Researchers at Massachusetts General Hospital have identified a promising oral compound that stimulates bone formation in mice, increasing blood levels of calcium and vitamin D. The compound, SK-124, boosts bone formation and mass without short-term toxicity, offering new hope for preventing and treating osteoporosis.
SourceMassachusetts General Hospital·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateDec 6, 2022
Researchers are exploring how aging affects communication between bone and muscle, finding that imbalance can lead to muscle loss, falls, and bone fractures. They aim to develop novel interventions to restore this balance, potentially treating osteoporosis and sarcopenia.
SourceMedical College of Georgia at Augusta University·DateNov 17, 2022
A new calculator will assess an individual's risk and benefit of taking bisphosphonates for osteoporosis, considering factors such as fracture history and comorbid conditions. The calculator aims to provide personalized guidance on whether a drug holiday is beneficial or not.
SourceMedical College of Georgia at Augusta University·DateNov 15, 2022
The IOF and ESCEO position paper recommends retaining the current WHO diagnostic criteria for osteoporosis, which has served the field well. The paper suggests that distinguishing between diagnostic and intervention thresholds can help improve treatment of patients at high risk of fractures.
SourceInternational Osteoporosis Foundation·JournalOsteoporosis International·TypeCommentary/editorial·DateNov 10, 2022
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
A study found that higher levels of inflammatory markers are associated with lower trabecular bone scores, indicating poorer bone health. Dietary intervention with prunes may counteract inflammation's negative effects on bone health, preserving cortical bone density and strength in postmenopausal women.
Researchers at Tokyo Medical and Dental University identified a compound LAMZ that stimulates muscle cell growth, reduces bone resorption, and promotes bone formation. Administered to mice with locomotor frailty, LAMZ improved muscle and bone health.
SourceTokyo Medical and Dental University·JournalBone Research·DateSep 13, 2022
A new study predicts a sharp increase in hip fractures globally, with men and the oldest old facing particularly high risks. The study's findings highlight the urgent need for improved prevention and care strategies to address this growing public health concern.
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers found that high blood pressure induced in young mice led to significant bone loss and osteoporosis-related damage comparable to older mice. The study suggests a possible link between inflammation, high blood pressure, and accelerated bone aging in humans.
A new mathematical framework predicts the most effective combinations of drugs to treat postmenopausal bone loss in patients. The model identifies optimal orderings that boost bone density and reduce long-term bone loss, improving treatment outcomes.
Researchers have developed an ultrasound method that can screen for bucked shin in young horses, a condition that occurs in about 70% of animals during training. The technique uses axial transmission to detect irregularities in bone formation, allowing for early diagnosis and treatment.
SourceAmerican Institute of Physics·JournalThe Journal of the Acoustical Society of America·DateAug 9, 2022
Researchers have identified a new protein called IFT80 that regulates osteoclasts, the cells responsible for breaking down bone. The study found that mice lacking IFT80 developed severe osteopenia, highlighting its potential as a therapeutic target for treating bone loss diseases.
SourceUniversity of Pennsylvania·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJul 28, 2022
A recent study published in The New England Journal of Medicine found that supplemental vitamin D did not lower the risk of fractures in healthy US adults. The research, which involved over 1,991 incident fractures and 5.3 years of follow-up, also showed no effects on major osteoporotic fractures or wrist/pelvic fractures.
SourceBrigham and Women's Hospital·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateJul 27, 2022
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers found that CXCL9 levels were higher in pre-fracture blood samples of Chinese men with subsequent hip fractures, improving the prediction of osteoporotic hip fracture risk in men. In contrast, no association was found between CXCL10 and hip fracture risk in either gender.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalJournal of Bone and Mineral Research·TypeRandomized controlled/clinical trial·DateJul 12, 2022
The International Osteoporosis Foundation proposes a screening strategy to identify women at high risk of hip fracture, which could lead to a reduction in treatment gaps and improved identification of fractures. The approach combines low-cost assessment with targeted intervention using low-cost generic treatments.
SourceInternational Osteoporosis Foundation·JournalArchives of Osteoporosis·TypeLiterature review·DateJun 29, 2022
A UNLV study analyzed nearly 30,000 broken bone cases and found that smoking increases the risk of breaking a bone by as much as 37%. The study also found that men are more likely to experience fractures, particularly in the wrists, spine, and shoulders, due to nicotine's negative impact on bone cells and calcium absorption.
SourceUniversity of Nevada, Las Vegas·JournalScientific Reports·TypeMeta-analysis·DateJun 8, 2022
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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A new AI approach can diagnose osteoporosis from hip X-rays with superior diagnostic performance than traditional methods. This could lead to faster treatment and reduced risk of fractures. Researchers developed a deep-radiomics model using image processing and analysis to identify patterns associated with disease.
SourceRadiological Society of North America·JournalRadiology Artificial Intelligence·DateMay 25, 2022
A study identified an 18-base osteogenetic ODN (iSN40) that promotes the differentiation of mouse osteoblasts and induces the expression of genes required for bone formation. This discovery offers a promising treatment option for osteoporosis, which affects 200 million people worldwide.
SourceShinshu University·JournalNanomaterials·TypeExperimental study·DateMay 23, 2022
Exercise strengthens bones, reduces fracture risk, and improves posture in people with osteoporosis. A consensus statement recommends a balanced routine of muscle strengthening exercises on 2-3 days and moderate impact activities on most days.
SourceBMJ Group·JournalBritish Journal of Sports Medicine·TypeCommentary/editorial·DateMay 16, 2022
A large observational study found that calcium supplements increased the risk of death and cardiovascular disease in older adults with aortic valve stenosis. The study, published in the journal Heart, suggests that long-term continuous calcium supplementation should be avoided for patients with high-risk cardiovascular disease.
SourceBMJ Group·JournalHeart·TypeObservational study·DateApr 25, 2022
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The UK National Osteoporosis Guideline Group has published a new guideline for the prevention and treatment of osteoporosis, which includes updated recommendations for vertebral fracture detection and anabolic treatment options. The guidance aims to improve service provision in both primary and secondary care settings.
SourceInternational Osteoporosis Foundation·JournalArchives of Osteoporosis·TypeLiterature review·DateApr 20, 2022
A new series of expert reviews explores less common causes of bone loss, including pregnancy-associated osteoporosis and anorexia nervosa-related osteoporosis. The reviews provide comprehensive information on these unusual conditions and their impact on bone health.
SourceInternational Osteoporosis Foundation·JournalCalcified Tissue International·TypeCommentary/editorial·DateApr 13, 2022
A recent study suggests that many older adults with rheumatoid arthritis are not prescribed disease-modifying medications, despite guidelines calling for early and aggressive treatment. Only 45% of patients over 65 were prescribed these medications, highlighting the need to improve prescribing practices among primary care physicians.
SourceMichigan Medicine - University of Michigan·JournalACR Open Rheumatology·TypeObservational study·DateApr 7, 2022
Researchers at UCLA found that premenopausal women with low levels of anti-Mullerian hormone are at a higher risk of experiencing significant bone loss within two to three years. The study suggests that measuring AMH levels could help physicians identify women at risk and provide targeted treatment.
SourceUniversity of California - Los Angeles Health Sciences·JournalJournal of Bone and Mineral Research·TypeMeta-analysis·DateApr 4, 2022
A recent study suggests that eating nutrient-rich prunes every day may benefit bone health in postmenopausal women by reducing inflammatory factors. The research found significant reductions in inflammatory markers in prune-eating groups compared to a control group.
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Teréza Hough, CEO of the National Osteoporosis Foundation South Africa, has been awarded the IOF CNS Medal for her outstanding contributions to bone health advocacy. Her work in raising awareness and advancing education among the public and healthcare professionals in South Africa is recognized globally.
SourceInternational Osteoporosis Foundation·DateMar 25, 2022
Dr Nicholas Fuggle, a UK researcher, has been awarded the prestigious ESCEO-IOF Pierre Meunier Young Scientist Award for his significant contributions to research in musculoskeletal ageing. He is recognized for his work on determinants of musculoskeletal ageing and digital healthcare.
SourceInternational Osteoporosis Foundation·DateMar 25, 2022
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
Professor René Rizzoli has been recognized for his significant and longstanding contribution to the advancement of osteoporosis research through his work on bone metabolism and mineralization. He is a respected researcher, clinician, and leader in the field of osteoporosis, with a strong focus on prevention and treatment.
SourceInternational Osteoporosis Foundation·DateMar 24, 2022
Professor Elaine Dennison has been awarded the IOF Olof Johnell Science Award for her significant work in musculoskeletal aging, osteoporosis, and metabolic bone diseases. She is recognized as an internationally renowned clinician, researcher, and educator.
SourceInternational Osteoporosis Foundation·DateMar 24, 2022
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The International Osteoporosis Foundation awarded Professor Thierry Thomas the IOF Committee of Scientific Advisors (CSA) Medal of Achievement for his outstanding scientific contributions to osteoporosis. The award recognizes his work on secondary fracture prevention and post-fracture care coordination programs.
SourceInternational Osteoporosis Foundation·DateMar 24, 2022
The International Osteoporosis Foundation awarded five young researchers for their groundbreaking work on the role of nutrition in musculoskeletal health. The winners, from Australia, India, and Switzerland, were recognized for their studies on vitamin K1 intake, calcium sources, and dietary inflammatory index.
SourceInternational Osteoporosis Foundation·DateMar 24, 2022
The Virtual WCO-IOF-ESCEO 2022 Congress will feature leading experts on osteoporosis, osteoarthritis, and musculoskeletal diseases, with a focus on new clinical research and advances in prevention and patient care. Prestigious awards will also be presented.
SourceInternational Osteoporosis Foundation·DateMar 24, 2022
The World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO) 2022 will discuss secondary fracture prevention. Global experts will provide clinical guidance and information on post-fracture care through various sessions.
SourceInternational Osteoporosis Foundation·DateMar 4, 2022
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that men with high levels of body fat are more likely to have lower bone density and an increased risk of fractures. The researchers analyzed data from over 10,800 people under 60 years old and found a strong positive association b...
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateFeb 10, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Prunes have been found to help prevent or delay bone loss in postmenopausal women by reducing inflammation and oxidative stress. This is due to their potential to alter the gut microbiome, which can lead to lower levels of pro-inflammatory cytokines and markers of oxidative damage.
SourcePenn State·JournalAdvances in Nutrition·TypeMeta-analysis·DateFeb 9, 2022
Scientists have identified connexin (Cx) 43 hemichannels on the surface of bone cells as a potential new target for medications to treat osteoporosis and other conditions that cause bone loss. The study, published in eLife, reveals how these channels play a crucial role in responding to mechanical stress and building stronger bones.
SourceeLife·JournaleLife·TypeExperimental study·DateFeb 8, 2022
A new review by the International Osteoporosis Foundation highlights the importance of comprehensive post-fracture care, including exercise, nutrition, physiotherapy, and patient education. The study concludes that individualized exercise approaches can improve recovery and reduce future fracture risk.
SourceInternational Osteoporosis Foundation·JournalOsteoporosis International·TypeLiterature review·DateFeb 2, 2022
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A UMass Amherst study found associations between oral contraceptive use and certain tubal ligation methods with lower levels of antimüllerian hormone (AMH), a biomarker for ovarian aging. This may suggest an increased risk for early menopause in women who have used oral contraceptives or undergone specific types of tubal ligation.
SourceUniversity of Massachusetts Amherst·JournalMenopause·TypeObservational study·DateFeb 2, 2022
A new European report reveals a massive treatment gap and disparities in osteoporosis care, with significant economic burden and projected increases in fragility fractures. The report emphasizes the need for improved service provision and uptake, particularly in countries with high disease burdens.
SourceInternational Osteoporosis Foundation·JournalArchives of Osteoporosis·TypeData/statistical analysis·DateFeb 1, 2022
A new Irish survey found that no trauma sites capture all fracture patients, with only 50% receiving osteoporosis medication within four months of a fracture. Implementing a national Fracture Liaison Service (FLS) would bring services in line with international standards and reduce hospital admissions.
SourceRCSI·JournalOsteoporosis International·DateJan 31, 2022
A new study found that oral bisphosphonates risedronate and alendronate equally protect against hip fractures during a 2-year drug holiday. However, the risk increases slightly for those taking a break from risedronate.
SourceUniversity of Toronto - Leslie Dan Faculty of Pharmacy·JournalAnnals of Internal Medicine·TypeData/statistical analysis·DateJan 12, 2022
A study identified factors at midlife associated with a decline in women's physical health 10 years later. Higher body mass index, smoking, osteoarthritis, and depressive symptoms were found to be significantly linked to clinically important declines in physical health.
SourceBrigham and Women's Hospital·JournalJAMA Network Open·DateJan 10, 2022
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A registry study found that people with inflammatory RMDs, such as rheumatoid arthritis and psoriatic arthritis, tolerate their COVID vaccine well, with short-lived reactions being the most common side effect. The majority of participants were able to continue on their normal medication with no changes.
SourceEuropean Alliance of Associations for Rheumatology (EULAR)·JournalAnnals of the Rheumatic Diseases·DateJan 7, 2022
Researchers found that bisphosphonate treatment stimulates lung macrophages to mount a stronger response against pathogens, enhancing immune function. This could lead to improved health outcomes for the older population at higher risk of pneumonia and osteoporosis.
SourceGarvan Institute of Medical Research·JournaleLife·DateJan 5, 2022
Katherine Tucker, a renowned nutritionist, has been awarded the top honor at UMass Lowell for her exceptional teaching, research, and service to the university. She will deliver the annual Distinguished University Professor Lecture and continue to lead her research team in establishing long-term interventions for diverse populations.
SourceUniversity of Massachusetts Lowell·DateDec 6, 2021
A randomized-controlled clinical trial found that eating prunes daily reduces biomarkers of bone breakdown and improves bone geometry in healthy men aged 50-79. The study adds to existing research on the beneficial effects of prunes on bone health, particularly for men.
SourceFleishman-Hillard, Sacramento·JournalJournal of Medicinal Food·TypeRandomized controlled/clinical trial·DateNov 30, 2021
UArizona researchers created osseosurface electronics, a wireless device that grows to the surface of bone to monitor health and healing. The thin structure allows for accurate measurements over long periods, enabling personalized orthopedic care.
SourceUniversity of Arizona College of Engineering·JournalNature Communications·DateNov 18, 2021
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Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Recent clinical and experimental data suggest that vascular calcification and bone loss share common pathophysiological mechanisms. The International Osteoporosis Foundation's new review elucidates the key associations between the two disorders.
SourceInternational Osteoporosis Foundation·JournalNutrients·TypeLiterature review·DateNov 15, 2021
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
SourceUniversity at Buffalo·JournalJournal of Dental Research·DateNov 12, 2021
A study published in Nature Communications reveals that the transcription factor Sp7 and its target gene osteocrin play a crucial role in osteocyte dendrite formation. Deletion of Sp7 causes severe defects in dendrites, but activating osteocrin can reverse these defects in mice.
SourceMassachusetts General Hospital·JournalNature Communications·DateNov 1, 2021
A new study from the University of Eastern Finland found that postmenopausal women experience a significant decrease in bone mineral density, but at a lower rate than previously assumed. Women who received hormone replacement therapy and those with weight gain during follow-up showed minimal bone loss.
SourceUniversity of Eastern Finland·JournalJournal of Bone and Mineral Research·DateOct 27, 2021
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GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers at University of Virginia Health System have discovered a new treatment target for osteoporosis and bone loss from rheumatoid arthritis. A cellular protein called ELMO1 promotes the activity of osteoclasts, which break down bone, leading to excessive bone degradation.
SourceUniversity of Virginia Health System·JournalNature Communications·DateOct 14, 2021
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
SourceUniversity of California - San Francisco·JournalNature·DateOct 14, 2021
Stephanie Grainger, Ph.D., awarded $2.375M grant to explore Wnt molecular pathway's role in healthy development and disease, including cancer, osteoporosis, and heart conditions.
A new study found that alendronate, a widely used osteoporosis treatment, may reduce the risk of developing type 2 diabetes by 34% compared to non-users. The study, published in Diabetologia, also suggests that longer treatment duration is associated with lower risk of type 2 diabetes.
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Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
SourceMax-Planck-Gesellschaft·JournalNature Aging·TypeExperimental study·DateSep 14, 2021
The North American Menopause Society (NAMS) has released a new position statement on the management of osteoporosis in postmenopausal women. The guidelines emphasize an individualized approach with regular follow-up to prevent fractures and maintain mobility and independence. Key findings include recommendations for calcium, vitamin D,...
SourceThe Menopause Society·JournalMenopause·TypeLiterature review·DateSep 1, 2021
The HIPGEN study, a multinational trial, investigates the efficacy and safety of allogeneic placenta-expanded adherent stromal cells to improve recovery after hip fracture arthroplasty. The trial aims to combat immobility and associated problems by strengthening periarticular hip musculature.
SourceInternational Osteoporosis Foundation·DateAug 23, 2021
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Researchers have discovered a link between cognitive decline and faster bone loss in women, increasing future fracture risk. Cognitive decline over five years was associated with a 1.7-fold increase in fracture risk in subsequent 10 years.
SourceGarvan Institute of Medical Research·JournalJournal of Bone and Mineral Research·DateJul 21, 2021
Chronic kidney disease patients are at high risk of fragility fractures, yet most receive no osteoporosis therapy. A new review provides concise recommendations for clinicians to manage osteoporosis in these patients, outlining diagnosis, risk assessment, and intervention thresholds.
SourceInternational Osteoporosis Foundation·JournalOsteoporosis International·DateJul 15, 2021