Articles tagged with Osteoporosis
A new study reveals that the Estrogen–SIRT5–FDX1 axis preserves osteogenesis by inhibiting cuproptosis in mesenchymal stem cells (MSCs). SIRT5 demalonylates ferredoxin 1 (FDX1), reducing cuproptotic signaling and preserving osteogenic differentiation.
A new hypothesis proposes that women's reproductive resilience is key to understanding longevity, with menopause representing an important inflection point in the loss of reproductive resilience. This framework challenges traditional views on aging and fertility, highlighting the importance of studying women in longevity research.
The new position statement offers practical recommendations for the assessment, diagnosis, and management of PLO. It recommends individualized management, including pharmacological treatment where appropriate.
A research team developed a bioceramic material that releases magnesium ions in accordance with the stages of osteoporotic fracture healing, suppressing inflammatory immune responses. The study suggests advanced fracture treatment materials could regulate immune responses to promote bone regeneration.
The IOF Musculoskeletal Rare Diseases Training Course bridges latest scientific advances with current clinical guidance, covering disorders-specific programs. Clinicians can access high-quality educational content at their own pace to deepen expertise in rare skeletal conditions diagnosis and management.
Researchers found a link between periodontitis and osteoporosis through gut bacteria, showing how oral inflammation can accelerate whole-body bone deterioration. This study suggests maintaining oral health may play a role in systemic bone health.
A new nationwide Austrian study found that bone fractures are often part of a complex pattern of multiple conditions, underscoring the need for consistent osteoporosis screening at the time of a fracture. Osteoporosis is not systematically documented for many fracture types, highlighting a diagnostic gap, especially in men.
A new position statement calls for systematic bone health optimization before joint replacement and spinal fusion surgery. Key findings include the progressive mechanical failure of bone-implant constructs resulting from compromised bone quality, particularly due to osteoporosis.
Researchers have successfully mapped the cells and genes that regulate bone formation and loss, revealing blood vessel cells play a critical role in bone health. The discovery has the potential to enable the development of new therapies to reverse bone loss and improve treatments for osteoporosis and other skeletal conditions.
Researchers found that CAR3 coordinates bone formation and regeneration by forming a molecular complex with collagen type I alpha 1 and recruiting bone sialoprotein. The study identified CAR3 as a previously unrecognized regulator of osteoblast differentiation, highlighting its potential for treating bone disorders.
A retrospective cohort study found that menopausal hormone therapy significantly reduces the risk of low bone mineral density by 69% compared to non-users. This suggests that hormone therapy could be an effective way to prevent bone loss and lower fracture risks in women after menopause.
A new review highlights advances in preventing bone loss in people with rheumatoid arthritis, showing that modern antirheumatic therapies can significantly reduce both localized erosions and generalized bone loss. Emerging imaging technologies like HR-pQCT have been found to detect subtle bone erosions earlier and more sensitively.
Researchers investigate MDK's role in bone remodeling and inflammation, finding its inhibition enhances osteogenesis while suppressing inflammatory response. Inhibition also restores PI3K/Akt pathway activity, promoting osteogenic gene expression and enhancing bone formation.
Researchers identified a vitamin K-dependent GAS6 pathway that controls osteoclast maturation and bone resorption in mice. Osteoblasts use Vitamin K signals to regulate osteoclast fusion via the GAS6 pathway.
The Capture the Fracture program has achieved a major milestone, identifying over one million patients with fragility fractures every year. This growth reflects increasing recognition of coordinated post-fracture care services as an essential component of modern hospital care.
A study found that accelerated retinal aging is associated with lower bone mineral density and an increased risk of fractures. The researchers developed a method to estimate biological age in the retina, which can predict incident osteoporosis.
A new editorial by IOF members highlights the alarming high post-fracture mortality in Africa and emphasizes the need for a targeted, Africa-driven strategy. The authors propose five strategic priorities to build bone health into national health systems, education, and policy.
The International Osteoporosis Foundation is seeking an Editor-in-Chief for the European office of Osteoporosis International, a world-leading peer-reviewed journal focused on osteoporosis and metabolic bone diseases. The successful candidate will oversee content development, peer review, and strategic oversight of the journal.
The International Osteoporosis Foundation has awarded Professor Roland Chapurlat the prestigious IOF Olof Johnell Science Award for his seminal contributions to understanding and managing osteoporosis, osteoarthritis, and skeletal rare bone diseases. He is recognized as one of the leading clinical academics in the field worldwide.
Professor Radmila Matijevic received the IOF CNS Medal for her outstanding work in advancing bone health awareness, diagnosis, and management. Her contributions to osteoporosis research and clinical practice have improved patient care in Serbia and the wider Balkan region.
Twenty-three young investigators from 16 countries received the ESCEO-IOF Young Investigator Awards for their outstanding abstracts submitted to the WCO-IOF-ESCEO 2026 Congress. The awards aim to support and attract young researchers to the field of musculoskeletal research.
Professor Thierry Chevalley has received the prestigious IOF President's Award for his significant contributions to advancing bone health and osteoporosis prevention. With extensive research expertise in geriatrics and bone health, he serves on various scientific committees and leads efforts to develop fracture liaison services.
Professor Noriko Yoshimura has received the IOF CSA Medal of Achievement for her pioneering work on epidemiology and prevention of locomotive organ disorders and osteoporosis. Her research, including the ROAD Study, has significantly advanced understanding of musculoskeletal health.
Researchers discovered that APOE4 causes bone quality deficits specifically in female mice, through a mechanism invisible to standard imaging. The study reveals an unexpected biological link between Alzheimer's risk and skeletal health, pointing to osteocytes as potential early warning signals for both conditions.
A laser-based cell isolation system enabled researchers to isolate and analyze osteoblasts, revealing a new mechanism regulating bone formation. A combination therapy strategy targeting both WNT and TGF-β signaling pathways is proposed to enhance treatment efficiency.
A new study identifies TIGAR as a key regulator of osteoblast redox homeostasis and bone formation under glucocorticoid stress. TIGAR mitigates oxidative damage and apoptosis by activating autophagy-dependent Nrf2 signaling.
A new study from Tulane University found that women with high predicted cardiovascular risk face nearly double the risk of hip fracture. The association was stronger in women under 65, and higher cardiovascular risk was linked to fractures in weakened bones in major areas.
A new platform, Build Better Bones, offers evidence-based guidance and practical resources for osteoporosis management. The platform, developed by the International Osteoporosis Foundation, provides a trusted place for people with osteoporosis to start their journey, with a focus on exercise, nutrition, and home safety.
Copper metabolism plays a crucial role in inflammatory bone diseases, with copper overload suppressing glycogen synthesis and increasing inflammatory activity. Researchers found that cuproptosis, a form of programmed cell death, can lead to bone weakening and osteoclast formation, providing a potential new therapeutic target.
Research reveals that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. Microbial metabolites like indole-3-lactic acid inhibit osteoclast differentiation and activity.
Researchers have discovered that two osteoporosis drugs, etidronate and tiludronate, can bind to excess iron, reducing oxidative stress and preventing cell damage. This finding holds promise for patients with iron overload diseases, but further studies are needed to confirm its potential as a treatment.
Researchers from UPF and 3D-Shaper Medical developed a new computational system to predict and prevent the risk of hip fracture among people with osteoporosis. The system, which simulates the functioning of hip bone tissue using 3D images and finite elements modeling, has been shown to be a robust alternative to current clinical methods.
Primary biliary cholangitis (PBC) is associated with a high incidence of osteoporosis, characterized by reduced bone mass and increased fracture risk. The pathogenesis involves immune dysregulation, cholestasis, liver damage, and metabolic alterations, highlighting the need for PBC-specific management strategies.
A new review highlights the need for planned sequential bone therapy to reduce the risk of spontaneous vertebral fractures after denosumab therapy. Denosumab discontinuation can trigger a 'rebound phenomenon' marked by rapid bone turnover, bone loss, and potentially multiple vertebral fractures.
A new study from Imperial College London finds that hormone replacement therapy applied via the skin is the best way to protect bone density in women whose periods have stopped due to anorexia or intense exercise. This is because transdermal HRT and teriparatide demonstrate clinically significant benefits on bone mineral density, with ...
A new study from McGill University found that a liver-derived protein helps regulate bone growth in male mice, but not in females. The protein, plasma fibronectin, builds up in bones to modulate formation, suggesting men rely more heavily on it for bone strength.
Researchers found that hormone treatment reduces abnormal nerve invasion and improves chronic back pain by limiting nerve growth inside damaged spinal tissue. The study suggests that parathyroid hormone can reverse the process by activating natural signals.
Vertebral fractures are a devastating complication of advanced kidney disease, associated with increased risk of further fractures and cardiovascular events. The first global consensus statement offers practical recommendations for clinicians to identify and manage vertebral fractures in patients with chronic kidney disease stages G4–G5D.
A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
A comprehensive genetic investigation by Dr. Feng Liu and collaborators identifies shared genetic loci between schizophrenia and osteoporosis, suggesting overlapping biological pathways. The study found that psychiatric patients face elevated fracture risks due to these molecular connections.
Scientists have discovered that studying 7% of the bone mass can accurately predict whether a woman with osteoporosis will suffer a hip fracture. The new computational model has an accuracy rate of 95%, allowing for personalized treatments tailored to specific areas of need.
The Asia Pacific Regional Audit highlights key trends, gaps, and opportunities in 22 countries and regions. The audit reveals a steep rise in fracture rates due to poor bone health and an ageing population, with China, Malaysia, and Australia experiencing significant increases.
A study of over 10,000 women aged 65 and older found that moderate tea consumption was associated with higher bone mineral density, a key indicator of osteoporosis risk. In contrast, excessive coffee consumption, particularly in those who drink alcohol, may be detrimental to bone health.
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
Researchers developed a two-layer shell to encapsulate estradiol, delivering it directly to weakened bones and reversing osteoporosis. The new drug-delivery system showed improved bone density in treated mice without uterine side effects.
Researchers developed an AI tool to detect bone loss using CT scans originally taken for other purposes, revealing trends in bone loss across a diverse patient population. The study found that young women had higher bone density than men of the same age, with steeper declines among postmenopausal women.
Researchers found that PAI-1 levels increase with age in both sexes, but only female mice lacking the gene experienced significant protection against age-related muscle and bone loss. Female mice maintained stronger grip strength and greater muscle mass, while showing less cortical bone loss.
The International Osteoporosis Foundation unveils a global fundraising and engagement platform called Give For Your Bones, aiming to motivate individuals and organizations to support bone health worldwide. The platform provides creative ideas for fundraising and physical activity challenges, making it easy to support IOF's mission of p...
A large-scale study uncovered a strong connection between osteoporosis and rotator cuff tears, finding that individuals with osteoporosis are 1.56 times more likely to suffer an RCT. The study also identified common genetic variants influencing both conditions, suggesting a possible biological explanation for the link.
Researchers found miR-378 suppresses bone marrow stromal cell osteogenesis and hinders fracture healing in an OVX-induced osteoporosis model. MiR-378 overexpression increased osteoclastogenesis by activating NF-κB signaling pathways, impairing bone formation.
Brazilian researchers analyzed over 60 scientific articles on microplastics and their impact on bone health. They found that the materials can impair bone marrow stem cells, accelerate cell aging, and promote inflammation, leading to potential bone weakening and fractures.
Research focuses on lysosome, iron, and mitochondria connections in osteoclasts. Lysosomes regulate intracellular iron mobilization and mitochondria rely on iron for energy metabolism.
A new study published in Clinical Chemistry and Laboratory Medicine has developed a practical tool to support harmonization and quality improvement in vitamin D testing. The multicentre study evaluates the measurement uncertainty of various 25-(OH)D assays and their ability to detect physiologically relevant changes over time.
The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.
A new review emphasizes the importance of both physical activity and reduced sedentary time for optimal skeletal health. Emerging evidence reveals that prolonged sitting and inactivity can harm bone health, even among regular exercisers.
A comprehensive study of Singaporean women in their 20s-30s found that nearly one in four healthy-weight Chinese women already have low muscle mass and weaker bones, despite appearing healthiest by BMI standards. The study highlights the need for healthcare approaches that consider body composition beyond simple weight measurements.
A recent study published in the Journal of the Endocrine Society found that skipping breakfast and having late dinners are associated with an increased risk of osteoporosis. Additionally, unhealthy eating habits were linked to other lifestyle risk factors such as physical inactivity, smoking, and insufficient sleep.
Researchers explore the benefits of nucleic acid aptamers in targeted therapies for bone tissue regeneration, revealing their potential in managing orthopedic conditions. Aptamers can modulate key molecular pathways involved in bone repair, advancing the standard of care for fractures and various types of bone diseases.
The International Osteoporosis Foundation has issued an updated joint position statement on managing aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer. The guidelines incorporate recent clinical trials and systematic reviews to provide evidence-based treatment algorithms for assessing fracture risk ...
Scientists at Leipzig University have discovered that the adhesion G protein-coupled receptor GPR133 plays a central role in building and maintaining healthy bone. By mimicking natural activation, a new active substance AP503 can strengthen bones and potentially treat osteoporosis.