Articles tagged with Adipose Tissue
Researchers at Saint Louis University found that silencing a protein in liver and adipose tissue significantly improves blood sugar levels and reduces body fat in animal models. This breakthrough could lead to new treatments for insulin-resistant obese or overweight patients.
Researchers identified seven new areas of the genome linked to body fat distribution in a study involving over 18,000 individuals. The findings provide new insights into the biological mechanisms influencing cardiometabolic diseases.
Research in mice shows that microbes communicate with hosts by sending metabolites that act on histones, influencing gene transcription. Diet composition impacts microbiome and epigenetic changes, with healthy diets promoting beneficial metabolite production.
Research suggests that obesity causes chronic inflammation in visceral adipose tissue, which leads to comorbid cardiovascular and metabolic diseases. A new study found that a specific T cell subtype associated with aging accumulates in obese mice, causing insulin resistance and obesity-like inflammation.
Research suggests that maternal B12 deficiency during pregnancy may predispose children to metabolic problems such as type-2 diabetes. The study found that babies born to mothers with low B12 levels had higher leptin levels, which can lead to insulin resistance and an increased risk of type-2 diabetes.
Researchers found that supplementing healthy mice with NMN reduced signs of aging such as weight gain, loss of insulin sensitivity, and declines in physical activity. Long-term effects showed improved energy metabolism, better liver function, and increased tear production.
Scientists have discovered that the Rap1 gene plays a crucial role in energy balance and that its inhibition can restore sensitivity to leptin, a hormone that regulates appetite and body weight. The study suggests that targeting Rap1 may be a potential therapeutic approach for treating human obesity.
A recent study published in Sports Medicine found that exchanging sedentary behavior with even low-intensity physical activity reduces adipose tissue and enhances cardiorespiratory fitness in 6-8-year-old children. The intensity of physical activity is crucial for the association with enhanced cardiovascular fitness.
A study has discovered a new mechanism in the mouse brain that regulates obesity, finding that Rap1 gene inhibition can reduce body weight and improve leptin sensitivity, potentially leading to a new therapeutic target for treating human obesity.
A longitudinal study of extreme preemies born between 1977 and 1982 found that they are four times more likely to develop dysglycemia than normal birth weight peers. By their early 30s, 26% of ELBW babies have abnormal blood glucose levels.
A large population-based study from Uppsala University found a strong correlation between linoleic acid in adipose tissue and lower mortality among older men. The study suggests that consuming more polyunsaturated fats may reduce the risk of premature death.
Researchers discovered leukemia stem cells in fatty tissue of obese patients were more resistant to chemotherapy, using fatty acids as their energy source and actively signaling fat for lipolysis. This adaptation could help explain poorer outcomes in obese patients, potentially shedding light on new strategies to target cancer stem cells.
Researchers found cavefish have high body fat levels and insulin resistance but remain healthy. They may hold the key to understanding human diseases like non-alcoholic fatty liver disease and type 2 diabetes.
Researchers developed a microfluidic chip to study adipose-derived adult stem cells' development into mature fat cells. The platform successfully converted cells into mature fat cells while decoding signalling pathways.
Standard BMI may underestimate global obesity levels by over 400-500 million, particularly in East Asian populations with slimmer builds. Researchers propose adjusting BMI cutoffs for basal slenderness to better estimate obesity and undernutrition rates worldwide.
A study found that a cellular sorting protein called SORLA disrupts fat metabolism by recycling molecular receptors for insulin. This causes fat cells to become overly sensitive to insulin, leading to excessive fat deposits and obesity. The researchers discovered this link in human samples, mouse models, and cell cultures.
Research suggests poor physical fitness and sedentary behavior are associated with increased pain conditions in children. Introducing pause exercises can prevent the development of pain conditions.
A new study at NYU Langone Health found a link between high saturated fatty acids and invasive ductal carcinoma in postmenopausal women. The research developed a novel method to measure fat composition using MRI, which could lead to greater understanding of breast cancer development.
Researchers found higher levels of saturated fatty acids and lower levels of monounsaturated fatty acids in the breasts of postmenopausal women with invasive ductal carcinoma. This may indicate a new risk factor for breast cancer.
Researchers found that subcutaneous fat has an intrinsic circadian rhythm in insulin sensitivity, peaking at noon and decreasing by midnight. This internal clock may contribute to daily rhythms in glucose tolerance observed in humans.
A new study published in Diabetes Care found that babies born to mothers with gestational diabetes have 16% more body fat at two months old compared to babies born to healthy mothers. The research used MRI scanning to measure body fat in 86 babies, revealing significant differences in body composition despite no differences at birth.
A multicomponent intervention to reduce sitting time has shown potential health benefits, including a 0.61 percentage point reduction in body fat percentage after just one month.
A study found that acute exenatide administration enhances glucose uptake and reduces insulin resistance in the liver and adipose tissue of patients with non-alcoholic fatty liver disease. This treatment also improves glucose control in the liver and fatty cells, offering promising benefits for individuals with this condition.
Researchers at NIST have developed a widely useful standard for breast cancer MRI, mimicking human tissue to test imaging systems. The phantom supports quantitative MRI and is used in clinical trials, enabling accurate images for diagnosis, staging, and treatment monitoring.
A recent study found that US adults are struggling to adopt healthy lifestyle behaviors, with only 2.7% meeting the criteria for a 'healthy lifestyle' and a low risk of cardiovascular disease. The study measured four key behaviors: good diet, moderate exercise, recommended body fat percentage, and non-smoking habits.
Researchers discovered a microRNA called miR-181b that controls the function of vessels in adipose tissue, improving insulin sensitivity and glucose levels. The study found that reconstituting this microRNA in obese mice reduced inflammation in adipose tissue, suggesting potential new targets for obesity and diabetes treatment.
A recent study by Children's Hospital Los Angeles found that excess fat accumulation in the lower legs of children with myelomeningocele is primarily associated with muscle-associated adipose tissue. This type of fat has been linked to increased risk for metabolic disorders, including diabetes.
A large-scale study found no link between physical activity and breast density, contradicting previous findings. Women with high breast density are still at a higher risk of developing breast cancer, but lifestyle changes such as a healthy diet can lower their risk.
A new study found that losing just 5% of body weight has significant health benefits for obese patients, including reduced risk for diabetes and cardiovascular disease. The study also showed improvements in metabolic function in liver, fat, and muscle tissue.
A recent study at Children's Hospital Los Angeles found that standard Body Mass Index (BMI) is insufficient for measuring changes in body composition in children with leukemia. The researchers discovered a correlation between increases in body fat and losses of lean muscle mass during treatment.
A Finnish study found that high body adiposity and low physical activity are related to poorer physical fitness in children. However, physically active overweight children performed better in fitness tests compared to inactive peers.
Researchers at the University of Florida have discovered a protein that stimulates fat metabolism when stressed, leading to weight gain. The study found betatrophin, a previously touted diabetes treatment, has a new role in regulating body fat.
A new study from Drexel University found that women with greater fat stores in their midsections reported being less satisfied with their bodies and were more likely to develop loss-of-control eating. The researchers suggest that targeting individuals with centralized fat distribution could be beneficial for preventing eating disorders.
Children exposed to high levels of PFOA during pregnancy experience rapid body fat gain and higher body fat by age 8 compared to those with lower exposure. The study found a significant association between prenatal PFOA levels and childhood adiposity, raising concerns about potential effects on type 2 diabetes.
A Newcastle University study found that stressed baby starlings grow into fat and greedy adults, changing their eating behavior as a result. The research showed that chicks that faced greater competition for food as juveniles tend to overeat when presented with freely available food.
Research suggests that adipose tissue acts as an HIV reservoir, hosting virus-producing cells and contributing to chronic immune activation. The study found similar results in human patients undergoing surgery, highlighting the potential for modulating fat tissue to limit viral persistence and inflammation.
A new study published in Scandinavian Journal of Medicine and Science in Sports found that low levels of physical activity, weaker physical fitness, and higher body fat content are linked to arterial stiffness in 6-8 year-old children. Regular high-intensity exercise may help improve arterial health.
A recent NIH study found that restricting dietary fat led to a 68% higher rate of body fat loss compared to cutting the same number of carbohydrate calories. The researchers discovered that fat restriction resulted in a greater imbalance between consumed and burned fat, leading to more significant weight loss.
A study by Kevin Hall found that restricting dietary fat leads to greater body fat loss than carb restriction, even though a low-carb diet increases fat burning. The research used controlled feeding studies and measured participants' food intake over two 2-week periods.
A high-protein breakfast containing 35 grams of protein prevented gains of body fat and stabilized glucose levels among overweight teens who skipped breakfast. Eating a high-protein breakfast also led to reduced daily food intake and improved feelings of hunger.
A study found that leaner children consume more polyunsaturated fatty acids, leading to improved body composition. The research suggests a link between PUFA consumption and reduced body fat and abdominal adiposity in diverse groups of children.
Researchers found that injecting specific adult fat tissue cells early after Chagas Disease infection can modify the animal's response, reducing parasite presence and heart inflammation. The study aims to explore the use of these cells as a potential treatment for cardiac damage caused by the disease.
Researchers found that body fat can send signals to the brain, affecting its regulation of energy balance and stress responses. This discovery sheds new light on the relationship between stress, obesity, and metabolism.
A study by University of Florida researchers found that body fat can send signals to the brain, affecting how it deals with stress and metabolism. The discovery reveals a novel fat-to-brain feedback network that was previously thought to be mainly driven by the brain.
Researchers found that sleep loss for one night altered the regulation and activity of clock genes in human tissues, particularly in adipose tissue and skeletal muscle. This could suggest a link between disrupted circadian rhythms and impaired glucose tolerance and metabolic pathologies.
A clinical trial found that exercising 300 minutes per week reduced total body fat and abdominal fat in postmenopausal women, with greater effects seen in obese women. The study supports the recommendation for postmenopausal women to exercise at least 300 minutes/week for cancer prevention.
A study published in PLOS ONE has identified a genetic mutation associated with premature aging and severe loss of body fat in children. The mutation was found in the CAV1 gene and is linked to a syndrome characterized by severe premature aging, lipodystrophy, and other serious medical problems.
A new study found that children's brains respond differently to high- and low-calorie foods based on their body weight. Children with more lean body mass had a greater brain response to high-calorie foods, while those with higher body fat had reduced activity in the brain when looking at healthier options.
The study found that Akkermansia muciniphila is associated with lower fasting blood glucose and insulin levels, as well as a smaller waist:hip ratio and reduced body fat cell volume. Those with higher abundance of the microbe showed stronger improvement in their metabolic profile after calorie restriction.
Researchers found that exercising diabetic patients can improve glycemic control, waist circumference, and percentage of body fat, even for those who don't see cardiorespiratory benefits. The study suggests broadening the definition of 'non-responder' to include participants with limited improvement in exercise capacity.
Researchers found that teenagers and young adults with congenital adrenal hyperplasia have significantly more abdominal fat tissue, which increases their risk for harmful conditions such as cardiovascular disease. The study suggests a need for targeted prevention and therapeutics to avoid these adverse effects.
A new study found that individuals with earlier exposure to moderate light had lower body mass index (BMI) and percent body fat. The study, published in the journal Sleep, suggests changes in environmental light exposure may impact body weight regulation.
Boosting a naturally occurring molecule in the body can help protect against obesity-related diseases by reducing inflammation in fat tissues. The study found significant disease improvement, primarily affecting fat tissue, and demonstrated the potential of fundamental research to reduce inflammation.
Researchers discovered IRF5 helps prevent metabolic complications by storing fat subcutaneously. In contrast to intra-abdominal fat, which leads to type 2 diabetes, this storage form reduces inflammation and promotes tissue remodelling.
A new technique combining liposuction and fat grafting has been shown to produce excellent results in buttock augmentation. In a study of 106 women, the procedure resulted in high satisfaction rates with minimal morbidity and no major complications.
Dr. Philipp Scherer, Director of UT Southwestern's Touchstone Center for Diabetes Research, receives the prestigious Banting Medal for his significant contributions to understanding and treating diabetes. His research focuses on adipocytes and has demonstrated an initially protective role for obesity in regulating metabolism.
The study found that a key enzyme produced by fat tissue regulates brain function and energy levels, suggesting an optimal amount of body fat for maximizing health and longevity. Mice with low NAMPT in fat tissue had impaired energy levels and physical activity, while those with high NAMPT exhibited increased physical activity.
Yeonhwa Park's significant contributions to bioactive lipids have led to discoveries of CLA's role in reducing body fat and improving bone mass. Her research also explores the interaction between CLA and muscle, revealing improved exercise outcomes.
Researchers discovered a gene called Plexin D1 that controls fat storage and cell shape, which is associated with health risks. Zebrafish without the gene had less abdominal fat and were protected from insulin resistance.
Researchers have programmed bacteria to generate a hunger-suppressing lipid, leading to reduced body fat and staved-off diabetes in mice. The therapeutic bacteria could provide sustained drug delivery, potentially improving weight loss outcomes for humans.