Researchers identify caveolae's role in protecting adipocytes from rupture and inflammation; this discovery opens new avenues for treating metabolic diseases like obesity. The study highlights the importance of the caveolin-1 protein in maintaining cellular integrity.
A new study from Queen Mary University of London has identified the genetic drivers of early onset type 2 diabetes in South Asians, revealing a strong link to lower insulin production and unfavorable body fat distribution. The research also sheds light on treatment responses, highlighting the need for precision medicine approaches.
A study by ETH Zurich researchers has found that epigenetic markers in fat cells can lead to the yo-yo effect, where weight drops but returns. The researchers also found evidence of this mechanism in humans, suggesting that obesity can leave a lasting mark on gene expression.
Researchers at Anglia Ruskin University are investigating the complex relationship between fat tissue and colorectal cancer. The study aims to enhance knowledge of the tumour microenvironment, uncover new molecules crucial for cancer growth, and develop more effective treatments.
Metformin, a widely prescribed diabetes drug, may increase risks of obesity and diabetes in newborns when given to pregnant women. The study found that the drug accumulated in the fetal kidneys, liver, and other organs, leading to growth restriction, which has been linked to an elevated risk of obesity and insulin resistance in childhood.
Researchers identify interleukin-17A as a key regulator of fat storage, carrying implications for addressing obesity and preventing wasting. The discovery highlights the interaction between the immune system and circadian rhythms, which may hold therapeutic potential for metabolic disorders.
Researchers found that physically fitter patients with metastatic lung cancer live longer and respond better to chemotherapy. The study identified biomarkers in blood plasma that can indicate which patients are most likely to respond to treatment.
A team of scientists from NTU Singapore and HKU found that electro-acupuncture can reverse the effects of obesity in obese individuals and mice on a high fat diet. The treatment targets osteoprotegerin, a protein linked to fat cell formation and obesity development.
The ISSCR 2025 Annual Meeting will bring together stem cell scientists from diverse backgrounds to share knowledge and collaborate on innovative research. Scientists can submit abstracts by January 21, 2025, for oral presentations and qualify for awards.
A new study found that a high body roundness index over 6 years was associated with an increased risk of developing cardiovascular disease in adults older than 45. The study, published in the Journal of the American Heart Association, suggested that BRI may be a valuable predictor of cardiovascular disease risk.
A study from the University of Copenhagen detected lipid biomarkers in obese children that indicate a higher risk of developing type 2 diabetes, liver, and heart disease later in life. A one-year lifestyle intervention lowered these biomarkers, demonstrating the importance of early intervention for children with obesity.
A study of 32,409 participants found a strong association between abdominal fat and chronic musculoskeletal pain, especially in women. Reducing visceral adipose tissue and subcutaneous adipose tissue may be key to managing chronic pain in multiple body sites.
High levels of lipoprotein (a) found in 20-34% of Polish patients with heart disease or at risk. Lp(a) measurements may be crucial in preventing cardiovascular diseases and atherosclerosis progression.
Researchers used genetic method Mendelian randomization to show high levels of fasting insulin cause reduction in Lp(a), rather than the other way around. Low Lp(a) is unlikely to be a risk factor for type 2 diabetes, independent of pre-existing hyperinsulinaemia and insulin resistance.
Research from the University of Eastern Finland found that obesity-induced inflammation increases the secretion of extracellular vesicles from human adipocytes, which may contribute to the detrimental health effects of obesity. Visceral adipose tissue secretes more extracellular vesicles than subcutaneous adipose tissue.
Scientists discovered a way to kill pancreatic cancer in mice by combining a ketogenic diet with an existing cancer drug. The diet blocks the cancer's only source of fuel, allowing the drug to take effect and shrink tumors. This finding opens a new vulnerability for treating cancer with diet and personalized therapies.
A new study found that digital health tools can improve health and wellbeing by keeping people active, boosting steps, and improving diet and sleep. The research synthesised data from 206,873 people across 47 studies, indicating that electronic and mobile health interventions can help people achieve positive outcomes.
Dr. Elks' research focuses on the communication loop between fat cells and immune cells, which promotes inflammation and insulin resistance when disrupted. The grant aims to uncover patterns in cell communication that can be used to treat obesity and other metabolic diseases.
Researchers are studying the role of stress hormones and mineralocorticoid receptors in bone health as we age. The goal is to understand how balance between these factors affects our skeletons. By investigating this complex relationship, scientists hope to develop new insights into osteoporosis and other age-related bone disorders.
A large-scale study published in JACC shows that promoting healthy habits in elementary school children can effectively reduce abdominal fat and obesity markers. The study found that early intervention, particularly during the first three years of school, was more effective than delayed interventions.
A recent study published in Nature Medicine confirms the health benefits of a diet high in unsaturated plant fats, such as the Mediterranean diet. The research used lipidomics to measure diet-related fat changes in the blood and link them to disease risk.
Researchers found that lower adiponectin levels and higher leptin concentrations in parents during pregnancy may predict offspring mental health disorders. These biomarkers could enable early interventions for children at risk.
A six-year study found that consuming diets more closely aligned with the Mediterranean and DASH diets can lower levels of harmful blood markers and reduce cardiovascular disease risk. These dietary patterns emphasize plant-based foods, healthy fats, lean proteins, and low intake of processed foods and sugars.
Research highlights need for prevention and treatment approaches for children with obesity born underweight, finding links between low birth weight and cardiometabolic disease risks. Visceral fat storage issues contribute to type 2 diabetes risk.
The Pennington Biomedical Research Center is conducting a clinical trial to better understand lipedema. Participants will undergo comprehensive assessments and imaging techniques to help advance medical knowledge related to chronic disease. Compensation of up to $475 is offered for participation in the three-month study.
Researchers developed a metabolic health score based on clinical parameters and used it to explore its genetic underpinnings in mice, validating findings in human data. The study identified two significant genetic regions linked to metabolic health and pinpointed candidate genes associated with metabolic traits.
Research from Stockholm University reveals that marsupials possess a not fully evolved form of brown fat, a crucial finding for understanding the origin and regulation of this heat-producing organ. The study suggests that the gene networks required to enable thermogenesis existed before the divergence of marsupials and placental mammals.
Researchers found that Werner syndrome mice experience age-dependent and sex-specific changes in their livers and immune systems, including fatty liver accumulation and altered lipid metabolism. These findings suggest a potential link between immunoglobulin variants and fatty liver progression in the disorder.
A new study reveals how accumulation of IMAT drives diseases such as muscle loss, type 2 diabetes, and cardiovascular disease. Regular exercise and healthy diet can prevent and reverse IMAT accumulation.
A new study found that children who are sedentary for more than six hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood. Engaging in light-intensity physical activity for at least 3 hours a day can reverse premature liver damage.
Researchers from Ben-Gurion University of the Negev have discovered a link between proteomic biomarkers and liver fat percentage, which may improve patient monitoring and therapy targeting for NAFLD. The study, conducted over 18 months, found that specific protein changes were independently associated with liver fat relative change.
A new study highlights the benefits of intermittent fasting and protein-pacing on gut health, weight loss, and metabolic responses. Participants showed improved diversity of the gut microbiota, decreased symptoms of gastrointestinal problems, and increased beneficial microbes linked to a lean body type.
Researchers at USask have discovered a new peptide that lowers lipid accumulation in human liver cells, offering new avenues for treating metabolic diseases. The finding is hopeful news as there's a lack of new therapies available for these diseases.
A new study reveals that a cancer drug can improve insulin sensitivity and lower blood glucose levels, but eliminating a specific gene related to fat metabolism worsens insulin resistance. The research highlights the interconnectedness of fat metabolism in organs and the need for simultaneous treatment of obesity and insulin sensitivity.
Chronic Chagas Disease can cause irreversible heart damage due to the destruction of adipose tissue by Trypanosoma cruzi, releasing particles that induce dysfunction. The study reveals that adipome release regulates immunometabolic signaling and promotes inflammation in cardiac remodeling.
Higher childhood body size may reduce breast cancer risk by forming less dense breast tissue, which is a known risk factor for the disease. The study found that over 50% of the protective effect is explained by changes in dense breast tissue.
Researchers discovered a link between high arm fat and low bone quality, particularly in the spine. Those with excess body fat, regardless of BMI, had lower bone quality and strength in their vertebrae.
A Swedish study of people living with obesity found that poor muscle health is associated with a higher risk of an early death. Adverse muscle composition was up to three times more likely to lead to death during the course of the study than those with healthy muscles.
A Swedish study found that individuals with large fat cells tend to lose weight over time, while those with small fat cells gain weight. The study suggests that measuring the size of fat cells could be important for weight management later in life.
Researchers have identified a population of mesothelial-like cells in omental adipose tissue that limit fat cell formation, offering new insights into the mechanisms underlying obesity. These cells secrete Insulin-like Growth Factor Binding Protein 2, which inhibits adipogenesis and regulates metabolic behavior.
Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.
Researchers at Karolinska Institutet have discovered a new class of drugs that block mitochondrial function and reverse diet-induced obesity, fatty liver, and diabetes in mice. The treatment increased fat metabolism, leading to drastic weight loss and restored glucose tolerance.
The study reveals that TM4SF19 protein inhibits a pump in lysosomes, impeding macrophage clearance of dead cells. Macrophages lacking TM4SF19 demonstrate enhanced efficacy in clearing dead adipocytes, reducing weight gain and metabolic dysfunction. The findings may open new avenues for treating obesity and related metabolic disorders.
A study of over 7,500 US adults found that higher abdominal obesity, measured by waist circumference-to-height ratio, was associated with a higher risk of fecal incontinence. The researchers suggest that this may be due to increased intra-abdominal pressure and visceral fat-related inflammation.
Research reveals specific lipids accumulate in tissues as we age and can be decreased through exercise, according to a recent study published in Nature Aging. The findings suggest that exercise may have a role in reversing age-related changes in human muscle tissue.
A study published in Psychiatry Research confirms that weight training improves symptoms of anxiety and depression in old people. The analysis of over 200 articles identified the types of training most indicated for these cases, recommending exercises done three times a week with short sets and proper structure.
Researchers found that CMS121 reduced body weight gain by 40% and improved glucose and lipid indexes in aging mice. The compound also showed anti-inflammatory effects and increased mitochondrial biogenesis, suggesting potential therapeutic applications for metabolic diseases.
New research at Hokkaido University reveals that acoustic fat bodies in toothed whales were once jaw muscles and bone marrow. The findings suggest an evolutionary tradeoff between auditory and feeding ecology, leading to the loss of chewing muscles and adaptation to echolocation.
A new study found that both starting smoking and lifetime smoking may increase abdominal fat, especially visceral fat. Visceral fat is hard to see but raises the risk of serious illness. Researchers used genetic studies to determine whether smoking causes an increase in abdominal fat.
A new study found that waist circumference-to-height ratio detects excess fat mass and distinguishes it from muscle mass in children and adolescents significantly better than body mass index (BMI). The measure is inexpensive and accurate, making it a promising alternative to BMI for diagnosing childhood obesity.
A one-year interdisciplinary therapy program reduced inflammation and cardiometabolic risk in obese adolescents, improving insulin resistance and weight management. The semi-intensive model produced better results than previous intensive models, reversing hyperlipidemia and promoting energy balance.
A recent study published in PNAS suggests that impaired macrophage function plays a key role in the development of type 2 diabetes in obese individuals. The research found that collagen breakdown is handled by macrophages, which become deactivated in obesity and insulin resistance, leading to the accumulation of collagen fragments.
A new study found that young adults who reported higher stress as adolescents were more likely to have high blood pressure, obesity, and other cardiometabolic risk factors. This highlights the importance of stress management from an early age to prevent these health issues.
Researchers studied the effects of resveratrol on circadian clock gene expression in young and older human adipose-derived progenitor cells. They found increased levels of some components in older-APCs compared to young-APCs, but also observed gained rhythmicity of some components after resveratrol treatment.
A recent study published in Nature reveals that mitochondrial dysfunction disrupts dietary lipid processing in enterocytes, leading to abnormal fat accumulation and impaired nutrient delivery. The findings provide new insights into the gastrointestinal symptoms of mitochondrial disease and may lead to novel therapeutic approaches.
A new study by Concordia researchers found a strong positive relationship between percentage body fat and echo intensity, indicating more fat within the muscle. The study also revealed differences in lumbar multifidus characteristics between male and female athletes, with females having larger LMs than males.
A new study found that light physical activity (LPA) can completely reverse childhood obesity caused by sedentary behavior, but moderate-to-vigorous physical activity (MVPA) has limited effect. LPA reduced total body fat mass by 950 grams during growth from childhood to young adulthood.
Research shows that Australian children are at risk of excessive weight gain and declining fitness during school holidays. The two-year study found that body fat increased at a faster pace and aerobic fitness declined faster than in-school periods. Promoting physical activities during holidays could help address unhealthy weight gain.
A study by researchers from Osaka University found that HSP47, a collagen-specific molecular chaperone, is significantly expressed in fat tissue and correlates with body fat levels. High or low HSP47 expression was linked to high or low body fat levels in both humans and mice.
A study published at the Radiological Society of North America annual meeting found that higher amounts of visceral abdominal fat in midlife are associated with increased risk of Alzheimer's disease. The research also showed that this type of fat is linked to brain inflammation, which may contribute to the development of the disease.