Articles tagged with Neural Stem Cells
Researchers successfully grafted human induced pluripotent stem cells into rats with spinal cord injuries, causing the formation of mature neurons and extensive nerve fiber growth across long distances. However, functional recovery was not restored due to scar tissue blocking beneficial effects.
Researchers at University of California, San Diego School of Medicine and Veteran's Affairs San Diego Healthcare System report that neurons derived from human induced pluripotent stem cells (iPSC) extended tens of thousands of axons across the rats' central nervous system. The study suggests a promising approach for treating spinal cor...
Researchers at Harvard University's H SCI have identified a promising new potential treatment for ALS, using compounds already in clinical trials. The study found that inhibiting a specific receptor in glial cells increased survival time in an animal model of the disease.
Researchers at UCSF have developed a method for analyzing hundreds of cells individually using microfluidic technology, which reveals novel molecular features in diverse cell types. This approach holds promise for understanding how the human cortex arises from cells spun off from stem cells.
Researchers propose transplanting neural progenitor cells to build a neuronal relay across the injured spinal cord. The model focuses on forming two synaptic connections, one between host axons and graft-derived neurons, and the other between graft axons and target sites within the host, aiming to restore connectivity and function.
Recent advances in stem cell biology offer immense hope for treating various diseases and conditions. Key findings include the potential for stem cells to replicate any other cells in the body and their possible applications in regenerative medicine.
Researchers investigated the impact of cellular senescence on adipose-derived stem cell morphology and function. The study found that senescence compromises the clinical application of these cells for peripheral nerve regenerative cell therapy. Senescence modulating factors influence adipose-derived stem cell behavior.
Researchers developed a novel scaffold for repairing spinal cord injuries, utilizing a double-layer collagen membrane with unequal pore sizes. This innovative approach enhanced the delivery of neural stem cells to the target site, promoting improved repair and recovery outcomes.
Research by Dr. Hyung-Seok Kim reveals that early expressions of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous NSCs after focal cerebral ischemia. Additionally, neural precursor cells can be recruited from nearby areas to promote neurofunctional recovery.
Intravenous transplantation of BMSCs has been shown to promote nerve cell regeneration in injured cerebral cortex, supplementing lost nerve cells. This study provides evidence for the potential use of BMSCs as a therapeutic option for traumatic brain injury treatment.
Researchers found that Zhichan decoction increased dihydroxyphenylacetic acid levels up to 10-fold after neural stem cell transplantation, promoting the differentiation of dopaminergic neurons. This study suggests a potential treatment for Parkinson's disease using traditional Chinese medicine.
Researchers found that citalopram increases the efficiency of bone marrow stem cells (BMSCs) differentiating into neuronal-like cells. This improvement in cellular differentiation is associated with increased cell proliferation and survival while maintaining neuronal characteristics.
Researchers found that microRNA miR-21 regulates the differentiation of neural crest stem cells (NCSCs) from human hair follicles into Schwann cells. By binding to the 3'-UTR of SOX2 mRNA, miR-21 down-regulates SOX protein expression, increasing SC differentiation capacity.
Researchers discovered that dental pulp stem cells can protect retinal ganglion cells from death and promote regeneration of their axons. The study found that these stem cells naturally express neurotrophic factors, providing a potentially limitless source of growth factors for injured neurons.
Researchers at Sanford-Burnham Medical Research Institute have identified a chemical switch controlling neuron generation and survival in the brains of Alzheimer's patients and stroke victims. This switch, MEF2, may be a potential therapeutic target to protect against neuronal loss in various neurodegenerative diseases.
Researchers describe a new strategy that pinpoints a genetic variant predisposing individuals to schizophrenia and reveals deficits in nerve development. The study uses induced pluripotent stem cells to identify CYFIP1 as a critical gene maintaining nerve cell structure.
Researchers have discovered that spiral ganglion stem cells in the inner ear can regenerate and differentiate into mature spiral ganglion cells, neurons, and glial cells. This breakthrough finding makes these stem cells a promising source of replacement cells for therapies aimed at regenerating neural structures in the inner ear.
Researchers have discovered that simultaneous transplantation of neural and vascular progenitor cells reduces brain damage and improves behavioral recovery after ischemic stroke. The study suggests that cotransplantation of these two cell types is more effective than single-cell therapy in promoting recovery.
Researchers at San Raffaele Scientific Institute developed a new method to convert fibroblasts into neurons, which improved motor function in rodents with parkinsonism. The study used technology that allowed the neurons to express engineered proteins and respond to specific drugs.
Inhibition of Rho-associated kinase (ROCK) and subsequent cofilin dephosphorylation can promote neurite outgrowth in PC12 cells, a key step towards treating neurodegenerative disorders. Additionally, mesenchymal stem cell transplantation has shown promise in repairing and protecting damaged brain tissue after traumatic injury.
Scientists are exploring the potential of adult stem cells from bone marrow to treat brain damage by manipulating neural markers. The research, published in Developmental Biology, aims to develop a way to introduce stem cells into the brain and modify them to repair damaged brain cells.
Duke researchers discovered a novel neuron population in the adult brain that instructs stem cells to produce new neurons. The finding opens up possibilities for brain repair and regeneration through neural circuits.
Pericytes, a type of stem cell found in the brain, play a key role in brain repair after a stroke by migrating to damaged areas and converting into microglia cells. This discovery opens up new possibilities for targeting pericytes as a potential treatment for stroke treatment.
The new method uses transcription factors to promote cell differentiation and maturation, producing nerve cells with functional characteristics similar to mature cells found in the body. This breakthrough could accelerate the development of new drugs and stem cell-based regenerative medicine for age-related diseases such as Parkinson's...
Researchers found that human neural stem cells can repair damage caused by multiple sclerosis (MS) in mice, allowing them to walk again. The breakthrough has significant implications for developing a new treatment approach for MS patients.
A study by Whitehead Institute researchers has identified a potential treatment for Niemann-Pick disease, a rare genetic disorder. The researchers found that combining low doses of cyclodextrin with the drug carbamazepine can lower cholesterol levels and restore autophagy defects in cells affected by the disease.
Researchers at TSRI have developed a new stem cell therapy that shows promise for treating multiple sclerosis in humans. In a mouse model, the therapy resulted in significant recovery of mobility and function after implantation of human stem cells into the spinal cord.
Researchers at the Salk Institute used stem cells to study neural function in people with schizophrenia, finding unusual activity in early developmental stages that may lead to diagnostic tests. The study suggests that events during pregnancy could contribute to the disease.
A mouse study found that NAD levels decrease with age in the brain, leading to a loss of neural stem cell function. The researchers discovered that supplementing NAD synthesis could prevent this decline, offering potential therapeutic implications.
Researchers developed methods to convert stem cells into eye cells that could be used to replace damaged tissue in patients with impaired vision. The studies involved converting cells into nerve cells or introducing stem cells to a growth factor, resulting in tissue resembling the developing eye.
Researchers at the University of Adelaide have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting they could be used as a therapy for stroke. These cells have the potential to form complex networks and communicate like normal neurons, offering hope for new treatments.
Researchers successfully transplanted human neural stem cells into nonhuman primate brains and observed their long-term survival and differentiation into neurons. The study holds promise for treating neurodegenerative diseases such as Parkinson's and Alzheimer's.
A new study by Harvard neuroscientists reveals that myelin, the electrical insulating material in nerve cells, is not uniformly distributed along axons. Instead, more evolved neurons in the cerebral cortex have intermittent myelin patterns, which may enable increased neuronal communication and complex behavior.
Genetically modified neural stem cells have been shown to produce neprilysin, an enzyme that breaks down amyloid-beta, reducing its accumulation in the brain. The approach has shown promising results in two different mouse models, with a significant reduction in amyloid-beta plaques compared to controls.
Human embryonic stem cells grown on soft, synthetic micropost carpets made of polydimethylsiloxane turn into nerve cells faster and more often than those grown on traditional plates or rigid carpets. This breakthrough could advance stem cell therapies for diseases such as amyotrophic lateral sclerosis.
A study funded by the National Institutes of Health's National Institute of Neurological Disorders and Stroke found that mutations in the LRRK2 gene may cause excessive protein production, leading to cell death. This could provide a new target for monitoring Parkinson's disease and developing therapies.
New research sheds light on how environmental stressors affect the cells of the developing brain, leading to conditions like schizophrenia and post-traumatic stress disorder. Yale scientists discovered a single molecular trigger, HSF1, that activates in brain cells exposed to toxins, making them susceptible to neuropsychiatric disorders.
Researchers at UC Irvine's Sue & Bill Gross Stem Cell Research Center found that bone marrow stem cells significantly improved multiple outcome measures in animal studies of stroke. The effects were robust regardless of dosage, timing, or method of administration.
A University of Wisconsin-Madison researcher has pinpointed an error in protein formation that could be the root of amyotrophic lateral sclerosis. Motor neurons that control foot muscles are affected due to a shortage of one of three proteins in neurofilaments, leading to tangles and nerve fiber malfunction.
Researchers at Harvard University have discovered a link between ALS mutations and motor neuron hyperactivity, suggesting a new therapeutic target. The approved medication for epilepsy may be effective in reducing this hyperexcitability, paving the way for clinical trials.
Researchers derived stem cell lines from people with bipolar disorder to study brain cell development and behavior. The comparison revealed specific differences in gene expression, neuron development, and response to lithium, which may lead to new treatment options and personalized medicine.
Researchers developed a new technique using spatial light interference microscopy (SLIM) to measure human neural networks, showing how neurons grow, organize, and transport materials. The study provides insights into the formation of neural networks and could lead to advancements in understanding diseases like Alzheimer's.
Researchers at the University of Pittsburgh School of Medicine have made a groundbreaking discovery using human muscle-derived stem cells to repair damaged nerves. The study found that these stem cells could differentiate into neurons and glial support cells, leading to full regeneration of the sciatic nerve in animal models.
A team of researchers from Duke-NUS Medical School discovered a protein complex that disrupts dedifferentiation, a process promoting tumor development. This breakthrough has implications for understanding neural stem cells and developing future cancer therapies.
Researchers at the University of Edinburgh's Roslin Institute have created working nerve cells from horse stem cells, paving the way for cell therapies targeting neurological conditions. The breakthrough could also benefit horses affected by grass sickness, a previously untreatable condition.
Researchers at Harvard University have successfully converted patient skin cells into human brain cells, offering a new model for studying and developing treatments for early-onset Alzheimer's disease. The study found that preventing amyloid-beta imbalances can reduce levels of distorted tau protein.
Researchers isolated and characterized zebrafish neural crest cells that can differentiate into various cell types, including neurons and melanocytes. The study found that retinoic acid significantly inhibits proliferation but enhances migration in these cells.
Researchers discovered that a well-known protein UPF1 controls the biological circuit to determine whether an immature neural cell remains in a stem-like state or becomes a functional neuron. The study's findings have significant implications for developing new therapies for neurological disorders such as autism and schizophrenia.
Researchers found that chronic stress generates more myelin-producing cells and fewer neurons in the brain, disrupting communication and potentially leading to mental problems like anxiety and depression. This long-term change in brain structure may also contribute to conditions such as PTSD, schizophrenia, and ADHD.
A University of Southern California study identifies a new population of mesenchymal stem cells in nerve and artery bundles that help maintain homeostasis. The discovery reveals that these stem cells are rich in the bundles, which contain nerves and blood vessels, and are regulated by the protein Shh.
Two UC Irvine research teams will use the grants to investigate the fundamental structure and function of stem cells, with potential applications for treating cancer, neurological diseases, and injuries. The funded projects aim to uncover specific properties of human stem cells used in transplants.
A new study suggests that a population of support cells called astrocytes could provide a promising approach to treat Parkinson's disease. Astrocytes, which are critical to maintaining a healthy environment in the brain, were found to repair multiple types of neurological damage caused by the disease.
A study published in Nature Neuroscience reveals that non-CpG methylation occurs later and more dynamically in neurons than previously thought, acting as a system of gene regulation. This finding challenges the long-held idea that once genes are silenced by methylation, they remain so forever.
Researchers successfully transplanted skin-derived stem cells into collagen tubes to bridge gaps in injured nerves, resulting in functional recovery and saving the upper arms from amputation. The study provides a promising new avenue for treating peripheral nerve injuries.
Researchers have developed a technique combining cell transplantation and gene therapy to target BACE1, the key enzyme in amyloid beta protein production. This approach reduces Aβ protein production by downregulating the BACE1 gene, offering new therapeutic avenues for Alzheimer's disease.
Researchers create progerin-induced aging in stem cells, accelerating disease modeling by weeks, not years. This breakthrough opens avenues for preventing and treating late-onset disorders.
Researchers found that potassium current density increased sharply after 2 weeks of neural stem cell differentiation, indicating functional neurons. Neural stem cells from newborn rat hippocampus can be cultured and induced to differentiate into mature neurons in vitro.
Researchers from Bonn University discovered that immature nerve cells secrete chemical attractants that prevent mature brain cells from migrating into the brain. Inactivating these attractants improves nerve cell migration in animal models, offering a promising universal approach to treat Parkinson's and Huntington's diseases.
Scientists have found a critical mechanism to keep newborn neurons alive, which may help understand underlying causes of diseases like Alzheimer's and mental illness. The discovery suggests that parvalbumin-expressing interneurons release GABA, a chemical signal that promotes the survival of new brain cells.
A traditional Chinese medicine, Buyang Huanwu Decoction, has been shown to improve neurological function in patients with stroke. The decoction increases the number of cells positive for markers of neuronal differentiation and synaptic plasticity in ischemic rat cerebral regions.