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A Mount Sinai-Led team creates model for understanding how the brain’s decision-making is impacted in psychiatric disorders

A computational framework has been created to understand how the brain's striatum region influences everyday decisions and impaired decision-making in individuals with psychiatric disorders. The study suggests that modulating striosomal activity could be a new approach to addressing psychiatric abnormalities.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNature Communications·TypeComputational simulation/modeling·DateAug 14, 2025

Fluorescent dope

Researchers from Kyoto University and Cambridge University developed a fluorescent dopamine sensor to monitor dopamine signals in primate brains. The study found that dopamine signals varied depending on the location in the striatum, with distinct patterns observed in the anterior putamen and caudate head.

SourceKyoto University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMar 11, 2025
Sky & Telescope Pocket Sky Atlas, 2nd Edition

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Learning behavior differs between OCD and problem gambling

Research reveals that individuals with OCD exhibit lower-than-normal learning rates when rewards are less than expected, while those with problem gambling display boosted learning from high rewards and blunted learning from low rewards. This study highlights the benefits of using neurocomputational approaches to understand psychiatric ...

SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateMar 14, 2023

New brain map could enable novel therapies for autism and Huntington's disease

USC scientists have created a comprehensive map of the dorsal striatum, a part of the brain responsible for motor learning and coordination. The study identifies 29 distinct areas and hubs that coordinate complex limb movements, potentially leading to new treatments for autism and Huntington's disease.

SourceUniversity of Southern California·JournalNature Neuroscience·DateJun 20, 2016
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Yale team deciphers sugar's siren song

Researchers found that the brain prioritizes calorie intake over taste quality when it comes to sugary foods. The study suggests that the brain has two separate pathways for processing sweetness and energy signals, with calorie-rich foods dominating our desire for sweets.

SourceYale University·JournalNature Neuroscience·DateJan 25, 2016