Articles tagged with Osteoporosis
The International Osteoporosis Foundation awarded five young researchers for their groundbreaking work on the role of nutrition in musculoskeletal health. The winners, from Australia, India, and Switzerland, were recognized for their studies on vitamin K1 intake, calcium sources, and dietary inflammatory index.
The Virtual WCO-IOF-ESCEO 2022 Congress will feature leading experts on osteoporosis, osteoarthritis, and musculoskeletal diseases, with a focus on new clinical research and advances in prevention and patient care. Prestigious awards will also be presented.
Professor René Rizzoli has been recognized for his significant and longstanding contribution to the advancement of osteoporosis research through his work on bone metabolism and mineralization. He is a respected researcher, clinician, and leader in the field of osteoporosis, with a strong focus on prevention and treatment.
Professor Elaine Dennison has been awarded the IOF Olof Johnell Science Award for her significant work in musculoskeletal aging, osteoporosis, and metabolic bone diseases. She is recognized as an internationally renowned clinician, researcher, and educator.
The International Osteoporosis Foundation awarded Professor Thierry Thomas the IOF Committee of Scientific Advisors (CSA) Medal of Achievement for his outstanding scientific contributions to osteoporosis. The award recognizes his work on secondary fracture prevention and post-fracture care coordination programs.
The World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO) 2022 will discuss secondary fracture prevention. Global experts will provide clinical guidance and information on post-fracture care through various sessions.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that men with high levels of body fat are more likely to have lower bone density and an increased risk of fractures. The researchers analyzed data from over 10,800 people under 60 years old and found a strong positive association b...
Prunes have been found to help prevent or delay bone loss in postmenopausal women by reducing inflammation and oxidative stress. This is due to their potential to alter the gut microbiome, which can lead to lower levels of pro-inflammatory cytokines and markers of oxidative damage.
Scientists have identified connexin (Cx) 43 hemichannels on the surface of bone cells as a potential new target for medications to treat osteoporosis and other conditions that cause bone loss. The study, published in eLife, reveals how these channels play a crucial role in responding to mechanical stress and building stronger bones.
A new review by the International Osteoporosis Foundation highlights the importance of comprehensive post-fracture care, including exercise, nutrition, physiotherapy, and patient education. The study concludes that individualized exercise approaches can improve recovery and reduce future fracture risk.
A UMass Amherst study found associations between oral contraceptive use and certain tubal ligation methods with lower levels of antimüllerian hormone (AMH), a biomarker for ovarian aging. This may suggest an increased risk for early menopause in women who have used oral contraceptives or undergone specific types of tubal ligation.
A new European report reveals a massive treatment gap and disparities in osteoporosis care, with significant economic burden and projected increases in fragility fractures. The report emphasizes the need for improved service provision and uptake, particularly in countries with high disease burdens.
A new Irish survey found that no trauma sites capture all fracture patients, with only 50% receiving osteoporosis medication within four months of a fracture. Implementing a national Fracture Liaison Service (FLS) would bring services in line with international standards and reduce hospital admissions.
A new study found that oral bisphosphonates risedronate and alendronate equally protect against hip fractures during a 2-year drug holiday. However, the risk increases slightly for those taking a break from risedronate.
A study identified factors at midlife associated with a decline in women's physical health 10 years later. Higher body mass index, smoking, osteoarthritis, and depressive symptoms were found to be significantly linked to clinically important declines in physical health.
A registry study found that people with inflammatory RMDs, such as rheumatoid arthritis and psoriatic arthritis, tolerate their COVID vaccine well, with short-lived reactions being the most common side effect. The majority of participants were able to continue on their normal medication with no changes.
Researchers found that bisphosphonate treatment stimulates lung macrophages to mount a stronger response against pathogens, enhancing immune function. This could lead to improved health outcomes for the older population at higher risk of pneumonia and osteoporosis.
Katherine Tucker, a renowned nutritionist, has been awarded the top honor at UMass Lowell for her exceptional teaching, research, and service to the university. She will deliver the annual Distinguished University Professor Lecture and continue to lead her research team in establishing long-term interventions for diverse populations.
A randomized-controlled clinical trial found that eating prunes daily reduces biomarkers of bone breakdown and improves bone geometry in healthy men aged 50-79. The study adds to existing research on the beneficial effects of prunes on bone health, particularly for men.
UArizona researchers created osseosurface electronics, a wireless device that grows to the surface of bone to monitor health and healing. The thin structure allows for accurate measurements over long periods, enabling personalized orthopedic care.
Recent clinical and experimental data suggest that vascular calcification and bone loss share common pathophysiological mechanisms. The International Osteoporosis Foundation's new review elucidates the key associations between the two disorders.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
A study published in Nature Communications reveals that the transcription factor Sp7 and its target gene osteocrin play a crucial role in osteocyte dendrite formation. Deletion of Sp7 causes severe defects in dendrites, but activating osteocrin can reverse these defects in mice.
A new study from the University of Eastern Finland found that postmenopausal women experience a significant decrease in bone mineral density, but at a lower rate than previously assumed. Women who received hormone replacement therapy and those with weight gain during follow-up showed minimal bone loss.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
Researchers at University of Virginia Health System have discovered a new treatment target for osteoporosis and bone loss from rheumatoid arthritis. A cellular protein called ELMO1 promotes the activity of osteoclasts, which break down bone, leading to excessive bone degradation.
Stephanie Grainger, Ph.D., awarded $2.375M grant to explore Wnt molecular pathway's role in healthy development and disease, including cancer, osteoporosis, and heart conditions.
A new study found that alendronate, a widely used osteoporosis treatment, may reduce the risk of developing type 2 diabetes by 34% compared to non-users. The study, published in Diabetologia, also suggests that longer treatment duration is associated with lower risk of type 2 diabetes.
Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
The North American Menopause Society (NAMS) has released a new position statement on the management of osteoporosis in postmenopausal women. The guidelines emphasize an individualized approach with regular follow-up to prevent fractures and maintain mobility and independence. Key findings include recommendations for calcium, vitamin D,...
The HIPGEN study, a multinational trial, investigates the efficacy and safety of allogeneic placenta-expanded adherent stromal cells to improve recovery after hip fracture arthroplasty. The trial aims to combat immobility and associated problems by strengthening periarticular hip musculature.
Researchers have discovered a link between cognitive decline and faster bone loss in women, increasing future fracture risk. Cognitive decline over five years was associated with a 1.7-fold increase in fracture risk in subsequent 10 years.
Chronic kidney disease patients are at high risk of fragility fractures, yet most receive no osteoporosis therapy. A new review provides concise recommendations for clinicians to manage osteoporosis in these patients, outlining diagnosis, risk assessment, and intervention thresholds.
A new international guidance on HR-pQCT provides an overview of current clinical applications and future directions in adults. The technology holds promise for fracture risk prediction, monitoring anti-osteoporosis therapy response, and assessing metabolic bone disorders.
Researchers at UVA School of Medicine have identified 19 new genes linked to bone mineral density, providing insights into osteoporosis. The study's novel approach uses laboratory mice to overcome human study limitations.
Research from the UK Biobank and the Genetic Factors for Osteoporosis consortium found that heavier birth weight is associated with a higher risk of bone fracture and osteoporosis. The study suggests that genes affecting birth weight may also influence an individual's risk of developing osteoporosis as they age.
Researchers at Shinshu University Hospital developed a novel method to detect untreated osteoporosis through a low-cost, physical function test during routine health checks. The test measures two-step distance and body height to identify high risk individuals. Proper treatment can help avoid serious fractures and reduce mobility issues.
A new report by the International Osteoporosis Foundation reveals that fragility fractures result in 4.3 million cases and €56.9 billion in healthcare costs each year in Europe. The report also highlights significant service provision gaps, with only half of women at high fracture risk receiving therapy for osteoporosis.
Researchers from Brigham and Women's Hospital analyzed data from nearly 144,000 women and found a 40% higher risk of moderate or worse hearing loss in those with osteoporosis or low bone density. Bisphosphonates did not alter this risk, suggesting that other factors may contribute to the development of age-related hearing loss.
Professor Cyrus Cooper has been recognized with the European Calcified Tissue Society's (ECTS) Steven Boonen Clinical Research Award for his significant progress and contribution to bone clinical bone disease research. The award honors his work on osteoporosis, metabolic bone disease, and fracture prevention.
Research strongly links thin and brittle bones to increased heart attack and stroke risk in women. Thinning lower spine, top thigh bone, and hip were independently associated with a heightened risk, while osteoporosis was linked to a 79% higher cardiovascular disease risk.
The International Osteoporosis Foundation has published a new Executive Summary outlining key guidance for managing osteoporosis in hematologic stem cell transplant recipients. The summary provides expert recommendations for monitoring, evaluation, and treatment of bone loss in HSCT patients, including a helpful management algorithm.
The IFCC-IOF Committee for Bone Metabolism found significant within- and between-assay variation for ß-CTX measurement, calling for harmonization and the use of EDTA plasma for precise results. The study's recommendations aim to improve bone health globally through standardized assays.
A study found that osteoporosis treatment is rarely prescribed to patients who break a hip, despite medical associations recommending evaluation and treatment. The study's lead author suggests that the diagnosis of osteoporosis is often overlooked, even in patients with disease-defining fractures.
Researchers have discovered a new type of bone cell called 'osteomorphs' that may reveal new therapeutic approaches for osteoporosis and other skeletal diseases. The cells have a unique genomic profile, suggesting promising targets for therapy.
A study of 36,590 patients found that many fractures are potentially preventable by identifying those at greatest risk and initiating proven interventions. By improving the use of existing databases, billions of euro in healthcare costs could be saved annually by 2040.
Scientists identify critical enzyme KDM4B as key factor in skeletal aging and bone loss, leading to brittle bones and fractures. The study provides promising insights into the development of strategies to reverse bone-fat imbalance and prevent osteoporosis.
Researchers developed a bioactive coating that sequentially turns on and off inflammation on bone implants under osteoporotic conditions. The coating harnesses the power of immune responses to enhance implanting efficacy without increasing the number or stimulating function of bone cells.
The Covid-19 pandemic has profoundly altered global osteoporosis care, assessment and treatment. Healthcare providers reported delays in DXA scanning, interrupted medication supply, and increased reliance on telemedicine consultations.
Researchers developed a computational model to calculate 'skeletal age', a personalised estimate of an individual's risk of bone fracture and premature death. The skeletal age calculator aims to better identify those at risk of a first bone fracture and subsequent fractures, as well as estimates how fractures impact life expectancy.
Vertebral fractures often remain undetected despite their significance as risk factors for future fractures. Routine use of VFA in fracture liaison services helps physicians detect unrecognized fractures and inform treatment decisions. The IOF position paper emphasizes the potential of improved detection of vertebral fractures within FLS.
The Asia Pacific Consortium on Osteoporosis has launched the first pan-Asia Pacific clinical practice standards for screening, diagnosis, and management of osteoporosis. The standards aim to provide optimal care for high-risk groups and reduce the burden of osteoporosis worldwide.
A new review describes the current status of commercial assays for Procollagen type I N-propeptide (PINP) and C-terminal telopeptide of type I collagen (β-CTX) in blood. The authors recommend harmonization or standardization of these assays to improve clinical implementation and international multicentre trials.
A new report warns of significant increases in osteoporosis patients and fragility fractures in Eurasian countries, with expected demographic changes and poor diagnostic resources exacerbating the problem. The report highlights the need for urgent action to address this growing health issue.
Researchers at Purdue University developed a stabilized form of human calcitonin, a peptide hormone that inhibits bone resorption and increases bone mass. The new drug form, which is less prone to fibrillation, may provide a more effective option for osteoporosis patients.
A recent study has discovered a cell type that governs bone formation and maintenance, shedding light on the mechanisms behind osteoporosis. Researchers found that bone marrow adipogenic lineage precursors (MALPs) play a distinct role in regulating bone remodeling, and targeting these cells could lead to more effective therapies.
The new European consensus statement provides practical recommendations for diagnosing and treating osteoporosis in advanced stage CKD. The guidelines aim to reduce the care gap and promote proactive fragility fracture prevention in high-risk patients.
A large-scale study found that LDCT scans can identify a significant number of adults with low bone mineral density, equating to 49 million and 22.8 million Chinese citizens, respectively. The study revealed an unexpectedly high prevalence of osteoporosis in men, which may impact management strategies.
Research published in Thorax finds a clear association between steroid treatment and an increased risk of osteoporosis and fragility fractures. Patients prescribed high doses or multiple courses of steroid tablets were more likely to develop these conditions, highlighting the need for bone protection guidance in asthma management.
A new study found that the COVID-19 pandemic had a significant impact on osteoporosis management worldwide. With FRAX fracture risk calculations down by 58% in April 2020 alone, it's estimated that over 0.5 million patients were excluded from risk assessment and necessary treatment within a 3-month period.