Articles tagged with Muscles
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Researchers discover that deleted versions of the DUX4 gene trigger its overexpression in FSHD patients, leading to disease progression. The finding provides a crucial step in understanding the disease and offers a potential therapeutic target for treatment.
Research published in the Journal of Physiology found that astronaut muscles deteriorate to that of an 80-year-old after just 180 days in space. The study highlights the need for effective exercise countermeasures to protect muscle and bone on long-duration space missions.
A new study at McMaster University shows that using lighter weights can build muscle just as effectively as heavier ones. The key is to lift until fatigue sets in, pumping iron for a specific duration.
Harvard researchers have found that exercise and caloric restriction can reverse the deterioration of nerve connections in older mice, a potential explanation for their age-related benefits. The study reveals that these lifestyle factors can attenuate or even reverse the decline in synapses, which are crucial for brain function.
A University of Alberta study discovered that muscular heart failure patients with more muscle mass tend to have better nutritional status and reduced severity of the disease. Higher body fat is associated with increased inflammation and reduced exercise capacity, suggesting a potential benefit from having lower body fat.
A recent study found that walking flat-footed after wearing high heels causes discomfort due to shortened muscle fibers and stiffened tendons. High heel wearers' calf muscles remained the same size as those of flat shoe wearers, but their tendons became thicker and stiffer to compensate for the shortened fibers.
Researchers at Stanford University School of Medicine developed a technique to grow muscle stem cells on a synthetic matrix that mimics the elasticity of real muscle, allowing them to maintain their self-renewing properties. This breakthrough may revolutionize the production of adult stem cells for therapies.
New research reveals the TRPML1 channel plays a crucial role in lysosome function, offering new avenues for treating conditions like ALS and CMT. The findings suggest that activating this channel could help overcome membrane traffic defects caused by disease-causing mutations.
Researchers at Mount Sinai School of Medicine identified a new way diseases develop through understanding how cells control gene expression. They found that protein DPF3b plays a critical role in the transcription process for muscle growth and heart development.
Researchers found that saber-toothed cat forelimbs were stronger than those of modern felines, with thicker cortical bone and larger diameters, suggesting they used their arms to pin prey before delivering a fatal bite.
Research published in Science reveals that muscle weakness and coordination problems in children with neonatal diabetes are caused by neurological issues rather than muscle problems. The study provides implications for developing improved treatments for the disease, which affects one in 100,000 infants in the UK.
A clinical study by Heidelberg cardiologists found that acupuncture increases skeletal muscle strength, allowing heart patients to cover greater distances during exercise. The treatment also reduced inflammation messengers in the blood, which contribute to muscle fatigue.
The study found that male zebra finches use their stronger vocal muscles to control the pitch of their songs, while females rely on lung pressure. This discovery sheds light on how birds learn to sing and the complex mechanisms behind birdsong.
New research reveals that high doses of caffeine increase muscle power and endurance during sub-maximal activities, such as everyday tasks or running a marathon. The study's findings have implications for the use of caffeine in sports to enhance performance, although caffeine remains unlisted by the World Anti-Doping Agency.
Researchers gathered to discuss novel muscle processes and clinical implications of complex macromolecular machines controlling muscle contraction. Key findings include insights into the DHPR–RYR1, actin–myosin interactions, and the multifunctional role of the dystrophin–glycoprotein complex in skeletal muscle.
Researchers found Botox significantly reduced short-term pain in TOS patients after a single low-dose injection. The treatment avoids surgery's drawbacks and offers a non-invasive alternative.
A study by Indiana University found that inspiratory muscle training can reduce the oxygen required by breathing muscles during exercise, making more oxygen available for other muscles. This improvement in whole-body endurance performance was previously reported following IMT.
Research suggests that drinking fat-free chocolate milk after exercise can help retain, replenish, and rebuild muscle. It also helps reduce markers of muscle breakdown and improves subsequent exercise performance.
A McMaster University study found that women who drank two large glasses of milk a day after weightlifting gained more muscle and lost more fat compared to those who consumed sugar-based energy drinks. The researchers attributed the gains to the combination of calcium, high-quality protein, and vitamin D in milk.
Researchers found that excessive HSP10 production can preserve muscle strength and halt the aging process. The study, funded by BBSRC, suggests that artificially increasing HSP10 levels could be used as a therapeutic measure to prevent age-related muscle loss.
Researchers at the University of Georgia found that daily ginger supplementation reduces exercise-induced muscle pain by 25 percent. The studies also showed that heat-treating ginger does not enhance its pain-relieving effects.
Research at the University of Texas Medical Branch found that elderly people's muscles don't respond to insulin by expanding their blood vessels like younger people do. This response is necessary for muscle protein synthesis and growth, with implications for improving strength and health in older adults.
A study published by Greek researchers found that electrical muscle stimulation (EMS) can prevent critical illness polyneuromyopathy (CIPNM), a common complication of ICU stay. EMS reduced the risk of CIPNM and improved muscle strength in patients, shortening weaning periods and ICU stays.
Neuromuscular electrical stimulation (NMES) may reduce muscle atrophy in patients with severe chronic obstructive pulmonary disease (COPD). NMES improved quadriceps and calf muscle mass, increasing the anabolism to catabolism ratio in muscle proteins.
Researchers at UTMB found that restricting blood flow during low-intensity resistance exercise increases protein synthesis and stimulates muscle growth in older men. The study offers hope for patients who need to regain muscle mass after surgery or due to conditions like arthritis.
A new study by University of Illinois labor expert John Dencker found that restructuring shifts workplace power towards firms, leading to performance-based bonuses that slow payroll growth. The shift creates fears of termination for managers, affecting their wages and career stability.
Researchers will assess MRI technology to measure muscle tissue in children with Duchenne muscular dystrophy, aiming to facilitate therapy testing and improve disease management. The study may provide valuable guidelines for MRI use in clinical trials and drug tests targeting DMD treatments.
A study found that ultrasound can effectively diagnose muscle tears in soccer players during games, allowing for immediate play cessation. This non-invasive imaging modality helps prevent further injuries by detecting partial or complete muscle tears on-site.
University of Missouri researchers have documented satellite cell movements and behaviors using time-lapse photography. Understanding the interactions between these cells and their 'host' myofiber may help overcome obstacles to gene therapies for muscular dystrophy.
A new study suggests that higher dietary protein intake can lower the risk of hip fractures in elderly individuals. The research, conducted on 946 seniors from the Framingham Osteoporosis Study, found that those consuming more protein had a significantly lower incidence of hip fractures compared to those with lower protein intake.
UBC researchers have developed a new biomaterial that closely mimics the elasticity of muscle, showcasing high resilience at low strain and toughness at high strain. The material's mechanical properties can be fine-tuned to develop biomaterials with diverse useful properties.
Engineered proteins mimic titin, a key muscle protein, to create a tough yet extensible scaffold for muscle regeneration. The biodegradable biomaterial could aid in the healing process by allowing new tissue to grow across injuries.
Researchers at the University of Rochester Medical Center found that mexiletine is effective in alleviating myotonia, a central symptom of myotonic dystrophy. The medication reduces muscle stiffness and relaxation time by 38-59% in patients with the condition.
A new study found that PARL protein levels decline with age, contributing to muscle defects and insulin resistance. The researchers suggest increasing PARL levels may bring metabolic benefits, potentially leading to a new drug target for age-related diseases.
Research presented at Experimental Biology 2010 highlights the importance of high-quality protein foods for promoting health throughout life. Experts recommend consuming 25-30 grams of protein per meal to maintain muscle function and prevent diseases such as obesity, heart disease, and type 2 diabetes.
Recent evidence suggests that bones and muscles are interconnected, releasing signals to affect each other's function or disease state. The discovery could lead to novel therapies for age-related muscle and bone disorders, which cost the US $14 billion annually.
New research shows that high phosphate levels in sodas and processed foods can accelerate the aging process in mice, contributing to age-associated complications like chronic kidney disease. Humans need a balanced diet, and avoiding phosphate toxicity may be important for longevity.
Research suggests that optimal vitamin D levels are associated with better physical function in seniors, which can improve their overall quality of life. The study found that participants with higher circulating 25-hydroxyvitamin D had better physical function, including improved walking ability and balance.
Professor Kathleen Keef is awarded a four-year, $1.2 million grant from the National Institute of Health to investigate the control of motility in the internal anal sphincter. This research has significant implications for fecal incontinence, affecting millions of Americans and leading to various quality-of-life issues.
A new study aims to investigate whether erectile dysfunction drugs can improve muscle blood flow and reduce fatigue in muscular dystrophy patients. The research, led by Ronald G. Victor, will test the effects of tadalafil on muscle blood flow during exercise in adult males with Becker muscular dystrophy.
A study in JCB identifies TWEAK as a key trigger for muscle breakdown in disused skeletal muscle. Blocking this pathway could prevent muscle loss in immobilized patients. Inhibiting TWEAK with an antibody was sufficient to block muscle breakdown, suggesting its potential as a therapeutic target.
Researchers at Karolinska Institutet identified the role of VEGF-B protein in regulating fatty acid transport proteins in blood vessel walls, leading to increased fat intake and potential new treatments for metabolic diseases. The study found that blocking VEGF-B signalling may reduce insulin resistance and blood glucose levels.
A new procedure using grafts of muscle and connective tissue from the neck has resulted in improved appearance for at least two years. The amount of vermilion showing increased by an average of 20 percent to 24 percent, while the average projection of the upper and lower lip increased by an average of 0.9 to 0.99 millimeters.
A new gene therapy approach has shown promising results in treating spinal muscular atrophy (SMA) in mice by improving muscle strength, coordination, and locomotion. The treatment involves injecting the gene-carrying therapeutic directly into the brain and spinal cord of newborn mice.
A study by Henry Ford Hospital researchers found Mechanomyography (MMG) to be extremely effective in detecting the presence of nerves during minimally invasive surgical procedures. MMG detected nerves on average 1.2 seconds earlier than Electromyography (EMG), using approximately half the amount of stimulating current.
A new study published in The Journal of Physiology found that short-term high-intensity interval training (HIT) can be an effective alternative to traditional long-term exercise. By incorporating brief bursts of intense exercise, individuals can improve muscle function and burn fat without needing extensive exercise time.
A recent study by Dr. Richard Kremer found that nearly 60% of healthy young women had insufficient vitamin D levels, leading to increased body fat and decreased muscle strength. The research highlights the importance of vitamin D in maintaining overall health and suggests a potential link between low vitamin D levels and various diseases.
A team of scientists at UC San Diego identified a protein called Sestrin as a natural inhibitor of aging and age-related pathologies in fruit flies. Sestrin regulates the AMP-dependent protein kinase (AMPK) and Target of Rapamycin (TOR) signaling pathway, which controls aging and metabolism.
A study published in Scandinavian Journal of Medicine and Science in Sports found that soccer training increases bone density, muscle mass, and postural balance in both young and older adults. The results suggest that soccer is an effective method for reducing the risk of falls and fractures, particularly among women and elderly men.
A Stanford University School of Medicine review confirms FDA concerns about quinine's effectiveness and safety for treating muscle cramps. The study suggests alternative therapies like vitamin B complex, calcium-channel blocking agents, and anti-epileptic drugs may be effective but require further research.
Research shows that eye position has no effect on speed and agility in mammals, with some species able to travel as fast as cheetahs without blurring vision. The vestibulo-ocular reflex is adapted through muscle switching, allowing the brain to cope with changing eye positions.
The American Academy of Neurology has released a new guideline evaluating the treatment options for muscle cramps. Quinine is no longer recommended for routine muscle cramps due to potential serious side effects, while naftidrofuryl and diltiazem may be considered as alternative treatments. More research is needed on these options.
Researchers found that humans' heel-first gait is more efficient for walking due to reduced energy loss and improved muscle efficiency. However, there was no significant difference in efficiency between heel-first and toe-first postures while running.
Researchers discovered a link between antioxidant enzyme deficiency and impaired mitochondrial function, leading to muscle cell death. The findings offer new insights into sarcopenia and neuromuscular diseases, potentially paving the way for future muscle-preserving therapies.
A study published in CMAJ found that low handgrip strength at 85 and 89 years is associated with increased all-cause mortality, highlighting its potential as a tool to assess mortality. The researchers also found that handgrip strength has a greater impact on mortality as people age.
A team of Marshall University researchers has successfully developed bionanomotors that can efficiently transport and manipulate single molecules at the nanoscale. Using myosin and actin proteins, they created a system that can move cargo with controlled movement and stop it at designated points.
Researchers identify potential new targets for preventing early loss of transplanted pancreatic islets, which could improve the efficiency of pancreatic islet transplantation. Meanwhile, studies show that engineering macrophages to store triacylglycerol protects mice from diet-induced insulin resistance and inflammation.
A study published in Physical Therapy found that decreased muscle strength is associated with difficulty performing daily activities like stooping, crouching, and kneeling. Older adults with weakened trunk extensor, knee extensor, and ankle flexion muscles had significant difficulties with these tasks.
Researchers at Kansas State University found that antioxidants can cause harm by suppressing key signaling mechanisms necessary for muscle function. The study suggests that increasing blood flow and oxygen delivery to the skeletal muscle is crucial during physical activity.
A new study published in the Journal of Applied Physiology suggests that human running speeds can exceed 28 mph due to limitations imposed by muscle fiber contractile speed. Researchers found that elite sprinters' foot-ground contact times are brief, implying a biological limit on how quickly muscles can generate forces.