Articles tagged with Adipose Tissue
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
Researchers at UVA Children's will use a sophisticated computer model to better understand and treat Crohn's disease, which can have lifelong consequences for young patients. The team hopes to identify biological markers or metabolic signatures that can be used for early diagnosis and personalized medicine.
Researchers discovered that stopping GH activity in fat cells improves health and increases lifespan in mice. The study found approximately 23% lifespan extension due to GHR disruption, with improved insulin sensitivity and reduced frailty scores.
A recent mouse study published in Diabetes found that maternal and paternal exercise significantly improved metabolic health in offspring. The study used metabolomics profiling to examine the effects of parental exercise on tissue metabolites, revealing extensive changes in glucose and fatty acid metabolism.
A recent study published in Journal of Science and Medicine in Sport reveals that high aerobic fitness does not protect children from metabolic syndrome. In contrast, a lower risk was observed when considering body size and composition.
Research at Northwestern University finds that eating during the daytime is ideal for dissipating energy as heat, while nighttime eating disrupts this process. This study's findings have broad implications for dieting, sleep loss, and patient nutrition, particularly in cases of Type II Diabetes.
A study found that leptin stimulates liver fat export and lowers liver fat content in healthy men, suggesting a new approach for treating fatty liver disease. The findings imply that the brain plays a role in liver fat metabolism via the autonomic nervous system, opening up potential new treatment options.
A study of 15 transgender women found they exceeded the cardiopulmonary capacity and muscle strength of their cisgender peers even after years of hormone therapy. However, their performance was lower than that of cisgender men. The findings could inform policy on transgender women's sports participation.
A UK trial found that 70% of people with normal weight and type 2 diabetes entered remission by losing around 10% of their body weight, supporting the concept of a personal fat threshold. The study showed that even though participants had normal BMI, they had higher levels of fat in their liver and pancreas than healthy controls.
Researchers at the University of Houston have discovered a way to activate the soleus muscle, which can sustain elevated oxidative metabolism and improve blood glucose regulation for hours. The 'soleus pushup' movement has been shown to increase oxygen consumption and reduce insulin requirements.
Researchers found that waist-to-hip ratio is a stronger predictor of early death than body mass index (BMI), which doesn't take into account fat distribution. A lower waist-to-hip ratio is associated with lower mortality risk, regardless of population studied, and may be a better measure of healthy weight.
A randomized clinical trial found that protein restriction diets can lead to weight loss, improved blood sugar and lipid levels, and controlled blood pressure. The study involved 21 patients with metabolic syndrome, who were given either a calorie or protein restriction diet for 27 days.
The Healthy-Day-App assesses time use patterns in children and predicts outcomes on body fat percentages, wellbeing, and academic performance. Shifting screen time to physical activity results in improved health outcomes, including 4.2% lower body fat and 2.5% better wellbeing.
Dr. Nathan Hogaboom has won the prestigious Ernest Bors, MD Award for Scientific Development for his pioneering work on regenerative rehabilitation research in spinal cord injury. His award-winning study applied novel principles to treat debilitating shoulder pain in wheelchair users with spinal cord injury.
Research suggests that arterial stiffness increases blood pressure in adolescents due to insulin resistance, not body fat. Healthy lifestyle choices like exercise and a balanced diet may help lower blood pressure in this age group.
Researchers have identified a stream of messages between fat tissue and the brain, revealing a previously unknown pathway for adipose tissue to communicate with the brain. The discovery suggests that sensory neurons play a crucial role in regulating fat metabolism and may hold potential for treating obesity and metabolic diseases.
A new study found that a fast food diet before pregnancy can negatively impact breast milk quality and baby's health, increasing the risk of conditions like heart disease and diabetes. Even short-term consumption of high sugar and fat diets affects women's health and fertility.
The England Men's Cricket Team has become leaner and fitter over the past seven years, with a significant drop in body fat and substantial improvements in fitness levels. The study found players have 18% less body fat and increased cardiovascular capability.
Researchers discover G6PD's pivotal role in activating pentose phosphate pathway to counter oxidative stress, leading to increased cell death and tumor shrinkage. Ovarian cancer cells' reliance on fatty acid metabolism fuels oxidative compound production, which can be offset by G6PD inhibition.
Researchers have discovered that human urine-derived stem cells have the ability to regenerate tissue and become various cell types, making them a promising source for stem cell therapy. The study also highlights the importance of telomerase activity in maintaining regenerative potential.
An artificial intelligence model trained on histological images of surgical specimens accurately classified patients with and without Crohn disease recurrence. The model revealed previously unrecognized differences in adipose cells and mast cell infiltration, enabling stratification by prognosis for postoperative Crohn disease patients.
A new study published in Scientific Reports reveals that regular high-intensity interval training exercise can significantly decrease fasting glucose levels and waist circumference, while improving oxygen consumption rates in patients with non-alcoholic fatty liver disease. Exercise also modifies amino acid metabolism in adipose tissue...
Researchers found that different regions of fat tissue contribute to disease risk differently in men and women, with visceral fat in men and subcutaneous fat in women being linked to diabetes onset. The study suggests that understanding these sex-specific differences can inform better clinical approaches to treating the disease.
Researchers at the University of Illinois created quantum dots to visualize macrophages in fat tissue, shedding light on chronic inflammation's role in diseases. The new technology enables accurate cell counting and tracking over time, offering a potential diagnostic tool for insulin resistance and metabolic syndrome.
A study by Osaka University investigated the relationship between autophagy and metabolism during fasting. Autophagy was found to play a key role in promoting fat loss during fasting, particularly through the upregulation of adipogenic genes. The findings may have important implications for understanding metabolism during aging.
Researchers identified peripheral tissues as source of blood amyloid beta, which regulates blood glucose levels and suppresses insulin secretion. The study suggests a possible mechanism linking type 2 diabetes to Alzheimer's disease development.
A new study found that a ketogenic diet significantly improves MS symptoms, including fatigue, depression, and cognitive function. Patients on the keto diet experienced reductions in neurologic disability and enhanced overall quality of life.
A new University of Copenhagen study reveals that well-functioning fat tissue is crucial for overall health and may help prevent diseases such as type 2 diabetes, cancer, and obesity. High levels of lifelong exercise have been shown to improve mitochondrial function in fat cells, reducing oxidative stress and damage.
Researchers found that moderate calorie restrictions improved health by rejuvenating the thymus gland, which produces essential white blood cells. Participants who restricted calories showed less fat and greater functional volume in their thymus glands after two years.
Researchers from Tel Aviv University have engineered 3D human spinal cord tissues and implanted them in lab models with long-term chronic paralysis, resulting in an 80% success rate in restoring walking abilities. The team aims to conduct clinical trials in human patients within a few years to make the treatment commercially available.
Research reveals that obesity leads to a decline in adipose tissue's ability to respond to changes, causing insulin resistance and inflammation. This loss of function can be addressed through modulating fat tissue phenotypes for therapeutic purposes.
Researchers found a significant association between higher body fat levels, particularly visceral fat, and lower cognitive performance scores among adults. The study of 9,100 participants showed that individuals with higher levels of body fat were more likely to experience cognitive decline.
A new study found that excess body fat is a risk factor for reduced cognitive function in adults, including processing speed. The association remained even after adjusting for cardiovascular risk factors. Maintaining healthy weight and physical activity may help preserve cognitive function and prevent dementia.
A study by Michigan Medicine researchers found that people with diabetes have more macrophages in their fat tissue, particularly the anti-inflammatory CD206+ subtype. This subtype is unique in terms of gene expression and may play a role in the development of diabetes.
A comprehensive study of exercise performed at different times of the day has identified distinct health-promoting signaling molecules produced by the body in an organ-specific manner. The findings suggest that exercising at the right time can optimize health benefits, particularly for individuals at risk of obesity and type 2 diabetes.
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
Research from the University of Cincinnati reveals that female fat tissue contains more mitochondria, providing protection against obesity and metabolic diseases. The study suggests a link between mitochondrial gene Ndufv2 and lower incidence of complications such as diabetes and high cholesterol.
The MUSC Hollings Cancer Center researchers are exploring the role of macroenvironment in pancreatic cancer-induced cachexia to address this debilitating condition. The team aims to provide new biological insight, which will be coordinated by four cores within the program project grant.
A multi-center study found micro-fragmented adipose tissue injections to be highly effective in reducing knee pain, improving function, and enhancing quality of life. Positive effects were observed for up to 12 months, with notable differences in efficacy among demographics.
A new study found that increasing childhood cardiorespiratory fitness can reduce the adverse effects of metabolic syndrome traits on atherosclerosis. The researchers discovered a two-way connection between arterial health and fat mass, with healthy arteries associated with higher fat mass in children.
Researchers used autologous adipose micrografts to treat tendon injuries in sheep, achieving similar diameter and hardness to healthy tendons within two months. The study suggests a safe, reliable, and relatively fast way to promote tendon healing, with potential for human treatment.
The University of Maryland associate professor will use genetics, cell biology, and pharmacology to examine the mechanisms of copper transport and its connection to thermogenesis and fat burning. The research aims to improve human health by understanding how copper relates to hypothermia, obesity, and diabetes.
A new study has found that harmful body fat can increase the risk of dementia and stroke, with grey matter atrophy being a key indicator. The research used genetic data from over 336,000 individuals to establish a link between obesity and declining brain health.
Researchers at Karolinska Institutet discovered industrial chemicals in the organs of fetuses conceived decades after many countries banned the substances. The study found that 15 out of 22 persistent organic pollutants were present in every organ, with four chemicals detected in all tissues in all fetuses.
A new study reveals that high genetic running capacity promotes more efficient amino acid metabolism in skeletal muscle, potentially contributing to healthier metabolism with aging. Adipose tissue may also play a key role in promoting healthy aging, contradicting previous assumptions.
A recent study has identified a constellation of genetic variants in the FTO gene that correlate with metabolic and behavioral changes linked to obesity. The research found that these variants influence the expression of IRX3 and IRX5, which collectively mediate risk of obesity.
A study in mice reveals genes and metabolic processes that could aid or hinder recovery after a heart attack, with potential targets for treatments. The research used systems biology approaches to analyze gene activity across multiple tissues, identifying common and tissue-specific responses.
Recent studies refute the theory that excessive carbohydrate consumption leads to insulin-driven weight gain. Instead, basal insulin levels in response to energy balance are key to regulating weight gain, suggesting alternative models for body fat regulation.
A new study suggests that inhibiting GKN1, a stomach-specific protein, can lead to significant weight loss and reduced body fat in mice. The researchers found that models without GKN1 had improved metabolism and resistance to weight gain on high-fat diets.
Researchers found obesity reduces mitochondrial function in fat tissue, leading to proinflammatory state and increased risk of diseases like diabetes and liver disease. Muscle tissue also shows decreased mitochondrial function, but to a lesser extent.
Researchers found that body fat percentage is a key predictor of exercise capacity and cardiovascular disease risk in individuals with Type II diabetes. Machine learning approaches were used to analyze data and make accurate predictions.
Semaglutide treatment leads to reduced excess body fat and increased lean body mass in adults with obesity. The medication has the potential to reduce the risk of heart disease, diabetes, and stroke by improving body composition. The STEP 1 trial found that semaglutide significantly improved body weight loss and reduced visceral fat.
Researchers found that dieting impairs the energy-producing machinery of fat tissue, resulting in rapid weight regain, whereas bariatric surgery improves mitochondrial function and reduces regaining weight. The study used transcriptomics analysis to examine the effects of dieting and surgery on adipose tissue mitochondria.
A new UCLA study finds that women with high muscle mass and high body fat have a greater degree of protection against heart disease-related death than those with low body fat. Meanwhile, men with high muscle mass and low body fat show a significant decrease in risk, but not as pronounced as seen in women.
Researchers mapped out changes in fat tissue during intermittent fasting, showing visceral 'belly' fat becomes resistant to weight loss by adapting to repeated fasting periods. The study provides insights into the mechanisms behind this resistance and potential diet interventions.
A team of researchers has identified genes linked to both high body fat and protection from negative health impacts of obesity. The findings shed new light on the biology behind this disconnect, offering potential targets for therapies that lower diabetes and heart disease risk.
A study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that girls with excess body fat developed fully mature breasts more slowly but started their period sooner. The researchers also found higher levels of reproductive hormones, including testosterone, in girls with obesity.
Researchers used a novel 3D microscopy technique to study crownlike structures in adipose tissue, finding they are actually concentric spheres surrounding an empty core. This discovery may lead to new treatments for obesity-related diseases like type 2 diabetes and cardiovascular disorders.
A recent study published in BMC Public Health found that obesity and excess body fat likely accounted for more deaths than smoking among older adults, but still contributed to more deaths among younger adults. The analysis also suggests that gender played a role in the contributions of these factors to estimated deaths.