Articles tagged with Brain Tissue
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Researchers have developed a new noninvasive light-based imaging technology that can see inside the living brain, providing a tool to study how diseases change brain tissue over time. The method doubles the image depth range, enabling examination of acute and chronic morphological or functional vascular changes in the deep brain.
UK cage fighters are engaging in potentially hazardous behaviors to shed pounds quickly, with two-thirds using 'water loading' and one-third taking diuretics. The researchers warn of increased risk of brain damage from head blows sustained during loss of consciousness.
Researchers at Lund University have developed implantable electrodes that capture signals from single neurons without causing brain tissue damage. The electrodes, called 3-D electrodes, are extremely soft and flexible, enabling stable recordings over long periods.
Inserm researchers have developed a noninvasive brain imaging method using MRI that provides the same information as physical palpation, allowing for early diagnosis of brain tumors or Alzheimer's disease. The technique uses noise correlation to detect natural shear waves in the brain, enabling building images of the brain's elasticity.
Researchers found changes in brain representation for affected muscles due to nerve damage caused by leprosy, indicating evidence of brain plasticity. The study may lead to new treatment strategies for individuals suffering from this ancient disease.
Researchers at Johns Hopkins found that fluoxetine prolongs physical therapy's effectiveness for stroke victims, especially those too ill to start intensive rehabilitation. Early intervention with fluoxetine improves motor function recovery in mice, suggesting potential benefits for human stroke patients.
Researchers have identified a new type of prion causing Multiple System Atrophy (MSA), a neurodegenerative disorder with similarities to Parkinson's disease. The discovery raises concerns about treatments and research involving contact with brain tissue from MSA patients.
EPFL scientists have developed a new method called cryofixation to preserve the brain's true structure, overcoming distortion caused by traditional fixation methods. This breakthrough allows for unprecedented detail in brain imaging and has significant implications for understanding brain anatomy and function.
Researchers at Toyohashi University of Technology developed a methodology to temporarily enhance the stiffness of flexible microneedles, allowing them to penetrate biological tissues without causing damage. The dissolvable material expands opportunities for flexible microneedles used for brain penetrations.
Researchers at ARC Centre of Excellence for Electromaterials Science develop a 6-layered structure incorporating neural cells, mimicking brain tissue. The breakthrough enables important insights into brain function and provides an experimental test bed for new drugs and electroceuticals.
Researchers used OCT to study brain vascular imaging during real-time experimental stroke, revealing high-resolution images of in vivo vascular networks and biologically initiated rescue mechanisms. This could provide guidance for clinicians treating stroke patients.
Researchers discovered differences in brain inflammation between people with Down syndrome and Alzheimer's disease alone. The study found higher levels of inflammatory markers M2b in Down syndrome-related Alzheimer's, highlighting the need for tailored treatments.
Researchers developed a method for fabricating nano-scale electronic scaffolds that can be injected via syringe, monitoring neural activity, stimulating tissues and promoting neuron regeneration. The technology has the potential to revolutionize the interface between electronics and biology.
Researchers have identified the epicenter of the brain's predictive ability in limbic tissue, which also plays a key role in emotions. This discovery challenges traditional theories on emotion and suggests that the brain is wired to ask questions about past experiences rather than react to external stimuli.
A study published in Scientific Reports reveals a direct link between amyloid-beta protein and memory loss in healthy brains, even before physical signs of degeneration appear. The research found that administering amyloid-beta to pond snails caused significant impaired memories, despite no visible brain damage.
A new study published in Radiology found that degeneration of white matter in the brain may be an early marker of specific types of Alzheimer's disease. White matter damage was found to be more severe and widespread in patients with atypical AD forms, suggesting a potential biomarker for early diagnosis.
A new study finds that carbon monoxide can help accelerate the natural process of clearing heme, a toxic component of red blood cells, and reduce neuronal injury in mice with subarachnoid hemorrhage. The study suggests that low amounts of CO may be used to treat patients with ruptured cerebral aneurysms.
Researchers at UC Berkeley discover a small-molecule drug that perks up old stem cells in the brains and muscles of mice, potentially leading to multi-tissue rejuvenation. The drug inhibits TGF-beta1, a growth factor that depresses stem cell activity with age.
A recent UCI study found the brain adapts quickly to vision loss in low-light conditions, contradicting earlier research. This discovery opens the door to novel treatments and rehabilitation techniques that could help restore vision.
Researchers found that writing and speaking are supported by different parts of the brain, revealing a high-level distinction between word construction. This understanding could help educators teach children to read and write more effectively and improve therapies for those suffering from aphasia.
The study found that a key enzyme produced by fat tissue regulates brain function and energy levels, suggesting an optimal amount of body fat for maximizing health and longevity. Mice with low NAMPT in fat tissue had impaired energy levels and physical activity, while those with high NAMPT exhibited increased physical activity.
Researchers at the University of Virginia Health System identified a surprising contributor to Rett syndrome: immune cells bearing a mutated MeCP2 gene. These macrophages amplify disease progression by failing to maintain tissue homeostasis, highlighting the immune system as a promising therapeutic target.
Vitamin E deficiency may lead to neurological damage by interrupting the supply of essential nutrients and robbing the brain of necessary building blocks. The study found that zebrafish fed a vitamin E deficient diet had lower levels of DHA-PC, a critical component of brain cells.
A recent study published in The Lancet Neurology has found that a clot-busting drug called alteplase can benefit stroke patients without increasing the risk of bleeding. Researchers analyzed over 3,000 people and discovered that patients with early tissue damage from strokes still benefit from receiving the drug.
Researchers at Washington University in St. Louis have developed a high-speed imaging method that enables the visualization of blood flow, blood oxygenation, and oxygen metabolism in living mouse brains. The new technique, called photoacoustic microscopy, achieves high-resolution images with capillary-level resolution at a rate of 100 ...
Brown fat tissue communicates with the brain through sensory nerves, possibly sharing information that is important for fighting human obesity. The study found that when brown fat tissue was activated with a drug, it talked back to the brain by activating sensory nerves.
Researchers identified patients who donated their body to medical research and had undergone multiple MRI exams. Brain tissue samples showed measurable quantities of gadolinium deposited in the brain tissue of exposed patients, but no specific symptoms or diseases were linked to this finding.
Researchers at MIT have developed a method to stimulate brain tissue using external magnetic fields and injected magnetic nanoparticles. The approach can provide an implant-free means of providing brain stimulation and mapping, potentially treating neurological diseases such as Parkinson's disease.
Research at Tufts University reveals that bioelectrical signals regulate embryonic brain development and can even repair genetic defects. The study found that manipulating these signals can induce the growth of new brain tissue in locations where it would not normally grow, offering a promising approach for regenerative medicine.
A study found that retigabine, an epilepsy drug, protected the brain against ischemic stroke damage in mouse models. The medication acted directly on nerve cells to minimize damage, showing protective effects up to five days after the stroke.
A recent study found that methamphetamine chronically used by adolescents causes greater brain damage and alterations in the 'executive function' area compared to adults. The research, conducted on South Korean participants, revealed significant changes in gray matter thickness and white matter integrity in adolescent users.
Researchers discovered that organs have varying DNA repair capabilities, with the heart exhibiting the highest capacity, followed by other tissues. The brain showed no ability to repair damaged DNA, leading scientists to suggest that this may be linked to memory loss and dementia.
Researchers found that retigabine, an approved anti-epilepsy drug, preserved brain tissue in a mouse model of stroke and prevented loss of balance control. Histological analysis showed significantly reduced damage to the tissue after the stroke, up to five days after.
Researchers found that xanthohumol, a compound in hops, can protect neuronal cells from oxidative damage, potentially slowing the development of brain disorders like Alzheimer's and Parkinson's diseases. The study suggests xanthohumol could be a promising candidate for fighting neurodegenerative conditions.
Scientists used a modified form of superabsorbent chemical to expand brain structures, enabling the use of common microscopes for high-resolution imaging. This technique, called expansion microscopy, has potential to study diseases in human brain tissue and answer various scientific questions.
Researchers at MIT have developed a method to enlarge tissue samples by embedding them in an expandable polymer gel, making it easier to image large biological specimens with nanoscale resolution. This technique allows for the imaging of brain cells and mapping how they connect across large regions.
Researchers found that nanowires shorter than 2 micrometres cause no harm to the brain tissue, while longer ones lead to inflammation and neurotoxic effects. The study suggests developing electrodes with smaller and more flexible nanowire coatings for safer neural implants.
A new study finds that gray matter loss in the brain is a precursor to psychosis, with increased inflammation accelerating this process. Researchers analyzed brain scans of young adults at clinical high risk for psychosis and healthy controls, revealing a significant correlation between proinflammatory cytokines and gray matter thinning.
Researchers create e-Dura implant to reduce inflammation and rejection, allowing long-term application on spinal cord. The flexible device closely mimics living tissue, enabling simultaneous electrical stimulation and pharmacological delivery.
Scientists used genetic analysis and mathematical modeling to discover millimeter-sized abnormalities in brain tissue that may cause unpredictable seizures. These 'microlesions' could lead to spontaneous electrical currents causing epilepsy.
A new study published in the American Heart Association journal Stroke found that CT scans taken within 24 hours of a mild, non-disabling stroke can identify patterns of damage associated with different levels of risk for a subsequent stroke. The analysis revealed that patients with certain types of brain damage were at a higher risk o...
A new compound, ethane-beta-sultam, has been developed to reduce brain cell loss and inflammation caused by binge drinking. This breakthrough could lead to a treatment for Alzheimer's and other neurological diseases that damage the brain.
A team of researchers discovered a mechanism linked to brain damage after stroke and found that removing it reduces damage. They identified an ion channel called TRPM2, which opens in the presence of reactive oxygen species, causing neuronal cell damage.
A new study by Penn and Dresden researchers has identified the protein Del-1 as a key player in blocking multiple sclerosis relapses in mice. The protein, also found to prevent inflammation and bone loss in gum disease, shows promise as a potential therapeutic target for treating neurodegenerative diseases.
Researchers at RIKEN Quantitative Biology Center in Japan have developed a method to image tissues and whole organisms with high precision. They discovered that aminoalcohols included in the CUBIC reagent can elute heme from hemoglobin, making organs dramatically more transparent.
A study published in the journal Development reveals that cells at the head-trunk junction communicate not only about tissue type but also location, ensuring proper alignment. The findings have important implications for treating congenital defects like Spina Bifida and Chiari malformations.
Researchers identified six hub regions as crucial for cognitive function and found that damage to these areas caused widespread cognitive impairments. In contrast, lesions to other locations resulted in significantly less impairment. This study's findings may improve diagnosis and prognosis for brain injury patients.
A new class of compounds has been shown to protect brain cells from damage caused by blast-mediated TBI. The compounds, called P7C3 series, block axon damage and preserve normal brain function, even when treatment is delayed until 24-36 hours after injury.
Researchers studied white matter damage and cognitive impairments in patients with traumatic axonal injuries. The study found that diffusion tensor imaging (DTI) can detect early white matter compromise and associate it with functional outcomes.
Damage to the prefrontal lobe is often overlooked but critical for socialization, emotional control and real-life decisions. Studies have shown that distinct areas of the frontal lobes are essential for complex human skills and behavior.
Researchers at Yerkes National Primate Research Center discovered that the amygdala has an inhibitory effect on stress hormones during early development, contrary to adult responses. Monkeys with neonatal amygdala damage show increased cortisol levels and elevated CRF, yet exhibit reduced fear and aggression.
The Tufts team created a modular design that replicated fundamental features relevant to the brain's tissue-level physiological functions. The model exhibits biochemical and electrophysiological responses, offering new options for studying brain function, disease, and trauma, and treatment.
Researchers have successfully created functional 3D brain-like tissue that exhibits grey-white matter compartmentalization and can survive in the lab for over two months. The tissue displays physical properties similar to rodent brain tissue, enabling scientists to study traumatic brain injury in real-time.
Researchers developed a technique using high-frequency pulsed electric fields to open the blood-brain-barrier, allowing effective treatment of brain cancer and neurological disorders. The technology, called VEIN pulses, can be applied without causing muscle contractions, enabling potential treatments under conscious sedation.
Researchers have created protocols to clear entire organs and bodies, enabling visualization of long-range cellular connections and fine-grained structures. This breakthrough paves the way for better understanding of brain-body interactions, accurate clinical diagnoses, and new therapies.
Researchers tested mechanical tissue resuscitation by applying negative pressure to induce localized TBI in swine, showing a significantly smaller area of brain contusion and reduced bleeding. The procedure appeared safe without seizures or brain deformation, with all animals surviving after five days of vacuum application.
A new study indicates that depression is a true risk factor for dementia and that targeting depression may help prevent cognitive decline. People with mild cognitive impairment were more likely to have higher levels of depression symptoms before diagnosis.
A recent study by UTSA researchers reveals that the shock wave from explosive blasts can cause significant eye damage, leading to partial or total blindness. The optic nerve is particularly vulnerable to injury, even at low pressures, and may be a contributing factor to visual deficits associated with traumatic brain injuries.
New technologies solve bottlenecks in CLARITY, a technique for peering into the brain, making it easier to understand brain wiring and probe brain diseases. The advancements enable faster data collection and reduce risks associated with imaging valuable clinical samples.
A new method developed by Johns Hopkins researchers uses MRI scans to measure damage to the blood-brain barrier, allowing for more precise administration of intravenous tPA. The technique shows promise in predicting which stroke patients will benefit from treatment and which may suffer bleeding complications.