Articles tagged with Osteoporosis
Researchers at Lund University developed a new 3D-simulation method to identify individuals at high risk of osteoporotic fractures. The method uses 2D X-ray images to produce 3D models of the thigh bone, enabling simulations of different scenarios and assessing risk more accurately.
A new Australian study found that implementing simple bone-strengthening strategies throughout the community can lead to a substantial decrease in hip fractures. The study analyzed data from over 3000 individuals aged 60+ and showed a 45% decline in hip fractures despite only a 3% increase in bone mineral density.
A five-year study will enroll 2,634 adults with a fragility fracture to compare Augmented-Fracture Liaison Service Care with Enhanced Usual Care. The primary measure of effective patient care will be the number of subsequent fractures in each group.
A new study by the PhyloBone project at the University of Turku has identified 255 proteins in 30 species of vertebrates that may play a key role in regulating bone formation and regeneration. The research could lead to new treatments and preventive measures for osteoporosis, a condition that affects millions worldwide.
Scientists have identified a molecule that regulates nerve cell sensors, which could lead to new therapeutics for obesity, osteoporosis, and inflammatory diseases. The molecule can be modified into peptide-based therapeutics to boost the activity of channels involved in bone strength and satiety.
Researchers have identified a protein called Hmga1 that may help prevent bone loss associated with postmenopausal osteoporosis. Increasing the expression of this protein in rats partially reversed bone loss in ovariectomized animals, suggesting its potential as a therapeutic target.
A new review describes the development and impact of a Latin American mentorship program for Fracture Liaison Services (FLS), resulting in 64 FLSs getting started and providing coverage for over 17,200 patients. The program also supports the establishment of active communities of mentors across Mexico, Brazil, Colombia, and Argentina.
The Capture the Fracture Partnership has successfully driven global Fracture Liaison Services implementation, effectiveness, and sustainability. The partnership's unique approach, including policy, coalitions, mentorship, and scalable solutions, has delivered impactful resources and activities to prioritize secondary fracture prevention.
Researchers will compare two care models to improve care for patients with fractures, including bone-strengthening medications and deprescribing care models. The study aims to provide high-quality care after a broken bone and reduce falls and injuries.
A new position paper reviews TBS for fracture risk prediction, treatment initiation and monitoring in osteoporosis. The evidence-based guide provides practical guidance for clinicians to integrate TBS into clinical practice.
Researchers developed a portable electrochemical device that can detect five genetic variations associated with increased osteoporosis risk in finger-prick blood samples. The test is quick (15 minutes), inexpensive (<$0.5 per SNP) and offers great potential for point-of-care settings.
A comprehensive review of biochemical markers for bone fragility in diabetes identifies low bone turnover and alterations in bone quality as key factors. The study suggests that glycemic control, AGEs, and serum IGF-1 may have predictive value for fracture risk in patients with diabetes.
Research in the BMJ Open journal suggests that mid-life structural changes to the jawbone may signal subsequent height loss in women. The study, conducted on a cohort of women in Gothenburg, Sweden, found that severe cortical erosion and sparse trabeculation in the jawbone predicted significant bone shrinkage over time.
A new $7 million study at Wake Forest University is investigating the impact of resistance training, bone-loading exercises, and osteoporosis medication on bone health in older adults who are losing weight. The study aims to determine whether these interventions can help preserve bone mass and reduce fracture risk.
A novel 'robotic pill' has been found to safely deliver the osteoporosis medication teriparatide orally, with comparable bioavailability to traditional injections. This breakthrough technology could offer a painless and more accessible treatment option for patients suffering from chronic conditions.
A global study predicts a significant increase in hip fractures worldwide by 2050, with the number projected to nearly double compared to 2018. The study highlights a post-fracture treatment gap in fracture prevention, particularly for men, leading to increased mortality and dependency.
Scientists discovered a novel method to activate G protein-coupled receptors from inside cells, which can help develop drugs with fewer or no side effects. This new process uses a non-peptide message molecule called PCO371 that binds to the intracellular region of the receptor and interacts directly with G protein subunits.
Researchers analyzed data from 120 clinical trials and found no evidence that treatment efficacies differ depending on the number of comorbidities. The study suggests that modest levels of comorbidities do not affect treatment outcomes, providing valuable insights for clinicians to make informed recommendations.
A new study has defined analytical performance specifications for 24,25-dihydroxyvitamin D examinations, which is essential for developing accurate methods to detect this metabolite. The findings show that the variation of 24,25(OH)2D concentration over time was significantly associated with 25(OH)D concentrations and body mass index.
A study of nearly 67,200 postmenopausal women found that the Fracture Risk Assessment Tool (FRAX) was inadequate for identifying osteoporotic fracture risk across racial/ethnic categories. However, the Osteoporosis Self-Assessment Tool (OST) was excellent for detecting osteoporosis within each category.
Researchers developed a 'Skeletal Age' metric to assess impact of fractures on mortality, revealing a loss of one to seven years of life depending on gender, age, and bone site. The online calculator measures bone fragility to help doctors and patients understand fracture risks.
The new FRAXplus beta version offers a more user-friendly platform to refine risk factor information, allowing clinicians to explore the impact on individual patients. The tool provides helpful features such as saved data and export options to facilitate sharing.
Professor Nicholas Harvey received the prestigious IOF Olof Johnell Science Award for his outstanding scientific contributions to osteoporosis. The award recognizes his work on fracture risk assessment tools and musculoskeletal research.
A new study confirms that hormone therapies increase lumbar spine bone mineral density and protect against bone loss in postmenopausal women. The benefits of hormones on bone health persist even after therapies are discontinued.
The IOF Medal of Achievement is awarded to individuals who significantly advance osteoporosis research and increase awareness of the disease. Professor Jean-Yves Reginster has made major impacts on the field through his original scientific contributions, education, and advocacy.
Renowned astronaut Samantha Cristoforetti received the International Osteoporosis Foundation President’s Award for her collaboration on the "Lift Off For Bone Health" public awareness campaign. The campaign reached over three million people, with videos viewed close to two million times.
Professor Osvaldo Daniel Messina was awarded the 2023 IOF CNS Medal for his significant contributions to osteoporosis prevention. He has expanded IOF's messages and outreach in Argentina and internationally, promoting fracture prevention and healthy mobility.
Bernard Cortet receives ESCEO-IOF Herbert Fleisch Medal for groundbreaking contributions to osteoporosis research, including publications on clinical recommendations and patient outcomes. He is recognized for his leadership roles in French Society of Rheumatology and Osteoporosis Research and Information Group.
Professor Bess Dawson-Hughes has been recognized with the 2023 IOF President’s Award for her significant contributions to advancing osteoporosis research and treatment. Her extensive body of work has led to a greater understanding of nutrition's role in age-related bone loss.
The International Osteoporosis Foundation (IOF) has awarded five young investigators grants for their research on nutritional factors and musculoskeletal health. The winners' projects focus on various aspects of diet, exercise, and bone health, with potential to lead to clinical advances or preventative strategies.
The IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases is the largest international scientific event devoted to musculoskeletal disorders. The congress presents new clinical advances and research on osteoporosis, osteoarthritis, sarcopenia, frailty, and rare skeletal disorders.
The Build Better Bones platform provides practical guidance on strengthening bones through targeted exercises and bone-healthy nutrition. The platform also offers helpful information for caregivers, including support with daily tasks and medical specialty knowledge.
A study analyzing 34,000 people found that lowering sclerostin levels may increase the risk of heart attack, stroke, and type 2 diabetes. The research suggests that strategies to minimize potential impact on heart attack risk are needed.
A new study by Van Andel Institute scientists identifies KDM5C as a key driver of low bone density, preserving bone mass in mice. The discovery may lead to more effective treatments for women with osteoporosis, reducing the risk of fractures and improving quality of life.
A large study found that air pollution accelerates bone loss from osteoporosis in postmenopausal women, particularly on the lumbar spine. Nitrogen oxides were identified as a major contributor to this damage.
A University of Gothenburg study found that wheelchair users had significantly lower rates of fractures compared to ambulatory older adults. The study, which included 55,442 wheelchair users in Sweden, showed that wheelchair use was associated with a reduced risk of fractures, particularly osteoporotic and hip fractures.
A new study found that long-term voluntary wheel running improved skeletal muscle and bone parameters in female mice, but the effects varied depending on body weight. High body weight was more beneficial for muscle and bone health with aging, especially when combined with exercise.
A new economic model estimates the health benefits and budget impact of Fracture Liaison Services, showing significant reductions in fragility fractures, hospital bed days, and social care costs. The model suggests that FLS implementation would lead to improved patient outcomes and cost-effectiveness.
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.
Patients with high fracture risk and complex medical conditions are less likely to receive osteoporosis treatment and have poorer health outcomes. The study highlights the need for a comprehensive treatment approach that considers the patient as a whole, rather than just focusing on individual diseases and treatments.
The American College of Physicians recommends bisphosphonates as initial pharmacologic treatment to reduce fracture risk in osteoporosis patients. Long-term use may increase risks, so treatment duration should be limited to 5 years or less.
Researchers compared zebrafish and medaka bones, finding medaka lacks bone cells but retains water-absorbing Proteoglycans. The study suggests a new explanation for why some bones respond better to stress than others.
Despite the availability of accurate tests, bone density screenings for women over 65 years old have dropped significantly since 2009. The decline coincided with a reduction in Medicare reimbursements for office-based scans, particularly affecting rural communities.
Researchers from Complexity Science Hub and Medical University of Vienna found that high doses of cholesterol-lowering statins impair bone quality in mice, with a significant increase in osteoporosis risk. The study confirms previous findings on the correlation between statin use and osteoporosis diagnosis in humans.
Researchers found that vitamin D deficiency increases the risk of dynapenia, an age-associated loss of muscle strength, by 70-78%. Vitamin D supplementation was shown to reduce this risk. The study analyzed data from over 3,000 individuals aged 50 and over, highlighting the importance of vitamin D for maintaining muscle strength.
Researchers at Massachusetts General Hospital have identified a promising oral compound that stimulates bone formation in mice, increasing blood levels of calcium and vitamin D. The compound, SK-124, boosts bone formation and mass without short-term toxicity, offering new hope for preventing and treating osteoporosis.
Researchers are exploring how aging affects communication between bone and muscle, finding that imbalance can lead to muscle loss, falls, and bone fractures. They aim to develop novel interventions to restore this balance, potentially treating osteoporosis and sarcopenia.
A new calculator will assess an individual's risk and benefit of taking bisphosphonates for osteoporosis, considering factors such as fracture history and comorbid conditions. The calculator aims to provide personalized guidance on whether a drug holiday is beneficial or not.
The IOF and ESCEO position paper recommends retaining the current WHO diagnostic criteria for osteoporosis, which has served the field well. The paper suggests that distinguishing between diagnostic and intervention thresholds can help improve treatment of patients at high risk of fractures.
A study found that higher levels of inflammatory markers are associated with lower trabecular bone scores, indicating poorer bone health. Dietary intervention with prunes may counteract inflammation's negative effects on bone health, preserving cortical bone density and strength in postmenopausal women.
Researchers at Tokyo Medical and Dental University identified a compound LAMZ that stimulates muscle cell growth, reduces bone resorption, and promotes bone formation. Administered to mice with locomotor frailty, LAMZ improved muscle and bone health.
A new study predicts a sharp increase in hip fractures globally, with men and the oldest old facing particularly high risks. The study's findings highlight the urgent need for improved prevention and care strategies to address this growing public health concern.
Researchers found that high blood pressure induced in young mice led to significant bone loss and osteoporosis-related damage comparable to older mice. The study suggests a possible link between inflammation, high blood pressure, and accelerated bone aging in humans.
A new mathematical framework predicts the most effective combinations of drugs to treat postmenopausal bone loss in patients. The model identifies optimal orderings that boost bone density and reduce long-term bone loss, improving treatment outcomes.
Researchers have developed an ultrasound method that can screen for bucked shin in young horses, a condition that occurs in about 70% of animals during training. The technique uses axial transmission to detect irregularities in bone formation, allowing for early diagnosis and treatment.
Researchers have identified a new protein called IFT80 that regulates osteoclasts, the cells responsible for breaking down bone. The study found that mice lacking IFT80 developed severe osteopenia, highlighting its potential as a therapeutic target for treating bone loss diseases.
A recent study published in The New England Journal of Medicine found that supplemental vitamin D did not lower the risk of fractures in healthy US adults. The research, which involved over 1,991 incident fractures and 5.3 years of follow-up, also showed no effects on major osteoporotic fractures or wrist/pelvic fractures.
Researchers found that CXCL9 levels were higher in pre-fracture blood samples of Chinese men with subsequent hip fractures, improving the prediction of osteoporotic hip fracture risk in men. In contrast, no association was found between CXCL10 and hip fracture risk in either gender.
The International Osteoporosis Foundation proposes a screening strategy to identify women at high risk of hip fracture, which could lead to a reduction in treatment gaps and improved identification of fractures. The approach combines low-cost assessment with targeted intervention using low-cost generic treatments.
A UNLV study analyzed nearly 30,000 broken bone cases and found that smoking increases the risk of breaking a bone by as much as 37%. The study also found that men are more likely to experience fractures, particularly in the wrists, spine, and shoulders, due to nicotine's negative impact on bone cells and calcium absorption.