Fragility fractures are a serious yet neglected complication of both type 1 and type 2 diabetes, with increased risk of fragility fractures in people with diabetes extending across the life span.
This is a concern as, globally, the prevalence of diabetes in adults is expected to increase from almost 425 million today, to approximately 629 million by 2045. At the same time, many clinicians who treat patients with diabetes are not aware of their patients' heightened risk of disabling and potentially life-threatening fractures.
Given this scenario, the International Osteoporosis Foundation (IOF) Bone and Diabetes Working Group has published a new expert review that summarizes key research, highlights clinical issues, and provides a helpful 'decision-tree' style algorithm for the identification and management of diabetic patients at increased fracture risk.
Download: Diagnosis and management of bone fragility in diabetes: an emerging challenge
Professor Serge Ferrari, chair of the IOF Committee of Scientific Advisors and of the IOF Bone and Diabetes Working Group, stated:
"The link between diabetes and skeletal health is complex and the optimal approach to the management of bone health in patients with diabetes is not yet definitive and may change over time as findings of new clinical studies become available. This new review will inform clinicians about the current state of knowledge, and, importantly, the clear algorithm will facilitate the clinical assessment and management of fragility fracture risk in their patients according to current best practice."
The review outlines the clinical characteristics of bone fragility in adults with diabetes, and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction (FRAX). It also looks at the impact of diabetes drugs on bone, as well as the efficacy of osteoporosis treatments in these patients.
Key messages include:
###
Reference:
Ferrari SL, Abrahamsen B, Napoli N, Akesson K, Chandran M, Eastell R, El-Hajj Fuleihan G, Josse R, Kendler DL, Kraenzlin M, Suzuki A, Pierroz DD, Schwartz AV, Leslie WD on behalf of the Bone and Diabetes Working Group of IOF (2018) Diagnosis and management of bone fragility in diabetes: an emerging challenge. Osteoporos Int (2018) https://doi.org/10.1007/s00198-018-4650-2
https://link.springer.com/article/10.1007%2Fs00198-018-4650-2
About IOF
The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers as well as 240 patient, medical and research societies in 99 locations, work together to make fracture prevention and healthy mobility a worldwide heath care priority. http://www.iofbonehealth.org http://www.facebook.com/ @iofbonehealth
About Osteoporosis International
An international multi-disciplinary journal which is a joint initiative between the International Osteoporosis Foundation (IOF) and the National Osteoporosis Foundation (NOF) of the USA, ' Osteoporosis International ' provides an interdisciplinary platform for the communication of high quality original, experimental or clinical papers on all aspects of osteoporosis and other metabolic bone diseases. It publishes studies pertaining to the diagnosis, prevention, treatment and management of osteoporosis, and the spectrum of disorders that deficiencies in bone density can produce.
Editors in Chief: John A. Kanis, Felicia Cosman
2017 Impact Factor: 3.856, 5-year Impact Factor: 4.011
Ranked 40th of 143 journals in the category Endocrinology and Metabolism
Osteoporosis International