Articles tagged with Neural Stem Cells
Researchers at Kanazawa University discovered a biochemical signaling pathway that cancels out biological noise in the differentiation process of neural stem cells. The JAK/STAT pathway reduces stochastic neuroblast differentiation, contributing to correct organismal development.
Researchers developed a protocol to isolate dopaminergic neurons from stem cells, improving cell-replacement therapy outcomes. The study found that transplanted cells with the contactin 2 protein exhibited better dopamine release and reduced motor symptoms in Parkinson's disease models.
Researchers at University of Georgia have successfully reproduced the effects of traumatic brain injury and stimulated recovery in neuron cells grown in a petri dish. The procedure has significant implications for studying and treating such injuries.
Researchers from D'Or Institute and L'Oréal R&I successfully generated functional human sensory neurons that respond to painful stimuli. The breakthrough discovery has significant implications for the study of chronic pain, analgesic drugs, and the development of reconstructed human skin with enhanced neuro-inflammation predictivity.
Scientists discovered that neural stem cells in spinal cords are the limiting factor for tail regeneration. Unlike salamanders, lizard neural stem cells cannot produce diverse cell types needed for bony vertebrae development. This finding may aid understanding of why humans can't regenerate their tails.
Researchers created a mathematical model that captures cellular intent by analyzing mRNA changes over time. This approach helps analyze cell function, disease, and organ development, providing insights into treatment efficacy.
Scientists at University of California San Diego School of Medicine have successfully created a line of spinal cord neural stem cells that can be used to model diseases and potentially provide a scalable source of replacement cells for spinal cord injuries. The diverse cells, derived from human pluripotent stem cells, show promise in a...
A KAIST research team identified where glioblastoma mutation drivers originate, revealing that normal SVZ tissue away from the tumor contains low-level mutations. The study suggests novel ways to treat glioblastoma and implies a new paradigm for therapeutic strategies.
Researchers developed a computational method to accurately predict cell subpopulation conversions, enabling potential applications in regenerative medicine. The platform, TransSyn, identifies subtle genetic differences between cell subtypes, allowing for targeted gene expression alteration and cell reprogramming.
Researchers at the University of Guelph have discovered that leopard geckos can create new brain cells using a specific type of stem cell. This finding has implications for treating brain injuries and diseases, as it suggests that geckos may be able to regenerate parts of their brains.
UNIGE researchers found that bioelectrical potential is a driving force for stem cells to generate different types of neurons during embryogenesis. This discovery reveals an unexpected role for electrical charge in generating neuronal diversity, which could help explain how neurological disorders affect brain development.
Researchers at UNC School of Medicine found that mossy cells regulate adult neural stem cells to control neurogenesis, which is disrupted in many common brain disorders. Targeting these cells may offer a new treatment strategy for conditions like Alzheimer's disease and depression.
Researchers discovered fibro-adipogenic progenitor cells promote muscle wasting and scarring in spinal cord injury, ALS, and SMA models. By targeting IL-6-STAT3 signaling, they found a potential new avenue for treating or testing motor neuron diseases.
Disrupted transportation routes in nerve cells cause Parkinson's disease by destroying synapses and leading to cell death. Researchers identified alpha-synuclein protein as the trigger for these traffic jams.
Researchers at Mainz University Medical Center found that pericytes, a type of connective tissue cell in the brain, can be directly converted into neurons by manipulating signaling pathways. The cells must pass through a neural stem cell-like state before differentiating into two classes of neurons.
A novel stem cell-based model system mimics human brain tissue and reproduces features of Alzheimer's disease, indicating that modulating the immune system can trigger neuronal repair processes. The study suggests a potential approach to therapy by unlocking the potential of neural stem cells to build new neurons.
A study published in Cell found that a specific region of the brain's frontal lobe controls vocal pitch, enabling humans to convey meaning through speech and language. By examining neural activity and using brain sensors, researchers identified increased activity in this region when participants altered their voice pitch.
Researchers have identified a novel form of calcium signaling called store-operated calcium entry (SOCE) as the key to expressing specific proteins on individual neurons. This discovery has implications for understanding brain development, behavior, and disease, including neurodegenerative disorders such as spinocerebellar ataxia 15.
Researchers find subplate neurons don't die but become part of the adult cerebral cortex, influencing brain disorders. They identify a connection between subplate neurons and certain brain conditions and outline innovative stem cell techniques for treatment.
Researchers found that different neuronal types can acquire similar features using distinct mechanisms, shedding light on how complex brain tissue forms. This discovery enhances our understanding of brain cell development and holds potential for medical advancements, such as cell replacement therapy.
A USC research team discovered 150 proteins affecting brain development and cell activity that contribute to mental disorders. The study used stem cells to determine chemical reactions influencing nerve growth and cell functions in people.
A study published in Neuron has found that a neural precursor protein called PRDM16 plays a crucial role in shaping the organization of the cerebral cortex. The researchers discovered that when PRDM16 is active, it helps to regulate the migration of neurons and their ultimate positioning in the cortex.
Researchers at Drexel University successfully transplanted V2a interneurons into injured rodent spinal cords, improving respiratory function and demonstrating potential for future treatment of paralyzed patients. The study capitalizes on previous findings that these cells contribute to plasticity and self-repair in the spinal cord.
A first-in-human phase I clinical trial using neural stem cells to treat chronic spinal cord injuries showed measurable improvement in three of four participants. No serious adverse effects were observed, suggesting the approach can be performed safely.
Researchers discovered three human-specific genes influencing brain size, involved in genetic defects associated with neurological disorders. The genes, part of the Notch family, regulate neural stem cell development and delayed maturation, leading to larger brain sizes in humans.
Researchers identify NOTCH2NL genes as key to human-specific cortex development and large brain evolution. These genes delay neuron differentiation, resulting in more neurons across development.
Researchers found myelin stimulates axonal outgrowth in precursor neurons and stem cells, enhancing threefold growth. This breakthrough supports the use of neural precursor cells and iPSC-derived stem cells for repairing spinal cord injuries.
Researchers at Helmholtz Zentrum München discovered that cerebrospinal fluid flow stimulates neural stem cell division through ENaC channel protein. The study highlights a new mechanism controlling neural stem cell proliferation and has implications for brain function and treatment.
A Canadian research team has discovered how brain stem cells collaborate to build brain circuits during development. This understanding may lead to new treatments for neurodevelopmental disorders in children. The study also suggests that manipulating these brain-resident stem cells could promote brain repair.
Researchers successfully grafted induced pluripotent stem cell-derived neural precursor cells into the spinal cords of genetically identical adult pigs, eliminating the need for immunosuppression measures. The grafted cells survived long-term and displayed differentiated functionality without causing tumors.
Researchers at the University of Calgary have shed new light on the identity of brain stem cells that exhibit neural stem cell function. The study found that ependymal cells do not become neural stem cells when activated by injury, but rather regulate their function.
Salk scientists develop a new way to study brain cell connections, revealing how communication is altered in people with schizophrenia. By creating multiple types of neurons from stem cells and observing their interactions, the team showed that CA3 pyramidal neurons form physical connections both to other CA3 neurons and to DG neurons.
Researchers discovered Zika virus can infect and destroy human CNS tumor cells, reducing tumor mass and increasing survival rates. The virus shows a greater affinity for CNS tumor cells than healthy neural stem cells.
Researchers discovered that mature ependymal cells require continuous Foxj1 production to maintain shape and function, but viruses can shut down this process, leading to hydrocephalus. This study may lead to alternative treatments for the condition.
Researchers generated hypothalamic-like neurons from human induced pluripotent stem cells of super-obese and normal-weight individuals. These brain cells responded differently to hunger hormones and obesity-related genes. The study provides a platform for modeling complex polygenic diseases like obesity.
Researchers at Cedars-Sinai have discovered a new way to treat amyotrophic lateral sclerosis (ALS) by transplanting altered neural cells into the brain. Laboratory rats that received the transplants lived 8 percent longer and were free of paralysis 10 percent longer than untreated animals.
Scientists have developed a new method to create more sophisticated brain-like organoid models by transplanting them into rodents, enabling longer survival and increased complexity. This breakthrough could lead to better therapies for neurological disorders, as well as the potential for human cell transplantation in the brain.
Researchers have found that older adults can produce thousands of new hippocampal neurons, similar to younger individuals, which may suggest that senior citizens remain more cognitively intact than believed. However, they also had less vascularization and reduced connections between new neurons.
Evan Y. Snyder, a leading researcher on stem cells and neural development, has been elected to the Association of American Physicians for his groundbreaking contributions to human health. He will be inducted at the AAP annual meeting on April 21, 2018.
A study published in Journal of Clinical Investigation found that adult-onset progressive degenerative diseases have their roots in early developmental defects. Researchers used a mouse model of spinocerebellar ataxia type 1 and discovered altered neural circuitry in the cerebellum, which sets the stage for later disease vulnerability.
Researchers have identified over 30 different subtypes of retinal ganglion cells, the neurons responsible for processing visual information. This comprehensive understanding will enable the development of more tailored drug development and treatment strategies for neurodegenerative vision disorders.
Researchers at Stanford University School of Medicine have found that young neural stem cells store large protein aggregates in lysosomes. Clearing these aggregates rejuvenates the cells' ability to activate and makes new neurons. The study highlights the importance of maintaining precise control over protein production and disposal.
A study published in the Journal of Neuroscience found that Müller glia play a crucial role in preserving retinal synapses and preventing vision loss in macular degeneration. The research suggests that Müller glia are an important therapeutic target for treating degenerative eye diseases.
Using a stab injury model in adult zebrafish, researchers discovered that neural stem cells can regenerate brain tissues in the optic tectum. New neurons were generated from radial glia through Wnt signaling, providing insights into regenerative processes and potential applications for human CNS restoration.
Researchers have identified over 250 genes involved in brain aging, including Dbx2, which can prematurely age stem cells. The study found that increasing the activity of Dbx2 in young brain stem cells slows their growth, causing them to behave more like older cells.
Researchers studied angiogenin's entry into central nervous system cells to better understand its role in brain diseases like ALS and dementia. The study found that angiogenin uptake has multiple biochemical pathways, revealing a more intricate mechanism than initially thought.
Scientists successfully grafted human neural progenitor cells into rhesus monkeys with spinal cord injuries, growing hundreds of thousands of human axons and synapses. The findings represent a major step toward future human clinical trials for paralyzing spinal cord injuries.
Researchers at the University of Cambridge have shown that skin cells re-programmed into brain stem cells can help reduce inflammation and repair damage caused by multiple sclerosis. The study suggests that using a patient's own skin cells could provide a personalized route to treating chronic inflammatory diseases like MS.
A team from the University of Liège has discovered a new crosstalk between the migrating inhibitory interneurons and the stem cells that generate the excitatory neurons. This control regulates the production of excitatory neurons, leading to cortical malformation previously associated with autism in mice.
Researchers found that neural cells from schizophrenic patients produce less pro-angiogenic molecules and more anti-angiogenic proteins, impairing blood vessel formation. The study provides new insights into the causes of schizophrenia and potential therapeutic solutions.
Researchers at the University of Georgia have developed a new stem-cell based treatment for stroke that reduces brain damage and accelerates the brain's natural healing tendencies. In preclinical studies, the treatment showed a 35% decrease in brain atrophy rates and a 50% reduction in brain tissue loss.
Researchers observed stem cell divisions in the adult mouse hippocampus for the first time, showing that most stem cells divide only briefly before maturing. This process explains why newborn cells dramatically decline in number with advancing age.
Researchers found subtle changes in fetal brains infected with Zika virus during pregnancy, which can lead to significant learning problems and mental health disorders. The study suggests that children infected with the virus at a young age may also be at risk of brain damage.
Researchers at USC discovered a cellular mechanism that limits the number of 'cellular janitors' in the nervous system, leading to increased risk for ALS and frontotemporal dementia. The study found that a mutation in the C9ORF72 gene causes toxicity in nerve cells, resulting in cell death and degeneration.
Researchers discovered that a mutation in the C9ORF72 gene causes toxicity in nerve cells, leading to ALS and FTD. By reprogramming blood cells into motor nerve cells, they found that adding supplemental protein could stop degeneration, highlighting potential new drug targets.
Researchers found that electrically stimulating implanted adult stem cells led to increased production of the animal's own stem cells and faster stroke recovery. The study suggests a promising approach for using stem cells to treat patients after stroke.
Children's National Hospital researchers aim to develop a treatment using human stem cells to address hypoxia, which can severely impair brain development in infants born with CHD. The goal is to reverse or halt injury and promote neurogenesis in affected brains.
An international team of researchers identified a specific mechanism leading to Zika virus-associated microcephaly, involving protein misfolding and endoplasmic reticulum stress. This triggers the unfolded protein response, promoting apoptosis in neuronal cells and reducing cortical neuron development.
A comprehensive atlas of gene expression in human brain cells reveals new insights into autism, intellectual disability, and schizophrenia. The study identifies links between neural stem cell populations and neurodevelopmental disease, opening up new avenues for research.
Researchers created 3D mini brains using bioengineered 'asteroids' to study neural connections and accelerate disease research. The model allows for rapid screening of drugs and analysis of mutations, paving the way for potential treatments and clinical trials to improve or regenerate impaired nervous systems.