Articles tagged with Neurons
Researchers developed a graphene-based sensor to record real-time electrical activity of a beating heart, offering high sensitivity and parallel detection. The 'graphene camera' allows for imaging entire networks of cells simultaneously, enabling new studies on neural networks.
The Pew Charitable Trusts has funded 10 postdoctoral fellows from six Latin American countries to conduct research in the US, exploring topics such as molecular interactions and gut bacteria. The program aims to advance scientific knowledge and develop a robust biomedical research community in Latin America.
A new study from Arizona State University and MIT sheds light on how Alzheimer's disease manifests in patients, highlighting the link between toxic proteins, neurodegeneration, and glial cells. The analysis captures a detailed molecular profile of changes in protein levels and alterations in brain tissue.
The study identifies a correlation between the progression of Alzheimer's disease and nuclear aggregates in brain cells. The findings suggest that these aggregates have a function in manipulating gene expression and may be part of AD pathology.
Scientists have identified two brain areas involved in tracking uncertainty about unwelcome events, such as negative news. The anterior cingulate cortex and ventrolateral prefrontal cortex were found to encode information about attitudes toward good and bad possibilities separately.
Researchers identified microglia as key cell type responsible for brain changes in OUD, revealing a critical role for neuroinflammation in driving pathological alterations. The study also uncovered new mechanisms by which opioids alter brain structure and function, leading to behavioral changes.
A new study reports that Elovanoids, a bioactive compound, block the virus that causes COVID-19 from entering cells and protect lung tissue. The researchers found that Elovanoids also triggered the production of protective proteins that counteract lung damage.
The NIH has launched the UNITE initiative to address structural racism in biomedicine, focusing on increasing diversity and inclusion. The initiative aims to tackle issues such as lack of representation from underrepresented racial and ethnic groups, persistent disparities in grant success rates for Black scientists.
Researchers uncover how an RNA named NORAD drives a protein to form liquid droplets that tightly regulate its activity. This phenomenon, known as phase separation, protects against disease by preventing chromosomal abnormalities and promoting cellular homeostasis.
A new study by researchers at MIT's Picower Institute advances understanding of how a mammalian brain enables visual recognition memory. As novel patterns become familiar, the transition is marked by stark changes in the visual cortex, including a shift from gamma rhythms to lower frequency beta rhythms.
Researchers from the University of Liège have developed a Bistable Recurrent Cell (BRC) that enables recurrent networks to learn temporal relationships over 1000 time steps, surpassing classical methods' limitations. This breakthrough could improve AI's ability to process time-series data and predict future events.
Researchers found that neural replay of a newly learned skill occurred during waking rest periods, approximately 20 times faster than the actual behavior. Frequent replay events were associated with greater skill consolidation and improved performance.
Scientists discovered that the genome is organized like a library system, with liquid parts accessible and solid-like islands storing unused information. This organization relies on physics of different states of matter, providing new insights into disease mechanisms and potential treatments.
A new study led by Kumi Kuroda at RIKEN Center for Brain Science identified the calcitonin receptor as a crucial brain protein driving nurturing behaviors in mice. The research found that this protein motivates mothers to care for their infants, suppressing self-interest and risk-taking behaviors.
Researchers studied the brain activity of singing male and female plain-tailed wrens, discovering that they synchronize their duets by inhibiting the song-making regions of their partner's brain. This inhibition allows for a seemingly telepathic performance, with the birds becoming a single entity through sensory linkages.
Researchers at UCalgary have found that even low levels of Bisphenol A (BPA) exposure during pregnancy can impact brain development in mice, affecting circadian rhythms and behavior. The study adds to growing evidence on the harms of BPA and highlights the need for stricter safety guidelines.
A new study by University of Virginia researchers identifies the final step in cell division as crucial for proper brain growth and function. Understanding this process may lead to potential treatments for microcephaly, a birth defect affecting brain development.
Researchers have made significant breakthroughs in understanding how the production of antibodies is regulated in human cells, using cutting-edge technologies to sequence genes in individual cells. This knowledge could lead to enhanced antibody production in vaccines and treatments for diseases such as autoimmunity and allergy.
Physicists at DTU have developed a microscopic harvester controlled by AI, eliminating the need for chemical and mechanical processes. The technology can extract valuable substances directly from plant cells, reducing pollution and costs.
Researchers found that light exposure triggers the formation of brain tumors in genetically prone mice, which could help prevent similar tumors in children at high risk. The study suggests using cool sunglasses or repurposing drugs to block unwanted neuronal activity and reduce tumor growth.
Researchers at Duke University have developed a machine learning platform that can identify activated neurons in videos faster and more accurately than current techniques. The technology enables researchers to watch an animal's brain activity in real-time as they behave, allowing for new insights into how the brain works.
Researchers at EPFL discovered that bile acids can trigger satiety in the brain by activating specific receptors. Bile acids reach the brain shortly after a meal and suppress food intake by blocking appetite-stimulating signals. This study suggests a new role for bile acids in regulating eating behavior.
Researchers found that the defective Cullin 3 gene leads to increased levels of Plastin 3, causing neurons to migrate slower and accumulating in the cortex. This study provides new insights into the mechanisms underlying autism spectrum disorder and may pave the way for therapeutic treatments.
Researchers have successfully catalogued the effect of individual genes on human neuron function and survival, revealing unexpected results. The team's findings suggest that switching off certain genes can lead to an increase in oxidative stress, which may contribute to neurodegenerative diseases.
A study published in Nature Aging suggests that low oxygen levels in senile plaques reduce immune system's defensive capacity against Alzheimer's disease. Reduced oxygen supply also compromises microglial activity, leading to increased pathology associated with the disease.
Researchers have shown that microglia play a central role in maintaining normal brain function and can fail to do so, leading to serious brain disorders. This new understanding has the potential to develop better diagnostics and treatments for these diseases.
Researchers have successfully grown sesame-seed-sized heart models using human pluripotent stem cells, which spontaneously self-organize into a hollow chamber without experimental scaffolds. The cardioids' wall-like tissue contracts rhythmically to squeeze liquid around the inside cavity, mimicking natural development.
A new study suggests that DJ-1 protein, which protects against free radicals inside cells, worsens inflammation outside the cell, leading to exacerbated pathologies in ischemic stroke. The researchers identified DJ-1 as a previously unknown inflammatogenic DAMP that may be a potential target for therapeutic intervention.
A new cognitive construct called 'decision acuity' was identified as a stable factor underlying diverse decision-making abilities in adolescents and young adults. Decision acuity was linked to factors such as fast learning, reward sensitivity, and low propensity for retaliation, and predicted performance in decision-making tasks.
Researchers discovered that a population of regulatory T cells serve as tissue repair engineers to promote functional recovery after stroke. Boosting these cells improved behavioral and cognitive functions in mice for weeks after a stroke, pointing to potential immunotherapy.
Case Western Reserve researchers have identified a potential new approach to controlling epileptic seizures by stabilizing the sodium channel through neddylation. This finding, published in The Journal of Clinical Investigation, offers hope for future research and potential drug development to prevent epilepsy.
Academic institutions must improve support for disabled faculty members, including those with visible and invisible disabilities. The commentary highlights the challenges created by high demands for grant money and frequent research publications, which can lead to reduced funding and staff retention.
Researchers at the University of Oregon have discovered a cell division machinery in fruit flies that produces brain cells, revealing a mechanical cycle involved in differentiation. The study provides insights into brain development and potential regenerative therapies for injuries.
Scientists at Johns Hopkins Medicine counted brain cells in fruit flies and three mosquito species, revealing an average of 200,000 neurons. This estimate likely represents a baseline number of brain cells required for complex behaviors. The study provides insight into the intricate processing capabilities of these insects.
Scientists at Gladstone Institutes create an artificial intelligence system that can follow hundreds of cells in a petri dish, revealing key findings on cell behavior and leadership patterns. The AI approach provides a comprehensive view of how cells cooperate and form complex organs, with potential applications for therapeutic purposes.
Researchers at Massachusetts General Hospital have discovered that sevoflurane can cause tau to leave neurons and enter microglia, stimulating inflammation and cognitive impairment. The study suggests that inhibiting tau phosphorylation or extracellular vesicle generation could prevent this tau spreading.
Researchers used advanced imaging technology to film Zebrafish brains while they were alive, revealing that the activation of stem cells responsible for generating neurons is not random, but rather coordinated. This finding has important implications for understanding brain development and may lead to new treatments for neurodegenerati...
Researchers will investigate potential mechanisms using mouse models and systems biology approach to identify new drug targets for Alzheimer's disease. The study aims to understand how altered mitochondrial calcium transport contributes to neurodegeneration and disease progression.
Rice University neurobiologist Rosa Uribe wins $2 million NIH grant to study enteric nervous system development in zebrafish embryos. The 5-year study aims to decipher the mechanisms of neural crest cell transformation into neurons and other cell types.
A joint research group found a previously unknown cell type in the adrenal glands that might be the origin of neuroblastoma tumour cells. This discovery could provide a basis for effective treatments.
Researchers found that calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells, activating an enzyme that promotes their clearance. This process is crucial for maintaining body health and preventing tissue damage caused by unremoved dead cells.
Researchers have mapped the genetic profile of osteocytes, a type of bone cell that controls skeleton growth and decay. The study identifies novel genes associated with rare and common skeletal diseases, paving the way for new treatments and improved diagnosis.
Researchers at Carnegie Mellon University have developed a new noninvasive therapy using low-intensity focused ultrasound that can target specific cell types in the brain. The technology has shown promise in treating conditions such as Parkinson's Disease, epilepsy and insomnia.
Biomedical engineer Chase Cornelison is exploring ways to harness cancer cells to treat spinal cord injuries and restore function following brain damage. His research aims to retrain neural cells to suppress inflammation and promote repair, potentially reversing the damage caused by paralysis and diseases.
Researchers at the Wellcome Sanger Institute have developed a new method called nanorate sequencing (NanoSeq) that enables accurate study of genetic changes in human tissues. The study challenges the idea that cell division is the main mechanism driving genetic changes and opens up new avenues for research into cancer and ageing.
A team at Kanazawa University found that vasopressin neurons play a critical role in regulating the timing of output from the molecular clock, which governs circadian behaviors. The study used mice with altered GABA signaling to demonstrate the importance of these neurons in maintaining behavioral rhythms.
Researchers at the Salk Institute have developed a new technique to model brain cells in older patients with Alzheimer's disease. The study reveals that affected neurons lose their cellular identity and exhibit changes similar to those seen in cancer cells, providing potential targets for therapeutics.
A team of University of Michigan researchers identified many genes crucial for fruit fly neuron development, including three previously unknown ones. The discovery provides insights into the complex process of neurogenesis and may lead to new approaches for understanding human brain development and regeneration.
Researchers identified a new cell type called neuromast-associated ionocytes in zebrafish sensory organs that play a crucial role in regulating the fluid composition. These cells are responsible for maintaining balance and spatial orientation, and their dysfunction is linked to hearing loss and vestibular defects.
Researchers have identified a critical role for DNA replication timing in controlling the packing of DNA with its regulatory factors, known as the epigenome. The study found that disrupting this program can lead to inappropriate cellular functions and negative health outcomes.
A new UCLA study finds that a one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia. The therapy, developed from glial cells, stimulates the brain's own repair processes and enhances neural connections.
Scientists discovered that mice categorize surprisingly well, even assigning patterns they've never seen before into correct categories. Category-selective neurons in the prefrontal cortex gradually develop during category learning, playing a key role in long-term memory.
Researchers have successfully altered feeding and anxiety-like behaviors linked to anorexia in mice by targeting the MC3R receptor. The study suggests that fine-tuning the receptor's activity could help change feeding habits and promote weight gain in patients with eating disorders, offering a potential new treatment for anorexia.
Researchers at Champalimaud Centre for the Unknown discover distinct compartments within the VMH that control female receptivity and rejection. Progesterone receptors exhibit significant changes across reproductive cycle, suggesting a complex neural basis for female socio-sexual behavior.
Researchers at Massachusetts General Hospital discovered three distinct types of pulmonary neuroendocrine cells (PNECs) that line the human airway, which may be involved in breathing-related diseases in infants. The study found higher numbers of certain PNECs in autopsied tissues from children who died from SIDS and other conditions.
Researchers discovered a new molecule, K162, that inhibits beta-amyloid toxicity and protects neurons from damage. The study provides hope for alternative therapeutic strategies against Alzheimer's disease.
A University of Colorado Boulder study reveals that tau aggregates interfere with RNA splicing, leading to neurodegeneration in Alzheimer's disease and other tauopathies. The findings provide new insights into the mechanism of action of tau tangles, shedding light on potential therapeutic targets.
Researchers found that Staufen1 accumulates in brains of patients with neurodegenerative disorders, disrupting normal cellular function. Lowering Staufen1 levels may improve pathology and rid cells of stress granules, a key finding for potential treatment approaches.
The new Neuropixels 2.0 probes have improved recording-site density and long-term stability, allowing scientists to track individual neurons for weeks. This enables the study of complex phenomena like learning and memory in mice.
A study by researchers at Tokyo Medical and Dental University found that the Distal-less homeobox 5 (Dlx5) gene plays a significant role in directing cell fate in the mouse head. Higher expression levels of Dlx5 were linked to enhanced cartilage and bone formation, suggesting its importance in proper cranial development.