Articles tagged with Brain Tissue
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study has found a significant link between lead exposure and long-term brain cell loss and damage. Researchers measured the brains of former employees exposed to lead in their workplaces, finding those with higher levels had smaller brain volumes and more damage.
A recent study has found that damage to the right insula area of the brain is associated with a significantly higher risk of heart muscle injury after a stroke. This discovery has potential implications for identifying at-risk patients and tailoring treatment approaches.
A University of Toronto study found that increasing vitamin E levels during pregnancy may alter the onset of cancer in adult life. While it reduced in utero deaths, it also accelerated cancer development, suggesting a potential link between antioxidant intake and cancer risk.
Researchers at the University of Leicester have made a breakthrough in understanding the cause of brain damage and its link to various neurological diseases. The study identified glutamate receptors as the culprit behind oligodendrocyte damage, paving the way for potential treatments to block these receptors and prevent injury.
Researchers found that anandamide, a brain's own cannabis compound, protects neurons from inflammation after damage. Adding AEA to damaged brain tissue abolished inflammatory damage, but not primary excitotoxic damage.
A team of Canadian and American scientists reports the first-ever finding of elevated levels of creatine, a newly discovered agent of Alzheimer's, in brain tissue. The study used infrared spectroscopy to detect creatine directly in situ, revealing an overlooked aspect of energy disturbance in Alzheimer's disease.
Researchers at Emory University Health Sciences Center found that administering neuregulin-1 reduces cell death by 90% and protects neurons from damage after surgically induced strokes. The compound's therapeutic window is longer than existing treatments, offering potential for new stroke therapies.
A new study found that measles immunization can prevent fatal brain infections caused by SSPE. The researchers discovered wild-type measles virus in brain tissues from vaccinated individuals with SSPE, suggesting that the vaccine is highly effective in preventing these infections.
Researchers found that AIDS selectively attacks the brain's motor, language and judgment centers, but leaves other areas intact. Brain scans revealed specific patterns of tissue damage correlated with physical and mental symptoms, including impaired motor coordination and slowed reflexes.
The new imaging technique enables rapid acquisition of three planes, reducing examination time to 12 minutes compared to the standard method. Fetal MRI is being increasingly performed due to its excellent view of brain tissue and lack of radiation, usually done when ultrasound is inconclusive.
A study by USF researchers found that green tea's epigallocatechin-3-gallate (EGCG) decreases production of the Alzheimer's-related protein beta-amyloid, leading to a 54% reduction in brain-clogging plaques. EGCG may be effective in preventing and treating Alzheimer's disease through dietary supplementation.
Researchers have created a handheld device that uses two-photon microendoscopy to image individual cells in living subjects, enabling insights into cellular behavior and its impact on organisms. The technique has been successfully demonstrated using live mice, providing detailed images of blood vessels in the hippocampus.
A new study by UCLA researchers reveals that heart-failure patients suffer from both physical and mental injuries, with brain damage impacting their ability to exercise. The findings emphasize the need for cardiologists to recognize this connection and develop therapies to prevent brain injury and boost brain function.
A U of T study published in Free Radical Biology and Medicine found that a single exposure to methamphetamine during pregnancy can cause long-term neurodevelopmental problems. The developing fetus is vulnerable to DNA damage from the drug due to its lack of enzymes protecting it against free radicals.
Researchers discovered that neural stem cells can migrate to damaged brain areas and turn off activated immune cells, reducing inflammation. In a breakthrough, mice with MS-like disease showed significant recovery after transplanting, with reduced relapses and myelin damage.
A new study reveals severe tissue injury in the brains of children with CCHS, disrupting cardiovascular function and breathing control. Researchers hope to develop new strategies to help the brain compensate for the injury, including injecting nerve growth factors.
This study investigates the effects of alcohol on brain structure and function, highlighting permanent and transient changes due to excessive drinking. Abstinence has been shown to reverse some brain damage, including dendrite shrinkage, which may improve cognitive functions.
A new fluorescence device using time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) has been developed to detect atherosclerotic plaque and brain tumors. The technique shows promising results in distinguishing between inflamed and stable plaque areas, as well as detecting tumor cells left behind after surgery.
Researchers at UC San Diego found that damage to a specific brain area, the angular gyrus, affects patients' ability to comprehend metaphors. The study suggests that this region plays a crucial role in processing conceptual metaphors and cross-modal abstractions.
A study found that damage to the orbital frontal cortex impairs an animal's ability to learn from new cues, leading to slowed neural responses. The researchers discovered a critical role of the OFC in decision-making and learning, with potential implications for treatments of brain injury and trauma.
A new study published in Experimental Neurology found that rats fed diets rich in blueberries, spinach, or spirulina experienced less brain cell loss and improved recovery after a stroke. The antioxidant-rich diets may counteract the burst of free radicals involved in brain cell death triggered by an ischemic stroke.
A new diagnostic technique, conformation-dependent immunoassay (CDI), is being considered as the standard approach for brain biopsies of patients suspected of having prion disease. The study found that CDI detected prions in 100% of samples studied, while traditional tests failed to detect them in a high proportion of cases.
Recent studies suggest that brain avalanches, triggered by neurochemicals, may be optimal for information storage. This discovery could lead to new treatments for memory disorders.
Researchers have discovered that reducing Abeta buildup in the brain can rapidly reverse structural nerve damage associated with Alzheimer's disease. The study used a mouse model to demonstrate the effectiveness of an anti-Abeta antibody treatment, suggesting a potential new approach for treating the condition.
Researchers have identified integrin [alpha]v[beta]6 as a key risk factor for developing early-stage colorectal cancer. The molecule's high levels are also predictive of patient survival, with low expression associated with better outcomes.
Research found that cigarette smoking accelerates brain damage in individuals with alcohol dependence, particularly in the frontal lobes. This can lead to compromised executive functions, problem-solving abilities, and emotional regulation. Chronic smoking also impairs neuronal viability and cell membranes in other brain regions.
Long-term obesity is associated with a significant loss of brain tissue, particularly in the temporal lobe, increasing dementia risk. The study found that women with higher BMI experienced greater atrophy and increased dementia risk over time.
Weight-reduction surgery patients are at risk of developing peripheral neuropathy, a condition causing pain, numbness, and weakness. Following nutritional guidelines and attending post-surgical care programs can help prevent nerve damage.
Researchers identify a new mechanism for stroke damage, revealing acid-sensing ion channels as major players. Blocking these channels with existing pharmacologic agents may provide a potential therapeutic target for stroke therapy.
A study of healthy individuals aged 60-64 found a significant relationship between high homocysteine levels and changes in deep white matter hyperintensities in the brain, which may be related to mild cognitive impairment. However, HCY levels were not associated with brain atrophy.
Researchers at NIH/National Institute on Aging created synthetic prions that caused neurological disease in mice, distinct from other strains of prions. The study sheds light on the conversion process leading to dementing diseases like Creutzfeldt-Jakob and Alzheimer's.
Researchers found that genes critical for learning and memory are reduced in older brains, while those associated with stress and repair mechanisms are elevated. These changes suggest that gene damage may be contributing to age-related cognitive decline.
Researchers discovered that choroid plexus cells can stimulate stem cell production and release neurotrophic factors after a stroke, reducing damage in animal models. The study suggests potential for new therapy to supplement the natural healing response of this tissue.
A study suggests that peripheral blood analysis can help develop surrogate biomarkers of stroke risk and prognosis, providing insights into cellular and pathological mechanisms. Blood studies offer a faster and more practical alternative to brain tissue samples, allowing for serial data collection throughout the ongoing stroke.
Elderly individuals with white matter abnormalities and infarcts exhibited accelerated cognitive decline compared to those with fewer abnormalities. A serious increase in white matter lesions was associated with a higher risk of developing dementia and depression over a period of five years.
A new study has found that Bim regulation plays a crucial role in determining hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. The researchers suggest that understanding the molecular mechanisms underlying this relationship may lead to new therapeutic strategies for treating these conditions.
A new imaging probe detects small tumors in the brain, providing crucial information to surgeons during operations. The technology uses near-infrared fluorescence optical imaging to identify tumor margins and improve surgical treatment.
A new study found that exposure to low-level magnetic fields can cause significant DNA damage and increase cell apoptosis in rat brain cells. The cumulative effect of duration may be as damaging as intensity, suggesting a need for further research on the risks involved.
Researchers at Duke University Medical Center have confirmed that cord blood stem cells can differentiate into heart muscle cells and produce a critical enzyme to halt progressive damage. Additionally, cord blood transplants appear to slow or halt brain damage caused by metabolic diseases such as Sanfilippo Syndrome.
Researchers tested a cooling helmet on patients with severe ischemic stroke, finding that it preferentially cools the brain rapidly and profoundly. The study showed excellent functional recovery in younger patients but only 20% in elderly patients.
A new corkscrew-shaped retrieval system has been shown to restore blood flow and reverse paralysis in 61 of 114 patients with ischemic strokes. The device, MERCI Retrieval System, was able to dissolve clots and open blood vessels in patients who were not eligible for standard tPA therapy within three hours.
Researchers at Johns Hopkins Medicine have made a groundbreaking discovery that prostaglandin-E2 (PGE2) protects brain cells from damage caused by stroke. The finding provides a new strategy for tackling and understanding the condition, which affects 4 million Americans annually.
Researchers discovered subtle brain damage in HIV patients taking antiretroviral drugs, despite no apparent symptoms or viral suppression. The study used brainwave recordings, neuropsychological testing, and MRI scans to compare 39 HIV-positive individuals with 35 control subjects.
Researchers found that four out of six patients treated with stents and tPA experienced permanent improvement in neurologic symptoms, while two critically ill patients died due to large clots. The study suggests a combined treatment approach may offer superior results for most patients with acute vertebrobasilar ischemic strokes.
The study found that oxidation damages certain kinds of messenger RNA, leading to abnormal protein processing and neuronal death. Researchers discovered specific types of mRNA susceptible to oxidative damage, which may contribute to the onset and progression of Alzheimer's disease.
A study of 115 stroke patients found that lowering blood pressure within the first 24 hours can lead to poorer outcomes. Blood pressure drops significantly in this period, reducing brain tissue flow and causing more damage.
Miguel Nicolelis and colleagues present results from long-term studies in monkeys, showing that the same set of brain cells can control two distinct movements using a brain-machine interface. This finding has important practical implications for spinal-cord patients, offering flexibility in introducing electrodes or functional enhancem...
Preliminary research suggests that cranberry extract can reduce the severity of stroke by 50% in brain cell death. Cranberries also have powerful antioxidant capabilities and unique bacteria-blocking properties, which may help prevent heart disease and certain cancers.
Researchers found that cranberry extract can significantly reduce brain cell death after a simulated stroke. The study suggests that consuming cranberries may aid in recovery from stroke, particularly in its earliest stages.
Silverman's research focuses on inhibiting an enzyme that produces nitric oxide, a compound linked to high blood pressure, stroke, and neurological diseases. His work aims to block the overproduction of nitric oxide in the brain without affecting its normal function.
Researchers at the University of California, San Diego, have developed a new technique using ultrafast lasers to obtain high-quality images of brain tissue. This technique enables scientists to automate and modernize histology, mapping neurotransmitter production and normal cell function.
A new imaging technique, using second harmonic generation microscopy, allows for the observation of microtubule polarity in living brain tissue. This enables researchers to study neuronal development and repair, as well as neurodegenerative diseases such as Alzheimer's.
A study by Purdue professor Howard Zelaznik and colleagues suggests that stroke victims may retain some motor skills thought to be lost to cerebellar damage. The research found that patients with cerebellum damage struggled with tasks requiring a start-stop nature, but retained ability in continuous rhythmic motions.
Researchers found lower concentrations of amino acid N-acetylaspartate in the right hippocampus of males with bipolar disorder. The study suggests a progressive nature of the disease, with decreasing levels of NAA seen over time.
Research found extensive changes in brain processing of simple motor movements in patients with all three illnesses. The primary motor cortex took over hand motion control in some cases, while others relied on the cerebellum for coordination.
Researchers at Columbia University have found that astrocytes can degrade beta-amyloid proteins, a key component of Alzheimer's plaques, suggesting potential therapeutic targets for the disease. The study suggests activating astrocyte activity may be beneficial in reducing plaque buildup and improving treatment outcomes.
A study on infant rats suggests that high-fat diets and increased production of uncoupling protein 2 (UCP2) may protect the newborn brain from seizure-induced cell injury. The ketogenic high-fat diet is shown to work in human children to prevent or reduce seizures, sparking new research into its potential benefits.
The iScope system provides a platform for researchers to study mouse brain tissue samples and advance understanding of complex traits such as dyslexia and schizophrenia. By enabling real-time access to high-resolution images and genetic data, the iScope facilitates international collaboration and accelerates discoveries in neuroscience.
Key findings from brain bank research highlight the importance of standardized protocols and consideration of quality-related factors. The use of brain banks has led to a better understanding of alcohol-induced brain shrinkage, with potential implications for prevention and reversal of this condition.
A new study confirms the link between exercise and brain changes in aging humans using high-resolution MRI. Fitness slows down age-related decline in brain density, particularly in gray and white matter.