Articles tagged with Neuroimaging
Researchers identified distinct brain activity patterns in people with depression, which may contribute to the experience of feeling stuck. The study suggests depression involves a form of brain-state entrapment, where the brain becomes more likely to enter certain patterns of activity and less likely to transition out of them.
The new section in JMIR Neurotechnology focuses on the responsible and ethical use of neurotechnology. Submissions welcome for original research, case series, theoretical viewpoints, and data-driven analyses on ethics and policy in neurotechnology.
Researchers have developed a digital brain twin using multimodal data, providing anatomically accurate brain models that can be used in experimental and clinical settings. The models were reconstructed simultaneously with brain anatomy and dynamics from neural data.
A USC study found subtle but widespread differences in the brain's communication networks in people with bipolar disorder, relating these differences to illness severity and treatment. The research team analyzed brain scans from 449 individuals with bipolar disorder and 510 healthy controls, revealing less densely connected networks an...
FireANTs, an open-source algorithm, combines AI optimization and geometry to quickly match complex medical images. The new method can accomplish what took weeks in minutes, detecting subtle changes that signal disease or cognitive decline, making it practical for clinical practice.
A new AI tool, AIDD, combines brain scans with machine learning to accurately diagnose two common forms of dementia. The tool showed near-perfect accuracy in identifying Alzheimer's disease and dementia with Lewy bodies, offering a promising future for clinicians.
A large Japanese study found that maintaining a healthier profile with lower lifestyle and health risks can significantly lower dementia risk in people with one or no APOE ε4 alleles. However, individuals carrying two APOE ε4 alleles may require different preventive or therapeutic approaches.
A new study demonstrates that acupuncture can significantly improve muscle function recovery in patients who experienced a stroke. The true-acupoint group showed significant improvements in motor recovery tests, with positive correlations between increases in gray matter volume and limb motor function recovery.
A new study by researchers at the University of Tokyo found that readers of paper manga took longer to answer complex questions than those who read on tablets, indicating a potential advantage of printed materials for comprehension. Brain scans revealed reduced activation in frontal language-related brain regions when reading on paper.
A groundbreaking study created a world's first pure cerebral microbleed model by targeting brain vascular collagen IV using CRISPR/Cas9 gene editing. The research implicated dysfunctional collagen in tiny brain hemorrhages, which are strongly associated with dementia and cognitive decline.
Researchers identified two distinct subtypes of autism based on brain connectivity patterns, one characterized by reduced connectivity linked to synaptic pathways and the other by increased connectivity associated with immune-related systems. The study's findings offer a biological basis for personalized care and support.
A new brain imaging test can detect Alzheimer's disease pathology in twice as many people before symptoms appear. The test uses a new tau PET tracer that identifies more tau-positive cases than the current standard, leading to better decisions about who is on an Alzheimer's trajectory.
Researchers found biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults. These biomarkers, measuring tau and amyloid plaque, were associated with a greater chance of cognitive decline, particularly in processing speed and executive function.
A new study by UC3M researchers reveals how extracellular acidosis destabilizes microtubules, the 'avenues' that organize internal cellular traffic, leading to disruptions in cellular function. This finding holds significant implications for understanding pathologies like cancer, diabetes, and certain infectious processes.
Researchers have discovered that errors in the final step of cell division can cause dramatic changes in developing brain cells, leading to abnormalities such as multiple nuclei and cilia. The study found that a protein called p53 acts as a guardian of brain development by triggering the self-destruction of abnormal cells.
A new study at Florida Atlantic University maps the neural wiring system linked to a fly's split-second escape behaviors, revealing a decentralized communication strategy. The findings provide insight into how brains process information at extraordinary speed and may represent a conserved blueprint shared across species.
A novel antibody, NG101, accelerates the regeneration of damaged spinal cord tissue by neutralizing a protein that blocks nerve fiber growth. This therapy enables new nerve fibers to form functional connections, allowing patients to become more independent and potentially recover arm and hand function.
Researchers developed multiplexed MRI technology, enabling simultaneous imaging of signals from multiple molecules in the brain. The technology provides a comprehensive view of the brain's structure, physiology, and molecular processes, allowing for more precise diagnosis and individualized treatment planning.
Genomic Press launches Brain Health, a new peer-reviewed journal dedicated to the science of lifelong brain resilience, featuring research on glial plasticity and recovery from depression. The inaugural issue explores the intersection of fields including cognitive reserve, sleep, aging biology, nutritional psychiatry, and social sciences.
For the first time, researchers have identified the direction of neural signals in the brain using functional MRI. The study showed that feedforward and feedback nervous impulses each have unique signatures that can be detected with a new method called uFLARE.
Researchers at the University of Colorado Boulder have discovered that experienced ballroom dancers' brains synchronize when they move together. The study used EEG caps and movement sensors to track brain activity and found that neural synchronization increased as dancers moved in sync, revealing a phenomenon called interbrain coupling.
A new study suggests that language and theory of mind, two complex cognitive functions, have distinct origins in the brain in young children. Researchers found separate but related brain regions for these skills, which do not overlap or grow more distinct as the mind matures.
A new Stanford Medicine study shows that brain-scan averages obscure individual brain dynamics, particularly in children with attention-deficit/hyperactivity disorder. By analyzing data from over 4,000 children, researchers found distinct patterns of brain activity when data is analyzed individually versus as a group.
Researchers found three distinct trajectories of cognitive decline: stable, slow and fast decline. Biomarker data showed that participants who declined faster had higher P-tau217 levels and smaller hippocampi.
The EBRAINS Roadmap Symposium will bring together the global neuroscience community to shape the EBRAINS 10-Year-Roadmap. A total of 159 submissions from 134 unique contributors across 25 countries have been received, reflecting the momentum of Europe's digital neuroscience landscape.
The Individual Brain Charting project has released its fifth update with a new set of cognitive tasks, expanding the dataset to 40 hours of scanned data per participant. This provides an exceptionally rich resource for studying individual variability in brain organisation and understanding brain function.
The 2026 cohort of Leon Levy Scholars in Neuroscience will pursue research projects addressing neurological disorders and developing new treatments. The program provides scientific and professional career development opportunities, including mentorship and networking.
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Researchers from UMBC discover that inputs from the dorsal and ventral hippocampus interact closely on the same neurons in the nucleus accumbens, integrating memories of places and contexts with drive to pursue rewards. This convergence may help animals form associations between rewarding outcomes and environments, essential for survival.
The research team will analyze mouse models and human brain tissue to identify cell types that show early signs of stress before neurons die. The multiscale model simulates how the progressive loss or disconnection of specific neurons disrupts memory-related brain networks.
A secondary analysis of the ANGEL-ASPECT trial found EVT to be beneficial for patients with anterior-circulation LVO and a large ischemic core and absent-to-moderate white matter lesions. In contrast, those with severe WMLs showed less pronounced benefits, suggesting uncertainty about EVT's efficacy in this subgroup.
Researchers have demonstrated that noninvasive brain stimulation can alter the activity of the hippocampus, a critical deep brain region involved in emotion and memory. Personalizing the stimulation site using a patient's unique brain connectivity pathway increases the neuromodulation effect.
The NIH grant will support the creation of a comprehensive long-term dataset on Hispanic and Latino brain aging, examining the factors that matter most for healthy cognitive aging. The study aims to understand how Alzheimer's disease, vascular injury, and other brain changes develop over time in Latino adults.
A Northwestern University study found that imagination is not just a copy of sensation, but emerges at later stages of processing when the brain represents information holistically. The researchers mapped brain activity during imagination and perception, finding overlap in higher-level association areas.
A new study uses optogenetics to control specific communication pathways in the common marmoset brain, offering a clearer view of complex behavior and brain disorders. This method enables researchers to manipulate individual long-range brain circuits with greater precision than before.
A research team led by LEE Doyun and KIM Yee-Joon found that the primary visual cortex encodes motion summaries and variability before higher brain regions transform them into category signals. This process, known as ensemble perception, allows the brain to capture the overall structure of a scene at a glance.
Researchers discovered that stroke survivors with severe motor impairment show signs of brain 'youthfulness' in undamaged regions, suggesting the brain's ability to adapt and compensate. This finding provides new insights into neuroplasticity and may guide personalized rehabilitation strategies.
Researchers found that immersive dreaming, even with wake-like brain activity, leads to a greater feeling of deep sleep. Vivid dreams are associated with subjective deeper sleep, while abstract thoughts are related to more shallow feelings.
A systematic review and meta-analysis of 33 studies found that nature exposure is associated with reductions in negative emotions and increases in positive emotions. Experts recommend integrating nature into urban design to promote brain health and treat mental illnesses.
Research suggests that persistent pain drives progressive changes in the hippocampus, a brain region involved in emotional regulation. This can shape whether people develop depression or remain emotionally resilient. The study's findings challenge the idea that depression is an inevitable consequence of long-term pain.
Dr. Phillips's laboratory identifies abnormalities in prefrontal-striatal-limbic circuitry as biomarkers for bipolar disorder before symptoms appear. Her team tracks neural network development from infancy through young adulthood.
Researchers have developed an 'ECI patch' that reads brain signals and controls cars with 93.5% accuracy. The patch, powered by ultra-thin sheets called MXene, detects fatigue and mental states without causing skin irritation.
Researchers at Kyushu University develop a new tissue-clearing reagent, SeeDB-Live, enabling repeated, reversible, and real-time imaging of living brains at greater depth and clarity. This breakthrough allows scientists to visualize neural activity in living mice and brain slices, offering new insights into brain dynamics and function.
A team of researchers has developed a method to decode fluctuations in spontaneous pain intensity in individuals with chronic pain using extensively sampled functional MRI data. The study found that neural patterns underlying pain differ markedly between individuals, highlighting the importance of individualized brain-based biomarkers.
The Society for Brain Health is a new collaborative body dedicated to enhancing cognitive capacity, longevity, and proactive health optimization through cutting-edge research and tools. Its founding members include prominent neuroscientists and experts in the field of brain health.
Prolonged grief disorder (PGD) is characterized by intense emotional pain and longing for the deceased. Research highlights disruptions in reward-related brain networks as key to explaining why grief persists in some individuals.
Researchers found that brain synchrony between mothers and children is equally strong when playing in the native language or an acquired second language. This suggests that multilingualism can support healthy communication and learning without disrupting the brain-to-brain connection.
Researchers have explored how human mesenchymal stem cells can help repair brain injury in children born preterm. The PREMSTEM project has investigated the use of h-MSCs to address brain injury caused by early-life birth, with promising results showing a positive impact on brain damage and inflammation.
A new study by Leopoldo Petreanu's team shows that different visual experiences result in distinct patterns of organization in feedback connections. Mice with miniature goggles biased to see edges oriented at specific angles had unique tuning properties and patterns in these connections.
The FENS Forum 2026 will be Europe's largest neuroscience congress, covering areas of basic to translational research. Journalists can register for free and attend symposia and poster sessions.
Researchers at the University of Notre Dame investigated how brain networks are organized and work together to form a unified system. They found evidence for system-wide coordination in the brain that is both robust and adaptable, suggesting that intelligence reflects how brain networks are coordinated and dynamically reconfigured.
Researchers at Karolinska Institutet created the first activity-based maps of the prefrontal cortex, revealing a hierarchy of information flow rather than tissue structure. This challenges traditional definitions of brain regions and has major implications for understanding brain organisation overall.
A 12-month aerobic exercise program reduced brain age by 0.6 years, while a control group showed a slight increase. The study suggests that following current exercise guidelines may help keep the brain biologically younger in midlife, supporting clearer thinking and stronger memory.
JMIR Publications' JMIR Neurotechnology journal now accepts submissions on novel technological advances for neurological disorders. Researchers can submit review articles exploring emerging technologies, such as neurofeedback, neurosurgery, and brain-machine interfaces.
A study among WTC responders with chronic PTSD found measurable physical changes in their brain structure, including cortical changes and imbalance of myelinated to unmyelinated neurons. These changes were most strongly associated with re-experiencing symptoms in individuals with PTSD.
Research finds that musical improvisation involves a dynamic reconfiguration of the brain between emotion, technique, and structure. The study proposes a scalable method for exploring the neural basis of spontaneous creative behavior, highlighting the importance of interaction between networks over time.
A mouse study by Okinawa Institute of Science and Technology researchers has found that acetylcholine release is essential for breaking habits and enabling new choices to be made. The study's findings may help understand diseases such as Parkinson's disease, addiction, and obsessive-compulsive disorder.
Researchers at Brown University have created a bioluminescence tool that enables the measurement of activity in living brain cells without damaging them. The CaBLAM tool uses bioluminescent light production to capture single-cell and subcellular activity at high speeds, allowing for longer recordings and reducing hardware requirements.
A study published in Biological Psychiatry identifies a distinct immuno-inflammatory biomarker in the brain linked to immune system dysfunction and poorer response to standard treatments. The findings provide potential value for clinical prediction and precision therapies.