Articles tagged with Adipose Tissue
This issue of CVIA features papers on current management strategies for patients with heart failure and atrial fibrillation, as well as a systematic review on epicardial adipose tissue in obstructive sleep apnea. The journal also presents research on detecting myocardial infarction using late gadolinium enhancement MRI.
Regular aerobic exercise increases DICER expression, combating the harmful effects of aging and obesity on metabolism. This leads to improved energy consumption efficiency, enhanced muscle performance, and reduced body weight and visceral fat.
A new diagnostic tool has been developed by MIT engineers to detect both fatty liver disease and fibrosis, which can lead to liver failure. The sensor uses nuclear magnetic resonance (NMR) technology to measure water diffusion in tissue, revealing the presence of fatty or scarred tissue with high accuracy.
A UMass Medical School study finds that low levels of PAPPA, commonly screened for chromosomal disorders, are associated with adipose tissue remodeling and gestational diabetes. The protein is linked to insulin-like growth factor-1 (IGF-1), which promotes healthy adipose tissue development during pregnancy.
Researchers found that SARS-CoV-2 infects fat cells and alters the quantity of signaling molecules released into the bloodstream. Adipocytes release more exosomes containing inflammatory factors, which may contribute to damage in organs such as the heart, lungs, and nervous system.
The Hormones: The Inside Story podcast series explores the facts behind hormones and their impact on daily life, sleep, stress, body fat, fertility, and more. It cuts through myths and misinformation with expert-led science, empowering listeners to make informed decisions about their health.
A new study from the University of Eastern Finland shows that physical activity and dietary counselling significantly reduces insulin resistance in normal-weight children, preventing type 2 diabetes. The intervention also boosts metabolism in skeletal muscles, adipose tissue, and the liver.
A NYUAD study reveals that the β-actin protein plays a crucial role in activating genes essential for fat tissue formation. The discovery sheds light on the molecular basis of adipogenesis, which can help researchers develop new treatments for metabolic diseases such as diabetes and obesity.
Researchers identified Clostridium innocuum as the microbial invader triggering 'creeping fat' in Crohn's patients. The initial response is protective but can contribute to severe intestinal scarring and fibrosis.
Research reveals genetic differences in fat storage and formation affecting disease susceptibility in men and women. Six genes were identified as potential therapeutic targets for distinct outcomes in each sex.
A recent study published in The BMJ found that excess belly fat is associated with a higher risk of early death from any cause. In contrast, larger hips and thighs were linked to a lower risk of premature mortality. This suggests that measuring central fatness may be a more reliable indicator of risk than body mass index.
Researchers at CNIC have discovered a mechanism explaining how macrophages regulate obesity and related diseases like fatty liver disease and type 2 diabetes. The study shows that oxidative stress leads to mitochondrial metabolism changes in macrophages, fostering inflammation and obesity.
Adults with higher leg fat have reduced risk of high blood pressure, according to new research. The study found that participants with more leg fat were less likely to develop all types of high blood pressure.
Researchers found sex differences in gene expression in almost every type of human tissue, with effects observed in genes related to disease and clinical phenotypes. Sex biases were discovered in genes relevant to drug metabolism and placental development.
A study found that endurance exercise improves mitochondrial respiration in skeletal muscles but has no impact on adipose tissue. This difference affects insulin sensitivity, with women showing higher cellular respiration in adipose tissue than men.
A study of over 200,000 UK men found a link between central adiposity and the risk of death from prostate cancer. Those with larger waist circumferences were more likely to die from prostate cancer than those with smaller waist sizes.
A study published in Nature Communications found that reversing age-related changes in fat cells may help prevent the development of lifestyle diseases such as diabetes and fatty liver. The research team discovered that inhibiting autophagy in adipocytes can restore function and prevent metabolic disorders.
Researchers found that deleting a key gene in mice just their fat tissue made them insulin resistant and had other effects. The findings shed light on Type 2 diabetes and could have implications for human disease.
A new mapping approach based on near-infrared spectroscopy distinguishes between fat and muscle tissue in the heart, improving delivery and monitoring of ablation therapy. This could lead to increased efficacy and reduced complications for ventricular tachycardia patients.
Researchers found that certain immune cells in belly fat can reverse age-related impairments and chronic low-grade inflammation. This therapy promotes rejuvenation and improves physical fitness and vaccination responses in aged animals.
Researchers have identified Angiopoietin-2 as a hormone that enables the proper transport of fatty acids into blood vessels, preventing insulin resistance and promoting healthier weight distribution. By targeting this mechanism, scientists hope to develop novel therapeutic strategies for treating obesity-induced metabolic disorders.
Research suggests that a high amount of hip and leg fat mass is crucial to maintain metabolic health. Studies show that low visceral fat and high lower body fat may be equally important for retaining cardiometabolic health.
A study published in Journal of Internal Medicine found that weight loss surgery changes gene expression in fat tissue, leading to metabolic improvements and reduced type 2 diabetes risk. These changes persisted even after weight regain, suggesting a long-term impact on health outcomes.
Researchers from Aarhus University find that large muscle mass and high fat-free weight are associated with an increased risk of atrial fibrillation. The study suggests that the medical community should consider both body fat and lean body mass when assessing cardiovascular risk.
A recent study by Anglia Ruskin University found that women who drink two or three cups of coffee per day have significantly lower total body and abdominal fat compared to those who drink less. The study suggests that compounds in coffee may have anti-obesity properties, potentially making it a useful addition to a healthy diet strategy.
Northumbria University researchers received funding to advance our understanding of the Sun's impact on planets. They developed nanostimulators that enhance stem cells' regenerative powers, showing improved muscle recovery in mice with ischemia.
Researchers analyzed lipid residues from ceramic vessels in Kenya and Tanzania, providing direct evidence for milk consumption by ancient eastern African pastoralist societies. The findings shed light on the evolution of lactase persistence in the region, highlighting a unique dietary adaptation.
Researchers from Kumamoto University found that the DsbA-L protein plays a crucial role in maintaining lung function in the elderly. They discovered that variations in the DsbA-L gene are associated with changes in respiratory function and antioxidant functionality. The study suggests that boosting DsbA-L expression may help promote he...
Kidney stone disease is associated with impaired lipid metabolism and downregulation of fatty acid-binding protein 4 (FABP) 4. FABP4 plays a key role in kidney stone formation and may be a therapeutic target for prevention.
Researchers at the University of Melbourne discovered striking differences in male and female immune systems that may explain why men are more susceptible to obesity. The study found a novel type of stromal cell that communicates with Treg cells and is specific to males, leading to a sex-specific chain of events.
Brazilian researchers found a correlation between salivary uric acid levels and body fat percentages in teenagers, suggesting a reliable biomarker for early detection of chronic diseases. The study identified the level of uric acid in saliva as a good predictor of body fat percentage.
Researchers at Penn State are using a $2.8 million NIH grant to explore 3D bioprinting for craniomaxillofacial reconstruction. They will investigate bioprinting bone, skin, and other tissues directly during surgery to correct defects in the face, mouth, and skull.
Scientists developed a new method to evaluate meat quality using fluorescence spectroscopy, which is precise in classifying meat into standard quality categories. The method detects specific compounds that emit light of a specific frequency range, agreeing with the assumption that connective and adipose tissue make meat more tender.
A multidisciplinary team of researchers at UMass Amherst is investigating the effects of fat tissue on skeletal muscle structure and function. The study aims to understand how fat infiltration affects muscle strength and identify potential health benefits.
Researchers have found a causal link between high blood triglycerides and chronic inflammation, leading to kidney damage and vascular disease. A diet low in fat can significantly extend the life expectancy of patients with diabetes or high blood pressure.
Daily physical activity improved key measures of cardiovascular health, such as good cholesterol levels and aerobic fitness, in overweight children. Gradual reductions in body fat, like that experienced by exercise participants, is more beneficial than focusing on weight loss.
Researchers aim to provide evidence for micro-fragmented adipose tissue as a viable alternative to surgery for treating meniscal tears. The one-year study will monitor changes in meniscal tissue, pain levels, and functional activity.
A population-based study found that only 1.3% of eligible patients received weight-loss medications, highlighting a significant gap in treatment access. The study also showed that phentermine was prescribed for over 75% of medication days, with most patients filling it for more than four months.
Researchers found that reducing food intake in old mice has little to no beneficial effect on health and lifespan. Implementing reduced food intake early in life and sustaining it until the end of their lives is crucial for improving health in old age.
A new study by The Menopause Society shows that lifestyle coaching can effectively decrease BMI, body fat, and waist circumference in all women. However, the benefits are more noticeable in premenopausal women, who experience larger reductions in percentage of body fat and waist circumference.
Grizzly bears express a larger number of genes than any other species studied to cope with hibernation-induced metabolic stressors. They reverse the negative effects of fat accumulation by switching genes on and off based on the season.
A new study funded by the National Institutes of Health found that teenage girls who go to bed later are more likely to gain weight compared to those who sleep earlier. The research also showed a significant association between late bedtime and increased waist size and body fat in young females.
A new study at Karolinska Institutet found that lipid turnover in fat tissue decreases with age, making it easier to gain weight despite reduced caloric intake or exercise. The study showed that individuals who maintained higher lipid turnover rates after bariatric surgery were more likely to keep the weight off.
A study of nearly 157,000 postmenopausal women found those with normal weight and high abdominal fat had a higher risk of death compared to their counterparts with no central obesity. The findings highlight the importance of considering body shape and fat distribution in addition to BMI for obesity prevention.
A study published in JAMA Network Open found that women with normal weight but high waist circumference were 31% more likely to die from cardiovascular disease and obesity-related cancer. Waist size is a forgotten factor in defining obesity, and its inclusion could lead to better risk evaluation and intervention programs.
Aerobic and resistance exercise were found to reduce epicardial adipose tissue mass, while pericardial adipose tissue mass was reduced only by resistance training. The study's findings suggest that regular physical activity can help mitigate the risk of cardiovascular disease.
A study by Brigham and Women's Hospital found that a combination of high levels of dietary cholesterol with specific saturated fats exacerbates retinal damage in a preclinical model of diabetes. The research used an experimental rat model to examine the effects of different dietary fats on early molecular signs of inflammation and damage.
A new study found that postmenopausal women who store more fat in their legs have a significantly decreased risk of cardiovascular disease, even if they have a healthy BMI. This is the first study to look at where fat is stored and its association with CVD risk in these women.
A study of 1,986 patients found that those with variable sleep patterns lost less weight over a year compared to those with consistent sleep. Adopting good sleep habits may help maintain a healthy weight and prevent metabolic disorders.
Joslin researchers will contribute to mapping specific tissues in the healthy human body using chemical imaging and single-cell sequencing. The goal is to understand how disease affects cells and develop new treatments for metabolic diseases.
Increased visceral fat is associated with reduced brain structure and storage capacity, but oestradiol hormone protects women's brains in mid-life. Low oestradiol levels are linked to weaker memory performance during this age range.
Researchers discovered a new mutation in the leptin gene associated with severe early-onset obesity. The mutation causes Leptin proteins to be misfolded, rendering them ineffective and leading to excess body fat.
A new minimally invasive intervention has been shown to provide long-term relief from chronic refractory shoulder pain in wheelchair users with spinal cord injury. Autologous micro-fragmented adipose tissue was injected into the affected shoulder joint, resulting in significant pain reduction and functional improvement.
New research found that patients with high body fat mass had a four-fold increased mortality risk after heart bypass surgery, whereas BMI was not associated with an increased risk. The study also showed that lower lean body weight and higher fat mass were independently linked to longer ICU stays.
Researchers at Johns Hopkins Medicine have created a synthetic soft tissue substitute that encourages growth of new tissue and blood vessels. The material, well-tolerated and retaining its shape, may lessen the need for implants or grafts in reconstructive surgeries.
Scientists at DZNE and University of Bonn found that regulatory T cells use the protein HPGD to suppress inflammation in adipose tissue, preventing insulin resistance and type 2 diabetes. HPGD also showed a correlation with reduced levels in patients with diabetes.
Researchers found associations between body fat percentage and brain volume, with smaller gray matter volumes observed in men and women. The study suggests that obesity may contribute to negative health consequences such as dementia and cognitive decline.
The D.C. Council has passed the Breast Density Screening and Notification Act, requiring women with dense breast tissue to be informed and receive additional screenings. This legislation aims to reduce deaths from breast cancer by promoting early detection among high-risk groups.
A new study found that digital mammography is associated with a lower likelihood of high-density breast tissue compared to digital breast tomosynthesis (DBT) or synthetic mammography. This could have implications for personalized screening and recommendations for supplemental screening.
A new study has identified multiple genetic variants linked to how the body stores and distributes fat, paving the way for targeted interventions to reduce chronic illness risk. The findings also highlight the importance of lipid metabolism in body-fat distribution.