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Science News for December 30, 2008


Tips from the American Journal of Pathology

Researchers found that irradiation damages fat tissue in mice, reducing its weight and size, and altering its ability to support reconstruction. Additionally, a study on multiple sclerosis found that CXCL1 decreases disease severity by promoting remyelination. A new molecule, FPR-2, has been identified as a potential anti-inflammatory ...

SourceAmerican Journal of Pathology·JournalAmerican Journal Of Pathology·DateDec 30, 2008

Few DNA repair genes maintain association with cancer in field synopsis

A comprehensive review of 241 gene variants and cancer risk identified only two statistically significant associations, including an XRCC1 allele and ERCC2 allele linked to lung cancer. The findings suggest that genetic risks are typically modest, and large-scale evidence is needed to establish specific associations.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateDec 30, 2008

Safe new therapy for genetic heart disease

A new clinical trial suggests that long-term use of candesartan may significantly reduce symptoms of genetic heart disease, including left ventricular hypertrophy. The study found no adverse effects of candesartan use and highlights the need for customized treatment protocols based on individual patient gene mutations.

SourceAmerican Journal of Pathology·JournalJournal of Molecular Diagnostics·DateDec 30, 2008

Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial

A randomized controlled trial found that women taking vitamin C, E, or beta carotene had a similar risk of cancer as those not taking the supplements. Antioxidant supplements were previously thought to lower cancer risk due to high fruit and vegetable intake, but this study contradicts those findings.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateDec 30, 2008

Young blood fights cancer

Researchers at Tel Aviv University discovered that transfusions of 'young' blood –– blood stored for less than 9 days –– increased the odds of survival in animals with leukemia and breast cancer. Fresh blood may be a game-changer in cancer treatment, potentially improving survival rates.

SourceAmerican Friends of Tel Aviv University·JournalAnesthesiology·DateDec 30, 2008

Also in the Dec. 30 JNCI

Research suggests cisplatin ototoxicity is due to higher platinum concentration in inner ear, while high insulin levels are an independent risk factor for breast cancer. Studies found significant correlations between fasting insulin and increased breast cancer risk.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateDec 30, 2008