Articles tagged with Adipose Tissue
Researchers at UIC will enroll 500 men with early-stage prostate cancer to investigate the biological factors behind poorer outcomes in obese patients. The study aims to identify new approaches to preventing prostate cancer recurrence or progression after treatment.
Researchers have successfully used stem cells to grow on a scaffold made from tissue extract, overcoming two key challenges for organ transplantation. This breakthrough enables the creation of bioengineered organs that can be transplanted without rejection.
A study by University of Cincinnati researchers found that high-fat diets can cause inflammation in fat tissue surrounding blood vessels, potentially leading to cardiovascular disease. The study suggests a direct link between poor dietary habits and inflammation of blood vessels, independent of weight gain or cholesterol levels.
A study of 22,211 people found that abdominal obesity increased the risk of migraine headaches in those aged 20-55, especially in women. Losing weight around the stomach area may be beneficial for reducing migraine risk in this age group.
UT Southwestern researchers discovered that mice without the AGPAT2 enzyme accumulated excessive liver fat, leading to metabolic complications. A fat-free diet reduced liver triglycerides by approximately 50% in these mice.
A new study by UC Berkeley researchers reveals that disabling a key enzyme in fat cells allows mice to overeat without gaining weight. The enzyme, AdPLA, plays a crucial role in regulating fat metabolism and body weight, making it a promising target for obesity treatment.
Researchers found that irradiation damages fat tissue in mice, reducing its weight and size, and altering its ability to support reconstruction. Additionally, a study on multiple sclerosis found that CXCL1 decreases disease severity by promoting remyelination. A new molecule, FPR-2, has been identified as a potential anti-inflammatory ...
Researchers at Mayo Clinic found a strong association between dense breasts and increased breast cancer risk, citing tissue composition differences between dense and non-dense tissue. Dense breast tissue contains more epithelium and stroma, and higher aromatase enzyme levels than non-dense tissue.
Researchers at UT Southwestern Medical Center have found immature fat cells embedded in blood vessel walls that can grow into adult monsters with excess calories. These cells, called progenitor cells, could be used to treat obesity, diabetes and other metabolic conditions by isolating them from unwanted fat.
A new study from the University of Cincinnati found that Bisphenol A (BPA) suppresses a key hormone, adiponectin, which regulates insulin sensitivity and puts people at risk for metabolic syndrome. The study used fresh human fat tissues and found that BPA exposure resulted in suppression of this hormone.
A recent study published in Obesity found that having excess fat around the heart may increase the risk of heart attacks. Researchers discovered that the volume of pericardial fat was related to the development of calcified coronary plaque, a marker for increased cardiovascular risk.
A University of Missouri study found that Weight Watchers participants lost an average of 5% body weight, but mostly lean tissue. Fitness center members, despite little weight loss, improved health by reducing intraabdominal fat. Group support is crucial for success in both programs.
Researchers at UT Southwestern Medical Center identified four hidden fat compartments in the cheeks, which can be restored using fat or tissue fillers for a more youthful look. Restoring these compartments improves volume loss under the eyes and gives more curve to the upper lip.
Researchers found that a natural lipid, phosphatidylserine, can prevent collagen reduction and increase MMPs in both natural and UV-induced aging. Topical application of the molecule may be a simple way to slow down skin wrinkling.
Researchers followed Minneapolis school children from ages 11 to 19 to track the emergence of cardiovascular risk factors. By age 19, boys were at greater cardiovascular risk despite gaining muscle mass and losing fat during puberty.
A new study from Ohio State University found that conjugated linoleic acid (CLA) may need to be paired with the hormone leptin to prevent side effects of rapid weight loss. The study used mice genetically engineered to have no leptin, finding that CLA diets can result in weight loss but also insulin resistance.
A new study published in PLOS Computational Biology suggests that identical twins with the same lifestyle can have different body weights due to infinite number of possible body weight solutions. This challenges traditional understanding of body weight change, suggesting it may be influenced by multiple factors beyond diet and exercise.
A new study reveals that people with a normal body mass index (BMI) but high body fat percentage are at risk for metabolic disturbances and heart disease. The researchers found that these individuals had altered blood lipid profiles, high leptin levels, and higher rates of metabolic syndrome.
Researchers have found that adult stem cell changes underlie Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disease causing premature aging. The study reveals progerin's effect on adult mesenchymal stem cells, leading to accelerated maturation into bone and loss of fatty tissues.
Researchers have discovered that increasing lipid associated with apoE in the brain may decrease amyloid deposition in Alzheimer's patients. Meanwhile, a new study found that neutralizing IL-22 prevents psoriasis-like disease in mice, suggesting a potential approach to treating this chronic condition. Additionally, scientists have deve...
A study found that adults over 60 with higher cardiorespiratory fitness lived longer than unfit adults, independent of body fat levels. Higher fitness levels were inversely related to all-cause death in both normal-weight and overweight BMI subgroups.
A University of Wisconsin-Madison study reveals a genetic basis for why high-carb diets lead to weight gain. The SCD-1 gene in the liver is responsible for synthesizing fatty acids, and when this gene is active, mice on high-carb diets store excess energy as fat.
A new study led by McMaster researcher Dr. Mark Tarnopolsky shows that taking a combination of creatine monohydrate and conjugated linoleic acid with resistance exercise training provides even greater benefits for muscle endurance and fat-free mass in older adults. The six-month program resulted in improvements of functional ability an...
Researchers found a link between high-normal uric acid levels and mini strokes, which may contribute to mental decline in aging adults. High-UA levels were associated with increased volumes of white matter hyperintensities in the brain.
Children who had acquired high percentage body fat by age 3–1/2 were more likely to be obese at age 7. Rapid growth spurts, TV viewing time, and physical inactivity also contributed to obesity risk.
Researchers found an antiobesity gene that has kept critters lean since ancient times. Increased activity in fat tissue leads to a slimmer animal and better metabolic function.
Research reveals that estrogen receptors in the hypothalamus serve as a master switch to control food intake, energy expenditure, and body fat distribution. The study shows that when these receptors are destroyed, animals immediately begin to eat more, burn less energy, and gain weight.
Researchers at Washington University School of Medicine have found that protein CD36 facilitates the uptake of fatty acids and cholesterol in the proximal part of the intestine. The team believes that targeting this process may provide a useful tool for obesity treatment, as animals without CD36 absorb fat less efficiently and eat less.
Researchers have successfully engineered mesenchymal stem cells from human fat tissue into 'suicide genes' that seek out and destroy tumors. This gene therapy approach inhibits tumor growth by up to 68.5% in nude mice, showing promise as a novel cancer treatment strategy.
A Yale-developed weight management program cut diabetes risk and improved BMI in overweight children by increasing insulin sensitivity and reducing body fat. The Bright Bodies program, which combined nutrition education, behavior modification, and exercise, was more effective than traditional clinic-based counseling.
A family-based weight management program improved outcomes for overweight children compared to traditional weight counseling, reducing body fat and increasing insulin sensitivity. The study found significant differences in BMI, body weight, and cholesterol levels between the two groups after 12 months.
Researchers at the University of Pittsburgh successfully isolated and cultured human hematopoietic stem cells from fat tissue, suggesting an alternate source for life-saving bone marrow transplants. The study's findings indicate that these stem cells are integral to normal adipose tissue and may provide a safer alternative for patients...
Researchers found that increased body fat in elderly adults is associated with lower levels of vitamin D, regardless of sunlight exposure. Vitamin D is critical for maintaining bone health and low levels can increase the risk of bone fractures and osteoporosis.
Researchers have found a link between low HDL cholesterol and heart disease, suggesting that defective ABCA1 protein may play a role. Additionally, studies have shown that type 2 diabetes patients accumulate high levels of triglyceride-rich lipoprotein in the blood, which can contribute to heart disease.
Researchers discovered that plant-derived chemical harmine fights diabetes in mice without some of the side effects attributed to other antidiabetes drugs. Harmine increases insulin sensitivity by blocking a pathway that normally inhibits fat cells' production, providing a new approach for treating insulin resistance.
The study found that despite being lean, many teenagers have poor eating habits, with low intake of whole grains, fruits, and vegetables. Encouraging physical activity can help promote healthier eating habits and reduce the risk of chronic diseases like diabetes and heart disease.
Researchers have identified a protein on the inner surfaces of capillaries that delivers dietary fat to enzymes for entry into cells, revolutionizing our understanding of lipid processing. The discovery has implications for patients with chylomicronemia, a condition in which the body's ability to process dietary fat is impaired.
A team of researchers is exploring how polybrominated diphenyl ethers (PBDEs) affect fat storage and production in laboratory rats. Preliminary data suggests that chronic exposure to PBDEs may cause insulin resistance, a precursor to Type II diabetes.
A study by Michigan State University found that BMI does not accurately reflect body fat percentage in most cases, particularly among athletes and younger individuals. Researchers suggest reevaluating BMI cutoff points for different age groups and fitness levels to improve its accuracy as a fat indicator.
A new study uses MRI to measure intra-abdominal fat, a type of fat that can predispose children to adult diseases like heart disease and diabetes. The study found strong correlations between single-slice MRI measurements and clinical measures, suggesting that this method could be useful in monitoring adolescents at risk.
New research found that older adults gain fat and lose lean mass each year until age 80, contributing to disability. The study also revealed that those born later experienced higher body fat percentages, highlighting the impact of the obesity epidemic on aging
Researchers investigated how specific body characteristics affect the elderly's ability to regulate temperature during cold stress. The study found that certain traits, such as percent body fat and skeletal muscle mass, become more important with age, suggesting changes in the body's thermoregulatory responses.
A new surgical technique, 'beavertail' surgery, has given back the ability to swallow to patients with tongue cancer. The procedure involves modifying an existing technique by adding a 'jellyroll' of fat and connective tissue to replace diseased tongue tissue.
A new study reveals that grouped skunks do not enter a torpor-like state to conserve energy like solitary individuals do. Instead, they benefit from huddling, which minimizes water loss and allows them to maintain higher body fat reserves.
A diet with a high carbohydrate content but a low glycemic index may help promote weight loss and reduce the risk of cardiovascular disease. Participants on diets with lower glycemic loads experienced greater fat loss, particularly in women.
Researchers at UCLA have successfully transformed adult stem cells from human adipose tissue into functional smooth muscle cells, which can help regenerate damaged organs like the intestine, bladder, and arteries. The study's findings offer a promising alternative to using patient's own tissue for organ regeneration without anti-reject...
A recent animal study found that trans fat consumption can lead to weight gain despite controlled calorie intake. The study, led by Kylie Kavanagh and Lawrence L. Rudel, discovered that male monkeys fed a western-style diet rich in trans fat gained 7.2% more body weight compared to those on a monounsaturated fat diet.
Obesity disrupts hormone signaling pathways and leads to metabolic changes that worsen liver disease. Researchers recommend weight loss, insulin-sensitizing drugs, or increased dosages of combination therapy to improve treatment outcomes for hepatitis C patients.
Researchers used human fat and pig skin to test infrared laser light, finding three wavelengths that preferentially heated fat. The results provide a proof of principle for using lasers to target sebaceous glands, potentially replacing Accutane for acne treatment.
Fat cells surrounding coronary arteries release pro-inflammatory proteins and hormones that regulate inflammation, blood pressure, and insulin activity. These epicardial adipocytes also induce angiogenesis, a process that contributes to the development of atherosclerosis.
A study found that vitamin C depletion is associated with lower body fat, but not with weight loss in a short-term low-fat diet. Participants who took a vitamin C supplement had increased blood levels of vitamin C and improved ability to oxidize fat.
Research found a significant association between high leptin levels and asthma risk in women, but not men. The study suggests leptin may play an independent role in increasing asthma risk, rather than being linked to obesity.
A midriff bulge roughly doubles a woman's chances of needing gallstone surgery, according to a comprehensive study. The study, which monitored over 42,000 women for two years, found that women with larger waist sizes were more likely to develop gallstones.
A recent study found that people who restrict calories have hearts that are more elastic and function better than those of control subjects. The study also showed lower levels of inflammatory markers in the caloric restriction group, indicating reduced chronic inflammation.
Researchers discover that preventing amyloid deposition may be easier than curing established Alzheimer's disease through an immunization strategy targeting Abeta42. Additionally, a study finds that pre-treatment of patient T cells with IL-10 and vitamin D3 can overcome glucocorticoid resistance in asthma patients.
A study found that fat surrounding internal thoracic arteries produces a factor that can relax the artery, alleviating contraction during CABG surgery. Retaining this fat tissue may help improve blood flow, providing an alternative to drugs that cause cellular damage.
In a randomized study, animals received injections of their own adipose stem and regenerative cells after a simulated heart attack. This approach resulted in a statistically significant reduction in perfusion defects and improved ejection fraction.
A study by Duke University Medical Center discovered a gene that is more active in obese individuals, causing skeletal muscle tissue and cells to store excess fat. Exercise can potentially change this gene's activity, improving energy balance and enhancing fat burning.
A new study found that human fat cells produce C-reactive protein, a molecule linked to cardiovascular events. Aspirin and statin drugs effectively dampen production of CRP from fat cells.
A new study by Aviva Must and colleagues found that childhood obesity is a significant predictor of adult weight, rather than early menarche. The research used data from the Newton Girls Study and found that overweight girls mature earlier, but this does not predispose them to be overweight as adults.