Articles tagged with Osteoporosis
A recent study found that postmenopausal women who slept 5 hours or less per night had lower bone mineral density at all four sites assessed. Women reporting 5 hours or less per night were also at higher risk of experiencing low bone mass and osteoporosis, particularly in the hips and spine.
A multistakeholder coalition has issued clinical recommendations to prevent secondary fractures in older adults with osteoporosis. The guidelines recommend increased communication with patients regarding fracture risk and mortality outcomes, as well as fracture risk reduction strategies.
Researchers discovered a correlation between statin dosage and osteoporosis diagnosis in a large patient dataset. Lower doses of cholesterol-lowering drugs were found to protect against bone resorption, while higher doses increased the risk of osteoporosis.
Researchers discovered a dose-related decrease in bone density with high doses of vitamin D, contrary to initial predictions. Vitamin D supplementation above recommended levels (400-2000 IU daily) was not associated with an increase in bone density or strength.
Duke researchers identify biochemical receptor that can reverse bone degradation caused by osteoporosis, offering new potential treatment option. The study found that activating the adenosine receptor A2B can halt and even reverse bone deterioration in mouse models of osteoporosis.
Two studies found that nitrogen-bisphosphonates reduce the risk of osteoporotic fractures and premature mortality by 34% in individuals aged over 50. The treatment is particularly beneficial for those at risk of osteoporosis, with a significant reduction in bone loss contributing to the overall benefit.
A new study from the University of Bristol has linked puberty timing to bone strength, finding that teens who mature later may catch up on bone density but continue to have lower bone density into adulthood. The study suggests that late-maturing individuals may be at increased risk of fractures and osteoporosis later in life.
For high-risk patients, treatment continuation outweighs rare side effects; rapid bone loss occurs after denosumab discontinuation. Long-term studies showed no increased fracture risk with continued treatment.
A recent study published in JAMA Internal Medicine examines the impact of disease definition, comorbidity burden, and prognosis on hip fracture probability among late-life women. The research found that women with osteoporosis and comorbidities have a high probability of hip fractures despite competing mortality risk.
Romosozumab increases serum markers of bone formation and decreases those of bone breakdown, leading to improved bone mass and microarchitecture. The therapy also reduces the risk of bone fractures in postmenopausal women with osteoporosis.
A recent study published by The Endocrine Society found that women exposed to triclosan are more likely to develop osteoporosis. The study analyzed data from over 1,800 women and discovered that those with higher levels of triclosan in their urine were more prone to bone issues.
A recent study published in the Journal of the American Osteopathic Association found that 28% of men and 26% of women between 35 and 50 years old have osteopenia, a precursor to osteoporosis. This finding suggests that middle-aged adults can benefit from bone health assessments to understand their risk of osteoporosis.
A new study reveals that damage to mitochondria leads to an increased production of osteoclasts, which break down bone. This process is triggered by stress signaling in cells, leading to greater rates of bone resorption and potentially contributing to osteoporosis.
Stroke survivors are at up to four times greater risk of osteoporosis, bone breaks, and falls. Despite this, less than one-third of older women in the US are screened for osteoporosis.
A study published in Annals of Internal Medicine found that metformin helped patients maintain weight loss over a period of 15 years. The researchers identified being older and losing a greater amount of weight in the first year as key predictors of lasting weight loss.
Dr. Harry K. Genant received the 2019 International Osteoporosis Foundation Medal of Achievement for his innovative work in non-invasive and quantitative imaging methods, advancing knowledge on bone fragility and fracture risk assessment. This award recognizes his significant contributions to osteoporosis research.
The IOF Calcium Academy Awards honored five researchers for their new research on calcium and its role in bone health. The awards aimed to advance scientific knowledge in the field of bone nutrition and support the next generation of researchers.
Professor Jonathan D. Adachi was awarded the prestigious Herbert A. Fleisch ESCEO-IOF Medal for his exceptional contributions to bone and osteoporosis research. He has advanced knowledge about risk factors and therapies for osteoporosis through epidemiological research and clinical studies.
Dr Varta Babalyan, President of the Armenian Osteoporosis Association, has been recognized by the International Osteoporosis Foundation (IOF) for her dedication to osteoporosis prevention and awareness. She was awarded the IOF CNS Medal in 2019 for her work on expanding IOF's messages and outreach in Armenia.
Dr. Sabico recognized for outstanding scientific merit in vitamin D research, guiding local guidelines for osteoporosis prevention. He is a future thought-leader in musculoskeletal health, advancing awareness in the Middle East region.
The International Osteoporosis Foundation (IOF) has recognized Greg Lyubomirsky and Radmila Matijevic for their contributions to IOF and dedication to advancing education and awareness of osteoporosis. The award is presented annually to individuals representing IOF member societies, highlighting their exceptional commitment to the field.
Professor John A. Kanis has been recognized with the prestigious IOF Olof Johnell Science Award for his pioneering work in musculoskeletal research and policy implementation. The award acknowledges his development of FRAX models to calculate absolute fracture risk, which has revolutionized clinical practice.
The Endocrine Society's Clinical Practice Guideline recommends treating postmenopausal women with pharmacological therapies to reduce fracture risk, outweighing the risks of rare side effects. Guidelines also provide recommendations for monitoring and reassessing fracture risk after initial treatment.
The study found that the percentage of younger women initiating bisphosphonate treatment decreased over the 12-year period, while older women and those with osteopenia or osteoporosis increased. The overall percentage of osteoporosis among white and Asian women also rose.
Researchers found a connection between estrogen and protein Sema3A in maintaining bone health. As women lose estrogen with age, Sema3A levels drop, leading to osteocytes dying and bones losing support structure.
A review of 70 English-language osteoporosis guidelines worldwide found that less than 40% included patients' beliefs, values or preferences (BVPs). Guidelines from top countries like Australia, Canada, and the US often prioritized pharmaceutical company agendas over patient experiences.
A study found that a significant number of patients undergoing lumbar spine fusion had previously undiagnosed low bone density, with 44% diagnosed with osteopenia and 15% with osteoporosis. This discovery could lead to changes in surgical planning and treatment, potentially improving patient outcomes.
A recent study reveals significant disparities in osteoporosis treatment among elderly Americans, with men and blacks being undertreated compared to women and whites. The findings highlight the need for improved osteoporosis management strategies that address these disparities.
Researchers found ultrasound of the calcaneus to be equal to DXA data in assessing bone health, paving the way for widespread use of low-cost screenings for populations at risk. The findings support preventive lifestyle changes as the best approach to improving bone health and reducing osteoporosis risk.
Researchers identified a gene defect underlying childhood-onset osteoporosis in two Finnish families and four additional families worldwide. The SGMS2 gene mutation causes changes in bone metabolism and mineralisation, leading to severe short stature and disturbed bone development.
Researchers at Mayo Clinic reviewed health records of 89 people with osteoporosis or osteopenia and found 29 bony injuries, including compression fractures. They recommend modifying yoga poses to accommodate these conditions.
Research published in the Journal of Investigative Medicine found that US older women are three times more likely to receive treatment for osteoporosis than men of similar age. Men aged 80+ were particularly under-screened and undertreated, with only 10-13% having a bone density scan and fewer than 1 in 10 treated with bisphosphonates.
A recent study published by The Endocrine Society found that oral complications are rare in women taking medications for postmenopausal osteoporosis. Despite concerns among dentists and patients, the rate of osteonecrosis of the jaw (ONJ) was low, with only 5.2 cases per 10,000 patient-years reported.
Researchers at Hokkaido University found that inhibiting a bone receptor protein called Siglec-15 can increase bone mass and strength without impairing growth in young rats. This suggests that anti-Siglec-15 therapy could be an alternative treatment for juvenile osteoporosis, potentially with an ideal safety profile.
Researchers have created an atlas of genetic factors associated with estimated bone mineral density, explaining 20% of the genetic variance linked to osteoporosis. The study identifies over 500 genetic determinants, providing promising targets for novel therapeutics to prevent or treat the disease.
Scientists have discovered that irisin, a hormone released by muscles during exercise, directly acts on key regulatory cells that control the breakdown and formation of bone. Treating osteocytes with irisin protected them from age-related death and increased their production of sclerostin, a protein that triggers bone remodeling.
The International Osteoporosis Foundation and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases established recommendations for economic evaluations in osteoporosis. These guidelines aim to improve transparency and methodologic standards, promoting high-quality methodolo...
A large international study confirms measuring bone microarchitecture with new imaging technology accurately predicts risk of fracture in older women and men. The study found that deficits in bone density and structure contribute to fracture risk independently of bone mineral density.
Researchers have determined the three-dimensional structure of the PTH-1 receptor, a protein fragment involved in bone loss. This breakthrough enables the development of new drugs that may slow down or reverse osteoporosis without its current treatment's disadvantages.
The new guidelines review and update the 2013 European guidance for diagnosing and managing osteoporosis in postmenopausal women. Key findings include the importance of evaluating bone microstructure and using FRAX tools in fracture risk assessment, as well as the need for long-term dietary intakes and monitoring drug treatment.
A new imaging process will enable x-ray microscopy on living subjects, facilitating more detailed analysis of bone structure changes in osteoporosis. The European Research Council funds the project with a €12.3 million grant.
A new study found that denosumab improves spinal bone mineral density and reduces pain in patients with osteoporosis caused by transfusion-dependent thalassemia. The treatment also showed promise in increasing bone density in other areas, such as the wrist and femoral neck.
An interdisciplinary team will create a novel X-ray microscope to analyze bone microstructure in living individuals, enabling the study of osteoporosis and its progression. The '4D+ nanoSCOPE' will make it possible to monitor bones over time and assess the effects of aging and other factors on bone health.
A study published in Journal of Bone and Mineral Research found that 8.3% of patients with total hip replacements experienced atypical femoral fractures, a type of rare stress fracture. The researchers also discovered a strong association between bisphosphonate use and the risk of these fractures.
A new study found that cataract patients have a 29% increased risk of developing osteoporosis or fractures compared to healthy controls. Patients who underwent cataract surgery had a 42% lower risk of developing osteoporosis or fracture.
Researchers found that men have a three-fold higher risk of sustaining a secondary fracture within one year of a first fracture compared to women. Engaging in at least moderate physical activity can help reduce this risk and improve bone strength.
The ASBMR Fracture Prevention Initiative Coalition releases new clinical recommendations to tackle the public health crisis of osteoporosis and its debilitating hip and spine fractures. The guidelines aim to increase diagnosis and treatment of high-risk individuals, particularly those over 65 with a history of hip or vertebral fractures.
New studies from UC Davis Health reveal that fractures lead to bone density losses throughout the body, particularly around the time of fracture and in bones far from the site of injury. The research also identifies age-related recovery differences, with younger mice regaining pre-fracture bone mineral density levels.
Hematologic stem cell transplantation (HSCT) survivors are at risk of bone loss and osteoporosis, increasing the likelihood of fragility fractures. The IOF expert Working Group on Cancer and Bone Disease provides clinical guidance for monitoring, evaluation, and treatment of bone loss in these patients.
A recent study published in Nature Communications has identified SIRT7 as a key enzyme in regulating bone formation. The researchers found that SIRT7 deacylates the 368th lysine residue of SP7/Osterix, leading to increased osteoblast differentiation and bone density.
A new expert review outlines the clinical characteristics of bone fragility in adults with diabetes and provides valuable insights for diagnosis and treatment. The review highlights recent studies on bone mineral density, biochemical markers, and fracture prediction to inform clinicians about the optimal approach to managing bone healt...
A new genetic screen developed at Stanford University School of Medicine can predict a person's future risk of osteoporosis and bone fracture. The screen identified 899 regions in the human genome associated with low bone-mineral density, with those deemed high-risk being nearly 17 times more likely to develop osteoporosis.
A Mediterranean-type diet rich in fruits, vegetables, nuts, and olive oil reduced hip bone loss in people with osteoporosis within 12 months. The study, involving over 1,000 participants, showed a significant increase in bone density at the femoral neck. This could be a welcome addition to current drug treatments for osteoporosis.
The USPSTF updates its recommendation on screening for osteoporosis to include bone measurement testing for prevention of osteoporotic fractures in eligible populations. Approximately 12 million individuals in the US older than 50 years are expected to have osteoporosis by 2020.
A recent study found no correlation between circulating bone turnover markers and hip fracture risk among postmenopausal women. The research adds to the existing evidence that these markers are not useful for predicting hip fracture risk.
Researchers developed an improved method for calculating risk for heart attack or stroke, finding that 11 million Americans may need to discuss different prescriptions with their doctor. The new calculations suggest major changes to statin, aspirin, and blood pressure medication prescribing, particularly for African Americans.
A new expert consensus review found that a balanced diet with sufficient protein intake can benefit adult bone health, particularly in seniors with osteoporosis. Adequate calcium intake is crucial to support the benefits of dietary protein on bone density and reduce fracture risk.
A study published in Journal of Bone and Mineral Research found that alendronate reduced the risk of one-year cardiovascular death by 67% and heart attack by 45%. The medication also showed protective effects against stroke, with a 17% reduced risk over 10 years.
A recent study published in The BMJ found that vertebroplasty, a surgical procedure to repair spinal fractures, does not provide significant pain relief for patients with osteoporosis. The trial involved 180 adults and showed no difference in pain scores between those who received vertebroplasty and those who underwent a sham procedure.
Researchers at Hospital for Special Surgery are launching a two-year study to measure the bone effects of secukinumab in men and women with ankylosing spondylitis. The study aims to understand how the drug affects bone metabolism and identify potential benefits for patients with this condition.