disease.
Researchers at TU Dresden found that increasing the number of neurons generated from stem cells improves the sense of smell in mice. This breakthrough suggests that stem cells can be used to enhance brain function and may lead to new therapeutic approaches for neurodegenerative diseases such as Alzheimer's and Parkinson's.
Scientists at Harvard University have identified a potential biomarker and drug target for amyotrophic lateral sclerosis (ALS), a neurological disease that is difficult to diagnose and treat. The gene STMN2 was found to be involved in the loss of motor neurons, which leads to progressive paralysis.
A study by Salk researchers reveals measurable differences in the patterns and speed of development in stem cells from individuals with autism spectrum disorder. The findings could lead to diagnostic methods to detect ASD at an early stage, potentially allowing for preventive interventions.
Researchers discovered a novel function of nestin in regulating neurogenesis through Notch signaling from astrocytes to neural stem cells. Adult mice deficient in nestin show increased newly born neurons and impaired long-term memory, highlighting the complex role of astrocytes in brain plasticity.
Scientists have successfully reprogrammed human blood cells into a new type of neural stem cell, similar to those in early embryonic development. This breakthrough could lead to the development of regenerative therapies for treating diseases of the nervous system.
Researchers found that the ability of self-renewal declines in old age, especially in certain intermediate stages called transit amplifying progenitors. This leads to a halt in the production of olfactory cells as they tend to remain in the stem cell pool and become less active.
Researchers discovered a two-step control mechanism in neural stem cells that differentiates into neurons and astrocytes. PRC1 represses genes related to neuronal function temporarily and permanently at two distinct stages of brain development.
Researchers discovered that lab-grown kidney cells can contain rogue brain and muscle cells, making them imperfect models for human kidneys. However, they found a way to prevent most of these off-target cells from forming, which could accelerate progress in developing better treatments for kidney disease.
Researchers developed a technique to create tissue-like structures from human stem cells, which were then transplanted into mouse brains. This approach showed improved cell survival and differentiation compared to traditional methods.
Researchers created a biodegradable scaffold to transplant stem cells and deliver drugs, promising relief from central nervous system diseases and injuries. The nano-size scaffolds mimic natural tissue and show promise for advanced stem cell transplantation and neural tissue engineering.
A research group from Kumamoto University discovered a new neurogenic mechanism responsible for brain development, revealing that Matrin-3 regulates the differentiation of neural stem cells into neurons. The absence of this protein causes disordered differentiation and collapse of brain layer structure.
Researchers compared iSCs and BM-MSCs for CNS repair capacity. iSCs exhibit potential for neuronal differentiation, making them promising candidates as therapeutic agents.
A study reveals how a single mutation in the GFAP protein, the most common protein in astrocytes, produces devastating effects on brain cells. The mutated protein causes widespread tangles and disturbs cellular processing units, reducing myelin formation.
Researchers induced a mild brain injury in mice and used neural precursor cells to show recovery of lesions and improved motor functions. The study suggests that these cells may enable the brain's own cells to repair damaged areas.
Researchers at Tufts University have developed 3D human tissue culture models for the central nervous system that mimic brain structure and function. The models allow for the exploration of cell interactions, disease progression, and response to treatment, enabling the study of neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers find that the autonomic nervous system directly controls stem cell proliferation in the intestinal lining and potentially other parts of the body. This discovery opens up new avenues for targeting cancer stem cells or inducing desired tissue growth through targeted drug delivery.
Researchers accidentally convert mature inhibitory neurons into dopamine-producing cells using a cocktail of proteins. The new cells show rhythmic activity and network connections similar to native dopaminergic neurons.
Researchers at UT Southwestern Medical Center discovered that mature inhibitory neurons can be transformed into a different type of neuron without relying on stem cells. The study reveals the possibility of changing mature neurons in adulthood and may lead to therapeutic strategies for treating neurological diseases.
Researchers at the University of Minnesota Medical School have discovered a subset of muscle stem cells that are located close to blood vessels and are likely to be the more potent stem cell population in maintaining muscle health. This groundbreaking study uses 3D technology to study the interaction between stem cells and blood vessel...