Articles tagged with Neurons
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers aim to understand how electrical stimulation affects glia and vasculature in the brain, with potential implications for treating neurological diseases. They'll use two-photon microscopy and optogenetics to investigate inner workings of the brain.
Researchers at the University of South Florida Health found that SSH1 disrupts p62's ability to clear damaged tau proteins and mitochondria, leading to accumulation of toxic cellular waste. This defect may help develop SSH1 inhibitors to treat neurodegenerative diseases.
Researchers have discovered that female mosquitoes use four distinct types of neurons to detect the unique flavor of human blood, which may lead to new methods for preventing mosquito-borne illnesses. By studying these taste neurons, scientists hope to develop a drug or treatment that could deter mosquitoes from biting humans.
A team of neuroscientists has identified processes the brain uses to distinguish real and present dangers from those linked to past experiences in mice. The findings have significant implications for our understanding of post-traumatic stress disorder (PTSD), where patients struggle to distinguish between safety and threat cues.
Researchers found that genetic pathways allowing fish to regrow neurons remain present in mammals, but are turned off, blocking regeneration and healing. The study may advance genetic therapies for blindness and other neurodegenerative diseases.
A study in STEM CELLS Translational Medicine suggests that amniotic fluid stem cell-derived secretome can restore neuronal plasticity and improve cognition after an ischemic stroke. The findings offer a potential new avenue of treatment for ischemic stroke, which affects 87% of all strokes.
A team of researchers has identified networks of genes that regulate neuron regeneration in certain animals, such as zebrafish. This discovery may lead to the development of new treatments for neurodegenerative disorders, including blindness and Parkinson's disease.
Researchers at Northwestern University have developed a new cell perturbation system that can deliver DNA, RNA, and proteins into cells with high efficiency and low toxicity. The Nanofountain Probe Electroporation system has the potential to revolutionize medical treatments by enabling quicker and more customized treatment plans.
Researchers at Gladstone Institutes are studying how cells regulate their energy levels and exploring ways to target energy regulation processes to treat diseases such as neurodegeneration and heart failure.
Researchers find that cell adhesion proteins and a gradient of signaling molecule Sonic Hedgehog work together to create precise sorting of cells into domains. By combining experiments from biophysics, genetics, and developmental biology, the team successfully solves the puzzle of how patterns are created in developing organisms.
A new study reveals that microglia, immune cells in the brain, regulate behavioral responses by sensing neuronal activation and providing negative feedback. This novel mechanism of neuromodulation has implications for treating neurodegenerative and inflammatory diseases.
Breast and lung cancer cells use the Slit2 protein, normally produced by neurons, to signal their migration. This intricate mechanism enables them to escape primary tumors and spread to other organs. The findings could lead to novel diagnostics and treatments for metastasis.
Researchers have identified the cellular process by which Cisplatin chemotherapy causes neuronal damage, revealing that it induces senescence of peripheral neurons through overexpression of the p21 protein. This discovery provides new targets for neuroprotective treatments to alleviate or avoid the adverse effects of Cisplatin.
The desert locust's two internal compasses rely on the sun's position and sky polarization patterns. The protocerebral bridge in the central complex encodes 360 degrees of space, enabling navigation based on combined cues from the sky.
Researchers used deep learning to identify neural degeneration patterns in C. elegans, detecting physical symptoms more quickly than humans and distinguishing between causes of degeneration.
Researchers found that star-shaped brain cells, astrocytes, change dynamically across sleep-wake cycles and play a role in regulating sleep need. Astrocyte calcium activity increased during rest phases when sleep need is greatest, suggesting an essential role in sleep regulation.
Scientists have created a new nanodevice that acts like a brain cell and can be joined to form networks that solve problems in a brain-like manner. These systems can identify possible mutations in a virus, relevant for ensuring vaccine efficacy.
Research reveals cannabinoids reduce astrocyte glucose metabolism, impairing neuronal function and social interaction behaviors. The study identifies CB1 receptors as key players in this process.
Researchers at UCLA discovered that the brain measures seconds by changing patterns of neural activity, with two distinct 'clocks' in different regions. The study found that mice could anticipate rewards based on scents associated with specific time intervals.
Researchers have identified how brain cells work together to join up memories of separate experiences, allowing us to make educated guesses. The process happens in a region of the brain called the hippocampus and is also linked to creativity.
A new study in mice suggests that a molecular transporter, GLT-1, may play a crucial role in determining susceptibility to migraines. The researchers found that mice lacking the GLT-1 transporter were more prone to cortical spreading depression, a condition related to migraines, and had increased levels of glutamate outside of neurons.
Scientists have discovered the first X-ray crystallography structure of LSD bound to its target in the brain, revealing how it induces hallucinogenic effects. The study also uncovers images of a prototypical hallucinogen coupled with the entire serotonin receptor complex.
Researchers found neurons in the striosome contribute to both positive reinforcement learning and negative-reinforcement learning, highlighting the complex motivation-processing hub in this brain region. Understanding its function is critical for developing better treatments for mental illnesses such as depression and addiction.
New research suggests neural implants need to filter out correlated noise in retinal cells to achieve accurate signals, improving performance by 20-100% depending on light conditions
Scientists have discovered a potential effective treatment for Frontotemporal Dementia (FTD) using Ursodeoxycholic Acid, an already approved liver medication. The drug has been shown to increase protective proteins in neurons and prevent cell death, offering new hope for patients.
Researchers found that immune cells surrounding the brain produce a molecule called IL-17, which is then absorbed by neurons and appears to be necessary for normal behavior. The findings suggest that elements of the immune system affect both mind and body.
A new study from JNeurosci found that time-sensitive neurons in the supramarginal gyrus fatigue and distort our subjective experience of time. When repeatedly exposed to a fixed duration stimulus, these neurons wear out, leading to skewed perceptions of time.
Researchers created a synthetic 'molecular bridge' to restore lost connections in the spinal cord and brain of mice with neurological disorders. The molecule, called CPTX, has shown promise in repairing neuronal connections and improving motor performance in animal models.
A study by University of Maryland School of Medicine researchers identified GFI1 as a vital protein in the development of functioning adult hair cells. In its absence, embryonic cells were likely to develop into neuron-like cells. The findings could lead to new methods for regenerating lost hair cells and restoring hearing.
A new study from North Carolina State University has shed light on the earliest stages of Angelman syndrome, a genetic disorder affecting brain development and function. The research used human cerebral organoids to monitor the behavior of a key gene, UBE3A, revealing its role in early brain tissue development.
Researchers at CSHL and Stanford University found a direct connection between stress-sensitive neurons and insomnia-inducing neurons in mice. Stimulating this connection enabled mice to sleep peacefully, while disrupting it caused insomnia. The same connection also affects the immune system, weakening its defenses against threats.
Researchers at Rutgers University are exploring the link between uncontrolled inflammation and microglial cells in the brain, aiming to develop new therapies for neurodegenerative diseases. The team is designing nanomedicines that can target microglia to tamp down inflammation and protect neurons.
The Operation Outbreak platform simulates pandemics with different variables, including R0 and mode of transmission. The app uses Bluetooth-based contact tracing to generate data in the context of human behavior.
Researchers identified a specific brain circuit vulnerable to juvenile social isolation in mice, which may lead to treatments for sociability deficits and psychiatric disorders. Stimulation of this circuit restored normal social behavior in adult mice with juvenile isolation.
Researchers discovered a metabolic adaptation in nerve cells that allows them to counteract degeneration and promote survival. This 'metabolic rewiring' involves the activation of the Krebs cycle anaplerosis pathway, which makes neurons resistant to progressive damage.
Cells use self-generated chemotaxis to create attractant gradients, allowing them to read local and global information about their surroundings. This process enables cells to navigate vast distances through the human body during embryogenesis and other biological events.
Researchers found that a mutation in a tRNA gene can disrupt brain function and behavior, leading to imbalances in excitatory and inhibitory neurotransmission. This imbalance has been implicated in numerous neurological diseases, including epilepsies and autism spectrum disorders.
A new investigational therapy has shown to prevent the onset of Dravet syndrome symptoms in a mouse model, increasing gene expression up to 100 percent in neurons. The treatment uses an antisense oligonucleotide (ASO) that is reversible and non-invasive.
Researchers at West Virginia University aim to understand zinc's role in neuronal communication, using animal models and sensors to track activity. They hope to uncover the inner workings of the auditory cortex and develop new treatments for conditions like schizophrenia and Alzheimer's disease.
Scientists found that most cAMP molecules are bound to proteins, creating nanometer-scale 'prisons' that regulate signaling pathways. This discovery could lead to new targets for cancer and cardiovascular research.
In adult fruit flies, accumulating extra genome copies in brain cells may help prevent cell death caused by DNA damage. This novel anti-aging defence could also shed light on human age-related brain diseases.
A team of engineers has developed a low-power collision detector inspired by locusts' ability to avoid collisions. The device mimics the locust's response to incoming objects, responding in two seconds and using minimal energy.
Research using fruit flies found that certain stationary patterns trigger the perception of illusory motion. The brain's motion-detecting neurons play a key role in this phenomenon, driven by imbalanced responses to stationary edges.
Researchers at the University of Queensland discovered that neurons can fuse together, disrupting electrical circuits and leading to behavioral impairments in nematode worms. The study provides a novel cause for malfunction of brain's electrical circuits and a possible underlying cause of neurological diseases.
Scientists at Yale University found that flies perceive motion in static images similarly to humans, using a shared strategy for motion detection. By analyzing specific neuron types and behavior, the researchers developed a theory explaining how optical illusions work, which may also apply to human visual systems.
Researchers at the University of Bonn identify a disease mechanism where fat crystals cause immune system hyperreaction, leading to chronic inflammation. The study reveals that deoxysphingolipid crystals disrupt mitochondrial function and activate an inflammatory response in immune cells.
A new study by Osaka University researchers reveals that an abnormality of the C9orf72 gene leads to toxic protein production and hinders the cell's ability to destroy defective RNA. This creates a vicious cycle that accelerates disease progression in FTLD/ALS, opening up avenues for potential therapy options.
A new study led by Dr. Christopher Morrison reveals the nervous system cells and circuits that influence our metabolism and health in response to dietary changes. FGF21, a hormone produced by the liver, plays a crucial role in signaling to the brain when protein intake is low, triggering metabolic changes that improve health.
Scientists from Okayama University have developed genetically engineered proteins that can be controlled by light, offering a promising new tool for studying neurons. The engineered proteins, based on natural light-regulated channels, can be activated or silenced using different light frequencies, providing finer control over neural ac...
A team of Harvard researchers found that image-processing circuits in the primary visual cortex are more active when animals move, suggesting a complex relationship between vision and movement. The study's results offer new insights into how neural activity works in sensory regions of the brain.
Researchers discovered that mitochondria regulate the key event of neural stem cells becoming nerve cells during brain development. The study found that mitochondrial dynamics are important to cell fate choice and that this influence is limited to a specific time window, twice as long in humans compared to mice.
A team of researchers at Champalimaud Centre for the Unknown found that the ovipositor, a temporary tube-like structure protruding from the female's abdomen, stimulates the male to attempt mating. The study reveals a sequence of steps in male-female communication that resolves contradictory reports on courtship and copulation.
Researchers found that electroacupuncture can significantly reduce pro-inflammatory molecule levels and increase survival rates in mice with a life-threatening inflammatory condition. The treatment worked by exciting norepinephrine-producing nerves, which activated receptors that suppressed inflammation.
A study published in Nature Communications reveals how pollen tubes grow up to a thousand-fold to reach the ovule, creating electrical activity at the cell membrane and promoting faster growth. The findings have implications for understanding seed production, fungal growth, and neuronal development, and may lead to improved food crop v...
Researchers developed three techniques to replace malfunctioning microglia, with varying efficiencies and donor sources. The techniques offer promise for treating neurological disorders such as Alzheimer's, ALS, and Parkinson's.
Researchers at Baylor College of Medicine discovered a novel mechanism to regulate ATXN1 levels, reducing protein accumulation and improving SCA1 symptoms. Gene therapy targeting the cerebellum showed promising results by lowering ATXN1 levels and enhancing motor coordination in animal models.
Researchers developed a genetically engineered mouse to visualize fluctuations in circadian clocks of cell types. They found that removing clock genes from AVP neurons disrupted the entire SCN network, while VIP neurons were less affected.
Researchers synthesized current evidence on gene regulatory networks and neuronal networks to understand animal behavior. The integration of these networks reveals complex dynamics, including environmental factors and social behavior influencing gene expression changes.
A study by Tufts University researchers found that estrogen can have a disruptive effect on glucose metabolism in females, but not males, when a specific protein is absent. The study identified a key protein in the brain that mediates these effects and provides insight into the differences between men and women in their risk of diabetes.
Researchers discovered that REM sleep tunes eating behavior by reducing the activation of hypothalamic neurons in mice, indicating the importance of sleep quality in maintaining stable feeding habits. The study suggests a long-lasting effect on neuronal activity and feeding behavior.