Articles tagged with Osteoporosis
A new international guidance on HR-pQCT provides an overview of current clinical applications and future directions in adults. The technology holds promise for fracture risk prediction, monitoring anti-osteoporosis therapy response, and assessing metabolic bone disorders.
Researchers at UVA School of Medicine have identified 19 new genes linked to bone mineral density, providing insights into osteoporosis. The study's novel approach uses laboratory mice to overcome human study limitations.
Research from the UK Biobank and the Genetic Factors for Osteoporosis consortium found that heavier birth weight is associated with a higher risk of bone fracture and osteoporosis. The study suggests that genes affecting birth weight may also influence an individual's risk of developing osteoporosis as they age.
Researchers at Shinshu University Hospital developed a novel method to detect untreated osteoporosis through a low-cost, physical function test during routine health checks. The test measures two-step distance and body height to identify high risk individuals. Proper treatment can help avoid serious fractures and reduce mobility issues.
A new report by the International Osteoporosis Foundation reveals that fragility fractures result in 4.3 million cases and €56.9 billion in healthcare costs each year in Europe. The report also highlights significant service provision gaps, with only half of women at high fracture risk receiving therapy for osteoporosis.
Researchers from Brigham and Women's Hospital analyzed data from nearly 144,000 women and found a 40% higher risk of moderate or worse hearing loss in those with osteoporosis or low bone density. Bisphosphonates did not alter this risk, suggesting that other factors may contribute to the development of age-related hearing loss.
Research strongly links thin and brittle bones to increased heart attack and stroke risk in women. Thinning lower spine, top thigh bone, and hip were independently associated with a heightened risk, while osteoporosis was linked to a 79% higher cardiovascular disease risk.
Professor Cyrus Cooper has been recognized with the European Calcified Tissue Society's (ECTS) Steven Boonen Clinical Research Award for his significant progress and contribution to bone clinical bone disease research. The award honors his work on osteoporosis, metabolic bone disease, and fracture prevention.
The International Osteoporosis Foundation has published a new Executive Summary outlining key guidance for managing osteoporosis in hematologic stem cell transplant recipients. The summary provides expert recommendations for monitoring, evaluation, and treatment of bone loss in HSCT patients, including a helpful management algorithm.
The IFCC-IOF Committee for Bone Metabolism found significant within- and between-assay variation for ß-CTX measurement, calling for harmonization and the use of EDTA plasma for precise results. The study's recommendations aim to improve bone health globally through standardized assays.
A study found that osteoporosis treatment is rarely prescribed to patients who break a hip, despite medical associations recommending evaluation and treatment. The study's lead author suggests that the diagnosis of osteoporosis is often overlooked, even in patients with disease-defining fractures.
Researchers have discovered a new type of bone cell called 'osteomorphs' that may reveal new therapeutic approaches for osteoporosis and other skeletal diseases. The cells have a unique genomic profile, suggesting promising targets for therapy.
A study of 36,590 patients found that many fractures are potentially preventable by identifying those at greatest risk and initiating proven interventions. By improving the use of existing databases, billions of euro in healthcare costs could be saved annually by 2040.
Scientists identify critical enzyme KDM4B as key factor in skeletal aging and bone loss, leading to brittle bones and fractures. The study provides promising insights into the development of strategies to reverse bone-fat imbalance and prevent osteoporosis.
Researchers developed a bioactive coating that sequentially turns on and off inflammation on bone implants under osteoporotic conditions. The coating harnesses the power of immune responses to enhance implanting efficacy without increasing the number or stimulating function of bone cells.
The Covid-19 pandemic has profoundly altered global osteoporosis care, assessment and treatment. Healthcare providers reported delays in DXA scanning, interrupted medication supply, and increased reliance on telemedicine consultations.
Researchers developed a computational model to calculate 'skeletal age', a personalised estimate of an individual's risk of bone fracture and premature death. The skeletal age calculator aims to better identify those at risk of a first bone fracture and subsequent fractures, as well as estimates how fractures impact life expectancy.
Vertebral fractures often remain undetected despite their significance as risk factors for future fractures. Routine use of VFA in fracture liaison services helps physicians detect unrecognized fractures and inform treatment decisions. The IOF position paper emphasizes the potential of improved detection of vertebral fractures within FLS.
The Asia Pacific Consortium on Osteoporosis has launched the first pan-Asia Pacific clinical practice standards for screening, diagnosis, and management of osteoporosis. The standards aim to provide optimal care for high-risk groups and reduce the burden of osteoporosis worldwide.
A new review describes the current status of commercial assays for Procollagen type I N-propeptide (PINP) and C-terminal telopeptide of type I collagen (β-CTX) in blood. The authors recommend harmonization or standardization of these assays to improve clinical implementation and international multicentre trials.
A new report warns of significant increases in osteoporosis patients and fragility fractures in Eurasian countries, with expected demographic changes and poor diagnostic resources exacerbating the problem. The report highlights the need for urgent action to address this growing health issue.
Researchers at Purdue University developed a stabilized form of human calcitonin, a peptide hormone that inhibits bone resorption and increases bone mass. The new drug form, which is less prone to fibrillation, may provide a more effective option for osteoporosis patients.
A recent study has discovered a cell type that governs bone formation and maintenance, shedding light on the mechanisms behind osteoporosis. Researchers found that bone marrow adipogenic lineage precursors (MALPs) play a distinct role in regulating bone remodeling, and targeting these cells could lead to more effective therapies.
The new European consensus statement provides practical recommendations for diagnosing and treating osteoporosis in advanced stage CKD. The guidelines aim to reduce the care gap and promote proactive fragility fracture prevention in high-risk patients.
A large-scale study found that LDCT scans can identify a significant number of adults with low bone mineral density, equating to 49 million and 22.8 million Chinese citizens, respectively. The study revealed an unexpectedly high prevalence of osteoporosis in men, which may impact management strategies.
Research published in Thorax finds a clear association between steroid treatment and an increased risk of osteoporosis and fragility fractures. Patients prescribed high doses or multiple courses of steroid tablets were more likely to develop these conditions, highlighting the need for bone protection guidance in asthma management.
A new study found that the COVID-19 pandemic had a significant impact on osteoporosis management worldwide. With FRAX fracture risk calculations down by 58% in April 2020 alone, it's estimated that over 0.5 million patients were excluded from risk assessment and necessary treatment within a 3-month period.
Researchers found exposure to warmer temperatures improves bone strength, preventing bone density loss typical of osteoporosis. The gut microbiota plays a crucial role in this phenomenon, adapting to heat by disrupting polyamine synthesis and degradation, which affects osteoblasts and osteoclasts.
The Fracture Risk Assessment Tool (FRAX) is widely used to predict major osteoporotic fractures, but experts warn that failing to calibrate for ethnicity could lead to large errors in fracture risk assessment. Ethnicity-specific models have been calibrated for specific populations, and their inclusion is crucial for accurate stratifica...
Dr. Famida Jiwa, President and CEO of Osteoporosis Canada, received the IOF CNS Medal for her outstanding work in expanding osteoporosis awareness and outreach globally. She has led significant programs to improve patient care and education in Canada.
Dr. Daniel Pinto has been recognized with the prestigious award for his research on cost-effectiveness and patient preferences in arthritis management strategies. He is a specialist in orthopaedic physical therapy and a member of several IOF committees.
The International Osteoporosis Foundation's Skeletal Rare Diseases Academy Awards recognized five young researchers for their high-quality research on rare disorders of the skeleton. The winners received a certificate and grant, valued at $1000, in recognition of their outstanding contributions.
Researchers emphasize the importance of implementing effective post-fracture care coordination programs to reduce secondary fractures, frailty, and mortality in older patients. A novel FLS benefits calculator has been introduced to support decision-making at national and local levels.
Dr Basil Masri was awarded the IOF Medal of Achievement in 2020 for his significant contributions to understanding and managing osteoporosis. He has also made notable achievements in developing registries and tools, such as the Jordanian Hip Fracture registry and FRAX tool.
Dr Stefania Maggi, a leading geriatrician and epidemiologist, has been awarded the ESCEO-IOF Herbert Fleisch Medal for her groundbreaking work in advancing the epidemiology of chronic conditions associated with aging. Her research focuses on healthy ageing and disease prevention programs.
Dr Michael R. McClung received the IOF Olof Johnell Science Award for his significant contributions to osteoporosis research, guideline development, and clinical education. He has been recognized internationally for his work in bone density testing, therapy development, and clinical guidelines.
Three experts, Professor Maria-Luisa Brandi, Dr. Lee Joon-Kiong, and Professor Ego Seeman, have been awarded the IOF President's Award for their contributions to osteoporosis research, education, and public awareness. The award recognizes their efforts to expand the Foundation's programs and outreach in the scientific and policy spheres.
The virtual WCO-IOF-ESCEO 2020 Congress featured over 210 live and pre-recorded sessions on new clinical research and advances in osteoporosis, osteoarthritis, and related diseases. The Congress attracted a record number of registrants and was accredited by the EACCME with 16 European CME credits.
Researchers found that adolescents who engaged in moderate-to-vigorous intensity physical activity had stronger hips at age 25, while time spent in light intensity activity was less clear. The study suggests that supporting young people to remain active could benefit future bone health and prevent osteoporosis.
Researchers found that oxytocin administration reversed precursors of osteoporosis in female rats, including reduced bone density and decreased bone strength. The study suggests that oxytocin may be a strong ally in preventing osteoporosis during perimenopause.
Researchers identified a small protein that mobilizes bone resorbing cells under osteoporotic conditions. Chemical inhibitors targeting this protein show promise in blocking bone resorption without disrupting normal bone turnover.
Researchers identified lung-related factors associated with increased hip fracture risk in smokers, including emphysema and COPD exacerbations. These findings suggest that osteoporosis screening and management decisions should consider lung health in at-risk patients.
A study published in PLoS ONE found that inadequate calcium and vitamin D intake are prevalent among the US population, particularly those living below the poverty line. The research highlights the significant risk of osteoporosis for men and women from low-income backgrounds, with non-Hispanic Black men facing a two-fold increased risk.
A new study quantifies the effect of a recent sentinel fracture on 10-year fracture probability using data from Iceland's fracture register. The findings provide probability ratios to adjust conventional FRAX estimates by site, enabling early identification and treatment of high-risk individuals.
A comprehensive clinical review provides updated guidance on factors affecting peak bone mass, distinguishing low bone mass from proper osteoporosis in young women. The authors outline management and treatment options for premenopausal osteoporosis, including the use of antiresorptive and bone-forming drugs.
Researchers analyzed data from the Framingham Osteoporosis Study to explain the decline in hip fracture rates in the US. Lifestyle factors such as reduced smoking and excessive alcohol consumption contributed to the decrease, highlighting the importance of public health interventions.
A novel genetic measure called gSOS has been developed to assess fracture risk in osteoporosis, which could reduce the need for bone mineral density tests by 37-41%. This cost-effective approach may improve healthcare efficiency and identify individuals at higher risk of diseases like cancer and cardiovascular disease.
A study found that cardiac CT exams can effectively screen for osteoporosis by measuring thoracic spine bone mineral density, which is strongly associated with fracture risk. This non-invasive method can guide preventive measures and treatment decisions without adding time or radiation to the exam.
A large-scale study found that young women with few eggs collected during IVF treatment have a higher risk of age-related diseases, including cardiovascular disease and osteoporosis. This increased risk is associated with early ovarian ageing and may be linked to an accelerated ageing process.
Researchers have developed a novel geochemistry test that can identify osteoporosis before its clinical effects on bones. The test is more sensitive and can detect changes in calcium isotopes in blood and urine, allowing for earlier diagnosis and treatment.
A recent study found that N-BPs like alendronate are associated with a 24% lower risk of pneumonia and 35% lower risk of pneumonia mortality compared to no treatment. The results suggest that N-BP treatment may also protect against pneumonia, warranting further investigation into its potential for treating COVID-19 symptoms.
The new guidelines provide a standardized protocol for imaging distal radius and tibia sites, as well as recommendations on reporting results. The guidelines aim to facilitate the comparison of results across studies by minimizing technical variation in scan acquisition and analysis.
A global survey of 121 fracture liaison services from 31 countries found that adherence to basic DXA quality and reporting procedures was confirmed by less than 50% of services. The study emphasizes the need for targeted education for DXA machine operators and interpreters, particularly in adopting globally-endorsed standards.
A new study reveals an alarming treatment gap for fragility fractures in six European countries, resulting in estimated annual costs of €37.5 billion in 2017, which is expected to increase by 23% to €47.4 billion by 2030.
The International Osteoporosis Foundation has developed a new patient-level performance indicator set to measure the effectiveness of fracture liaison services (FLS) and guide quality improvement. The set includes 11 indicators that assess various aspects of FLS, including patient outcomes and treatment recommendations.
A new study found that artificial intelligence (AI) can accurately identify patients at risk of osteoporosis and fractures by analyzing electronic radiology reports, outperforming traditional manual methods. The AI tool, XRAIT, detected a significant number of major fractures, improving patient outcomes and reducing the burden of illness.
Bone mineral density (BMD) and finite element analysis (FEA) reflect actual femur strength, making them effective surrogate markers for hip bone strength. These estimates predict hip fracture risks, potentially leading to shorter and less expensive clinical trials.
A history of falls in postmenopausal women can predict a higher risk of subsequent fractures. Slip falls were associated with a greater risk of fracture than other types of falls.
Researchers at Cornell University have discovered a way to strengthen bone structure using computer software, potentially treating osteoporosis and creating lightweight materials for the aerospace industry. The team found that horizontal rod-like struts play a crucial role in extending the fatigue life of bone.
The new position paper provides practical guidance for managing postmenopausal osteoporosis, including easy-to-use algorithms that illustrate decision pathways based on absolute risk of fracture. The paper aims to offer the most appropriate interventions to patients, with a focus on targeting therapeutic interventions for low, high and...