Articles tagged with Neurology
A study by Queen Mary University of London and University of Nottingham found that patients with young onset dementia are at a high risk of suicide, particularly if under 65 or have psychiatric illness. Early recognition and support after diagnosis are crucial in reducing distress caused by this devastating condition.
The National Institutes of Health has awarded a $10.7 million grant to Cleveland Clinic to expand a national research consortium focused on improving diagnosis and treatments for Dementia with Lewy Bodies. The consortium, which includes multiple clinical sites, aims to identify biomarkers for disease and develop new therapies.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
A new study by Human Brain Project researchers unravels the mechanisms of psychostimulants like methylphenidate on attention and learning. The findings suggest that dopamine enhances task-relevant cortical signals, explaining variability in drug's cognitive effects across individuals.
A study by researchers at Linköping University and the Oregon Health and Science University has discovered that many cells in the inner ear react simultaneously to low-frequency sound, making it easier to experience these sounds. This new understanding may lead to improved cochlear implants for people with severe hearing impairments.
A new study found that the newer clot-busting drug tenecteplase outperforms traditional treatment for ischemic strokes in several key areas, including better health outcomes and lower costs. The shorter preparation and injection time with tenecteplase eliminated dosing errors and initiated transfers to advanced care sooner.
Researchers found that stressed mice exhibited decreased neuron excitability in the dorsal hippocampus, which may drive social avoidance, while resilient mice showed increased excitability. This difference was linked to changes in stress hormone receptors and HCN1 protein expression.
This review examines the known neurologic complications of smallpox and monkeypox, including their complications from vaccination. The study highlights the importance of understanding these neurological effects to improve treatment and prevention strategies.
A study from Children's National Hospital reveals that the circadian clock helps regulate the renewal of NG2-glia cells in the brain after injury. The findings provide new insights into how the body's internal clock promotes healing after traumatic brain injuries, which are currently managed with supportive care and rehabilitation.
A recent study found that telemedicine is a viable option for many patients, especially those with epilepsy and attention-deficit hyperactivity disorder. However, barriers remain, including limited access for socially vulnerable families and racial/ethnic minorities.
Researchers at Stevens Institute of Technology have developed an algorithm that can accurately track patients' level of consciousness using simple physiological markers. The algorithm proved as accurate as a trained clinical examiner, only slightly less accurate than expensive imaging equipment like fMRI machines.
A large-scale international study has identified dozens of gut bacteria associated with multiple sclerosis, revealing potential new mechanisms for disease development and treatment response. The study also found geographical location and participant's disease status as significant factors influencing gut microbiome variations.
A review of evidence found that 2-3% of monkeypox patients experienced severe complications such as seizure or encephalitis. Mood disorders like depression and anxiety were also common among infected individuals.
Scientists have developed a soft, bioresorbable device that cools peripheral nerves to reduce pain. The device was tested in rat models and found to be effective, reversible, and non-addictive, with potential applications for treating neuropathic pain after surgery.
A new study found that young Swiss military personnel with confirmed Covid-19 infections experienced symptoms like fatigue, reduced sense of smell, and psychological problems for up to 180 days. Long-term effects included increased BMI, high cholesterol, and lower physical stamina, suggesting a higher risk of metabolic disorders and ca...
A recent ECU study discovered that tRNS can enhance neuroplasticity, allowing the brain to form new pathways and connections. This technology has shown promise as a tool to assist individuals with learning difficulties or neurological conditions.
The report explores diffuse optical imaging methods applicable to noninvasive human studies, including near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). It introduces state-of-the-art technologies and software, exploring their impact on neuroscience and clinical applications.
Research linked blood type to early-onset stroke risk in young adults under 60. People with blood type A had a 16% higher risk, while those with blood type O had a 12% lower risk of having an early stroke. The study suggests potential new ways to predict and prevent strokes in young adults.
Researchers pinpointed the anterior cingulate cortex gyrus (ACCg) as the brain area involved in effortful altruistic behaviour. Individuals with high empathy levels showed stronger effort patterns in ACCg, suggesting a link between emotional connection and helping behaviour.
A study has found that pheasant meat can contain small fragments of toxic lead, which can be absorbed by the body and cause long-term harm. Researchers detected up to 10mg of tiny lead shards per pheasant, widely distributed within the bird's tissues.
Researchers developed a blood test that predicts poor outcomes in patients with traumatic brain injury (TBI), allowing clinicians to make decisions earlier on possible treatment. The test, which measures protein biomarkers GFAP and UCH-L1, showed high accuracy in predicting death and severe disability six months after injury.
Researchers found that astrocytes can transfer their mitochondria to damaged neurons after a brain hemorrhage, stimulating the production of an enzyme that neutralizes free radicals. This treatment showed improved neurological recovery in mice, but not if the mitochondria were without the protective enzyme Mn-SOD.
Researchers at UC San Francisco have discovered how to shift damaged brain cells from a diseased state into a healthy one using CRISPR technology. The study found that reprogramming microglia cells can help remove protein plaques and protect synapses, potentially treating Alzheimer's and other forms of dementia.
Researchers developed a blood test tool that predicts patient outcomes after traumatic brain injury (TBI), with 87% accuracy for predicting death and 86% for predicting severe disability. The tests are diagnostic and prognostic, easy to administer, swift, and inexpensive.
A recent case study at Kobe University reports a 15-month recovery process for a patient with impaired ACTH secretion due to COVID-19. The research team successfully restored hormone levels through ACTH replacement therapy, and the patient's condition improved significantly after one year and a half.
A new gene therapy approach using the neuroprotective protein SynCav1 has shown promising results in slowing down ALS disease progression and increasing life span in rodent models. The treatment preserved spinal cord motor neurons and extended longevity in mice, with similar effects observed in a rat model of ALS.
A novel subset of CD8+ regulatory-like T cells (CD8+TRLs) has been identified as 'first responders' to stroke, providing fast-acting and lasting protection. These cells reach the brain within 24 hours after stroke onset, releasing molecules that provide direct neuroprotective effects.
Researchers propose a new learning method for individuals with autism, utilizing 'memory flashes' to accelerate learning and improve visual perception capabilities. The study showed significant improvement in both learning speed and generalization of skills, even under new conditions.
A new study at the University of Missouri found that prenatal opioid exposure can trigger long-term neurological or behavioral effects in children. The research suggests that opioids impact the developing fetus' gut microbiome, leading to changes in metabolic pathways and potentially affecting overall health and wellness.
Researchers discover gene AVIL responsible for deadly brain tumor also causes two forms of childhood cancer, rhabdomyosarcoma. Blocking AVIL activity prevents formation of the disease in lab samples and mouse models.
A phase 3 clinical trial found that patients with relapsing-remitting multiple sclerosis treated with rituximab had a five-fold lower risk of relapse compared to those receiving standard dimethyl fumarate treatment. Rituximab also showed fewer new MS plaques on magnetic resonance imaging.
Women with conditions like MS, migraine, and epilepsy face increased unplanned pregnancy due to treatment effects on hormonal contraceptives. Teratogenic drugs used for neurological treatments may be restricted or unavailable during pregnancy.
A team of UCI biologists finds that interleaving old information with new knowledge helps artificial neural networks retain long-term knowledge without catastrophic forgetting. This discovery holds potential for tackling cognitive issues and improving algorithm efficiency in various applications.
A new study found that post-operative atrial fibrillation (POAF) is associated with a higher risk of hospitalization for heart failure among patients undergoing cardiac and non-cardiac surgery. POAF may be an early marker for heart failure, and its presence could contribute to the development of the condition.
Researchers with the Calgary Stroke Program have made a breakthrough in treating acute ischemic stroke with Tenectepele, a safe and well-tolerated drug that can be administered as a single dose. The study shows that TNK works better than current recommended drug tPA, restoring blood flow faster and for a longer period.
Residents in predominantly Black communities are more likely to live near a hospital with a certified stroke center but face lower chances of receiving optimal treatment. The study also reveals significant disparities in access to stroke centers based on income and geographic location.
Researchers found that 67.7% of stroke patients with previously undiagnosed major risk factors had one underlying condition, with dyslipidaemia being the most common detected vascular risk factor. The study suggests that identifying and treating these conditions can help prevent future strokes.
Researchers developed a low-cost 3D model of the brain to study SARS-CoV-2's neurological effects. The adapted virus replicates 30 times more efficiently in astrocytes than neurons, highlighting the importance of these cells in central nervous system infection.
A new study published in CMAJ found that youth hockey players with more years of bodychecking experience had a significantly higher risk of concussion than those with less experience. The researchers collected data on 941 players aged 15-17 and found that concussion was the most common injury, making up over one-third of all injuries.
A Finnish research group developed a wearable device to assess infants' motor abilities during playtime, allowing for accurate tracking of neurological development. The smart jumpsuit enables out-of-the-lab assessments, supporting early clinical diagnostics and therapies.
A new study demonstrates a computer tool, PrimSeq, that accurately identifies and counts arm movements in people undergoing stroke rehabilitation. The tool has shown to be 77% effective in tracking the intensity of patients' movements during therapy.
A UC San Diego longitudinal study found that most COVID-19 long-haulers continue to suffer from neurological symptoms six months after infection, with memory impairment and decreased concentration being the most prevalent. Researchers identified a new subgroup with advanced symptoms, including tremor and difficulty balancing.
A new study reveals that drumming can improve the life quality of young people diagnosed with autism by enhancing brain function and behavior. Participants showed fewer signs of hyperactivity, inattention, and repetitive behaviors, demonstrating better control of their emotions.
A recent study at UC San Francisco discovered that fragmented tau protein in diseased neurons could be a new target for existing drugs, potentially improving diagnosis and treatment of Alzheimer's. The researchers found that measuring the fragments in cerebrospinal fluid may help distinguish between different forms of dementia.
A new neurobiological model provides a unified framework for understanding various forms of creativity, including abstract thinking, improvisation, and divergent problem-solving. The model suggests that different brain areas are activated depending on the type of creativity, with dopamine playing a crucial role in controlling and optim...
Researchers at Johns Hopkins Medicine discovered a molecular connector, BASP1, that helps cocaine latch on to brain cells, even at low doses. This finding may explain why women are more susceptible to cocaine addiction and could lead to new treatments.
A study by UC San Diego Health found that sending patients a text message when their doctor is ready can reduce wait times and improve patient satisfaction. The 'telemedicine untethered' option showed a 55-minute time savings in clinic operations, with zero late appointments and increased flexibility for both patients and providers.
A study by Kyushu University has identified biomarkers in blood samples that distinguish healthy individuals from Hikikomori patients and predict the severity of the condition. Key findings include elevated ornithine levels, lower bilirubin levels, and higher long-chain acylcarnitine levels in patients.
A study of nearly 4.5 million children found a potential association between prenatal exposure to antiseizure medications and increased risk of neurodevelopmental disorders. The research suggests that further investigation is needed to confirm these findings.
Researchers propose a new method to study neural networks using intrinsic signal optical imaging (ISOI), which provides detailed maps of brain activity in living subjects. The study shows that ISOI can reveal cortical architecture at columnar resolution, offering a more accurate picture of brain network activity than existing methods.
A team from the University of Wisconsin-Madison found no significant differences in structural brain changes between participants who received short-term mindfulness training and those who did not. Despite this, participants reported increased mindfulness, suggesting that benefits may be related to wellness interventions more broadly.
A new circuit model provides an explanation for how deep brain stimulation (DBS) relieves Parkinson's disease motor symptoms by interrupting a vicious cycle between the subthalamic nucleus and the striatum. The model suggests that DBS restores a balance with other rhythm frequencies, enabling better movement control.
Researchers at the University of Bern have identified how the brain processes emotions during dream sleep. During REM sleep, the brain favors the discrimination of safety versus danger in the dendrites, but blocks the over-reaction to emotion, particularly danger. This decoupling is essential for optimizing survival and stability.
A novel network analysis technology can pinpoint seizure originating brain regions and predict a patient's seizure outcome before surgery, using only 10 minutes of resting state recordings.
Researchers found that genes expressed in the brains of fearless birds differ from those of fearful birds, influencing their behavior and adaptation to new environments. This study provides insights into the genetic basis of fear and boldness in wild animals, potentially leading to novel approaches for addressing anxiety disorders.
A gene therapy approach has effectively reduced neuropathic pain in mice with spinal cord or peripheral nerve injuries without detectable side effects. The treatment, which targets impaired neurons, resulted in long-lasting benefits persisting for at least 2.5 months.
A new study has identified specific groups of bacteria associated with poorer neurological recovery from ischaemic stroke. Fusobacterium and Lactobacillus were linked to increased stroke risk, while Negativibacillus and Lentisphaeria were associated with more severe strokes.
Researchers have discovered a new sleep molecule, microRNA-137 (miR-137), that regulates hypocretin levels for normal sleep. The study found that miR-137 is associated with hypocretin regulation and sleep disorders such as narcolepsy and insomnia.
A new study published in Bioelectronic Medicine found that high-frequency spinal cord stimulation (HF-SCS) was more effective at improving perceived pain reduction than low-frequency SCS (LF-SCS). HF-SCS also showed less subsequent use of opioids to mitigate pain.
Chronic pain causes maladaptive emotional states and is often comorbid with psychiatric disorders. Researchers identified the neuronal circuit involved in chronic pain-induced anxiety in mice, finding that restoring its activity attenuates anxiety.