Orexin

UT Southwestern research halts narcolepsy symptoms

Researchers at UT Southwestern Medical Center have discovered a potentially new avenue for treating human narcolepsy by introducing the brain chemical orexin into genetically engineered mice. The study, which uses knockout mice that lack orexin-producing cells, finds that artificially reintroducing orexin alleviates narcoleptic symptom...

SourceUT Southwestern Medical Center·JournalProceedings of the National Academy of Sciences·DateMar 15, 2004

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Yale researcher receives $1.4 million grant to study the hypocretin cells involved in narcolepsy

Narcolepsy is a lifelong problem characterized by sudden sleep episodes and muscle paralysis triggered by strong emotions. A new study aims to understand the role of hypocretin cells in controlling sleep and arousal, with potential breakthroughs for future treatments.

SourceYale University·DateFeb 7, 2002

A peptide whose absence leads to narcolepsy also might play role in pain sensation

Researchers found that hypocretin neurons from the hypothalamus establish direct connections with spinal cord nerve cells involved in pain perception. This discovery may lead to new treatments for pain, particularly in spinal cord injuries.

SourceYale University·JournalThe Journal of Physiology·DateFeb 1, 2002

Scientists pinpoint possible cause for debilitating sleep disorder narcolepsy

Researchers found a dramatic reduction in hypocretin neurons in people with narcolepsy, suggesting a potential link to neurodegenerative processes or autoimmune responses. The study suggests that replacing missing hypocretin cells may reverse symptoms of the disorder, paving the way for new treatment options.

SourceNIH/National Institute of Neurological Disorders and Stroke·JournalAnnals of Internal Medicine·DateAug 28, 2000