A new expert review outlines the clinical characteristics of bone fragility in adults with diabetes and provides valuable insights for diagnosis and treatment. The review highlights recent studies on bone mineral density, biochemical markers, and fracture prediction to inform clinicians about the optimal approach to managing bone healt...
Researchers have found that early farmers at Çatalhöyük turned to drought-resistant sheep and goats during a sudden climate event 8,200 years ago. The study used ancient animal fats in cooking pots to detect changes in precipitation patterns, providing new insights into past climate conditions.
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Scientists at MD Anderson Cancer Center have engineered a system allowing microscopic monitoring and imaging of cancer in mice, enabling better understanding and treatment of bone metastasis. The model reveals how cancer cells interact with bone and bone resident cells over time, providing insights into the disease's progression.
A new mouse model has been developed to study bone metastasis, allowing researchers to inject a large number of cancer cells without causing death. The model enables the detection of bone metastasis in the hind limbs with high efficiency and provides insights into cancer cell dormancy and reactivation.
Researchers have solved a 160-year-old mystery about the origin of vertebrates' skeletons by studying ancient fossils. They found that heterostracan skeletons were made from a unique tissue called aspidin, which is later revealed to be bone-like in structure.
A new study found that twice-weekly one-hour football training sessions combined with dietary guidance significantly improved bone health in untrained 55-70-year-olds with prediabetes. After 16 weeks, the participants showed marked improvements in clinically important sites, including a 3.2% increase in femoral neck bone mineral content.
Researchers discovered that snipefish use an elastic-boosted head flick to capture prey at unprecedented speed, with the fastest recorded events occurring in just two milliseconds. This mechanism allows the fish to pivot their heads rapidly and bring their mouth up close to the prey.
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Researchers analyzed over 4,000 mosasaur fossil specimens to determine if quality impacts our understanding of past biodiversity. The study found that the rich fossil record provides an accurate picture of mosasaur diversity and evolutionary history despite variable completeness.
Researchers found that the PGC-1α gene controls the equilibrium of bone and fat in bone marrow and affects how stem cells differentiate into bone or fat cells. Increasing PGC-1α expression may slow down bone loss and decrease bone marrow fat, suggesting a protective role in maintaining the bone-to-fat balance.
Researchers have discovered ancient tools in China that date back to 2.12 million years ago, challenging the long-held assumption that early humans left Africa at this time. The findings indicate that early human ancestors colonized East Asia over two million years ago.
University of Utah engineers uncover the reasons behind vertigo caused by specific sounds, linking it to a thinning of the bone enclosing the inner ear. The study reveals pathological fluid mechanical waves in the semicircular canals as the culprit, causing incorrect signals sent to the brain.
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This study evaluated perioral soft tissue changes after orthognathic surgery using 3D CT scans. Significant post-operative changes were observed in nasolabial and mentolabial angles, while lip width remained unchanged.
The USPSTF updates its recommendation on screening for osteoporosis to include bone measurement testing for prevention of osteoporotic fractures in eligible populations. Approximately 12 million individuals in the US older than 50 years are expected to have osteoporosis by 2020.
Researchers have identified the biological process of mineralization that occurs in young corals, shedding light on coral reef formation and the storage of atmospheric carbon dioxide. The discovery also holds implications for new biotechnological developments using coral extractions to regenerate human bones.
Experts argue that persistent musculoskeletal pain without an obvious cause cannot be 'cured' and should be managed as other long-term conditions. Clinicians must be honest about what can be achieved, and patients need to take control of their condition through lifestyle changes.
Researchers have found that probiotics can significantly reduce bone loss in older women, halving the rate of bone degeneration compared to those who received a placebo. This discovery has important implications for preventing fractures among the elderly and may offer a new preventive treatment for osteoporosis.
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A recent study found no correlation between circulating bone turnover markers and hip fracture risk among postmenopausal women. The research adds to the existing evidence that these markers are not useful for predicting hip fracture risk.
A new study challenges the classic image of dinosaurs, revealing that they couldn't stick out their tongues. Researchers compared hyoid bones of modern birds and crocodiles with those of extinct dinosaur relatives, finding that most dinosaurs had short, simple tongue bones anchored to the floor of their mouth.
The Anzick site in Montana has been dated to between 12,725 and 12,900 years ago, based on specific amino acid radiocarbon dating of human remains. This confirms the contemporaneity of human remains and Clovis artifacts, resolving long-standing dating issues and providing new insights into early human habitation in North America.
Researchers found that individuals living at high altitude have shorter lower arm segments but relatively similar upper arm and hand lengths compared to those living at low altitudes. This suggests the human body prioritizes energy allocation for growth, particularly in essential areas like manual dexterity.
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A large international study found that higher circulating vitamin D concentrations are significantly associated with lower colorectal cancer risk. Optimal vitamin D concentrations for colorectal cancer prevention may be higher than current recommendations.
Staphylococcus aureus uses specific amino acid biosynthesis pathways to obtain essential nutrients from host tissues during invasive infection. The discovery sheds light on how bacterial pathogens survive in bone and may lead to the development of new antimicrobial therapies.
Researchers at Rush University Medical Center identified two biomarkers that indicate patients likely to develop osteolysis, a condition causing joint loosening and potential revision surgery. These biomarkers can be detected up to six years before diagnosis.
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Researchers developed an improved method for calculating risk for heart attack or stroke, finding that 11 million Americans may need to discuss different prescriptions with their doctor. The new calculations suggest major changes to statin, aspirin, and blood pressure medication prescribing, particularly for African Americans.
Researchers found weight loss over 40 years linked to significant bone deterioration, increasing fracture risk by almost three-fold. Weight-bearing exercise and balanced diet may help counteract negative effects on the skeleton.
A 2.5 metre-deep excavation at Eastland Port uncovered moa bones and stone tools made of obsidian and chert, dating back to the early 1300s.
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New research suggests that a narrow corridor along Alaska's Pacific coast could have enabled early human migration to the Americas as far back as 17,000 years ago. The authors used dating and reanalysis of animal bones to reconstruct deglaciation and find that the area was habitable during this time period.
A $1.7 million NIH grant will aid in understanding citrate signaling for bone development and designing novel biomaterials. Researchers aim to mimic native tissue composition and induce bone growth through citrate-presenting biomaterials.
Researchers at UMass Lowell are using origami to create new biomaterials that can grow cells for repairing or regenerating tissues such as skin, bone, cartilage, and blood vessels. The team's paper-based platforms have shown promise in biocompatibility and potential applications for wound care.
Researchers used a novel approach to study the movement of ancient birds and reptiles, finding that many assumed poses were impossible due to ligament limitations. This challenges traditional views on pterosaur flight and provides new methods for assessing joint mobility in extinct species.
A new software tool called the automated bone scan index (aBSI) has been shown to be both accurate and speedy in calculating how extensively bones have been infiltrated by prostate cancer. The aBSI technology provided prognostic information about patient outcomes, including survival time and symptom progression.
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Researchers have discovered four separate lineages of green-blooded lizards, each with unique evolutionary history. The study suggests that high levels of biliverdin in these lizards may have adaptive value, potentially leading to new approaches to treating human diseases such as malaria.
A new expert consensus review found that a balanced diet with sufficient protein intake can benefit adult bone health, particularly in seniors with osteoporosis. Adequate calcium intake is crucial to support the benefits of dietary protein on bone density and reduce fracture risk.
A WSU research team has made a breakthrough in 3D-printed bone health by combining natural medical cures with modern biomedical devices. The addition of curcumin to ceramic scaffolds improved bone growth capabilities by 30-45%, offering new hope for treating bone diseases like osteoporosis.
Researchers used scanning transmission electron microscopy to reveal a filamentous pattern of long, curved crystals in bone. A previously unknown substructure was discovered: rose-shaped crystals arranged into left-handed helices.
Weight loss surgery can cause declines in bone mass and strength, with increased risk of bone fractures. Nutritional factors, mechanical unloading, hormonal changes, and body composition alterations contribute to poor bone health.
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Researchers found symbolic objects in Hayonim Cave, Israel, characterized by repetitive notches on scapulae and a hyoid of gazelle, suggesting cultural identification of the Levantine Aurignacian culture. The findings provide insights into the origins and spread of this ancient culture.
Brazilian researchers use human tissue samples from victims of the Hiroshima bombing to measure radiation dose absorbed by bones. The study confirms the feasibility of this method and opens up possibilities for future research, clarifying details of the nuclear attack.
A 3,000-year-old horse burial in Sudan has provided significant insights into the Kushite state formation and the role of horses in ancient Nubian culture. The discovery, dated to around 950 BC, reveals that horses were central to the state's identity and foreshadowed later developments in Nubian kingship.
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The International Osteoporosis Foundation's new interactive map reveals wide global variation in calcium intake, with low levels prevalent in Asia and Latin America. The map highlights the need for public health strategies to increase calcium intake throughout the lifespan.
A new mouse study reveals that environmental pollutants like dioxin and cigarette smoke interact with the HLA gene variant to cause more severe rheumatoid arthritis. The disease leads to excessive bone destruction through overactive osteoclasts, a process targeted by researchers for potential new treatments.
A recent study published in Communications Chemistry found that tungsten accumulates in specific regions of the bone, particularly in bone marrow and cancellous bone tissue. This accumulation raises concerns over the element's safety for human exposure, especially among young individuals.
Research suggests that bone cells can release signals driving prostate cancer progression and growth, especially when cancer metastasizes to bone. A study found that inhibiting BMP signaling in myeloid cells could restrict cancer cell production and tumor growth.
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Researchers at Texas A&M University have discovered a new class of clay nanoparticles that can direct human stem cells to become bone or cartilage cells. These nanoparticles, similar to flaxseed in shape, can grow tissue from stem cells in the absence of growth factors.
A new study reveals the existence of a unique defensive mechanism in stonefishes, featuring a 'lachrymal saber' that can deploy from their cheeks. Genetic analysis confirms the close relationship among related species, leading to a revised taxonomy and further insights into the evolutionary history of these deadly fish.
Researchers have identified the genetic basis of melorheostosis, a rare bone disorder characterized by excess bone formation resembling dripping candle wax. The study found that mutations in the MAP2K1 gene were responsible for the condition, offering potential treatment targets and insights into bone development.
The absence of Sp7 transcription factor halts tooth development in mid-stride, preventing the maturation of cells responsible for creating dentin and enamel. This discovery adds to our understanding of craniofacial abnormalities, which are common birth defects in humans.
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Sharon Truesdell, a Biomedical Engineering Ph.D. student at the University of Akron, has been awarded an NSF Graduate Research Fellowship to support her research on bone cells and diseases like osteoporosis. The three-year fellowship includes a $34,000 stipend and cost-of-education allowance.
The discovery of a 90,000-year-old Homo sapiens fossil in Saudi Arabia reveals early dispersals into Eurasia were more expansive than previously thought. The finding suggests that early humans colonized a broader region of southwest Asia than previously believed.
A team of engineers at Washington University in St. Louis studied the formation of new bone and teeth, discovering that miniscule gaps in collagen's fiber structure facilitate the nucleation of calcium phosphate. The findings provide a new view into the current theory of calcium phosphate nucleation in confined spaces.
Researchers have created a novel approach to restoring hearing by attaching bio-conjugated molecules to the cochlea, the shell-shaped ear bone. The molecules stimulate cell growth and connectivity in damaged inner ear cells, potentially treating hidden hearing loss and tinnitus.
A machine learning approach analyzed fossil remains in Spain and South Africa, finding that carnivore disturbance likely contributed to the disarray. The findings do not rule out potential hominin burials but instead highlight the role of nonhuman agents.
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A new study suggests that Silk Road cities had limited and monotonous diets, while nomadic communities enjoyed a diverse smorgasbord of foods. Researchers used isotopic analysis of human bones to unlock information about ancient dietary regimens.
Researchers have created new metal alloy rods with laquosuperelasticity, capable of restoring shape against large deformation, and high corrosion resistance. These alloys offer promise as biomaterials for bone implants and potential solutions to scoliosis treatment
A new study found that serious chest muscle injuries, including pectoralis major tears, are occurring with 'alarming frequency' among deployed service members who lift weights. The injuries required surgical repair and six months recovery.
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New research reveals that fish was a dominant source of protein in the Stone Age diet, with 50-60% of protein intake coming from marine sources. The study uses stable isotopes to analyze human bones and finds that fishing was surprisingly common, even in areas where land mammals were scarce.
A study of 5,177 male partners of infertile couples found that low sperm counts are associated with metabolic alterations, cardiovascular risk, and low bone mass. Men with low sperm counts were more likely to have a bigger waistline, higher blood pressure, and lower HDL cholesterol.
A new study found that Roux-en-Y gastric bypass surgery may increase the risk of non-vertebral fractures, such as hip and wrist fractures, compared to adjustable gastric banding. The study analyzed data from over 50,000 adults who underwent either RYGB or AGB surgery between 2006 and 2014.
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A new study published by The Endocrine Society found that estrogen replacement therapy can improve drive for thinness, body dissatisfaction, and uncontrolled eating in female athletes with exercise-induced menstrual irregularities. Female athletes with irregular periods reported more disordered eating behavior than those with regular p...
Research at the Ii Hamina cemetery found that the diet of medieval residents consisted mainly of fish, with 70% of protein consumption attributed to fish-based food. This suggests a strong reliance on waterways and an underemphasis on farming and dairying in the region.