Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
The International Osteoporosis Foundation's new interactive map reveals wide global variation in calcium intake, with low levels prevalent in Asia and Latin America. The map highlights the need for public health strategies to increase calcium intake throughout the lifespan.
A new mouse study reveals that environmental pollutants like dioxin and cigarette smoke interact with the HLA gene variant to cause more severe rheumatoid arthritis. The disease leads to excessive bone destruction through overactive osteoclasts, a process targeted by researchers for potential new treatments.
A recent study published in Communications Chemistry found that tungsten accumulates in specific regions of the bone, particularly in bone marrow and cancellous bone tissue. This accumulation raises concerns over the element's safety for human exposure, especially among young individuals.
Research suggests that bone cells can release signals driving prostate cancer progression and growth, especially when cancer metastasizes to bone. A study found that inhibiting BMP signaling in myeloid cells could restrict cancer cell production and tumor growth.
Researchers at Texas A&M University have discovered a new class of clay nanoparticles that can direct human stem cells to become bone or cartilage cells. These nanoparticles, similar to flaxseed in shape, can grow tissue from stem cells in the absence of growth factors.
A new study reveals the existence of a unique defensive mechanism in stonefishes, featuring a 'lachrymal saber' that can deploy from their cheeks. Genetic analysis confirms the close relationship among related species, leading to a revised taxonomy and further insights into the evolutionary history of these deadly fish.
Researchers have identified the genetic basis of melorheostosis, a rare bone disorder characterized by excess bone formation resembling dripping candle wax. The study found that mutations in the MAP2K1 gene were responsible for the condition, offering potential treatment targets and insights into bone development.
The absence of Sp7 transcription factor halts tooth development in mid-stride, preventing the maturation of cells responsible for creating dentin and enamel. This discovery adds to our understanding of craniofacial abnormalities, which are common birth defects in humans.
Sharon Truesdell, a Biomedical Engineering Ph.D. student at the University of Akron, has been awarded an NSF Graduate Research Fellowship to support her research on bone cells and diseases like osteoporosis. The three-year fellowship includes a $34,000 stipend and cost-of-education allowance.
The discovery of a 90,000-year-old Homo sapiens fossil in Saudi Arabia reveals early dispersals into Eurasia were more expansive than previously thought. The finding suggests that early humans colonized a broader region of southwest Asia than previously believed.
A team of engineers at Washington University in St. Louis studied the formation of new bone and teeth, discovering that miniscule gaps in collagen's fiber structure facilitate the nucleation of calcium phosphate. The findings provide a new view into the current theory of calcium phosphate nucleation in confined spaces.
Researchers have created a novel approach to restoring hearing by attaching bio-conjugated molecules to the cochlea, the shell-shaped ear bone. The molecules stimulate cell growth and connectivity in damaged inner ear cells, potentially treating hidden hearing loss and tinnitus.
A machine learning approach analyzed fossil remains in Spain and South Africa, finding that carnivore disturbance likely contributed to the disarray. The findings do not rule out potential hominin burials but instead highlight the role of nonhuman agents.
A new study suggests that Silk Road cities had limited and monotonous diets, while nomadic communities enjoyed a diverse smorgasbord of foods. Researchers used isotopic analysis of human bones to unlock information about ancient dietary regimens.
Researchers have created new metal alloy rods with laquosuperelasticity, capable of restoring shape against large deformation, and high corrosion resistance. These alloys offer promise as biomaterials for bone implants and potential solutions to scoliosis treatment
A new study found that serious chest muscle injuries, including pectoralis major tears, are occurring with 'alarming frequency' among deployed service members who lift weights. The injuries required surgical repair and six months recovery.
New research reveals that fish was a dominant source of protein in the Stone Age diet, with 50-60% of protein intake coming from marine sources. The study uses stable isotopes to analyze human bones and finds that fishing was surprisingly common, even in areas where land mammals were scarce.
A study of 5,177 male partners of infertile couples found that low sperm counts are associated with metabolic alterations, cardiovascular risk, and low bone mass. Men with low sperm counts were more likely to have a bigger waistline, higher blood pressure, and lower HDL cholesterol.
A new study published by The Endocrine Society found that estrogen replacement therapy can improve drive for thinness, body dissatisfaction, and uncontrolled eating in female athletes with exercise-induced menstrual irregularities. Female athletes with irregular periods reported more disordered eating behavior than those with regular p...
A new study found that Roux-en-Y gastric bypass surgery may increase the risk of non-vertebral fractures, such as hip and wrist fractures, compared to adjustable gastric banding. The study analyzed data from over 50,000 adults who underwent either RYGB or AGB surgery between 2006 and 2014.
Research at the Ii Hamina cemetery found that the diet of medieval residents consisted mainly of fish, with 70% of protein consumption attributed to fish-based food. This suggests a strong reliance on waterways and an underemphasis on farming and dairying in the region.
A study by University of Exeter researchers found that older mangrove rivulus fish can jump significantly further than younger ones. The study revealed that age itself was the most closely linked factor to jumping distance, contradicting previous findings.
Researchers discovered six new species of pterosaurs with remarkable diversity in size and shape, contradicting previous studies that suggested a decline before the mass extinction. The fossils date to just over 66 million years ago, revealing that these flying reptiles dominated the skies until their extinction.
Researchers used synchrotron microtomography to reveal that Archaeopteryx had adaptations similar to those of modern flying birds, suggesting it could have flown actively. This discovery provides insight into the early evolution of dinosaurian flight and challenges previous assumptions about its lifestyle.
Researchers found that calcium deposits in large arteries increased the risk of heart attacks and mortality. The study suggests bone density tests can also screen for cardiovascular disease, making them a valuable tool in screening.
A University at Buffalo study found that the absence of protein tristetraprolin (TTP) leads to rapid bone loss in mice, with oral bone loss increasing by nearly 20% over nine months. Overexpressing TTP reduced bone turnover by 13%. The research has implications for managing bone health in the elderly.
Mark C. Gebhardt, MD, is recognized for his efforts to increase diversity in orthopaedics, particularly among women and minority groups. He has mentored numerous medical students and residents, and advocates for recruiting and hiring diverse talent into the field.
Researchers found a correlation between flying following hip or knee arthroplasty and an increased risk of venous thromboembolism. VTE is a serious complication that can follow these surgeries, with 10 million cases occurring annually worldwide.
Children with vitamin D deficiency are at a higher risk of having more severe forearm fractures requiring surgical treatment. A new study found that 21% of patients were deficient and 49% had insufficiency, with those treated surgically having a significantly higher incidence rate.
The study projects a significant increase in total joint replacement procedures, with primary THR expected to grow 171% by 2030 and 330% by 2060. Revision TJR procedures are also expected to rise, particularly for TKR, which has been slowing its growth rate since 2008.
A study found that patients undergoing elective total hip arthroplasty (THA) have a slightly improved survival rate compared to the general population. After ten years, higher survival rates were observed among THA patients, particularly those with primary osteoarthritis.
A large randomized controlled trial found screening using FRAX calculator and bone density measurements to be highly cost-effective in preventing osteoporosis-related fractures. The study showed significant savings due to prevention of all fractures, including hip fractures.
Researchers found a connection between oxygen deprivation in bone cells and abnormally heavy bones, as well as low glucose levels. This discovery may lead to new treatments for conditions like osteoporosis, diabetes, and obesity.
A study published in the British Journal of Sports Medicine found that ball games and circuit strength training increased bone density by 44% and 46%, respectively, in children aged 8-10. These exercises also improved muscular strength and balance, reducing the risk of osteoporosis later in life.
A possible treatment for Hajdu-Cheney syndrome has been identified, which may also help with age-related osteoporosis. Researchers found that a medication called DAPT blocks osteoclast formation, reversing bone loss in mice with the disease.
Researchers recreated prehistoric projectiles and points from ancient sites in Alaska to understand technological choices made by early humans. The study found that composite microblade points were more effective on smaller prey, while stone and bone points had strengths for larger game.
Dr. Treena Arinzeh's bioactive composite matrix is designed to work alone or with patient's own bone marrow to repair bone defects, offering improved cell attachment, bone ingrowth and formation. The technology aims to reduce recovery time and cost associated with bone grafts.
Researchers found that initial bone parameters significantly correlate with the risk of fracture in postmenopausal women. Peak bone mass and density appear to play a more crucial role in fragility fractures than previously thought.
A new study from the University of Utah suggests that repeated stress from everyday activities like walking can cause microdamage to bones in older adults, leading to a higher risk of breakage. This theory, known as 'cyclic loading,' challenges the common-held belief that bone breaks are caused by single impacts or forces.
Scientists at ICN2 have found that bone's mineral component exhibits flexoelectricity, which triggers the bone repair process. This effect is localized to the tip of microfractures and signals to osteoblasts where damage needs repair.
Researchers develop optimized titanium-mesh scaffolds that promote faster and more effective bone regeneration. The study found that softer implants enhanced healing, with results applicable to various types of bone defects.
Researchers have developed a simplified musculoskeletal model that uses network science to predict how injuries in one area of the body can lead to increased strain on other areas. The model could help clinicians and physical therapists develop new treatments for injury prevention and management.
Researchers uncovered the origins of domesticated turkeys in ancient Mexico, finding they were valued for their cultural significance rather than just for meat. The study suggests a thriving turkey trade along Mesoamerica's expanding trade routes.
Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg found that a fiber-rich diet can reduce arthritis symptoms by changing the intestinal bacteria and increasing short-chained fatty acids. These fatty acids have anti-inflammatory properties and can help slow bone degradation.
Pooled data from 14 osteoporosis clinical trials indicate that reduced bone turnover markers are associated with lower vertebral fracture risks. The findings may aid in developing anti-resorptive drugs by optimizing dose and treatment schedules.
A new study published in Journal of Bone and Mineral Research found that more than 80% of bone loss in post-menopausal women is due to cortical bone, not trabecular. Cortical bone loss is likely to contribute to the occurrence of fractures in these women.
A new study found that an individual's history of past falls can significantly increase their risk of a new fracture. Even after accounting for FRAX and bone mineral density tests, past falls were associated with a 63%-71% increased risk of a new fracture occurring.
Researchers found that genes can be activated in human stem cells to initiate biomineralization, a key step in bone formation. The study used engineered silk derived from golden orb weaver spider webs and supercomputers Stampede1 and Comet to model the folding of proteins and predict osteogenesis.
A Loyola Medicine study found nearly four out of five diabetic patients with severe Charcot foot were able to walk normally after surgery. The study used a stricter standard for treatment success, with 77.6% of patients meeting the criteria, and Dr. Pinzur's Ilizarov circular external fixator technique showed promising results.
A recent study published in The Journal of Bone & Joint Surgery found that outpatient total knee replacement surgery is associated with a higher risk of certain complications, including infections, repeat surgery, and blood clots. Patients undergoing outpatient TKA were more likely to experience joint-related complications and medical ...
The oldest plesiosaur, Rhaeticosaurus mertensi, was a strong swimmer with modified limbs and a short tail. It had a streamlined neck and powerful muscles to propel itself through the water.
Researchers have developed a one-stage technology for producing artificial nano-hydroxyapatite with increased biocompatibility and controllable properties. The material can be used in orthopedics, pharmaceuticals, aesthetic medicine and coatings for medical devices.
Researchers developed an antibody called 15D11 that blocks Jagged1, a molecule making it easier for breast cancer cells to metastasize to bone. The antibody allows chemotherapy to keep cancer at bay by eliminating the protective effect of rebuilders in bone tissue.
A new study published in Scientific Reports found that monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in bone loss responses to parathyroid hormone (PTH) in hyperparathyroidism. Elevated MCP-1 levels have been correlated with elevated serum PTH levels, and its presence may serve as a marker for PTH's effects in humans.
A team led by Purdue University anthropology professor Erik Otárola-Castillo used 3D imaging, shape analysis, and Bayesian statistics to accurately measure animal bone cut marks with an 88 percent success rate. This technique improves upon existing archaeological methods, enabling a more accurate understanding of human evolution.
Researchers created customized prosthetic replacements for damaged middle ear parts using CT scans and 3-D printing. The technique has the potential to reduce high failure rates of surgical procedures. Custom-designed implants can improve hearing outcomes by providing a more exact fit, decreasing surgical time.
Research from Umea University shows that jawbone loss caused by periodontitis precedes and correlates with rheumatoid arthritis. Elevated levels of RANKL in the blood also indicate a causal link between the two conditions.
A recent study of 27,940 Chinese newborns found that low vitamin D levels at birth were associated with a higher risk of autism spectrum disorders (ASDs) at age 3. The risk was significantly increased in each lower quartile of vitamin D level compared to the highest quartile.
CVDVale's technology enables the use of ultrasonic drills without anesthesia in 70% of cases, allowing for faster and less painful dental procedures. The company's innovative approach to synthetic diamond production has also expanded its applications to orthopedic surgeries.
The LAB-IN-A-BOX portable DNA barcoding kit enables rapid species identification, improving enforcement responses against wildlife trafficking and invasive species. This technology has the potential to greatly impact conservation efforts in developing countries.