Articles tagged with Osteoporosis
The International Osteoporosis Foundation has presented the prestigious IOF President’s Award to Professor Peter Ebeling AO in recognition of his longstanding contributions to advancing the work of the IOF. He is an internationally renowned expert in bone health, with a total of over 536 peer-reviewed publications and a h-index of 93.
A comprehensive review examines the impact of osteoporosis on fracture healing and the effects of osteoporosis medications. The study concludes that there is no deleterious effect of osteoporosis medications on fracture healing, and prompt treatment can reduce the risk of secondary fractures.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis have issued new guidelines for managing osteoporosis in men. These recommendations cover disease burden, fracture risk assessment, treatment thresholds, and interventions to reduce the substantial morbidity and mortality ass...
A study from Lund University found that a ceramic bone substitute injection improves the strength of bone anchors and enhances peri-implant bone formation. The treatment combination shows promising results in increasing bone tissue density by up to 10% six months after surgery.
Research found a consistent association between green space and reduced risk of osteoporosis, with each increase in NDVI corresponding to higher bone mineral density and 5% lower risk. Lower levels of air pollution in green spaces were also significant contributors.
The new diagnostic tool, 3D-DXA, complements DXA with computational and statistical systems to estimate mineral density and obtain detailed three-dimensional images. This method has the potential to improve diagnoses and detect up to 50% more patients at high risk of femur fracture.
Researchers discovered two compounds in female ginseng with potent anti-osteoporotic activity and blocked key molecular pathways involved in bone loss. The study opens up possibilities for new osteoporosis treatments based on the compound, whether in its current form or as a structural template.
Researchers from Tokyo University of Science identify Cpeb4 protein's crucial role in mRNA splicing and osteoclast differentiation, shedding light on bone disease mechanisms. The study's findings may lead to new diagnostic techniques and treatments for conditions like osteoporosis.
Researchers found that one in five adults reported difficulty walking a kilometre, and those with more limitations had significantly higher fracture risks. The study suggests asking about walking ability could help identify individuals needing further screening and prescribe interventions to prevent fractures.
A new special issue of Calcified Tissue International & Musculoskeletal Research sheds light on sarcopenia's pathogenesis, clinical implications, and therapeutic targets. Researchers have made significant progress in evaluating, managing, and developing interventions for this condition.
Researchers found a clear dose-response relationship between long-term topical corticosteroid use and elevated risks of osteoporosis and major osteoporotic fractures. Women under 50 had higher risks compared to men and other age groups, emphasizing the importance of careful treatment.
A longitudinal study of Hispanic adolescents and young adults found that PFAS exposure is linked to lower bone mineral density and a higher risk of osteoporosis. The study's findings highlight the need for stricter regulation of PFAS to protect vulnerable populations.
A study published in the American Journal of Human Biology found that COVID-19 has negatively impacted bone tissue, particularly among young adults. The research indicates a significant decrease in bone mineral density during the pandemic compared to pre-pandemic measurements.
Researchers at Hudson Institute of Medical Research discovered a novel RUNX1 genetic variant linked to unexplained severe osteoporosis in young adults. The study's findings suggest that this mutation may be responsible for the condition's severity and potentially lead to targeted treatment options.
A new study has found that most patients with osteoporosis want to receive information on their fracture risk, but only half of them actually get it. Patients prefer visual representations, such as graphs with a colored traffic-light system, to communicate fracture risk and are more likely to take medication if presented in this way.
Researchers developed an innovative imaging technique to study cells in bones of mice, revealing distinct pockets of bone resorption activity. This knowledge could lead to new treatments for osteoporosis and dormant cancer cells.
Researchers used deep learning to identify dihydroartemisinin as a potential osteoporosis treatment that maintains mesenchymal stem cell stemness and produces more osteoblasts. The study found that administering DHA extract for six weeks significantly reduced bone loss in mice with induced osteoporosis.
The new comprehensive guideline from Osteoporosis Canada provides recommendations for exercise, nutrition, fracture risk assessment, treatment, and more to optimize skeletal health and prevent fractures. The guideline recommends screening in men and younger women, reflecting advances in risk assessment and nonpharmacologic and pharmaco...
A study of hospitalized adults with new-onset atrial fibrillation found that 1 in 3 patients experienced a recurrent episode of AF within a year. This rate is approximately 7 times higher than in matched control participants, suggesting that oral anticoagulation therapy may be warranted for these patients.
The presentation discusses newer non-invasive technologies like trabecular bone score (TBS) and vertebral fracture assessment (VFA) to assess bone health. These advances provide additional information beyond bone mineral density, helping to identify patients at risk for fractures.
Researchers at Lund University developed a new 3D-simulation method to identify individuals at high risk of osteoporotic fractures. The method uses 2D X-ray images to produce 3D models of the thigh bone, enabling simulations of different scenarios and assessing risk more accurately.
A new Australian study found that implementing simple bone-strengthening strategies throughout the community can lead to a substantial decrease in hip fractures. The study analyzed data from over 3000 individuals aged 60+ and showed a 45% decline in hip fractures despite only a 3% increase in bone mineral density.
A five-year study will enroll 2,634 adults with a fragility fracture to compare Augmented-Fracture Liaison Service Care with Enhanced Usual Care. The primary measure of effective patient care will be the number of subsequent fractures in each group.
A new study by the PhyloBone project at the University of Turku has identified 255 proteins in 30 species of vertebrates that may play a key role in regulating bone formation and regeneration. The research could lead to new treatments and preventive measures for osteoporosis, a condition that affects millions worldwide.
Scientists have identified a molecule that regulates nerve cell sensors, which could lead to new therapeutics for obesity, osteoporosis, and inflammatory diseases. The molecule can be modified into peptide-based therapeutics to boost the activity of channels involved in bone strength and satiety.
Researchers have identified a protein called Hmga1 that may help prevent bone loss associated with postmenopausal osteoporosis. Increasing the expression of this protein in rats partially reversed bone loss in ovariectomized animals, suggesting its potential as a therapeutic target.
A new review describes the development and impact of a Latin American mentorship program for Fracture Liaison Services (FLS), resulting in 64 FLSs getting started and providing coverage for over 17,200 patients. The program also supports the establishment of active communities of mentors across Mexico, Brazil, Colombia, and Argentina.
The Capture the Fracture Partnership has successfully driven global Fracture Liaison Services implementation, effectiveness, and sustainability. The partnership's unique approach, including policy, coalitions, mentorship, and scalable solutions, has delivered impactful resources and activities to prioritize secondary fracture prevention.
Researchers will compare two care models to improve care for patients with fractures, including bone-strengthening medications and deprescribing care models. The study aims to provide high-quality care after a broken bone and reduce falls and injuries.
A new position paper reviews TBS for fracture risk prediction, treatment initiation and monitoring in osteoporosis. The evidence-based guide provides practical guidance for clinicians to integrate TBS into clinical practice.
Researchers developed a portable electrochemical device that can detect five genetic variations associated with increased osteoporosis risk in finger-prick blood samples. The test is quick (15 minutes), inexpensive (<$0.5 per SNP) and offers great potential for point-of-care settings.
A comprehensive review of biochemical markers for bone fragility in diabetes identifies low bone turnover and alterations in bone quality as key factors. The study suggests that glycemic control, AGEs, and serum IGF-1 may have predictive value for fracture risk in patients with diabetes.
Research in the BMJ Open journal suggests that mid-life structural changes to the jawbone may signal subsequent height loss in women. The study, conducted on a cohort of women in Gothenburg, Sweden, found that severe cortical erosion and sparse trabeculation in the jawbone predicted significant bone shrinkage over time.
A new $7 million study at Wake Forest University is investigating the impact of resistance training, bone-loading exercises, and osteoporosis medication on bone health in older adults who are losing weight. The study aims to determine whether these interventions can help preserve bone mass and reduce fracture risk.
A novel 'robotic pill' has been found to safely deliver the osteoporosis medication teriparatide orally, with comparable bioavailability to traditional injections. This breakthrough technology could offer a painless and more accessible treatment option for patients suffering from chronic conditions.
A global study predicts a significant increase in hip fractures worldwide by 2050, with the number projected to nearly double compared to 2018. The study highlights a post-fracture treatment gap in fracture prevention, particularly for men, leading to increased mortality and dependency.
Scientists discovered a novel method to activate G protein-coupled receptors from inside cells, which can help develop drugs with fewer or no side effects. This new process uses a non-peptide message molecule called PCO371 that binds to the intracellular region of the receptor and interacts directly with G protein subunits.
Researchers analyzed data from 120 clinical trials and found no evidence that treatment efficacies differ depending on the number of comorbidities. The study suggests that modest levels of comorbidities do not affect treatment outcomes, providing valuable insights for clinicians to make informed recommendations.
A new study has defined analytical performance specifications for 24,25-dihydroxyvitamin D examinations, which is essential for developing accurate methods to detect this metabolite. The findings show that the variation of 24,25(OH)2D concentration over time was significantly associated with 25(OH)D concentrations and body mass index.
A study of nearly 67,200 postmenopausal women found that the Fracture Risk Assessment Tool (FRAX) was inadequate for identifying osteoporotic fracture risk across racial/ethnic categories. However, the Osteoporosis Self-Assessment Tool (OST) was excellent for detecting osteoporosis within each category.
Researchers developed a 'Skeletal Age' metric to assess impact of fractures on mortality, revealing a loss of one to seven years of life depending on gender, age, and bone site. The online calculator measures bone fragility to help doctors and patients understand fracture risks.
The new FRAXplus beta version offers a more user-friendly platform to refine risk factor information, allowing clinicians to explore the impact on individual patients. The tool provides helpful features such as saved data and export options to facilitate sharing.
Professor Nicholas Harvey received the prestigious IOF Olof Johnell Science Award for his outstanding scientific contributions to osteoporosis. The award recognizes his work on fracture risk assessment tools and musculoskeletal research.
A new study confirms that hormone therapies increase lumbar spine bone mineral density and protect against bone loss in postmenopausal women. The benefits of hormones on bone health persist even after therapies are discontinued.
The IOF Medal of Achievement is awarded to individuals who significantly advance osteoporosis research and increase awareness of the disease. Professor Jean-Yves Reginster has made major impacts on the field through his original scientific contributions, education, and advocacy.
Renowned astronaut Samantha Cristoforetti received the International Osteoporosis Foundation President’s Award for her collaboration on the "Lift Off For Bone Health" public awareness campaign. The campaign reached over three million people, with videos viewed close to two million times.
Professor Osvaldo Daniel Messina was awarded the 2023 IOF CNS Medal for his significant contributions to osteoporosis prevention. He has expanded IOF's messages and outreach in Argentina and internationally, promoting fracture prevention and healthy mobility.
Bernard Cortet receives ESCEO-IOF Herbert Fleisch Medal for groundbreaking contributions to osteoporosis research, including publications on clinical recommendations and patient outcomes. He is recognized for his leadership roles in French Society of Rheumatology and Osteoporosis Research and Information Group.
Professor Bess Dawson-Hughes has been recognized with the 2023 IOF President’s Award for her significant contributions to advancing osteoporosis research and treatment. Her extensive body of work has led to a greater understanding of nutrition's role in age-related bone loss.
The International Osteoporosis Foundation (IOF) has awarded five young investigators grants for their research on nutritional factors and musculoskeletal health. The winners' projects focus on various aspects of diet, exercise, and bone health, with potential to lead to clinical advances or preventative strategies.
The IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases is the largest international scientific event devoted to musculoskeletal disorders. The congress presents new clinical advances and research on osteoporosis, osteoarthritis, sarcopenia, frailty, and rare skeletal disorders.
The Build Better Bones platform provides practical guidance on strengthening bones through targeted exercises and bone-healthy nutrition. The platform also offers helpful information for caregivers, including support with daily tasks and medical specialty knowledge.
A study analyzing 34,000 people found that lowering sclerostin levels may increase the risk of heart attack, stroke, and type 2 diabetes. The research suggests that strategies to minimize potential impact on heart attack risk are needed.
A new study by Van Andel Institute scientists identifies KDM5C as a key driver of low bone density, preserving bone mass in mice. The discovery may lead to more effective treatments for women with osteoporosis, reducing the risk of fractures and improving quality of life.
A large study found that air pollution accelerates bone loss from osteoporosis in postmenopausal women, particularly on the lumbar spine. Nitrogen oxides were identified as a major contributor to this damage.
A University of Gothenburg study found that wheelchair users had significantly lower rates of fractures compared to ambulatory older adults. The study, which included 55,442 wheelchair users in Sweden, showed that wheelchair use was associated with a reduced risk of fractures, particularly osteoporotic and hip fractures.
A new study found that long-term voluntary wheel running improved skeletal muscle and bone parameters in female mice, but the effects varied depending on body weight. High body weight was more beneficial for muscle and bone health with aging, especially when combined with exercise.
A new economic model estimates the health benefits and budget impact of Fracture Liaison Services, showing significant reductions in fragility fractures, hospital bed days, and social care costs. The model suggests that FLS implementation would lead to improved patient outcomes and cost-effectiveness.
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.