Articles tagged with Adipose Tissue
Researchers discovered a gene called Plexin D1 that controls fat storage and cell shape, which is associated with health risks. Zebrafish without the gene had less abdominal fat and were protected from insulin resistance.
Researchers have programmed bacteria to generate a hunger-suppressing lipid, leading to reduced body fat and staved-off diabetes in mice. The therapeutic bacteria could provide sustained drug delivery, potentially improving weight loss outcomes for humans.
Women with very low breast tissue density experience shorter disease-free survival and overall life expectancies compared to those with high-density breasts. A six-year follow-up study of 270 breast cancer patients found that lower breast tissue density is an independent poor prognostic factor for breast cancer.
A new study reveals that mucosal-associated invariant T (MAIT) cells are dramatically reduced in individuals with type 2 diabetes and severe obesity, yet abundant in adipose tissue. MAIT cell abnormalities may contribute to obesity-associated metabolic alterations after weight loss restored circulating MAIT cells.
Researchers analyzed genetic samples from over 300,000 individuals to find genetic variations associated with obesity traits. They discovered 140 locations across the genome that play roles in various obesity traits, including waist-to-hip circumference ratio.
A new commentary suggests that mandatory screening for women with dense breast tissue without careful analysis of benefits and risks is unwise. Education on the increased risk and other important factors can help healthcare providers guide recommendations for supplemental screening.
Researchers found that vaginally delivered infants with longer gestations tended to develop more mature gut microbiota faster, while those born via Caesarean section took longer to acquire a healthy gut microbiota, leading to differences in body fat at 18 months.
Researchers discovered that specialised immune cells called regulatory T cells played a key role in controlling inflammation in fat tissue and maintaining insulin sensitivity. Treating fat tissues with IL-33 restored normal Treg cell levels, reducing inflammation and decreasing blood glucose levels.
Joining a walking group improves lung power, physical functioning, and general fitness, with few side effects, according to an analysis of available evidence published in the British Journal of Sports Medicine. The study found wide-ranging benefits for adults with various long-term conditions.
Researchers found that a fatty acid called myristoleic acid can help decode weight control by analyzing the lipidome, gene expression, and phenotype of obese women. This comprehensive insight may improve obesity management by understanding how adipose tissue responds to calorie restriction.
The study found that the Nordic diet reduced inflammation-associated gene expression in subcutaneous adipose tissue, even in overweight individuals. This suggests a possible link between diet and improved metabolic health.
Researchers found that γδ T cells contribute to systemic insulin resistance in obese mice by promoting low-grade inflammation in fat tissue. The study suggests that targeting γδ T cells may provide a new avenue for treating or preventing type 2 diabetes caused by obesity.
Researchers have discovered a receptor that can be activated by bile acids to reduce inflammation in fat tissue, which is associated with type-2 diabetes. This breakthrough could lead to the development of new anti-diabetes drugs.
Research suggests that pterostilbene, a phenolic compound found in certain foods and beverages, can help reduce body fat by decreasing fat synthesis and increasing fat oxidation. This study provides promising results for future human trials to confirm its anti-obesity effects.
Researchers developed a tool that uses mass spectrometry imaging to identify fatty acid substances in breast tissue, distinguishing between cancerous and normal tissue. The study found several fatty acids were more abundant in breast cancer tissue compared to normal tissue.
Emerging data suggests that being overweight may actually protect patients from cardiovascular mortality, with the risk of total and cardiovascular mortality highest among underweight individuals. Higher body mass index (BMI) has been associated with more favorable outcomes in many acute and chronic disease states.
Research from UT Southwestern Medical Center found that a level of 'healthy' inflammation is necessary to prevent fatty liver and metabolic diseases. Inflammation helps remodel fat tissue, preventing the buildup of excess lipids in other tissues.
Dr. Timothy J. Bartness, a world-renowned obesity researcher, has been awarded a five-year, $2.5 million MERIT grant to investigate lipolysis and thermogenesis in specialized fat cells. His research aims to understand the bidirectional communication between fat and the brain, which is thought to control body fat breakdown and metabolism.
A new study published in Pediatrics found that healthy-weight children who exercise have better body-fat distribution compared to those who don't. The study also showed that even healthy-weight children who don't exercise tend to gain excess weight and store fat in their abdomens.
A new method for assessing individual thermal comfort has been developed by VTT, considering factors such as gender, age, body mass index, and muscularity. The method finds that women feel the cold more than men due to their lower muscle tissue, which produces heat at a lower rate.
Researchers at Tufts University have discovered that deleting the FAT10 gene reduces body fat and extends lifespan in mice by 20%, improving insulin sensitivity and protection against type 2 diabetes. The study provides a promising lead for future research into the role of FAT10 in coordinating immunity and metabolism.
Researchers discovered that stem cells from a fatty fold of tissue, called the omentum, can help heal diseased kidneys when fused to the organs. This innovative approach uses the patient's own stem cells to treat chronic kidney disease, potentially alleviating the need for external cell sources.
Researchers at NYU Langone Medical Center found that blocking the action of a key signaling molecule, Netrin-1, stalls chronic inflammation and insulin resistance tied to obesity. This could lead to further advances against diseases such as type II diabetes and atherosclerosis.
Researchers at NYU Langone Medical Center discovered that blocking Netrin-1 stalls chronic inflammation and insulin resistance, a link between obesity and type II diabetes. The study found that Netrin-1 signaling promotes macrophage buildup in fat tissue, leading to inflammation and insulin resistance.
A new study published in The FASEB Journal suggests that an obese father's diet may contribute to his child's risk of developing obesity, type 2 diabetes, and chronic degenerative diseases. Researchers found altered gene expression in the pancreas and fat tissue of female offspring born to obese male rats on a high-fat diet.
A study published in The FASEB Journal reveals that obesity is associated with an abnormal amount of the inflammatory protein PAR2 on abdominal fat tissues, which can be blocked by a new oral drug. This finding suggests that obesity may be an inflammatory disease and that controlling inflammation could lead to weight loss.
Research by Brigham Young University suggests that a consistent bedtime and wake time can lead to lower body fat. The study found that those with the best sleeping habits had healthier weights, with quality sleep being an important factor in body composition.
A clinical study found that stem-cell enriched fat grafts retained 80.9% of their initial volume, compared to 16.3% for non-enriched grafts, after 121 days. The treated grafts showed significantly higher amounts of adipose tissue and newly formed connective tissue.
A study by Oklahoma State University found that college football players experience significant increases in strength and size over four years of training. However, speed and power show little to no change despite sophisticated training regimens.
A multicenter European study found that short-term hormonal therapy for transsexualism is effective and safe, with few side effects. The treatment, which involves large doses of male or female sex hormones, was shown to be effective in changing the external characteristics of trans individuals.
Research suggests prenatal BPA exposure causes increased inflammation in fat tissues after birth, leading to obesity and metabolic syndrome. The study found that prenatal BPA exposure interacts with postnatal diet to modulate inflammatory mechanisms in fat deposits.
A new Ohio University study reveals that male mice fed a high-fat diet and becoming obese are more likely to father offspring with similar higher levels of body fat. The study suggests epigenetic factors may be responsible for these inherited traits.
Researchers at Imperial College London found that middle-aged individuals with higher body fat experience stiffer arteries. This stiffness can lead to increased risk of cardiovascular disease and death.
A study by Michigan Medicine researchers found that consuming grapes reduced inflammation and fat storage in obesity-prone rats. Grape intake also improved antioxidant defense, particularly in the liver and kidneys.
Researchers discover adult progenitor cells are subject to cellular senescence, leading to age-related deterioration of skeletal muscle and fat tissue. The study suggests a potential therapeutic target for future treatments, particularly the tumor suppressor p53.
Researchers at Brigham and Women's Hospital found that restricting food intake to a lower-fat diet before surgery reduced the imbalance in fat tissue's chemical balance, leading to improved recovery outcomes. The study suggests that minimizing trauma during surgery can have a significant impact on fat tissue's response.
A study published in Environmental Research found a direct relationship between pesticide exposure and type 2 diabetes prevalence. Pesticide concentrations were significantly higher in the adipose tissue of people with type 2 diabetes, suggesting that pesticides may be an underlying factor in its development.
A new Northwestern Medicine study found that obese mothers pass on insufficient vitamin D to their babies, leading to lower levels in newborns. The study also suggests that obese women may need increased vitamin D supplementation to provide sufficient levels for their babies during pregnancy.
Approximately ten percent of 6 year olds have sleep-disordered breathing, with certain craniofacial morphology traits increasing the risk. Early intervention and diagnosis can prevent progression of the disease.
A new study published in the American Journal of Preventive Medicine found that bedroom TV viewing is associated with increased waist circumference and obesity risk in children. The research suggests that having a TV in the bedroom may disrupt healthy habits, such as sleep and regular family meals, contributing to weight gain and obesity.
Researchers found that African-American patients with coronary artery disease have significantly less fat around their hearts compared to Caucasian patients. The study suggests that epicardial adipose tissue may act as a protective buffer, contributing to lower risk of acute coronary events.
Overeating can cause a malfunction in brain insulin signaling, leading to increased fatty acid levels, inflammation, and worsened insulin resistance. The study suggests that the brain's response plays a crucial role in developing type 2 diabetes, making it a potential target for improving insulin function.
A recent study published in JAMA found that obese adults with excess visceral fat and biomarkers of insulin resistance are at a higher risk of developing type 2 diabetes. In contrast, those with higher amounts of total body fat and subcutaneous fat did not have this increased risk.
Scientists discovered that invariant natural killer T-cells (iNKT) in fat tissue regulate inflammation and protect against obesity, diabetes, and metabolic syndrome. iNKT cells can be restored through weight loss and activated by alpha-galactosylceramide, a lipid known to improve metabolism.
Researchers at University of Toronto develop microfluidic tool to track metabolic changes in living tissues without chemicals or drugs. The study reveals that pancreatic tissues stop metabolizing fat within twenty minutes of a glucose cocktail, offering new hope for understanding diabetes.
Researchers have discovered that cells from burn eschar can differentiate into multipotent mesenchymal stromal cells, which could be used to treat burn injuries. The study found that these cells had a resemblance to adipose-derived stem cells and may play a crucial role in wound healing.
A recent study shows that liposuction can lead to an increase in visceral fat, associated with cardiovascular disease. However, regular physical activity effectively prevents this compensatory growth. The study found that exercising after liposuction reduces the risk of weight regain and related health issues.
Researchers at UCLA discovered that purified human perivascular stem cells can form bone faster and with higher quality than traditional methods, potentially eliminating the need for invasive bone grafts. The study uses a fresh cell composition called stromal vascular fraction to isolate and purify the stem cells.
Researchers found that deleting GPR21 improves insulin sensitivity in diet-induced obese mice by reducing inflammation. The study suggests that GPR21 inhibitors could be promising treatments for type 2 diabetes.
Rutgers scientists found that surgical removal of abdominal fat from obese mice fed a high-fat diet reduces UV-induced skin cancer risk. The study suggests that removing original fat tissue may reduce the biochemical properties of new fat tissue, leading to less harmful cancer risks.
Global gene expression analysis reveals distinct molecular differences between perivascular and subcutaneous fat tissues. Perivascular fat tissue is highly inflamed in humans with coronary artery diseases, suggesting it as a key player in disease formation.
Researchers at the University of Cincinnati have found a cellular pathway linked to obesity-related disorders such as diabetes, heart disease, and fatty liver disease. Deleting the enzyme histone deacetylase 9 (HDAC9) completely protected mice against high-fat feeding's negative health consequences.
Researchers used public databases to find a novel gene associated with type-2 diabetes, which shows increased activity in fat tissue. The findings suggest that CD44, a cell-surface receptor, plays a major causal role in the disease's development.
A new study published in Physics in Medicine & Biology found that obese patients receive up to 62% more radiation during CT scans than normal-weight patients. This increase is due to excess fat tissue, which can reduce the quality of medical images unless adjusted accordingly.
A recent study published in PLoS ONE found that the Body Mass Index (BMI) substantially under-diagnoses obesity in the US, with 39% of Americans classified as overweight being actually obese. The researchers suggest using leptin levels in conjunction with BMI to provide a more accurate measure of adiposity.
The APOLLO trial demonstrated improvements in cardiac function, blood flow into the heart muscle, and reduced scar formation in patients with acute myocardial infarction. The study found a 52% reduction in left ventricle infarcted area and significant improvement of perfusion defects in ADRC-treated patients.
Dr. Philipp Scherer's groundbreaking research on adiponectin, a protein that declines with weight gain, has potential as a good predictor of diabetes, heart disease, and cancer risk. His work also highlights the importance of understanding fat cells' role in body energy homeostasis.
A recent study published by the Technical University of Munich found no evidence to support the theory that fish oil consumption during pregnancy prevents excessive infant adipose tissue growth. The INFAT study, which monitored 208 expectant mothers and their children for over a year, showed no difference in infant adipose tissue growt...
Studies found that p53 activation in fat tissue accelerates insulin resistance in heart failure patients. Researchers hope to develop an anti-aging therapy targeting inflammation without compromising tumor-fighting abilities.
A study of 25 healthy individuals found that consuming a low-protein diet resulted in less weight gain compared to normal and high protein diets, with calories alone contributing to an increase in body fat. Protein intake also affected energy expenditure and lean body mass.