Articles tagged with Neurology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new web-based application can predict which epilepsy patients will not benefit from stereo-electroencephalography (SEEG), a costly and invasive procedure. The '5-SENSE' score reliably identifies patients who will not have a focal seizure onset zone, allowing clinicians to avoid unnecessary procedures.
The human brain contains trillions of contact points, requiring massive computational resources. Researchers outline the need for exascale computing power to tackle brain complexity.
A new study by Ritsumeikan University reveals that whole-body dynamic balance training increases brain connectivity and improves motor learning. The research found significant changes in brain activity associated with offline learning, opening up new avenues for studying neural networks during natural tasks.
The insular cortex processes both positive and negative emotions and receives information from the body, including heart rate and breathing. In mice, the brain uses bodily signals to regulate fear, keeping it within a healthy range.
Researchers at Children's National Hospital have successfully developed a personalized T cell immunotherapy that targets and kills unique proteins in individual tumor cells. This approach, combining genetic sequencing and protein identification, offers a promising treatment option for children with hard-to-treat brain tumors.
Researchers at UCSF discovered a narrower blood pressure range during surgery that significantly improves neuromotor recovery in patients with spinal cord injuries. Patients whose mean arterial blood pressure was between 76 mmHg and 104-117 mmHg had maximal recovery, indicating a potential new treatment guideline.
Researchers at Universidad Complutense de Madrid have discovered alterations caused by ALS in the retina, which can be used as biomarkers for diagnosis and treatment monitoring. The study found changes in microglial cells and ganglion cell loss, with modifications evolving over the course of the disease.
Researchers found that candesartan reduces accumulation of extracellular matrix proteins and normalizes blood flow in mice with hereditary cerebral small vessel disease. The study suggests a potential new treatment avenue for age-related cerebral arteriopathy.
A peer-reviewed study published in Life journal proves Reflex identifies biomarkers for concussions, enabling accurate clinical diagnosis and decision-making. The study, conducted by Purdue University, uses pupillary light reflex to measure concussion patients' recovery and prevent compounding injuries.
A major Finnish–Norwegian study found that obesity does not lower the risk of subarachnoid haemorrhage, as smoking habits are a significant factor in the condition. The study analyzed over 200,000 individuals and comprehensively considered confounding factors.
Researchers at University of California San Diego School of Medicine identified the anterior insula's role in predicting and emotionally processing pain in HIV-DSP patients. The study suggests that reduced anterior insula activity or increased cingulate activity may improve pain outcomes for these patients.
Researchers found that future goals are represented by a pattern of neural activity resembling previous visits, and this activity can re-emerge upon decision to target a location. The orbitofrontal cortex plays a key role in representing future goals during navigation.
A new rapid screening test for glaucoma uses infra-red sensors to monitor eye movement, providing accurate results within seconds. The test could help advance early detection of the disease, a leading cause of irreversible blindness, and make it more accessible for national screening programs.
Researchers have made significant progress in generating neurons in the lab, a potential therapeutic option for replacing lost neurons in neurodegenerative conditions like Parkinson's disease. A $9 million grant will support further research and development of this novel treatment approach.
A first-in-human study at Cleveland Clinic found that targeting the dentate nucleus with deep brain stimulation was safe and feasible for promoting post-stroke rehabilitation, enabling significant functional improvement in upper extremity hemiparesis. The study's adaptive design allowed for extended treatment duration if patients conti...
A new study found that translocator protein 18 kDa (TSPO) correlates with worse survival outcomes in male glioblastoma patients compared to females. The variation in the protein's structure is associated with shorter overall and progression-free survival times, suggesting its potential as a prognostic biomarker.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
A recent study published by the American Academy of Neurology found that women are underrepresented in stroke clinical trials, with a participation-to-prevalence ratio of 0.84. This disparity may limit the applicability of trial results to the general population and affect access to new therapies.
A study published in JAMA Neurology found that long-term exposure to space can cause brain damage in cosmonauts. The research analyzed five Russian male cosmonauts who spent an average of 169 days in space, showing significant increases in biomarkers for brain cell damage upon their return to Earth.
Researchers found that clot-busting drugs rarely cause aneurysms to rupture after a stroke. For people with larger saccular aneurysms, additional consideration should be taken regarding treatment to minimize risk of aneurysm rupture.
A survey conducted by Michigan Medicine found that nearly two-thirds of respondents experienced difficulty with pet care during hospitalization or knew someone who did. This stress can impact a patient's decision about staying in the hospital. Researchers aim to develop better resources and formalized services to address this need.
An international team led by McGill University is developing biomarkers to identify people with REM sleep behavior disorder at risk of developing neurodegenerative diseases such as Parkinson's and dementia. The team will study over 430 participants, including those with the disorder and healthy controls, to develop targeted therapies.
Research finds that age-related DNA methylation of TDP-43 contributes to ALS, with increased gene expression levels in the motor cortex. This discovery may provide a new therapeutic approach for the disease.
A new study led by UCSF indicates that depression in early adulthood can increase the risk of cognitive impairment and dementia. The research found that moderate or high depressive symptoms were associated with a 73% higher odds of cognitive impairment among older participants.
Research by James Krause and his team has shown that people with spinal cord injuries who develop resilience tend to have better health outcomes and live longer. This resilience allows them to adapt and thrive in the face of difficult circumstances, including neuropathic pain and feelings of isolation.
A study published in Neurology Clinical Practice found that adults with neurologic conditions are more likely to have had adverse childhood experiences such as abuse or neglect. The study suggests that early recognition of these high adverse childhood experiences may improve health outcomes for individuals with neurologic conditions.
Researchers at Tokyo University of Science discover that vicarious social defeat can cause psychological stress in mice, leading to depression and decreased neurogenesis. The study sheds light on the pathophysiology of depression and may lead to the development of novel antidepressants.
Scientists discovered that recurrent neural networks (RNNs) play a crucial role in the frontal cortex, responsible for decision-making, expressive language, and voluntary movement. The research also found that RNNs are more complex than previously thought, with a unidirectional structure.
Researchers used mice to demonstrate that acquired knowledge is stored in early visual areas of the brain, highlighting the widespread storage of semantic memories. The study showed that part of category knowledge is already present in the visual cortex.
Brain activity during wakefulness presents large integrated and dynamic network modules, which tend to vanish or fragment during sleep or under general anesthesia. The researchers built artificial time-evolving networks to test and benchmark algorithms for detecting these structures.
A phase II clinical trial found that intensive rehabilitation of arm and hand use after a stroke is most effective 60 to 90 days after the event. The study showed significant improvement in hand and arm function, with benefits also seen when rehabilitation started at less than 30 days post-stroke.
A new study published in PLOS ONE found that children born with congenital Zika Virus-related microcephaly have varying levels of neurodevelopmental impairment. The researchers used a routine neurological assessment to track the children's development, revealing differences in cognitive and motor skills. The findings suggest that HINE ...
Researchers have identified a molecule called fractalkine that can boost the production of brain cells producing myelin, a key factor in diseases such as multiple sclerosis. The study's findings suggest that fractalkine could be used to treat certain neurodegenerative disorders by restoring lost myelin.
A randomized clinical trial of 125 young adults with concussions found that restricting screen time for 48 hours significantly reduced symptom duration. The study, published in JAMA Pediatrics, suggests that limiting screen time may be a useful strategy to accelerate concussion recovery.
A recent Austrian study found that approximately 7.8% of Austrians between the ages of 18 and 67 suffer from chronic insomnia, with symptoms affecting around 50% of respondents. The low rate of help-seeking behavior highlights a need for better public health initiatives and patient education to address this widespread issue.
A study by Anglia Ruskin University found that weaker internal connections between the brain and organs are linked to negative body image. Adults with less efficient brains at detecting internal messages are more likely to experience body shame and weight preoccupation.
A new study led by UC researcher Daniel Woo found high blood pressure to be a significant risk factor for strokes in Black and Hispanic patients. The study also identified sleep apnea as a novel risk factor for intracerebral hemorrhage (ICH) strokes, which are often deadly and cause high disability.
A preclinical trial has found that boosting a naturally occurring protein family may reduce damage from ischemic strokes. The study, published in The Journal of Clinical Investigation, discovered that administering supplemental IAIP after an ischemic stroke reduced the size of the damaged area and improved functional recovery.
A new study uses AI to predict the risk of stroke recurrence in individuals, identifying high blood pressure, raised cholesterol, and atrial fibrillation as key risk factors. This personalized approach aims to improve patient treatment adherence and reduce the likelihood of another stroke.
A telephone-delivered nursing care strategy combining heart failure care management with depression treatment improved patients' clinical outcomes. Patients receiving 'blended' collaborative care showed better mental health-related quality of life, including improved mood and reduced limitations in social activities.
A study published in Proceedings of the National Academy of Sciences has shed light on why it's difficult to learn a second language as an adult. Researchers found that clusters of neurons in the speech cortex fine-tune themselves as listeners gain familiarity with foreign sounds, indicating a crucial step in language learning.
A recent study by Mount Sinai researchers discovered that certain neurons in the brain's decision-making centers monitor body-state dynamics and hijack the decision-making process during intense states of arousal. This suggests that changes in heart rate and other bodily responses can impact the brain's ability to make rational decisions.
Scientists at Massachusetts General Hospital found that the hormone irisin drives cognitive benefits of exercise, potentially treating Alzheimer's disease. Elevated irisin levels improved cognitive function and neuroinflammation in mouse models for Alzheimer's disease.
New research from Georgetown University Medical Center found that certain brain functions associated with attention and executive control can improve in older individuals. These improvements may be due to lifelong practice and skill-building.
Researchers used MEG to measure brain activity while participants listened to simultaneous math equations and sentences, finding separate networks for each. The parietal lobe processed math and the temporal lobe processed language, with activity tracking every word and symbol.
A machine learning analysis has identified 50 genes strongly associated with neurological aging in both Drosophila fruit flies and humans. The study suggests that fruit flies could be used as a model organism to further investigate aging-related processes.
A new regional policy in Chicago has led to an increase in patients receiving endovascular therapy, a critical treatment for large vessel occlusions. The study suggests that this policy change can improve stroke outcomes and has the potential to have a major public health impact.
A team of scientists discovered molecules called 'toxin sponges' in poison frogs and birds that can act as mops to clean up the poisons, potentially leading to a treatment for paralytic shellfish poisoning. The study found that captive-raised poison frogs were resistant to deadly toxins due to these toxin-sponging proteins.
Researchers have developed a dual-drug therapy for alcohol use disorder by targeting the mTORC1 enzyme. Blocking this enzyme can halt cravings in mice engineered to have AUD, offering a promising alternative to current treatment options.
Researchers recreated damage seen in a widely studied form of frontotemporal dementia by growing special types of cerebral organoids. The study found that the mutated tau protein triggers the death of specific class of neurons, which can be prevented with an experimental drug.
A new study found that people with chronic pain have lower levels of GABA, a neurotransmitter that helps regulate emotions, leading to increased negative emotions and impaired emotional regulation. The researchers hope their online emotional recovery program may provide a non-pharmaceutical solution for those affected.
A large international study has identified over 200 symptoms of long COVID, affecting multiple organ systems. The research calls for widening medical guidelines and a national screening programme to address the complex range of symptoms and their impact on daily life.
Researchers found that undamaged neurons do not change their function after a stroke, contradicting the 're-mapping' hypothesis. Surround-responsive cells, which react to neighboring whiskers, also failed to take over damaged neurons' functions.
Researchers at NUS have identified two new proteins that contribute to EV-A71's ability to invade the central nervous system, making them potential targets for treating severe HFMD cases. This discovery could lead to the development of more effective treatments, particularly for young children affected by this illness.
Researchers used fMRI to measure brain activity in risk circuits, accurately forecasting stock prices based on average group activity. Prior trends and individual choices failed to predict dynamics.
Many children and adolescents hospitalized for COVID-19 or multisystem inflammatory syndrome experienced neurologic involvement, mostly with transient symptoms. Life-threatening and fatal conditions occurred infrequently and long-term effects on neurodevelopmental outcomes are unknown.
A review of nearly 28,000 emergency department records found that less than 2% of COVID-19 patients suffered an ischemic stroke. Those who did had a higher risk of requiring long-term care after hospital discharge.
Scientists discovered that brain activity changes in response to disagreement with group opinion, allowing for future adjustments. The brain retains a 'trace' of past conflicts, influencing future decisions.
A new Canadian TIA Score tool helps emergency physicians predict patients at greatest risk of having a major stroke within the week. The study showed the Canadian TIA Score accurately categorized patients into three risk groups, outperforming existing ABCD2 score.
The USPSTF advises against routine screening for asymptomatic carotid artery stenosis, as it poses a relatively small risk of stroke. This recommendation is consistent with the task force's previous 2014 recommendation.