Articles tagged with Adipose Tissue
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A new study reveals that protein kinase C epsilon (PKCε) is acting from fat tissue to worsen disease, pointing to a new function in this dynamic organ. Fat tissue reveals striking differences in cell shape and size in the presence and absence of PKCε.
A new animal study published in The FASEB Journal found that a ketone supplement reduced body fat and weight in mice on a high-fat diet. Researchers observed significant weight loss in mice given the supplement, suggesting it may be an effective alternative to low-carbohydrate diets.
A study found that a high-fat, high-sugar diet may accumulate fat around the uterus of female rats, potentially impairing future fertility. Researchers observed no change in glucose tolerance or insulin sensitivity compared to control animals.
Researchers at UBC Okanagan have discovered that TEMPO, a well-known artificial anti-oxidant, is significantly more effective than nature's best option, vitamin E. The study found that TEMPO can convert free radicals to harmless molecules up to 100 times faster than vitamin E in certain environments.
A 10-week pilot study found that participants who delayed their breakfast by 90 minutes and had their dinner earlier lost more than twice as much body fat compared to those in the control group. This reduction was partly due to decreased food intake, with 57% of participants reporting a decrease in eating opportunities.
Researchers at Cedars-Sinai Medical Center have developed a simpler and more accurate method to estimate body fat percentage than the widely used BMI. The new relative fat mass index (RFM) formula uses only height and waist circumference measurements, providing a better measure of body fatness without requiring expensive equipment.
A new study from Uppsala University found that one night of sleep loss can cause tissue-specific changes in gene expression and metabolism, leading to increased fat accumulation and muscle loss. This may explain why shift work and chronic sleep loss increase the risk of obesity and type 2 diabetes.
Researchers have identified a mechanism by which fat is transferred into tissues, revealing that blocking key receptors can limit fat delivery. Disabled mice on high-fat diets showed no weight gain, while control mice gained twice as much weight.
Researchers found that fat fibrosis in subcutaneous fat is predictive of unhealthy belly fat and insulin resistance in Asian participants. This difference could help explain why Asians develop type 2 diabetes at a lower body weight than Caucasians.
Researchers are investigating the relationship between obesity-induced changes in fat tissue metabolism and vascular disease. The study aims to characterize the role of protein FSP27 in the pathogenesis of obesity-related vascular disease.
Researchers developed a non-invasive method to measure arterial stiffness and peripheral arterial tone in adolescents aged 16-19. The study found that aortic pulse wave velocity is highly reproducible but augmentation index shows poorer reproducibility, especially among those with higher fitness levels or lower body fat.
Children and adolescents treated with antipsychotics for 12 weeks experience significant gains in body fat and decreased insulin sensitivity. Antipsychotic medications can be helpful but also have side effects involving fat gain and insulin resistance, important precursors to diabetes and cardiovascular disease.
A new study published in JAMA Psychiatry found that short-term treatment with antipsychotic medications can increase body fat and decrease insulin sensitivity in children, important early steps in the development of type 2 diabetes. Researchers used gold-standard methods to measure changes in whole body and abdominal fat as well as ins...
A study found that gut-inhabiting Enterobacter cloacae increases subcutaneous fat mass and causes liver damage in mice. Researchers observed hypertrophic obesity and insulin resistance in affected mice.
Obese individuals with larger waistlines are at a greater risk of developing vitamin D deficiency. The study found that lower levels of belly fat were associated with lower vitamin D levels in both men and women.
Researchers at Kessler Foundation are investigating a new treatment using micro-fragmented adipose tissue injection to alleviate chronic shoulder pain in wheelchair users with SCI. The pilot study has shown promising results, with all six participants experiencing improved range of motion and reduced pain.
Researchers found that mice lacking NAMPT in fat tissue gained no weight on high-fat diet and maintained better blood glucose control compared to normal mice. This study challenges the general view of NAMPT as an enzyme that should be boosted, and may pave the way for new treatments for obesity and metabolic disease.
Researchers found improved measures of cardiovascular health, beneficial changes in fat tissue, and reduced risk of diabetes in obese women with PCOS who used a hot tub regularly. Heat therapy may reverse some of the inflammation in fat that causes metabolic health impairment.
Researchers discovered that DOR protein deficiency stimulates the generation of new adipose cells and leads to a less harmful form of obesity. This type of obesity is characterized by an increase in the number of fat cells rather than their volume, which may be less susceptible to metabolic complications.
A common version of the FGF21 gene is associated with lower total body fat despite increasing carbohydrate intake, according to a new study. The gene variant also redistributes fat to the upper body, where it may cause harm.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that menopausal hormone therapy users tend to have less abdominal fat tissue than other menopausal women. The protective effect disappeared rapidly after treatment stopped.
A new study reveals that poor motor skills are associated with poorer reading skills in obese children, suggesting that motor skill training may improve reading abilities. The study found that daily physical activity should include opportunities for practicing and rehearsing motor skills to enhance academic achievement.
Research finds that postmenopausal women with higher body fat levels, even those with a normal BMI, have an increased risk of invasive breast cancer. Dual energy X-ray absorptiometry (DXA) measurements show that whole body fat levels are more accurately assessed than traditional BMI methods.
Researchers have found that changes in adipose tissue lipid metabolism contribute to the development of heart failure. The study suggests that targeting fat tissue may provide a new approach to treating heart disease.
Research at the University of Exeter found that obese individuals' fat tissue becomes distressed, scarred, and inflamed, leading to reduced energy storage and increased inflammation. This scarring can make weight loss more difficult and increase the risk of obesity-related health complications.
New research uses 3D imaging to visualize the inner workings of fat tissue in mice, identifying potential targets for new drugs to treat and prevent obesity and diabetes. The study reveals that beige fat, which can be induced to burn energy, has high potential for treatment.
Researchers have identified lymphocyte clusters in the pericardial adipose tissue as key regulators of the post-infarction immune response. These clusters stimulate an immune reaction that degrades damaged tissues, but also promote tissue repair. The findings suggest a critical role for this process in heart healing.
New research finds that eating breakfast decreases genes involved in fat metabolism and increases sugar uptake in fat cells. This may lead to lower diabetes and cardiovascular risk in obese individuals.
Researchers at the University of Michigan found that some obese adults store their body fat more healthily than others, breaking down fat at slower rates and having fewer inflammatory cells. Aerobic exercise may lead to healthier fat storage, with regular exercisers showing increased blood vessels in their fat tissue.
Researchers at University of California San Diego School of Medicine found exosomes from inflamed adipose tissue macrophages cause metabolic derangements of diabetes. Exosomes carry microRNA that inhibits key proteins, leading to insulin resistance.
Higher milk and low-fat dairy consumption was associated with a lower VAT/SCAT ratio, indicating more favorable abdominal fat distribution. Additionally, daily servings of low-fat dairy were linked to higher body lean mass, suggesting a possible mechanism for reducing obesity-related metabolic disorders.
Researchers found that individuals with high body fat percentages consumed most of their calories shortly before going to sleep when melatonin levels were high. This study provides evidence that the consumption of food during the circadian evening/night plays an important role in body composition.
A new approach uses a polymer sponge implanted in fat tissue to reduce weight gain and blood-sugar levels in obese mice. The treatment, which 'gets the fat to talk' again, shows promise as a simpler alternative to current diabetes treatments.
Researchers found that fatty liver disease can cause damage to other organs, particularly the pancreas. The protein fetuin-A produced by the fatty liver triggers an inflammatory response in the pancreas, leading to reduced insulin secretion and worsening of blood glucose regulation.
Research reveals NPGL, a newly discovered protein involved in brain signalling, controls appetite and increases body fat storage even on low-calorie diets. The study also shows NPGL's role in increasing food intake when high caloric foods are consumed.
A recent study published in Frontiers in Public Health found that up to 90% of adult males and 50% of children in the US may be overfat. The condition is linked to various health problems, including hypertension, coronary heart disease, and Type 2 diabetes.
Researchers at the University of Birmingham have discovered that increased male hormones, particularly AKR1C3 enzyme activity in fat tissue, drive PCOS women's risk to develop diabetes and fatty liver disease. Abdominal fat tissue is a major source of high levels of male hormones in women with PCOS.
A new reconstruction method for Electrical Impedance Tomography (EIT) is proposed to estimate abdominal fat, improving reproducibility and spatial resolution. The technique has shown promising results in detecting subcutaneous fat thickness, with further research needed to assess visceral fat volume.
Researchers found that irradiation of breast fat triggers an inflammatory response, protecting remaining cancer cells and allowing tumors to grow. Agents that block inflammation could improve radiotherapy effectiveness, potentially revolutionizing breast cancer treatment.
A high protein intake in early childhood is associated with a higher body mass index (BMI) due to increased body fat, not fat-free mass. The study found that children who consumed more animal-based protein sources were taller and heavier.
A new study found that higher body fat was linked with increased risk of developing chronic kidney disease. Waist circumference and BMI were shown to provide similar information on risk as more direct measures of different types of body fat, indicating these simple measures may be reliable for assessing an individual's risk.
A study published at European Congress on Obesity found that people with higher levels of visceral fat (internal fat around organs) and thigh muscle fat spend more nights in hospital. Visceral fat was significantly associated with healthcare burden, while thigh muscle fat infiltration had mixed results.
Researchers found that Vitamin D3 stimulates lipid metabolism through VDR-RXR heterodimers, activating Pgc1a for mitochondrial biogenesis and oxidative metabolism. This study reveals a basal nonskeletal effect of ancient VD/VDR signaling in teleosts.
Researchers found that tri-ponderal mass index (TMI) estimates body fat more accurately than traditional BMI in adolescents between the ages of 8 and 17. The study compared TMI to several different obesity indices, finding that it is the best overall body fat index for Caucasian adolescents.
A new study found that polyunsaturated fat caused epigenetic changes in participants' fat tissue, leading to differences in fat storage. The results suggest that polyunsaturated fat may have a more positive impact on health compared to saturated fat.
Researchers at Hiroshima University have identified a molecule, NPGL, that increases appetite during fasting and decreases it during gorging. This discovery suggests that the body has an evolved mechanism to maintain weight at a constant level, regardless of diet or energy intake.
Researchers found that rats fed high-sugar diets experienced increased body fat mass, liver damage, and brain inflammation. A balanced diet was shown to mitigate these effects, highlighting the potential risks of sugar-laden diet products.
A new study published in Neurology suggests that regular exercise, not body mass index, predicts a person's level of disability after a stroke. Exercise was defined as vigorous physical activity three times a week or more, and participants who exercised regularly were more likely to be independent before and after stroke.
A new review suggests that augmenting the function of HDL cholesterol rather than increasing its concentration is crucial for protecting against cardiovascular disease. The study highlights the importance of addressing adipose tissue-associated inflammation to support the atheroprotective role of HDL.
Researchers at the University of Birmingham found that higher active vitamin D levels are associated with increased muscle mass and strength. The study suggests a complex relationship between vitamin D, body fat, and lean mass, highlighting the importance of optimal vitamin D supplementation for healthy muscles.
Researchers at Hiroshima University have developed a technique to assess anti-inflammatory properties of fortified health foods and medications using bioluminescence imaging. This method reduces the number of lab mice sacrificed and could revolutionize medicinal drug testing, particularly for obesity-related metabolic disorders.
Researchers at Saint Louis University found that silencing a protein in liver and adipose tissue significantly improves blood sugar levels and reduces body fat in animal models. This breakthrough could lead to new treatments for insulin-resistant obese or overweight patients.
Researchers identified seven new areas of the genome linked to body fat distribution in a study involving over 18,000 individuals. The findings provide new insights into the biological mechanisms influencing cardiometabolic diseases.
Research in mice shows that microbes communicate with hosts by sending metabolites that act on histones, influencing gene transcription. Diet composition impacts microbiome and epigenetic changes, with healthy diets promoting beneficial metabolite production.
Research suggests that obesity causes chronic inflammation in visceral adipose tissue, which leads to comorbid cardiovascular and metabolic diseases. A new study found that a specific T cell subtype associated with aging accumulates in obese mice, causing insulin resistance and obesity-like inflammation.
Research suggests that maternal B12 deficiency during pregnancy may predispose children to metabolic problems such as type-2 diabetes. The study found that babies born to mothers with low B12 levels had higher leptin levels, which can lead to insulin resistance and an increased risk of type-2 diabetes.
Researchers found that supplementing healthy mice with NMN reduced signs of aging such as weight gain, loss of insulin sensitivity, and declines in physical activity. Long-term effects showed improved energy metabolism, better liver function, and increased tear production.
Scientists have discovered that the Rap1 gene plays a crucial role in energy balance and that its inhibition can restore sensitivity to leptin, a hormone that regulates appetite and body weight. The study suggests that targeting Rap1 may be a potential therapeutic approach for treating human obesity.
A recent study published in Sports Medicine found that exchanging sedentary behavior with even low-intensity physical activity reduces adipose tissue and enhances cardiorespiratory fitness in 6-8-year-old children. The intensity of physical activity is crucial for the association with enhanced cardiovascular fitness.
A study has discovered a new mechanism in the mouse brain that regulates obesity, finding that Rap1 gene inhibition can reduce body weight and improve leptin sensitivity, potentially leading to a new therapeutic target for treating human obesity.