Articles tagged with Brain Tissue
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Researchers found that male mice that lived with a female partner before and after a stroke had a much higher survival rate compared to those mice that lived alone. Socially housed mice suffered significantly less brain damage, with reduced inflammation and increased levels of anti-inflammatory cytokine IL-6.
Researchers found that immune cells known as killer T cells recruit other accessory cells to drive the disease, causing blood vessel damage. This discovery offers a new avenue for possible treatments for deadly meningitis.
Scientists discovered a key step in HIV's attack on brain cells and were able to reverse its effects by blocking the receptor. The discovery opens up a new avenue for researchers to explore in preventing or treating HIV's neurological effects, which have no currently approved treatment.
Neuroscientists at Arizona State University developed pulsed ultrasound techniques to remotely stimulate brain circuit activity, offering insights into noninvasive neurostimulation of brain circuits. The findings provide a new tool for modulating neural circuit activity, potentially treating post-traumatic stress disorders, traumatic b...
The McGovern Institute's MINT program awards up to $100,000 in seed funding for innovative collaborative projects in neuroscience research. Recent awards focus on developing alternative electrode materials, manipulating intracellular signaling pathways with light, and improving computational analysis of brain imaging data.
Researchers found two patients with hippocampal damage showed strikingly different patterns of memory performance, one with no deficit and the other impaired. The study suggests that subtle differences in brain pathology may be critical to understanding memory outcomes.
Researchers have developed an animal model to study the effect of small strokes on nearby neurons, finding that blockages can cause significant decreases in blood flow and death of neurons. A potential new tool for brain surgeons is being developed using optical measurements to detect and protect critical areas during surgery.
Purdue University researchers have developed a method of using nanoparticles to deliver treatments to injured brain and spinal cord cells. The team coated silica nanoparticles with a polymer to target and repair injured guinea pig spinal cords, showing improved physiological functioning in treated cells.
Scientists at Georgetown University Medical Center identified a new way to limit brain cell damage by reducing microglial activation. They found that a selective activator of a key receptor can turn off microglial activity, potentially treating conditions like stroke, Alzheimer's disease, and Parkinson's disease.
A new study finds that proteins modifying DNA play a key role in major depression and suicide, with brain tissue showing higher rates of epigenetic regulation. The research, led by Dr. Michael O. Poulter, identifies a gene involved in regulating brain activity as being heavily chemically modified in deceased individuals.
Studies found that patients with Huntington's disease have higher levels of immune-system signaling molecules, called cytokines, in their brain tissue. This suggests that the protein produced by the Huntington's disease genetic mutation is causing an overactive immune response, leading to damage to neurons in the brain.
Researchers at University of Western Ontario found a link between brain ventricle size and cognitive impairment in Alzheimer's patients. They suggest that MRI scans can measure ventricle changes to provide earlier diagnosis and assess treatment effectiveness.
A new study found that chronic alcohol abuse can decrease levels of genes needed for brain cells to respond to insulin/IGF, leading to neurodegeneration. Insulin resistance in the cerebellum and frontal lobe was associated with loss of neurons and decreased levels of neurotransmitters.
Researchers at Heidelberg University Hospital discovered that depolarization waves in the brain spread through adjacent areas after a stroke, leading to further cell death. The study's findings may enable the translation of decades-long experimental research into clinical applications.
Researchers at UCLA have discovered a link between sleep apnea and memory loss, finding nearly 20% smaller mammillary bodies in patients with the disorder. This suggests a long-lasting brain injury from repeated drops in oxygen, leading to cell death and inflammation.
Researchers identify increased fatty acids and phospholipids in CSF of SIV-infected monkeys, linked to CNS damage. The study provides insights into mechanisms of CNS damage in HIV patients using global metabolomics approach.
A new study by Dr. Martha Turner and colleagues found that patients with confabulation, a condition where memories are distorted after brain damage, all shared damage to the inferior medial prefrontal cortex. This discovery sheds light on how the human brain controls memory and distinguishes true from false recollections.
Researchers are developing cell-scaffold combinations to provide a framework for neural stem cells to regenerate lost brain tissue after stroke. The approach aims to support the growth of new tissue and promote functional repair, paving the way for potential clinical applications in stroke and neurodegenerative diseases.
Researchers at Harvard have developed gene probe eye drops that enable non-invasive monitoring of brain activity in living organisms. The technology uses MRI to detect tissue repair and has potential applications in treating neurological diseases, diagnosing conditions, and delivering therapeutic agents to the brain.
Researchers have developed a method using near-infrared light to identify microscopic changes in brain tissue associated with Alzheimer's disease. This technique can potentially detect the disease earlier than current methods, which rely on clinical symptoms or imaging tests.
A study of traumatic brain injury (TBI) patients found that more severe injuries result in greater brain tissue loss, affecting both white and grey matter. The research provides a clue to the nature of brain damage causing disability after TBI.
A recent study published in the Journal of Neuroimmunology found that mothers of autistic children may produce antibodies against their fetuses' brain tissue, which can cause changes leading to autism. The study suggests an association between maternal antibody production and developmental regression in children with autism.
A new study found that certain brain injuries, such as damage to the amygdala and ventromedial prefrontal cortex, may reduce the likelihood of developing post-traumatic stress disorder (PTSD) in combat-exposed veterans. The findings suggest that drugs or pacemaker-like devices targeting these areas might be effective treatments for PTSD.
Richard D. Smith, Battelle Fellow at PNNL, has been named to the prestigious Scientific American 50 list for his contributions in developing a new approach to neurological diagnostics. His research may help identify early stages of Alzheimer's and Parkinson's diseases by analyzing biochemical biomarkers.
A study by researchers at the University of California, Santa Cruz, found that certain marine mammals have evolved to protect their brains from conditions of low oxygen. The amounts and kinds of globins in the brain correlate with physical activity patterns of various wild mammals.
Normal aging is linked to brain system disruption, causing cognitive decline even in absence of Alzheimer's disease pathology. The researchers found a correlation between reduced functional connections and decreased white matter integrity.
Researchers discover mechanism by which rosemary's carnosic acid fights off free radical damage in the brain, potentially leading to new treatments for stroke and neurodegenerative diseases. The active compound activates a novel signaling pathway, providing a 'pathological-activated therapeutic' approach with reduced side effects.
Researchers found that diffusion tensor imaging can identify structural changes in the white matter of the brain, correlating to cognitive deficits even in patients with mild TBI. The study also discovered axonal damage and myelin abnormalities in more severe injuries.
Researchers found a link between high-normal uric acid levels and mini strokes, which may contribute to mental decline in aging adults. High-UA levels were associated with increased volumes of white matter hyperintensities in the brain.
A new device aimed at reducing deaths and brain damage from hypoxia in newborns will be developed with a $750,000 NIH grant. The device will measure the precise temperature of the brain, allowing doctors to maximize the benefits of therapeutic hypothermia.
Long-term memory retrieval in abstinent alcoholics shows lower brain activity in key regions, indicating latent lesions or subclinical pathology. This suggests that brain damages from alcohol use can occur without apparent cognitive impairments.
People with writer's cramp have reduced grey matter in specific brain regions, including the cerebellum and sensorimotor cortex. The study suggests that these changes may be a result of sustained repetitive movement, or an adaptation to the condition.
Researchers at Weill Cornell Medical College have discovered that preconditioning, a process where the brain is challenged with a small noxious stimulus, can shield blood vessels from stroke injury. This study found a 68% reduction in stroke intensity and a 114% boost in blood flow in areas unaffected by the stroke.
Researchers at the University of Edinburgh have found that people with bipolar disorder experience accelerated brain tissue loss, particularly in areas controlling memory, face recognition, and coordination. The study shows that repeated episodes of illness can lead to greater brain loss and decline in mental ability.
A recent study found that hyperintense lesions in older patients may indicate more severe brain damage, associated with conditions like dementia and memory problems. The study's lead author suggests that these lesions could be a sign of widespread disease in the brain.
Scientists have developed a method to amplify vCJD prions from human brain tissue extracts, enabling recognition by existing detection methods. This breakthrough could aid in confirming whether someone is infected with variant CJD, crucial for preventing further disease spread through infected blood donations.
Researchers found that people with damage to their left frontal lobe are more likely to correct mistakes, while those with right-brain damage struggle to track changing task rules. This study highlights the crucial role of self-monitoring functions in everyday situations.
Researchers are focusing on preventing further brain damage after a stroke, targeting the penumbra region where blood flow is reduced by 60%. They hope to restore normal electrical activity in neurons and promote recovery. Dr. Sergei Kirov's study uses real-time microscopical imaging and pharmaceuticals to stop anoxic depolarization.
Researchers have pinpointed how different types of damage to the DISC1 gene can cause schizophrenia and major depression. The study, published in Neuron, provides further evidence that these illnesses are inherited and may help doctors tailor treatments.
Research in mice shows migraines can lead to brain damage, with areas of the brain experiencing oxygen shortage. The study emphasizes the importance of preventing migraines through avoiding triggers and using prescribed medications.
Research reveals a strong link between stroke damage to brain region putamen and motor neglect, a condition causing slow movement on the left side. Treatment targeting dopamine-like compounds may ease this disability in patients with Parkinson's disease.
A study by neuroscientists from Harvard, USC, and Caltech finds that damage to the frontal lobe's ventromedial prefrontal cortex leads to abnormal moral choices. The research suggests that emotions play a crucial role in moral judgments, but also leaves intact other moral problem-solving abilities.
Researchers found a tight correlation between the severity of spatial neglect symptoms and the degree of impairment in communication within and between two brain networks. This study suggests that testing for communication breakdowns could improve clinical assessment and treatment of stroke and other brain injuries.
Research has found that brain damage to a specific area called the insula may help smokers quit by eliminating their addiction to nicotine. Twelve out of thirteen participants who experienced this type of damage were able to quit smoking without any reported struggles.
Researchers found that brain damage to insula region in smokers can completely eliminate the body's urge to smoke. Damage to this structure may offer leads for new therapies to help smokers quit or monitor their progress with existing treatments.
Researchers at Cedars-Sinai Medical Center successfully cultured stem cells from human bone marrow that can differentiate into neurons and other central nervous system cells. These cells exhibit behaviors similar to those derived from brain tissue, suggesting a promising approach for treating brain disorders and tumors.
Patients with hippocampal damage experience severe impairments in imagining new experiences and planning for the future. They struggle to visualize complex scenarios, instead seeing fragmented images. Researchers suggest a common brain mechanism underlying memory recall and imaginative thinking may be affected.
A team of physicists and neuroscientists has discovered a bottleneck in the brain's blood supply, specifically in penetrating arterioles, which makes it vulnerable to strokes. This finding may explain the origin of gray matter damage detected in brain scans, especially among the elderly.
Research reveals that alcoholics' brains can regain volume and function after six to seven weeks of abstinence, with increased levels of chemicals indicating nerve cell regeneration. Patients who abstain from drinking for longer periods show better performance in attention tests.
Researchers found a decrease in blood circulation in some areas of the brain and verbal memory performance among low-dose ecstasy users compared to non-users. The study suggests that even small amounts of ecstasy may cause subtle changes in brain structure and function.
Researchers at the University of Rochester Medical Center have developed a potential new treatment for stroke using Activated Protein C, which has shown promise in reducing brain damage by 70 percent. The treatment aims to temper the side effects of current medication TPA and expand its 'window' beyond three hours.
A new study uses MRI techniques to discriminate between patients who will benefit from clot-dissolving drugs and those who may be harmed. The technique helps doctors make informed decisions about treatment timing, potentially improving patient outcomes.
Researchers analyzed thousands of proteins from brain tissue samples to find novel changes related to cocaine addiction. The study reveals profound effects on brain function and identifies potential new targets for medication development.
Scientists found that orangutans confined to resource-limited areas of Borneo had smaller brains than those living in more abundant Sumatra. The study suggests an evolutionary connection between food availability and brain size in primates.
Researchers at Rice University and Baylor College of Medicine have been awarded a $2.9 million NIH grant to develop a stem cell repair therapy for stroke damage. The project aims to regenerate damaged brain cells and blood vessels, providing a new source of neural and vascular cells that can be transplanted into the damaged brain.
A study of 14 Swedish amateur boxers found higher levels of certain chemicals in their cerebrospinal fluid indicating injuries to neurons and astroglia after a bout. The findings suggest that amateur boxing is associated with acute neuronal and astroglial injury, warranting further investigation for medical counseling of athletes.
A Wake Forest University research team is analyzing brain changes in individuals with schizophrenia and bipolar disorder to better understand the diseases. They are comparing post-mortem brain tissue with normal tissue, focusing on the temporal lobe's structures involved in learning and memory.
A study published in Biochemistry reveals that damage to proteins caused by oxidative stress is linked to a natural byproduct called nitration, which could be used to predict the earliest stages of brain impairment. The research uses the most detailed proteomic analysis of a mammalian brain to date.
Researchers discover altered activity in NRG1-erbB4 and NMDA receptor pairs, suggesting a relationship between the two and contributing to schizophrenia symptoms. The study's findings provide new insights into the molecular mechanisms underlying the disease.
The 'brain-chip' from Martinsried allows biophysicists to visualize the influence of pharmaceutical compounds on neural networks. This breakthrough enables a novel test system for brain and drug research, advancing neurochip prosthetics and neurocomputation.