Articles tagged with Osteoporosis
A new position paper from the International Osteoporosis Foundation and International Federation of Clinical Chemistry proposes a unified nomenclature for bone status indices to enhance diagnostic consistency and clarity. The guidelines offer a comprehensive framework to unify terminology and improve comparability across studies.
The article highlights the critical role of Fracture Liaison Services (FLS) in combating rising osteoporosis-related fractures. FLS programs have been shown to reduce secondary fracture risk by up to 74% and deliver a return of $10.49 for every $1 invested.
Researchers discover that osteogenic CpG oligodeoxynucleotide iSN40 inhibits osteoclast differentiation and reduces bone resorption. This balanced approach could provide a new treatment option for osteoporosis, an imbalance in bone remodeling characterized by excessive bone resorption.
Researchers used AI on CT scans originally meant for tumors to detect calcium buildup in arteries, a sign of worsening cardiovascular disease. The study found that this opportunistic screening could predict heart attacks or other cardiovascular events with high accuracy.
This special issue of Calcified Tissue International presents a collection of critical reviews and original research articles on osteogenesis imperfecta (OI), covering essential aspects of the condition, including its nosology, genetics, and clinical presentation. The contributions also discuss treatment strategies for both children an...
Researchers have identified two genes, ATXN2L and MMP14, linked to both rheumatoid arthritis and osteoporosis. These genes play a role in apoptosis, immune regulation, and bone metabolism.
The International Osteoporosis Foundation's Capture the Fracture campaign highlights top-performing Fracture Liaison Services that deliver gold-standard care. These services prioritize continuous care, tailored treatment plans, and teamwork to reduce secondary fractures and improve patient outcomes.
A new study found that people with severe mental illness are more likely to experience fragility fractures than the general population. The researchers analyzed GP records of over 440,000 people between 2000 and 2018 and found a significant association between severe mental illness and fragility fractures.
A team of researchers discovered a protein that blocks bone-forming cells by preventing them from maturing. The study found that the protein CLEC14A reduces bone formation, while its absence leads to increased mineralized bone tissue.
A new study led by Penn State researchers found that high-level collegiate sports stress can lead to unhealthy attitudes about eating and inadequate caloric intake. Athletes, especially female ones, are at risk for energy deficiency, eating disorders, and bone loss if they don't consume enough calories.
Research at the University of Tsukuba found high vertebral instability and diffuse low-signal changes in T2-weighted MRI observations to be risk factors for deteriorated ambulation status following different conservative treatments. These findings could help predict whether a patient's ability to walk will be affected by these treatments.
A new study found that bone fracture rates in older women differ dramatically by race, with White women having the highest risk. Hispanic women had a lower risk of 10%, while Asian-American women experienced varying fracture rates depending on their ethnicity. The study highlights the need to better understand factors behind these diff...
Researchers found that osteoporosis is independently associated with rapid leukocyte telomere length shortening over a 2-year period. A total of 233 subjects were enrolled in the study, and multivariable linear regression analysis indicated that only osteoporosis was significantly linked to LTL shortening.
A new position paper argues that single race-agnostic FRAX models would unfairly discriminate against Black, Asian, and Hispanic communities. The authors recommend retention of ethnic and race-specific FRAX models for the US with updated data on fracture and death hazards.
Scientists have discovered a new hormone, CCN3, that helps maintain bone density and strength in breastfeeding women. In mice, CCN3 increased bone mass and strength, even when estrogen levels were low. The hormone also accelerated bone healing in fracture models, offering hope for treating osteoporosis and other bone conditions.
Researchers linked impaired blood vessel function with lower bone density and worse bone microstructure, but found no independent causal pathway. The study suggests shared risk factors may be more important in the development of osteoporosis than vascular dysfunction.
A research team from Osaka University identified a key osteoporosis-related gene, Men1, and developed a new animal model of the disease. The study found that inactivation of Men1 led to cellular senescence in osteoblasts, reducing bone formation activity and increasing bone resorption.
A newly developed deep learning algorithm has outperformed existing methods in predicting osteoporosis risk, potentially leading to earlier diagnoses and better outcomes. The model identified key factors such as weight, age, and grip strength as significant contributors to osteoporosis risk.
A yearlong randomized controlled trial found that daily prune consumption slowed bone loss connected to osteoporosis. Participants who ate at least four to six prunes every day maintained bone density and bone strength.
The International Osteoporosis Foundation (IOF) has released a position paper recommending rules for partnerships with member organizations and scientists operating in conflict zones. A survey of IOF member societies found strong consensus towards maintaining a neutral stance, supporting scientific collaboration and research.
Researchers have identified a novel target downstream of parathyroid hormone signaling that suppresses bone formation. Gprc5a negatively regulates osteoblast proliferation and differentiation by partially suppressing BMP signaling, potentially increasing teriparatide effectiveness in non-responding patients.
The IOF position paper emphasizes the need for population-specific vitamin D approaches, considering factors like diet, skin pigmentation, and supplement use. The authors also highlight the importance of standardized measures of 25(OH)D in future studies.
Research reveals that clonal hematopoiesis of indeterminate potential (CHIP) drives inflammatory bone loss diseases like periodontitis and arthritis. Rapamycin shows promise as a potential treatment for CHIP-driven inflammation.
Research presented at ENDO 2024 found that older women with low bone density are more likely to experience their first hip fracture in their 60s. A study analyzing NHANES data revealed a significant increase in osteoporosis, but surprisingly, a decrease in fragility hip fractures between 60-70 years.
Researchers discover novel suppressive role of Ctdnep1 in osteoclast differentiation and bone resorption, suggesting potential therapeutic targets for treating excessive bone loss. The study reveals that Ctdnep1 functions as a brake on osteoclast cell differentiation.
The International Osteoporosis Foundation (IOF) and ESCEO presented awards to 20 young investigators from 16 countries for their outstanding research abstracts. The awards recognize the researchers' contributions to the prevention, diagnosis, and treatment of osteoporosis and related musculoskeletal diseases.
Professor Leith Zakraoui was awarded the 2024 IOF CNS Medal for his dedicated work in advancing musculoskeletal health at both national and international levels. He has been a key figure in strengthening IOF activities in Africa and promoting education and awareness within the region.
The International Osteoporosis Foundation has presented the prestigious IOF President’s Award to Professor Peter Ebeling AO in recognition of his longstanding contributions to advancing the work of the IOF. He is an internationally renowned expert in bone health, with a total of over 536 peer-reviewed publications and a h-index of 93.
A comprehensive review examines the impact of osteoporosis on fracture healing and the effects of osteoporosis medications. The study concludes that there is no deleterious effect of osteoporosis medications on fracture healing, and prompt treatment can reduce the risk of secondary fractures.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis have issued new guidelines for managing osteoporosis in men. These recommendations cover disease burden, fracture risk assessment, treatment thresholds, and interventions to reduce the substantial morbidity and mortality ass...
A study from Lund University found that a ceramic bone substitute injection improves the strength of bone anchors and enhances peri-implant bone formation. The treatment combination shows promising results in increasing bone tissue density by up to 10% six months after surgery.
Research found a consistent association between green space and reduced risk of osteoporosis, with each increase in NDVI corresponding to higher bone mineral density and 5% lower risk. Lower levels of air pollution in green spaces were also significant contributors.
The new diagnostic tool, 3D-DXA, complements DXA with computational and statistical systems to estimate mineral density and obtain detailed three-dimensional images. This method has the potential to improve diagnoses and detect up to 50% more patients at high risk of femur fracture.
Researchers discovered two compounds in female ginseng with potent anti-osteoporotic activity and blocked key molecular pathways involved in bone loss. The study opens up possibilities for new osteoporosis treatments based on the compound, whether in its current form or as a structural template.
Researchers from Tokyo University of Science identify Cpeb4 protein's crucial role in mRNA splicing and osteoclast differentiation, shedding light on bone disease mechanisms. The study's findings may lead to new diagnostic techniques and treatments for conditions like osteoporosis.
Researchers found that one in five adults reported difficulty walking a kilometre, and those with more limitations had significantly higher fracture risks. The study suggests asking about walking ability could help identify individuals needing further screening and prescribe interventions to prevent fractures.
A new special issue of Calcified Tissue International & Musculoskeletal Research sheds light on sarcopenia's pathogenesis, clinical implications, and therapeutic targets. Researchers have made significant progress in evaluating, managing, and developing interventions for this condition.
Researchers found a clear dose-response relationship between long-term topical corticosteroid use and elevated risks of osteoporosis and major osteoporotic fractures. Women under 50 had higher risks compared to men and other age groups, emphasizing the importance of careful treatment.
A longitudinal study of Hispanic adolescents and young adults found that PFAS exposure is linked to lower bone mineral density and a higher risk of osteoporosis. The study's findings highlight the need for stricter regulation of PFAS to protect vulnerable populations.
Researchers at Hudson Institute of Medical Research discovered a novel RUNX1 genetic variant linked to unexplained severe osteoporosis in young adults. The study's findings suggest that this mutation may be responsible for the condition's severity and potentially lead to targeted treatment options.
A study published in the American Journal of Human Biology found that COVID-19 has negatively impacted bone tissue, particularly among young adults. The research indicates a significant decrease in bone mineral density during the pandemic compared to pre-pandemic measurements.
A new study has found that most patients with osteoporosis want to receive information on their fracture risk, but only half of them actually get it. Patients prefer visual representations, such as graphs with a colored traffic-light system, to communicate fracture risk and are more likely to take medication if presented in this way.
Researchers developed an innovative imaging technique to study cells in bones of mice, revealing distinct pockets of bone resorption activity. This knowledge could lead to new treatments for osteoporosis and dormant cancer cells.
Researchers used deep learning to identify dihydroartemisinin as a potential osteoporosis treatment that maintains mesenchymal stem cell stemness and produces more osteoblasts. The study found that administering DHA extract for six weeks significantly reduced bone loss in mice with induced osteoporosis.
The new comprehensive guideline from Osteoporosis Canada provides recommendations for exercise, nutrition, fracture risk assessment, treatment, and more to optimize skeletal health and prevent fractures. The guideline recommends screening in men and younger women, reflecting advances in risk assessment and nonpharmacologic and pharmaco...
A study of hospitalized adults with new-onset atrial fibrillation found that 1 in 3 patients experienced a recurrent episode of AF within a year. This rate is approximately 7 times higher than in matched control participants, suggesting that oral anticoagulation therapy may be warranted for these patients.
The presentation discusses newer non-invasive technologies like trabecular bone score (TBS) and vertebral fracture assessment (VFA) to assess bone health. These advances provide additional information beyond bone mineral density, helping to identify patients at risk for fractures.
Researchers at Lund University developed a new 3D-simulation method to identify individuals at high risk of osteoporotic fractures. The method uses 2D X-ray images to produce 3D models of the thigh bone, enabling simulations of different scenarios and assessing risk more accurately.
A new Australian study found that implementing simple bone-strengthening strategies throughout the community can lead to a substantial decrease in hip fractures. The study analyzed data from over 3000 individuals aged 60+ and showed a 45% decline in hip fractures despite only a 3% increase in bone mineral density.
A five-year study will enroll 2,634 adults with a fragility fracture to compare Augmented-Fracture Liaison Service Care with Enhanced Usual Care. The primary measure of effective patient care will be the number of subsequent fractures in each group.
A new study by the PhyloBone project at the University of Turku has identified 255 proteins in 30 species of vertebrates that may play a key role in regulating bone formation and regeneration. The research could lead to new treatments and preventive measures for osteoporosis, a condition that affects millions worldwide.
Scientists have identified a molecule that regulates nerve cell sensors, which could lead to new therapeutics for obesity, osteoporosis, and inflammatory diseases. The molecule can be modified into peptide-based therapeutics to boost the activity of channels involved in bone strength and satiety.
Researchers have identified a protein called Hmga1 that may help prevent bone loss associated with postmenopausal osteoporosis. Increasing the expression of this protein in rats partially reversed bone loss in ovariectomized animals, suggesting its potential as a therapeutic target.
A new review describes the development and impact of a Latin American mentorship program for Fracture Liaison Services (FLS), resulting in 64 FLSs getting started and providing coverage for over 17,200 patients. The program also supports the establishment of active communities of mentors across Mexico, Brazil, Colombia, and Argentina.
The Capture the Fracture Partnership has successfully driven global Fracture Liaison Services implementation, effectiveness, and sustainability. The partnership's unique approach, including policy, coalitions, mentorship, and scalable solutions, has delivered impactful resources and activities to prioritize secondary fracture prevention.
Researchers will compare two care models to improve care for patients with fractures, including bone-strengthening medications and deprescribing care models. The study aims to provide high-quality care after a broken bone and reduce falls and injuries.
A new position paper reviews TBS for fracture risk prediction, treatment initiation and monitoring in osteoporosis. The evidence-based guide provides practical guidance for clinicians to integrate TBS into clinical practice.
Researchers developed a portable electrochemical device that can detect five genetic variations associated with increased osteoporosis risk in finger-prick blood samples. The test is quick (15 minutes), inexpensive (<$0.5 per SNP) and offers great potential for point-of-care settings.
A comprehensive review of biochemical markers for bone fragility in diabetes identifies low bone turnover and alterations in bone quality as key factors. The study suggests that glycemic control, AGEs, and serum IGF-1 may have predictive value for fracture risk in patients with diabetes.