Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A new study from The Ohio State University Wexner Medical Center reveals that female runners with a body mass index (BMI) of less than 19 are more likely to develop stress fractures. Lighter women who suffered stress fractures took longer to recover, highlighting the importance of maintaining a healthy BMI through resistance training.
A new study published in PeerJ introduces modern techniques to understand the landmark site's history, revealing that dinosaur bones were introduced to the deposit after death. The research suggests a combination of drought periods and flood events led to the accumulation of Allosaurus fossils, with environmental factors contributing t...
Aging stem cells lose their ability to make bone and muscle, leading to frailty and falls. Researchers are targeting the metabolite kynurenine and IDO inhibitors to reverse age-related damage and improve healthspan.
A recent genetic study has challenged long-held assumptions about the relationship between extinct and living elephant species. The research found that a species of giant elephant, Palaeoloxodon antiquus, is more closely related to African forest elephants than previously thought.
A recent study found that long-term bisphosphonate therapy did not significantly reduce the risk of bone fractures in older women. The research team examined data from over 5,000 women and discovered that those taking bisphosphonates for 10-13 years had higher fracture rates compared to shorter-term users.
Long-term malaria infections can cause chronic inflammation in the bone marrow, leading to increased bone resorption and substantial bone loss. Oral supplementation with alfacalcidol may reverse this side effect, suggesting a potential treatment strategy for improving bone health in malaria-infected individuals.
A new study reveals that Teleocrater rhadinus, a 3-meter-long, crocodile-shaped dinosaur, challenges earlier hypotheses on early dinosaur evolution. The discovery suggests that the most ancient dinosaurs' ancestors were quadrupedal, contradicting the long-held image of bipedal, chicken-like creatures.
Researchers discovered that fish can modulate fin stiffness by applying a u-shaped curvature at the base of their fins, altering force generation on the water. This allows them to swim with varying speeds and maneuverability in different currents. The study's findings could inspire the design of more agile robotic swimmers.
Researchers aim to genetically modify human bone marrow cells to produce more bone morphogenetic protein, a key factor in bone healing, to tackle challenging bone repairs such as extensive fractures and failed spinal fusions. The five-year grant will support the study's efficacy and safety assessment.
Researchers found that exercising burns fat in bone marrow, leading to improved bone health. The study suggests that exercise is beneficial even more so for obese individuals, who may experience greater bone formation and strength.
Researchers have developed a novel gene therapy method that utilizes microbubbles and ultrasound to promote bone growth and healing in nonunion fractures. The technique, which involves injecting genetic material for a bone growth factor into the affected area, has been shown to completely heal broken bones in pigs within eight weeks.
Researchers found T. rex could generate forces equal to three small cars while simultaneously applying world-record tooth pressures. The dinosaur's long conical teeth allowed it to drive open cracks in bone and produce catastrophic explosions.
Researchers at UPV/EHU develop biodegradable gelatin scaffolds that release growth factors to promote bone tissue regeneration. The scaffolds successfully imitate the body's natural processes, including protein release profiles and angiogenesis.
The study analyzed umbilical cord tissue from 669 babies and found a link between higher DNA methylation in the CDKN2A gene and lower bone mass at four and six years. This suggests that epigenetic modifications early in life may play a role in determining skeletal growth.
A new study found that elite rowers who engage in intense training sessions without adequate recovery periods may experience decreased osteoprotegerin levels and increased inflammation, leading to potential bone loss. The research suggests that very intense training without sufficient rest can compromise bone health.
The International Osteoporosis Foundation has released new position statement guidelines for managing aromatase-inhibitor related bone loss in breast cancer patients. The guidelines recommend regular assessment of fracture risk, calcium/vitamin D supplementation, and bone-directed therapy to prevent fractures and improve bone health.
Researchers developed a laboratory technique to test the effectiveness of treatments for breast cancer metastases in bone, mimicking interactions between cancer cells and bone cells. The 'bone-in culture array' model found that danusertib inhibits bone metastasis while other drugs stimulate growth of slow-growing cancer cells.
A study by Vanderbilt University researchers reveals that man-eating lions' actions were not driven by desperation, but rather a solution to a problem. The analysis found that the lions' teeth showed wear patterns similar to those of zoo lions fed soft foods.
A new study analyzing the teeth of Tsavo's famous man-eaters reveals that dental disease played a significant role in their unusual behavior. The researchers found that the lions' teeth showed less wear and tear than expected, contradicting the hypothesis that they turned to human prey due to food shortages.
Research reveals that major increases in environmental moisture caused widespread glacial-age grasslands to be replaced by peatlands and bogs, fragmenting populations of large herbivore grazers. The study found distinctive biochemical signals reflecting massive increases of moisture on the landscape.
A new species, Teleocrater rhadinus, discovered in Tanzania, has a long neck and tail, but walks on four legs like a crocodile. The finding sheds light on the distribution and diversity of ancestors of birds, crocodiles, and dinosaurs.
A HKU palaeontologist and his team reconstructed the first highly detailed body outline of a feathered dinosaur using high-definition images of its preserved soft tissues. The technique, known as Laser-stimulated fluorescence (LSF), reveals the shape of the dinosaur's wings, legs and foot scales with unprecedented detail.
The Society of Nuclear Medicine and Molecular Imaging has published appropriate use criteria (AUC) for bone scintigraphy in patients with prostate or breast cancer. The new AUC aim to improve healthcare outcomes by making the use of bone scintigraphy more consistent and reducing unnecessary imaging costs.
Researchers from Russia and US collaborate on radiocarbon dating of ancient porcupine fossils, revealing a 40,000-year-old record in the Urals. The study shows thermophilic porcupines disappeared from the region around 27,000 years ago due to climate change.
New research finds that lead bullets used at shooting ranges can cause serious health problems, particularly for women of child-bearing age. The study suggests a transition to copper bullets and lead-free primers is necessary to mitigate these risks.
A recent study found that high-calorie diets cause similar levels of bone loss in mice regardless of fat content. Glucocorticoid signaling in the skeleton plays a crucial role in diet-induced metabolic disturbances. Disrupting this signaling pathway may protect against obesity and related health issues.
A team of researchers has discovered a unique assemblage of prehistoric artefacts, including disc-shaped beads and pendant objects, dated to between 30,000 to 22,000 years ago. The findings challenge the theory that Pleistocene human culture declined in sophistication as Homo sapiens ventured beyond India into Southeast Asia.
A new measurement technique has reanalyzed vitamin D levels and lowered the estimated Recommended Dietary Allowance (RDA) from 800 to 400 International Units (IU) per day. This change may have significant public health implications, with easier-to-achieve daily intake of 400 IU recommended.
A study found that prolonged sleep disturbance can lead to reduced bone formation and increased osteoporosis risk. After three weeks of cumulative sleep restriction, healthy men had lower levels of a bone formation marker, indicating a potential bone loss window.
A decorated raven bone from the Zaskalnaya VI site in Crimea features two intentionally made notches, suggesting a visually consistent pattern. Researchers believe these modifications may have been symbolic additions used by Neanderthals to display a specific design.
Researchers discovered that clusters of specialized skin cells migrate over reforming bones and escort bone cells into the right positions to form a branched skeletal network. The process is driven by Sonic hedgehog protein, which interacts with bone-building cells to promote bone patterning.
Scientists analyzed seabird bones to find evidence of a significant change in the North Pacific's food web, likely caused by human activities such as industrial fishing. The study found that petrels' trophic level had declined over time, suggesting a shift in the structure of the ocean's ecosystem.
A new study by UBC researchers found that inactive teenagers have weaker bones than their active peers. The four-year study measured bone strength and found that kids who didn't meet daily physical activity recommendations had significantly weaker bones.
A study published by Pamela Hinton at the University of Missouri-Columbia found that weight-bearing exercises decrease sclerostin, a protein made in the bone, and increase IGF-1, a hormone associated with bone growth, promoting bone formation and increasing bone density.
Analysis of isotopes in bones and teeth from fifth-century cemeteries reveals hybridity among nomads and settlers, suggesting cooperation and coexistence. This challenges the traditional narrative of the Huns' violent attacks on settlements on the edge of the Roman Empire.
A large study of 309 adolescent boys and girls found that moderate to intense physical activity during growth spurt years significantly increases bone mass and strength. The study suggests a balance between physical activity and recovery time is needed to enhance bone health.
Researchers discovered that pre-menopausal South Asian women have higher levels of 'urinary N terminal telopeptide', indicating elevated bone resorption, making them more susceptible to osteoporosis and fractures. Fluctuating Vitamin D levels were also linked to increased bone resorption in white Caucasian women.
Researchers found that whole body vibration reduced body fat, improved insulin resistance, and increased muscle and bone strength in a mouse model of morbid obesity and diabetes. Circulating osteocalcin levels also rose, indicating potential benefits for glucose regulation.
Researchers found whole-body vibration (WBV) to be as effective as regular exercise in improving bone formation and insulin sensitivity in obese mice. WBV was shown to mimic the metabolic effects of exercise, with benefits seen in both genetically normal and obese mice.
A WSU researcher has discovered that activated enzyme MAOA facilitates the spread of prostate cancer to bones by activating osteoclasts and enhancing bone degradation. Treatment targeting this enzyme shows promise in reducing bone metastasis.
A new study introduces a steel alloy with a laminated nanosubstructure, inspired by bone structure, which is more resistant to cracking under repeated stress. This development has potential to improve the safety of buildings and components that experience cyclic loads.
Adults over 60 years old face a significantly increased risk of death following a pelvic fracture, particularly within the first four weeks. The study emphasizes the severity of these fractures and highlights the need for improved preventive strategies to reduce mortality rates.
Researchers at Columbia University Medical Center have discovered a bone-derived hormone that regulates food intake and blood sugar. The study found that the hormone, lipocalin 2, turns on brain neurons involved in appetite suppression, potentially leading to new targeted therapies for obesity and type 2 diabetes.
Early Mesolithic humans practiced selective hunting to conserve certain species, such as red deer, and hunted wild boars independently of age. A fish fermentation facility at the settlement revealed a more settled community than previously believed
Researchers at Tufts University found that exercise-induced irisin increases bone formation and thickness in mice, mimicking the effects of exercise on the skeletal system. The study suggests a potential new mechanism for regulating bone metabolism.
Scientists discover a tissue layer with extremely thin protein fibers at the interface between tendons and bones, explaining why athletes can withstand tremendous loads without damaging the bond. This breakthrough could lead to innovative connections in material research and tumour surgery.
A panel of international experts recommends abandoning the costly and ineffective treatment, citing a lack of benefit for outcomes important to patients. The guideline advises against using ultrasound therapy for bone healing after fracture, suggesting future research focus on other interventions that may speed up healing.
Researchers from Stanford University review biomimetic strategies to heal bone defects, focusing on cell transplantation and grafts based on soluble bone minerals or structural proteins. The study highlights the potential of biomimetics in regenerative medicine.
A new review identifies four main themes addressing gaps in osteoporosis care, including public awareness, reimbursement, and epidemiology. The authors stress the need for increased implementation of systematic approaches to prevent secondary fractures and improved management of patients with medicines negatively affecting bone health.
Long-term bisphosphonate therapy for Paget's disease of bone found no significant clinical benefits, increasing fracture risk instead.
Researchers have developed silver ion-coated scaffolds that can slow the spread of MRSA and even regenerate new bone. The biodegradable scaffolds were seeded with stem cells and found to inhibit MRSA while supporting bone tissue formation, offering a potential solution for treating osteomyelitis.
A new method of repairing injured bone using stem cells from human bone marrow and a carbon material with photocatalytic properties has been developed. The research team found that the material accelerates bone regeneration by activating key transcription factors, leading to increased osteoblast differentiation.
Researchers estimate dinosaur age by analyzing bone structures and repair procedures, with a similar process occurring in humans. The study's findings have implications for understanding the natural life span of dinosaurs.
Researchers discovered lipocalin-2 and prolactin proteins regulate mesenchymal stem cell activity in the lab and in mice with calvarial defects. This discovery aims to improve culture conditions for growing bone cells and develop therapies for bone repair.
The Endocrine Society has honored 21 outstanding researchers with the Early Investigators Award, recognizing their contributions to endocrine research and women's health. The award recognizes achievements in metabolic bone research, women's health, menopause, and endocrine disorders.
The IOF-ECTS Position Paper proposes measuring specific bone turnover markers to detect low adherence to oral bisphosphonates, a common issue in chronic diseases. This early identification enables discussion and intervention with patients, potentially improving treatment efficacy.
Researchers at the University of Missouri found that limiting maternal myostatin levels improved bone strength and density in mice with osteogenesis imperfecta. The study suggests a potential therapeutic approach to treating brittle bone disease.
A new study suggests that an anti-inflammatory diet rich in vegetables, fruits, fish, and whole grains can help prevent bone loss and fractures in post-menopausal white women younger than 63. The researchers found a correlation between lower-inflammatory diets and lower risk of hip fracture in this subgroup.
Researchers found that medaka fish lose bone density rapidly in space due to microgravity, which affects osteoclasts and osteoblasts differently than on Earth. The study suggests the participation of NO-GCR signal pathway in microgravity stress.
A 1-year football training program significantly reduces blood pressure, body fat percentage, and improves bone density in women with mildly high blood pressure. The study demonstrates the effectiveness of Football Fitness as a broad-spectrum medicine for women with high blood pressure.