Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
The Endocrine Society's Clinical Practice Guideline recommends treating postmenopausal women with pharmacological therapies to reduce fracture risk, outweighing the risks of rare side effects. Guidelines also provide recommendations for monitoring and reassessing fracture risk after initial treatment.
Researchers at UCLA have developed a new membrane class that can regenerate gum tissue and bone, offering a viable solution for periodontitis. The membranes have tissue and bone regeneration properties along with a flexible coating that adheres to biological surfaces.
Researchers have developed a nanofibrous membrane that enhances periodontal tissue regeneration and is absorbed by the body when healing is complete. The membrane, made from biocompatible polymers, promotes bone mineralization and regrows lost gum tissue in rats with periodontal defects within eight weeks.
Researchers from NUST MISIS created a nanomaterial that enhances the rate of bone cell division by 3 times, enabling the growth of new bone tissue. This breakthrough could potentially abandon bone marrow transplantation, offering hope to patients with osteoporosis and osteomyelitis.
Plant cellulose-based aerogel implants have shown 33% more bone growth in rats at three weeks and 50% more at 12 weeks compared to controls. The innovation has the potential to fill a $2-billion market with economical raw materials and applications in dental and joint replacement surgeries.
Chronic inflammation, not aging, is the main reason why bones heal more slowly with age. Researchers found that exposure to older mice's blood serum reduces stem cell multiplication and increases inflammation. Treatment with anti-inflammatory drugs restored skeletal stem cell function and bone healing ability in aged mice.
A new study suggests that combining blood flow restriction (BFR) therapy with traditional rehabilitation efforts may slow bone loss and reduce return to function time after ACL reconstruction. The addition of BFR was found to minimize muscle mass loss, preserve bone density, and improve functional outcomes in patients.
A new injectable bone healing drug has been developed to accelerate fracture healing by 50% and reduce recovery times. The technology, licensed through Purdue University's Research Foundation, has shown promising results in preclinical studies and is expected to transform treatment for broken bones.
A survey of 91 different multivitamins and vitamin D supplements for children in the UK found that many do not provide the recommended daily dose of 400 IU of vitamin D. Only one multivitamin was suitable for use from birth, while between a quarter and a third of available products supplied at least 400 IU/day for children over 6 months.
A new study confirms that obesity impairs vitamin D conversion in the liver, affecting its major form in the blood. This finding highlights the need for targeted treatment approaches, such as calcidiol, to address vitamin D insufficiency in obese individuals.
Scientists developed a new hybrid bone implant combining the properties of ultra-high molecular weight polyethylene (UHMWPE) and polyetheretherketone (PEEK). The implant's unique structure allows for improved strength, elasticity, and affordability.
A recent study published in The FASEB Journal revealed that Static Magnetic Field treatment can significantly enhance osteogenesis in human bone-derived mesenchymal stem cells. The researchers observed improved bone formation potential and better osteogenic markers in the SMF-treated cells compared to the control group.
A high-protein, low-calorie diet has been shown to help older adults with obesity lose more weight while maintaining muscle mass and improving bone quality. Participants lost about 18 pounds, mostly fat, without losing bone density.
A recent study published in the Journal of Biomechanics used advanced MRI techniques to track wrist bone movement in 18 individuals, revealing gender-based differences. The researchers found that while individual left and right wrists are similar, there are distinct differences between male and female wrists.
Researchers sequenced mitochondrial genomes to understand penguin evolution, revealing two new extinct species on the Chatham Islands. The discovery sheds light on how humans impacted New Zealand's marine biodiversity in the past.
A new review highlights the need for targeted approaches to address cancer therapies' impact on bone health. Efforts to limit these effects have largely relied on anti-resorptive agents with limited assessment of fracture risk reduction.
A new paper in Current Anthropology proposes that early human ancestors acquired a taste for fat by eating marrow scavenged from large animal skeletons. This fatty diet provided the necessary calories to develop bigger brains, contradicting the widely held view that meat consumption was crucial for human evolution.
Researchers at Hokkaido University found that inhibiting a bone receptor protein called Siglec-15 can increase bone mass and strength without impairing growth in young rats. This suggests that anti-Siglec-15 therapy could be an alternative treatment for juvenile osteoporosis, potentially with an ideal safety profile.
The ancient archosaur Smok wawelski exhibited bone-crushing behavior, consuming prey bones for their salt and marrow content. Researchers linked coprolites to the species through synchrotron microtomography and found crushed teeth and bite-marked bones.
Researchers at RCSI have developed a new treatment for osteomyelitis using a copper-rich glass implant. The implant attracts blood vessels and bone cells, accelerating bone repair and preventing bacterial growth. This breakthrough treatment has the potential to reduce antibiotic use and improve outcomes for patients with bone infections.
Researchers have identified a previously unknown blood vessel system in bones, which supplies bones with oxygen and nutrients. The 'trans-cortical vessels' connect bone marrow to the bloodstream, allowing immune cells to quickly reach the source of inflammation.
Researchers from Boston University School of Medicine suggest narrow searcher spacing and double passes can increase detection rates. This new methodology aims to improve the recovery of skeletal remains, making it easier to find missing individuals.
Researchers studying opioid addiction effects on bones are exploring how it impacts microscopic bone structures used to estimate age-at-death. Opioids upset the balance of bone remodeling towards more destruction and less formation of bone, leading to severely compromised age-at-death estimates.
Scientists use 3D printing to create articular cartilage and subchondral bone from mesenchymal stem cells. This technique shows promise in repairing osteochondral defects in mini-pigs' knees.
Researchers discovered that white blood cells respond to microparticles from prosthetic devices as harmful invaders and engulf them, leading to inflammation, tissue damage, and bone destruction. The study may lead to new therapies to reduce pain and prevent follow-up surgery for joint replacement patients.
Researchers have made a groundbreaking finding that blocking specific brain signals in female mice can lead to enhanced bone growth, resulting in stronger bones and reduced risk of osteoporosis. This discovery has the potential to develop new treatments for women and older individuals with fragile bones.
Researchers have discovered that dry-cured ham bones contain peptides with cardioprotective effects, inhibiting enzymes involved in cardiovascular disease. The use of ham bones to make broths and stews could have a positive impact on cardiovascular health.
Researchers at Medical University of South Carolina found that antibiotic disruption of the gut microbiome leads to increased osteoclast activity, dysregulating post-pubertal skeletal development. The study also revealed changes in immune cell populations, including an increase in myeloid-derived suppressor cells.
Researchers have identified two functional populations of hematopoietic stem cells: 'primed' and 'reserve', which act under normal conditions and during times of stress, respectively. The reserve cells are protected by N-cadherin+ bone-lining cells, which provide survival factors to support their function.
A new study from the University of Copenhagen suggests that early dogs helped humans hunt smaller prey like hares and foxes, driving them into enclosures. This technique may have led to an increase in hare populations at the site of Shubayqa 6 in northeast Jordan.
Researchers at North Carolina State University and the University of South Florida found significant flaws in forensic software DXAGE, which estimates age-at-death based on bone mineral density. The software's accuracy was off by an average of 14.25 years for women who died between 30s and 70s.
A new study published in the American Journal of Clinical Nutrition found that vitamin D supplements have no significant impact on bone mineral density or falls among older adults. However, higher doses may improve bone metabolism and be safe for those over 70.
Researchers have identified a surprising role for brain cells in controlling bone density, suggesting a new approach to preventing osteoporosis. Blocking estrogen signals in the brain causes female mice to build extraordinarily strong bones and maintain them into old age.
Researchers from Skoltech and MIPT analyzed the protein and lipid composition of a Siberian mammoth bone, identifying 98 proteins and 73 lipids. The study provides insights into the mammoth's diet, health, and nervous system development, complementing paleogenomics and paleoproteomics.
Researchers have created an atlas of genetic factors associated with estimated bone mineral density, explaining 20% of the genetic variance linked to osteoporosis. The study identifies over 500 genetic determinants, providing promising targets for novel therapeutics to prevent or treat the disease.
Biofabricated tissues with micropores allow for efficient nutrient and oxygen diffusion, enabling the growth of larger tissue samples. The novel approach uses stem cells derived from human fat and sodium alginate porogens to create porous tissue strands that can be implanted in bone or cartilage defects.
Researchers found children born in the 1990s are reaching skeletal maturity faster than those born in the 1930s. The 'new normal' for bone maturity timing directly impacts pediatric orthopaedic care for conditions like leg-length differences and scoliosis.
Researchers will assess bone strength and nutrition among men and women in the Boston area to develop interventions for preventing bone loss and fracture risk. The study aims to provide insight into the impact of advanced glycation end products (AGEs) on bone health.
Researchers discover that exercise-induced hormone irisin activates cells responsible for bone remodeling in mice. The study reveals irisin's impact on sclerostin, a major cellular regulator of bone structure, and holds promise for future osteoporosis treatments.
Scientists have discovered that irisin, a hormone released by muscles during exercise, directly acts on key regulatory cells that control the breakdown and formation of bone. Treating osteocytes with irisin protected them from age-related death and increased their production of sclerostin, a protein that triggers bone remodeling.
Modern broiler chickens are a defining feature of the Anthropocene, shaped by human biology and consumption. The rapid evolution of these chickens reflects a biosphere dominated by human activity.
A recent study found that treatment with active vitamin D did not decrease cardiovascular events in patients undergoing hemodialysis. Researchers tested oral alfacalcidol, an active form of vitamin D, to see if it improved clinical outcomes. The results showed no significant benefit for patients without secondary hyperparathyroidism.
A team of scientists has found medullary bone in a Cretaceous bird fossil, providing the first occurrence of this tissue outside of modern birds. The discovery links birds and dinosaurs, challenging previous assumptions about their relationship.
New research reveals that a species of ancient primate, Teilhardina brandti, found in Wyoming, is as old or older than its Asian and European relatives. This discovery challenges the prevailing hypothesis that Teilhardina first appeared in China. The study analyzed 163 teeth and jaws to determine the species' origins and migration patt...
A new imaging method, HR-pQCT, predicts fracture risk by analyzing bone microstructure. This method provides additional information beyond traditional BMD assessments, identifying deficits in trabecular and cortical bone density and structure as independent risk factors.
Researchers at the University of Arizona are working on a groundbreaking study to regenerate long bone segments using 3D printing and adult stem cells. The goal is to improve treatment outcomes for military personnel with devastating injuries, where current surgical treatments often fail.
Researchers have determined the three-dimensional structure of the PTH-1 receptor, a protein fragment involved in bone loss. This breakthrough enables the development of new drugs that may slow down or reverse osteoporosis without its current treatment's disadvantages.
The study reveals how calcium phosphate molecules crystallize and build up into a perfectly arranged bone structure. Researchers used an artificial biomaterial to mimic natural bone tissue functions, allowing them to study the phenomenon at an atomic level.
A new study reveals that women can be as resilient to extreme physical activity as men, contrary to previous claims about gender differences. The research found no significant negative health effects in six female participants who completed a transantarctic expedition.
A study published in Immunity found that Lactobacillus rhamnosus GG supplementation increased bone formation in female mice by stimulating the growth of butyrate-producing gut bacteria. This activation led to the expansion of regulatory T cells, which secrete a protein called Wnt10b, critical for bone development.
Researchers have found a potential Achilles' heel in micrometastasis that could be targeted with medications to reduce the risk of full-blown metastasis. Blocking calcium transfer through gap junctions and mTOR pathway results in cancer cell death or growth inhibition.
A novel technique uses 3D analysis to study bone wear patterns, providing controlled experimental protocol for archeological investigations. The study sheds light on the manufacturing and use of early human tools, revealing that duration of use is the largest determinant affecting surface wear.
A recent study found that pregnant women who gained normal weight had slightly increased bone mass in their children at age 7, while overweight mothers saw no benefit. The findings suggest following US pregnancy weight gain guidelines may not harm children's skeletal health.
Researchers analyzed ancient animal bones using ZooMS to discover that people were herding sheep, goat, and cattle by at least 4300 years ago. This technique provides new insights into the human story across Central Asia and opens up a whole new world of archaeological research possibilities.
A new imaging process will enable x-ray microscopy on living subjects, facilitating more detailed analysis of bone structure changes in osteoporosis. The European Research Council funds the project with a €12.3 million grant.
A Stanford-led study identifies uhrf1 and s100a10 as key genes driving rapid deer antler growth, a process that could inform new approaches for treating human bone conditions like osteoporosis. The researchers hope to apply the underlying biology of deer antlers to develop more efficient therapies.
An interdisciplinary team will create a novel X-ray microscope to analyze bone microstructure in living individuals, enabling the study of osteoporosis and its progression. The '4D+ nanoSCOPE' will make it possible to monitor bones over time and assess the effects of aging and other factors on bone health.
Researchers at University of Michigan discovered that a mineral-supplemented diet has a greater impact on bone mass and strength than exercise. The mice retained bone strength gains even after the exercise stopped, highlighting the long-term benefits of nutrition over exercise.
A new study identifies Th17 cells as drivers of periodontitis, a common disorder affecting nearly half of American adults over age 30. The research found that an unhealthy oral microbiome triggers the accumulation of these immune cells, leading to inflammation and bone loss.
A study published in PLOS ONE reveals that modern humans colonized Madagascar thousands of years later than previously thought. The research, led by Atholl Anderson, analyzed animal bone material and found evidence of megafaunal extinction starting around 1200 years BP.