Articles tagged with Osteoporosis
Researchers developed a computational model to calculate 'skeletal age', a personalised estimate of an individual's risk of bone fracture and premature death. The skeletal age calculator aims to better identify those at risk of a first bone fracture and subsequent fractures, as well as estimates how fractures impact life expectancy.
The Covid-19 pandemic has profoundly altered global osteoporosis care, assessment and treatment. Healthcare providers reported delays in DXA scanning, interrupted medication supply, and increased reliance on telemedicine consultations.
Vertebral fractures often remain undetected despite their significance as risk factors for future fractures. Routine use of VFA in fracture liaison services helps physicians detect unrecognized fractures and inform treatment decisions. The IOF position paper emphasizes the potential of improved detection of vertebral fractures within FLS.
The Asia Pacific Consortium on Osteoporosis has launched the first pan-Asia Pacific clinical practice standards for screening, diagnosis, and management of osteoporosis. The standards aim to provide optimal care for high-risk groups and reduce the burden of osteoporosis worldwide.
A new review describes the current status of commercial assays for Procollagen type I N-propeptide (PINP) and C-terminal telopeptide of type I collagen (β-CTX) in blood. The authors recommend harmonization or standardization of these assays to improve clinical implementation and international multicentre trials.
A new report warns of significant increases in osteoporosis patients and fragility fractures in Eurasian countries, with expected demographic changes and poor diagnostic resources exacerbating the problem. The report highlights the need for urgent action to address this growing health issue.
Researchers at Purdue University developed a stabilized form of human calcitonin, a peptide hormone that inhibits bone resorption and increases bone mass. The new drug form, which is less prone to fibrillation, may provide a more effective option for osteoporosis patients.
A recent study has discovered a cell type that governs bone formation and maintenance, shedding light on the mechanisms behind osteoporosis. Researchers found that bone marrow adipogenic lineage precursors (MALPs) play a distinct role in regulating bone remodeling, and targeting these cells could lead to more effective therapies.
The new European consensus statement provides practical recommendations for diagnosing and treating osteoporosis in advanced stage CKD. The guidelines aim to reduce the care gap and promote proactive fragility fracture prevention in high-risk patients.
A large-scale study found that LDCT scans can identify a significant number of adults with low bone mineral density, equating to 49 million and 22.8 million Chinese citizens, respectively. The study revealed an unexpectedly high prevalence of osteoporosis in men, which may impact management strategies.
Research published in Thorax finds a clear association between steroid treatment and an increased risk of osteoporosis and fragility fractures. Patients prescribed high doses or multiple courses of steroid tablets were more likely to develop these conditions, highlighting the need for bone protection guidance in asthma management.
A new study found that the COVID-19 pandemic had a significant impact on osteoporosis management worldwide. With FRAX fracture risk calculations down by 58% in April 2020 alone, it's estimated that over 0.5 million patients were excluded from risk assessment and necessary treatment within a 3-month period.
Researchers found exposure to warmer temperatures improves bone strength, preventing bone density loss typical of osteoporosis. The gut microbiota plays a crucial role in this phenomenon, adapting to heat by disrupting polyamine synthesis and degradation, which affects osteoblasts and osteoclasts.
The Fracture Risk Assessment Tool (FRAX) is widely used to predict major osteoporotic fractures, but experts warn that failing to calibrate for ethnicity could lead to large errors in fracture risk assessment. Ethnicity-specific models have been calibrated for specific populations, and their inclusion is crucial for accurate stratifica...
Dr. Daniel Pinto has been recognized with the prestigious award for his research on cost-effectiveness and patient preferences in arthritis management strategies. He is a specialist in orthopaedic physical therapy and a member of several IOF committees.
Dr. Famida Jiwa, President and CEO of Osteoporosis Canada, received the IOF CNS Medal for her outstanding work in expanding osteoporosis awareness and outreach globally. She has led significant programs to improve patient care and education in Canada.
The International Osteoporosis Foundation's Skeletal Rare Diseases Academy Awards recognized five young researchers for their high-quality research on rare disorders of the skeleton. The winners received a certificate and grant, valued at $1000, in recognition of their outstanding contributions.
Researchers emphasize the importance of implementing effective post-fracture care coordination programs to reduce secondary fractures, frailty, and mortality in older patients. A novel FLS benefits calculator has been introduced to support decision-making at national and local levels.
Dr Michael R. McClung received the IOF Olof Johnell Science Award for his significant contributions to osteoporosis research, guideline development, and clinical education. He has been recognized internationally for his work in bone density testing, therapy development, and clinical guidelines.
Three experts, Professor Maria-Luisa Brandi, Dr. Lee Joon-Kiong, and Professor Ego Seeman, have been awarded the IOF President's Award for their contributions to osteoporosis research, education, and public awareness. The award recognizes their efforts to expand the Foundation's programs and outreach in the scientific and policy spheres.
Dr Basil Masri was awarded the IOF Medal of Achievement in 2020 for his significant contributions to understanding and managing osteoporosis. He has also made notable achievements in developing registries and tools, such as the Jordanian Hip Fracture registry and FRAX tool.
Dr Stefania Maggi, a leading geriatrician and epidemiologist, has been awarded the ESCEO-IOF Herbert Fleisch Medal for her groundbreaking work in advancing the epidemiology of chronic conditions associated with aging. Her research focuses on healthy ageing and disease prevention programs.
The virtual WCO-IOF-ESCEO 2020 Congress featured over 210 live and pre-recorded sessions on new clinical research and advances in osteoporosis, osteoarthritis, and related diseases. The Congress attracted a record number of registrants and was accredited by the EACCME with 16 European CME credits.
Researchers found that adolescents who engaged in moderate-to-vigorous intensity physical activity had stronger hips at age 25, while time spent in light intensity activity was less clear. The study suggests that supporting young people to remain active could benefit future bone health and prevent osteoporosis.
Researchers found that oxytocin administration reversed precursors of osteoporosis in female rats, including reduced bone density and decreased bone strength. The study suggests that oxytocin may be a strong ally in preventing osteoporosis during perimenopause.
Researchers identified a small protein that mobilizes bone resorbing cells under osteoporotic conditions. Chemical inhibitors targeting this protein show promise in blocking bone resorption without disrupting normal bone turnover.
Researchers identified lung-related factors associated with increased hip fracture risk in smokers, including emphysema and COPD exacerbations. These findings suggest that osteoporosis screening and management decisions should consider lung health in at-risk patients.
A study published in PLoS ONE found that inadequate calcium and vitamin D intake are prevalent among the US population, particularly those living below the poverty line. The research highlights the significant risk of osteoporosis for men and women from low-income backgrounds, with non-Hispanic Black men facing a two-fold increased risk.
A new study quantifies the effect of a recent sentinel fracture on 10-year fracture probability using data from Iceland's fracture register. The findings provide probability ratios to adjust conventional FRAX estimates by site, enabling early identification and treatment of high-risk individuals.
Researchers analyzed data from the Framingham Osteoporosis Study to explain the decline in hip fracture rates in the US. Lifestyle factors such as reduced smoking and excessive alcohol consumption contributed to the decrease, highlighting the importance of public health interventions.
A comprehensive clinical review provides updated guidance on factors affecting peak bone mass, distinguishing low bone mass from proper osteoporosis in young women. The authors outline management and treatment options for premenopausal osteoporosis, including the use of antiresorptive and bone-forming drugs.
A novel genetic measure called gSOS has been developed to assess fracture risk in osteoporosis, which could reduce the need for bone mineral density tests by 37-41%. This cost-effective approach may improve healthcare efficiency and identify individuals at higher risk of diseases like cancer and cardiovascular disease.
A study found that cardiac CT exams can effectively screen for osteoporosis by measuring thoracic spine bone mineral density, which is strongly associated with fracture risk. This non-invasive method can guide preventive measures and treatment decisions without adding time or radiation to the exam.
A large-scale study found that young women with few eggs collected during IVF treatment have a higher risk of age-related diseases, including cardiovascular disease and osteoporosis. This increased risk is associated with early ovarian ageing and may be linked to an accelerated ageing process.
Researchers have developed a novel geochemistry test that can identify osteoporosis before its clinical effects on bones. The test is more sensitive and can detect changes in calcium isotopes in blood and urine, allowing for earlier diagnosis and treatment.
A recent study found that N-BPs like alendronate are associated with a 24% lower risk of pneumonia and 35% lower risk of pneumonia mortality compared to no treatment. The results suggest that N-BP treatment may also protect against pneumonia, warranting further investigation into its potential for treating COVID-19 symptoms.
The new guidelines provide a standardized protocol for imaging distal radius and tibia sites, as well as recommendations on reporting results. The guidelines aim to facilitate the comparison of results across studies by minimizing technical variation in scan acquisition and analysis.
A global survey of 121 fracture liaison services from 31 countries found that adherence to basic DXA quality and reporting procedures was confirmed by less than 50% of services. The study emphasizes the need for targeted education for DXA machine operators and interpreters, particularly in adopting globally-endorsed standards.
A new study reveals an alarming treatment gap for fragility fractures in six European countries, resulting in estimated annual costs of €37.5 billion in 2017, which is expected to increase by 23% to €47.4 billion by 2030.
The International Osteoporosis Foundation has developed a new patient-level performance indicator set to measure the effectiveness of fracture liaison services (FLS) and guide quality improvement. The set includes 11 indicators that assess various aspects of FLS, including patient outcomes and treatment recommendations.
A new study found that artificial intelligence (AI) can accurately identify patients at risk of osteoporosis and fractures by analyzing electronic radiology reports, outperforming traditional manual methods. The AI tool, XRAIT, detected a significant number of major fractures, improving patient outcomes and reducing the burden of illness.
Bone mineral density (BMD) and finite element analysis (FEA) reflect actual femur strength, making them effective surrogate markers for hip bone strength. These estimates predict hip fracture risks, potentially leading to shorter and less expensive clinical trials.
A history of falls in postmenopausal women can predict a higher risk of subsequent fractures. Slip falls were associated with a greater risk of fracture than other types of falls.
Researchers at Cornell University have discovered a way to strengthen bone structure using computer software, potentially treating osteoporosis and creating lightweight materials for the aerospace industry. The team found that horizontal rod-like struts play a crucial role in extending the fatigue life of bone.
The new position paper provides practical guidance for managing postmenopausal osteoporosis, including easy-to-use algorithms that illustrate decision pathways based on absolute risk of fracture. The paper aims to offer the most appropriate interventions to patients, with a focus on targeting therapeutic interventions for low, high and...
A recent study found that postmenopausal women who slept 5 hours or less per night had lower bone mineral density at all four sites assessed. Women reporting 5 hours or less per night were also at higher risk of experiencing low bone mass and osteoporosis, particularly in the hips and spine.
A multistakeholder coalition has issued clinical recommendations to prevent secondary fractures in older adults with osteoporosis. The guidelines recommend increased communication with patients regarding fracture risk and mortality outcomes, as well as fracture risk reduction strategies.
Researchers discovered a correlation between statin dosage and osteoporosis diagnosis in a large patient dataset. Lower doses of cholesterol-lowering drugs were found to protect against bone resorption, while higher doses increased the risk of osteoporosis.
Researchers discovered a dose-related decrease in bone density with high doses of vitamin D, contrary to initial predictions. Vitamin D supplementation above recommended levels (400-2000 IU daily) was not associated with an increase in bone density or strength.
Duke researchers identify biochemical receptor that can reverse bone degradation caused by osteoporosis, offering new potential treatment option. The study found that activating the adenosine receptor A2B can halt and even reverse bone deterioration in mouse models of osteoporosis.
Two studies found that nitrogen-bisphosphonates reduce the risk of osteoporotic fractures and premature mortality by 34% in individuals aged over 50. The treatment is particularly beneficial for those at risk of osteoporosis, with a significant reduction in bone loss contributing to the overall benefit.
A new study from the University of Bristol has linked puberty timing to bone strength, finding that teens who mature later may catch up on bone density but continue to have lower bone density into adulthood. The study suggests that late-maturing individuals may be at increased risk of fractures and osteoporosis later in life.
For high-risk patients, treatment continuation outweighs rare side effects; rapid bone loss occurs after denosumab discontinuation. Long-term studies showed no increased fracture risk with continued treatment.
A recent study published in JAMA Internal Medicine examines the impact of disease definition, comorbidity burden, and prognosis on hip fracture probability among late-life women. The research found that women with osteoporosis and comorbidities have a high probability of hip fractures despite competing mortality risk.
Romosozumab increases serum markers of bone formation and decreases those of bone breakdown, leading to improved bone mass and microarchitecture. The therapy also reduces the risk of bone fractures in postmenopausal women with osteoporosis.
A recent study published by The Endocrine Society found that women exposed to triclosan are more likely to develop osteoporosis. The study analyzed data from over 1,800 women and discovered that those with higher levels of triclosan in their urine were more prone to bone issues.
A recent study published in the Journal of the American Osteopathic Association found that 28% of men and 26% of women between 35 and 50 years old have osteopenia, a precursor to osteoporosis. This finding suggests that middle-aged adults can benefit from bone health assessments to understand their risk of osteoporosis.
A new study reveals that damage to mitochondria leads to an increased production of osteoclasts, which break down bone. This process is triggered by stress signaling in cells, leading to greater rates of bone resorption and potentially contributing to osteoporosis.
Stroke survivors are at up to four times greater risk of osteoporosis, bone breaks, and falls. Despite this, less than one-third of older women in the US are screened for osteoporosis.
A study published in Annals of Internal Medicine found that metformin helped patients maintain weight loss over a period of 15 years. The researchers identified being older and losing a greater amount of weight in the first year as key predictors of lasting weight loss.