Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A new method of repairing injured bones using stem cells and a carbon material with photocatalytic properties has been developed, showing promising results in accelerating bone regeneration. The technique uses red-light absorbing carbon nitride sheets to activate key transcription factors associated with osteoblast differentiation.
Researchers are conducting a £1.5 million trial to test two therapies on 390 people with Osteogenesis Imperfecta, aiming to reduce fracture risk. The six-year study will track participants for five years to assess the combination of teriparatide and zoledronic acid.
Researchers have revised the earliest known human settlement in North America to 24,000 years ago based on new radiocarbon dating from the Bluefish Caves in Yukon. The findings confirm the 'Beringian standstill hypothesis' suggesting that humans inhabited Eastern Beringia during the last ice age.
Researchers found immediate changes in gene expression of osteoblasts and osteoclasts in medaka fish exposed to microgravity. The study suggests a new area of research in gravitational biology, exploring the molecular mechanisms behind bone structure changes.
Researchers developed biocompatible scaffolds with controlled-release silver ions to inhibit MRSA bone infection. The antimicrobial properties of silver combined with bone-forming stem cells offer a potential implant system for treating and preventing bone infections.
Researchers linked RBC size to oxygen delivery efficiency in extinct mammals and birds using fossilizable indicators. They found that these organisms had smaller RBCs and were likely better athletes than earlier terrestrial vertebrates.
A new study found that consuming gelatin supplements combined with intense exercise can improve collagen synthesis and strengthen engineered lab-grown ligaments. The research suggests a potential role for gelatin and vitamin C in injury prevention and tissue repair.
The current approaches to preventing hip fractures have shown limited efficacy, with only a 50% reduction in risk. A new review suggests exploring complementary approaches and surgical interventions for patients at high risk, including prophylactic nailing and bone grafting.
Scientists have identified over a dozen genes linked to bone density and strength, using a novel approach that could speed up the development of new osteoporosis treatments. By mapping these genes onto existing genome-wide association study locations, researchers predicted 33 genes controlling bone mineral density.
Researchers at Kazan University have developed a novel gene therapy approach that combines demineralized bone with genetic material to stimulate blood vessel and bone growth. The treatment shows promise in treating pseudarthrosis and other bone defects, with plans to offer innovative treatments at the Kazan University Clinic.
Brown University's XROMM technology has been upgraded with new software and fluoromicrometry methods, allowing researchers to track muscle contractions and bone movements with precision. This advancement has led to discoveries such as the use of body muscles to power swimming in fish.
A UBC study shows that targeted email messages can increase calcium intake among Canadians, with participants consuming an extra 200mg of calcium per day. The research highlights the effectiveness of providing salient information and relevant strategies to promote healthy habits on a limited budget.
A recent study found that obesity in adolescence is associated with weakened bone structure, including increased cortical porosity and decreased trabecular density. This suggests that adolescents with high visceral fat mass and low muscle mass are at risk for permanent bone loss.
A new study found that small calcium deposits in fetal membranes may cause preterm births, which could be prevented through dietary changes. Researchers identified a link between calciprotein particles and the development of osteoblasts in fetal membrane tissue.
Researchers have found that suppressing a bone-specific protein via its neutralizing antibody can alleviate radiation-induced bone loss in an animal model. Weekly treatment with the protein blockage accelerated DNA repair and protected bone cells from turning into fat cells.
Breast cancer cells may use mesenchymal stem cells in bone marrow to spread to bone tissue. A study using a 3D scaffold model found that tumor-derived factors can promote maturation of MSCs into bone cells, with mechanical compression stimulating further bone development.
Archaeologists have discovered the oldest known physical evidence for chickens in Africa, dating back over 2,700 years. The discovery sheds new light on how domesticated chickens were introduced to Africa via trade routes along the Red Sea and East African coast.
Research shows vitamin D engages with genes influencing longevity, slowing aging-related protein misfolding and increasing lifespan by 33%. The study provides a link between aging and disease, offering new insights into the potential benefits of vitamin D supplementation.
A recent analysis of the ACTIVE trial results shows that abaloparatide-SC provides consistent protection against bone fractures in postmenopausal women with osteoporosis, regardless of baseline bone density or age. The therapy has been found to reduce fractures and increase bone mineral density in postmenopausal women with osteoporosis.
The discovery of Qilinyu rostrata expands our understanding of maxillate placoderms and reveals a complex relationship between marginal jaw bones and gnathal plates. The study finds that the maxilla, premaxilla, and dentary are homologous to the gnathal plates of placoderms, suggesting a shared dental arcade.
Abaloparatide stimulates bone formation without affecting resorption, reducing fractures in postmenopausal women with osteoporosis. The study's preclinical data are promising for continued development of abaloparatide as an osteoporosis treatment.
Researchers identify SIK2 enzyme as key to improved osteoporosis treatment, reducing bone breakdown and stimulating formation in animal model. A new compound YKL-05-099 mimics PTH effects, safely stimulating bone growth while suppressing bone resorption.
UK adolescents are at high risk of vitamin D deficiency due to limited sun exposure and northern latitudes' insufficient sunlight during winter. A study revealed the necessary vitamin D intake for adolescents is between 10-30 ug/day to maintain adequate levels and avoid deficiency.
A team of researchers used synchrotron x-ray tomography to study a 424 million-year-old fossil fish's jawbone, providing new insights into the origin of tooth replacement. The findings suggest that the process evolved independently in two different groups of early vertebrates, using distinct mechanisms.
A new study published in The FASEB Journal found that early life exposure to a diet high in soy protein isolate can protect against serious bone loss during adulthood. This is the first time scientists have used an animal model to show concrete evidence of a protective effect of an early-life soy protein isolate diet on adult bone loss.
Researchers used genetic profiling to predict osteoporosis risk in individuals with high accuracy, improving classification by 12% compared to traditional clinical risk factors. The findings have the potential to revolutionize bone disease management and treatment for Australia's 1.2 million osteoporosis sufferers.
A new report by the International Osteoporosis Foundation identifies 10 major care gaps that are preventing early assessment and treatment of osteoporosis. The report highlights the need for better case finding, communication, and public awareness to tackle the global healthcare crisis arising from fragility fractures.
A recent expert review from the International Osteoporosis Foundation confirms that both type 1 and type 2 diabetes increase the risk of bone fragility. The mechanisms behind this include hyperglycemia, oxidative stress, and microvascular complications, which alter bone turnover and material properties.
The osteotome technique provides a gentle method for immediate dental implant placement, retaining total bone mass and improving its quality. This technique also allows for increased tactile sensitivity, minimally invasive procedures, and faster prosthetic restoration.
A new study found that prevention programs significantly reduce the risk of ankle injuries in soccer players. These programs include neuromuscular, proprioceptive, strengthening, and stretching exercises, and have been shown to be effective in reducing injury rates by up to 40%.
Researchers discovered that fluoxetine, an antidepressant, causes bone loss by increasing epinephrine levels and impairing bone formation. However, co-treating with low-dose beta-blockers may prevent this effect. This finding has significant implications for preventing fractures in peri- and postmenopausal women.
The Artazu VII site contains at least 40 species of micro- and macro-vertebrates, including extinct species like cave lion and steppe bison, preserved in anatomical connection. The site reflects the fauna in the area during the Upper Pleistocene epoch, providing high-resolution palaeoecological and palaeoenvironmental insights.
Scientists at University of Würzburg have crystallized an antibody effective against Sclerostin, a protein involved in bone metabolism. The findings offer a promising treatment option for osteoporosis, a condition that affects elderly women and increases the risk of fractures.
A new orthotopic animal model has been created to study metastasis in Ewing sarcoma, allowing researchers to replicate the primary tumor's growth environment. The model provides valuable insights into metastatic processes and may become a tool for analyzing metastatic potential in other sarcomas.
Researchers at Tokyo Medical and Dental University have successfully stimulated local bone augmentation in mice jawbones using a protein/peptide combination carried by an injectable gel carrier. The study demonstrates the potential for non-surgical treatment of alveolar bone loss, which may lead to tooth loss.
New research from Purdue University suggests that soluble corn fiber can help young women build bone and retain calcium during adolescence, while also preserving bone health in older women post-menopause. The studies found improved bone calcium retention and absorption by 4.8% to 7%.
A Boston research team found that CT attenuation measurements can be used to differentiate between untreated osteoblastic (bone-related) metastases and enostoses (benign bone lesions). This discovery may help avoid unnecessary biopsies and radiologic studies.
A study suggests that ancient Teotihuacan residents bred and managed rabbits and hares for their diet, which includes human-farmed crops. This finding indicates small mammal husbandry in Mesoamerica.
Scientists have discovered that melanocortin agonism may effectively control the inflammation in gum tissue, leading to reduced alveolar bone resorption and improved quality of life. This innovative approach has opened new possibilities for treating gum disease.
A team of Osaka University researchers has developed a method to visualize the function of bone-resorbing cells (osteoclasts) in living mice. This allows for the measurement of bone resorption intensity, enabling early diagnosis and screening of new therapeutic drugs.
The discovery of 25 little bones in India suggests that primates native to the region played a crucial role in the early evolution of primates. The bones, dated to around 54.5 million years ago, show primitive features that do not clearly belong to either clade and may represent an early stage of primate evolution.
Researchers identified human remains on Oronsay island from the Late Mesolithic era, shedding light on Britain's transition to agriculture. The study used innovative bone collagen analysis techniques to determine species and diet of prehistoric groups.
A new study by University of Toronto researchers found that increased Gαq/11 signaling inhibits the anabolic response to PTH and exercise in mice. This suggests that suppressing Gαq/11 signaling could be a promising target for treating bone loss.
Kelly Schultz's NIH-funded project focuses on characterizing how mesenchymal stem cells interact with synthetic material to advance biomaterial design and tissue engineering. By understanding cell behavior in 3D environments, researchers hope to engineer cells to move faster, enabling quicker wound healing and tissue regeneration.
A new review published by the IFCC-IOF Working Group for Standardisation of Bone Marker Assays supports the potential for bone turnover markers to provide clinically useful information. The study highlights the importance of standardization and harmonization of units for reporting serum/plasma CTX and PINP concentrations.
Researchers analyze human bite marks on lamb bones to develop new method for identifying ancient meals. The study found that over half of the bones bore human bite marks, allowing for the differentiation between human and animal consumption.
Researchers at Drexel University discovered that a specific type of ceramic scaffold causes macrophages to transform into an M2c phenotype, promoting bone regeneration. Direct contact between macrophages and scaffolds is essential for this process.
A new study suggests a dual-targeting drug candidate could treat both type 2 diabetes and bone disease by expanding bone formation and turnover. The compound has shown promise in increasing bone mass regardless of body mass index.
Researchers at the University of Nottingham have secured £1.2m to develop injectable stem cell-carrying materials to treat osteoporosis and other bone-thinning diseases. The targeted therapy aims to promote bone regeneration through a quick, easy, and minimally-invasive treatment.
A study by University of Wisconsin-Madison professor Laura Hernandez found that increased serotonin levels lead to increased calcium levels in dairy cows, which could help treat milk fever. However, this effect may also cause bone loss in lactating women who take selective serotonin reuptake inhibitors (SSRIs) while breastfeeding.
Scientists at McMaster University have discovered a clear way to measure past changes in vitamin D deficiency, which affects over 1 billion people worldwide. They analyzed the microscopic structure of ancient teeth to reveal anomalies formed in dentin layers during periods of low sun exposure.
Researchers at Hokkaido University have developed a new kind of hydrogel that bonds spontaneously and strongly to defected bones. The gel overcomes the problem of bonding with other surfaces by adding hydroxyapatite to its surface.
A study found that a twice daily program of assisted range-of-motion exercises significantly improves bone strength in very low birth weight pre-term infants. This could lead to a reduced risk of osteopenia and future fractures.
High-risk osteoporosis patients often underdiagnosed and undertreated, despite effective fracture-preventing medications. The authors call for improved diagnosis and therapy to prevent fractures in this high-risk population.
Researchers found that metal ions released by cobalt-chromium-molybdenum alloys impair mesenchymal stromal cells' ability to differentiate into osteoblasts. This can lead to premature bone loss and revision surgery. The study's findings highlight the need for improved implant design and composition to optimize patient safety.
Researchers developed a technique to coat polymer implants with a bioactive film that significantly increases bonding between the implant and surrounding bone. The coating improved bone formation, density, and toughness of the implant, leading to better implant fixation.
Columbia University researchers develop groundbreaking technique to repair large bone defects in the head and face with lab-grown living bone. The innovative approach, which uses autologous stem cells derived from a patient's fat, enables precise anatomical replication and active bone remodeling.
Research finds high-impact physical activity strengthens bones in children genetically predisposed to weakness, even at a young age. High-impact activities like gymnastics and soccer show significant benefits for improved bone health.
A recent study found that sodium fluoride (Na-F-18) positron emission tomography/computed tomography (NaF-PET/CT) accurately detects bone metastases in patients with advanced prostate cancer. The imaging modality also correlates clearly with clinical outcomes and patient survival over time.
Researchers at MIT have designed a new bioinspired framework to improve concrete's strength and durability. By studying natural materials such as bones and shells, they have developed guidelines for engineers to design cement with precise control over its internal structure and properties.