Articles tagged with Osteoporosis
A study found that accelerated retinal aging is associated with lower bone mineral density and an increased risk of fractures. The researchers developed a method to estimate biological age in the retina, which can predict incident osteoporosis.
A new editorial by IOF members highlights the alarming high post-fracture mortality in Africa and emphasizes the need for a targeted, Africa-driven strategy. The authors propose five strategic priorities to build bone health into national health systems, education, and policy.
The International Osteoporosis Foundation is seeking an Editor-in-Chief for the European office of Osteoporosis International, a world-leading peer-reviewed journal focused on osteoporosis and metabolic bone diseases. The successful candidate will oversee content development, peer review, and strategic oversight of the journal.
Twenty-three young investigators from 16 countries received the ESCEO-IOF Young Investigator Awards for their outstanding abstracts submitted to the WCO-IOF-ESCEO 2026 Congress. The awards aim to support and attract young researchers to the field of musculoskeletal research.
The International Osteoporosis Foundation has awarded Professor Roland Chapurlat the prestigious IOF Olof Johnell Science Award for his seminal contributions to understanding and managing osteoporosis, osteoarthritis, and skeletal rare bone diseases. He is recognized as one of the leading clinical academics in the field worldwide.
Professor Radmila Matijevic received the IOF CNS Medal for her outstanding work in advancing bone health awareness, diagnosis, and management. Her contributions to osteoporosis research and clinical practice have improved patient care in Serbia and the wider Balkan region.
Professor Thierry Chevalley has received the prestigious IOF President's Award for his significant contributions to advancing bone health and osteoporosis prevention. With extensive research expertise in geriatrics and bone health, he serves on various scientific committees and leads efforts to develop fracture liaison services.
Professor Noriko Yoshimura has received the IOF CSA Medal of Achievement for her pioneering work on epidemiology and prevention of locomotive organ disorders and osteoporosis. Her research, including the ROAD Study, has significantly advanced understanding of musculoskeletal health.
A laser-based cell isolation system enabled researchers to isolate and analyze osteoblasts, revealing a new mechanism regulating bone formation. A combination therapy strategy targeting both WNT and TGF-β signaling pathways is proposed to enhance treatment efficiency.
Researchers discovered that APOE4 causes bone quality deficits specifically in female mice, through a mechanism invisible to standard imaging. The study reveals an unexpected biological link between Alzheimer's risk and skeletal health, pointing to osteocytes as potential early warning signals for both conditions.
A new study identifies TIGAR as a key regulator of osteoblast redox homeostasis and bone formation under glucocorticoid stress. TIGAR mitigates oxidative damage and apoptosis by activating autophagy-dependent Nrf2 signaling.
A new study from Tulane University found that women with high predicted cardiovascular risk face nearly double the risk of hip fracture. The association was stronger in women under 65, and higher cardiovascular risk was linked to fractures in weakened bones in major areas.
A new platform, Build Better Bones, offers evidence-based guidance and practical resources for osteoporosis management. The platform, developed by the International Osteoporosis Foundation, provides a trusted place for people with osteoporosis to start their journey, with a focus on exercise, nutrition, and home safety.
Copper metabolism plays a crucial role in inflammatory bone diseases, with copper overload suppressing glycogen synthesis and increasing inflammatory activity. Researchers found that cuproptosis, a form of programmed cell death, can lead to bone weakening and osteoclast formation, providing a potential new therapeutic target.
Research reveals that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. Microbial metabolites like indole-3-lactic acid inhibit osteoclast differentiation and activity.
Researchers have discovered that two osteoporosis drugs, etidronate and tiludronate, can bind to excess iron, reducing oxidative stress and preventing cell damage. This finding holds promise for patients with iron overload diseases, but further studies are needed to confirm its potential as a treatment.
Researchers from UPF and 3D-Shaper Medical developed a new computational system to predict and prevent the risk of hip fracture among people with osteoporosis. The system, which simulates the functioning of hip bone tissue using 3D images and finite elements modeling, has been shown to be a robust alternative to current clinical methods.
Primary biliary cholangitis (PBC) is associated with a high incidence of osteoporosis, characterized by reduced bone mass and increased fracture risk. The pathogenesis involves immune dysregulation, cholestasis, liver damage, and metabolic alterations, highlighting the need for PBC-specific management strategies.
A new review highlights the need for planned sequential bone therapy to reduce the risk of spontaneous vertebral fractures after denosumab therapy. Denosumab discontinuation can trigger a 'rebound phenomenon' marked by rapid bone turnover, bone loss, and potentially multiple vertebral fractures.
A new study from McGill University found that a liver-derived protein helps regulate bone growth in male mice, but not in females. The protein, plasma fibronectin, builds up in bones to modulate formation, suggesting men rely more heavily on it for bone strength.
A new study from Imperial College London finds that hormone replacement therapy applied via the skin is the best way to protect bone density in women whose periods have stopped due to anorexia or intense exercise. This is because transdermal HRT and teriparatide demonstrate clinically significant benefits on bone mineral density, with ...
Researchers found that hormone treatment reduces abnormal nerve invasion and improves chronic back pain by limiting nerve growth inside damaged spinal tissue. The study suggests that parathyroid hormone can reverse the process by activating natural signals.
Vertebral fractures are a devastating complication of advanced kidney disease, associated with increased risk of further fractures and cardiovascular events. The first global consensus statement offers practical recommendations for clinicians to identify and manage vertebral fractures in patients with chronic kidney disease stages G4–G5D.
A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
A comprehensive genetic investigation by Dr. Feng Liu and collaborators identifies shared genetic loci between schizophrenia and osteoporosis, suggesting overlapping biological pathways. The study found that psychiatric patients face elevated fracture risks due to these molecular connections.
Scientists have discovered that studying 7% of the bone mass can accurately predict whether a woman with osteoporosis will suffer a hip fracture. The new computational model has an accuracy rate of 95%, allowing for personalized treatments tailored to specific areas of need.
The Asia Pacific Regional Audit highlights key trends, gaps, and opportunities in 22 countries and regions. The audit reveals a steep rise in fracture rates due to poor bone health and an ageing population, with China, Malaysia, and Australia experiencing significant increases.
A study of over 10,000 women aged 65 and older found that moderate tea consumption was associated with higher bone mineral density, a key indicator of osteoporosis risk. In contrast, excessive coffee consumption, particularly in those who drink alcohol, may be detrimental to bone health.
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
Researchers developed a two-layer shell to encapsulate estradiol, delivering it directly to weakened bones and reversing osteoporosis. The new drug-delivery system showed improved bone density in treated mice without uterine side effects.
Researchers developed an AI tool to detect bone loss using CT scans originally taken for other purposes, revealing trends in bone loss across a diverse patient population. The study found that young women had higher bone density than men of the same age, with steeper declines among postmenopausal women.
Researchers found that PAI-1 levels increase with age in both sexes, but only female mice lacking the gene experienced significant protection against age-related muscle and bone loss. Female mice maintained stronger grip strength and greater muscle mass, while showing less cortical bone loss.
The International Osteoporosis Foundation unveils a global fundraising and engagement platform called Give For Your Bones, aiming to motivate individuals and organizations to support bone health worldwide. The platform provides creative ideas for fundraising and physical activity challenges, making it easy to support IOF's mission of p...
A large-scale study uncovered a strong connection between osteoporosis and rotator cuff tears, finding that individuals with osteoporosis are 1.56 times more likely to suffer an RCT. The study also identified common genetic variants influencing both conditions, suggesting a possible biological explanation for the link.
Researchers found miR-378 suppresses bone marrow stromal cell osteogenesis and hinders fracture healing in an OVX-induced osteoporosis model. MiR-378 overexpression increased osteoclastogenesis by activating NF-κB signaling pathways, impairing bone formation.
Brazilian researchers analyzed over 60 scientific articles on microplastics and their impact on bone health. They found that the materials can impair bone marrow stem cells, accelerate cell aging, and promote inflammation, leading to potential bone weakening and fractures.
Research focuses on lysosome, iron, and mitochondria connections in osteoclasts. Lysosomes regulate intracellular iron mobilization and mitochondria rely on iron for energy metabolism.
A new study published in Clinical Chemistry and Laboratory Medicine has developed a practical tool to support harmonization and quality improvement in vitamin D testing. The multicentre study evaluates the measurement uncertainty of various 25-(OH)D assays and their ability to detect physiologically relevant changes over time.
The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.
A new review emphasizes the importance of both physical activity and reduced sedentary time for optimal skeletal health. Emerging evidence reveals that prolonged sitting and inactivity can harm bone health, even among regular exercisers.
A comprehensive study of Singaporean women in their 20s-30s found that nearly one in four healthy-weight Chinese women already have low muscle mass and weaker bones, despite appearing healthiest by BMI standards. The study highlights the need for healthcare approaches that consider body composition beyond simple weight measurements.
A recent study published in the Journal of the Endocrine Society found that skipping breakfast and having late dinners are associated with an increased risk of osteoporosis. Additionally, unhealthy eating habits were linked to other lifestyle risk factors such as physical inactivity, smoking, and insufficient sleep.
Researchers explore the benefits of nucleic acid aptamers in targeted therapies for bone tissue regeneration, revealing their potential in managing orthopedic conditions. Aptamers can modulate key molecular pathways involved in bone repair, advancing the standard of care for fractures and various types of bone diseases.
The International Osteoporosis Foundation has issued an updated joint position statement on managing aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer. The guidelines incorporate recent clinical trials and systematic reviews to provide evidence-based treatment algorithms for assessing fracture risk ...
Scientists at Leipzig University have discovered that the adhesion G protein-coupled receptor GPR133 plays a central role in building and maintaining healthy bone. By mimicking natural activation, a new active substance AP503 can strengthen bones and potentially treat osteoporosis.
A study published by The Endocrine Society found that obesity and early type 2 diabetes in adolescence can interfere with bone development, potentially increasing the risk of fractures and osteoporosis later in life. Researchers followed 48 teenagers for a year, finding that teens with obesity and type 2 diabetes showed less improvemen...
A recent study published by The Endocrine Society found that osteoporosis treatment after a fracture can decrease both hospitalization and mortality in people older than 80. Researchers analyzed data from 88,676 patients aged 80 and older who suffered a fracture due to bone deterioration or weakness caused by osteoporosis.
Researchers have developed an AI-assisted diagnostic system that can estimate bone mineral density in the lumbar spine and femur with high sensitivity and specificity. The system has the potential to transform routine clinical X-rays into a powerful tool for opportunistic screening, enabling earlier detection of osteoporosis.
A team of researchers from the University of São Paulo identified agrin as a crucial protein in maintaining bone mass and quality. The study found that osteocytes produce agrin, which plays an essential role in preserving bone health. Without agrin, bone tissue becomes less dense and more fragile, making bones susceptible to fractures.
A new survey conducted by Ohio State University Wexner Medical Center found that only 1% of men are concerned about bone density, with cancer and heart disease being top concerns. Men can build back bone density through exercise, nutrition, and lifestyle changes, and early intervention can prevent deadly fractures.
A new study found that weighted vests and resistance training did not prevent bone loss in older adults undergoing intentional weight loss. The researchers call for alternative strategies to protect skeletal health in aging populations with obesity.
A comprehensive review highlights the impact of anti-cancer treatments on bone health, increasing the risk of fractures and bone fragility. The International Osteoporosis Foundation advocates for a multidisciplinary approach to early screening and proactive bone-protective strategies.
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
Scientists have discovered NELL2's dual role in boosting bone formation and inhibiting fat accumulation in osteoporosis, promoting osteoblast differentiation and suppressing adipocyte formation. The study reveals NELL2's activation of the FAK/AKT signaling pathway through interactions with Fibronectin 1 and integrins.
The IOF Advanced Course on Osteoporosis is a comprehensive, 18-hour online training programme designed to equip healthcare professionals with the latest knowledge in osteoporosis prevention, diagnosis, and management. The course aims to promote timely diagnosis and treatment, reduce patient burden, and improve global outcomes.
The European Society of Endocrinology and the European Hormone and Metabolism Foundation launch a global campaign to raise awareness about hormone balance and its impact on chronic diseases. Small steps can make a big difference in improving hormone health.
Twelve young researchers from around the world receive ESCEO-IOF Young Investigator Awards for their groundbreaking studies on osteoporosis. The prestigious awards were presented during the World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO 2025) in Rome, Italy.
Dr. Elizabeth M. Curtis has been awarded the ESCEO-IOF Pierre Meunier Young Scientist Award for her groundbreaking research on musculoskeletal health and bone disease. Her work focuses on the epidemiology of bone, muscle health, and joint health across the lifespan.
Professor Atsushi Suzuki, Chair of Endocrinology at Fujita Health University School of Medicine, Japan, received the IOF President's Award for his exceptional contributions to IOF. He has shared his expertise as a mentor and engaged member of the Capture the Fracture Governance.
Dr Ambrish Mithal, an Indian endocrinologist, has been awarded the prestigious IOF CSA Medal of Achievement for his groundbreaking work in advancing the field of osteoporosis. His pioneering efforts have significantly increased understanding and awareness of osteoporosis globally.