Research on muscle biology and repair. Covers tissue maintenance, Parkinson's protection, repair-cell preservation, and muscle strength with age.
A recent study found that higher muscle mass is associated with better insulin sensitivity and lower risk of pre- or overt diabetes. Building muscle may be a key factor in improving metabolic health, particularly for overweight individuals who struggle to lose weight.
A novel molecular technique has restored dystrophin protein production in Duchenne muscular dystrophy patients, offering a new therapeutic option. The treatment, using antisense oligonucleotides, was well-tolerated and showed significant dose-dependent increases in muscle protein levels.
Researchers from Northwestern University have discovered a brain chemical, Substance P, that causes abnormal bone growth in injured muscles. This discovery offers a potential molecular target for preventing and treating heterotopic ossification.
Deep brain stimulation is a therapy approved by the FDA for certain treatment-resistant dystonias and has shown sustained benefit for up to three years. Michele Tagliati, a movement disorders expert, led an international task force that reviewed current practice and research on DBS for dystonia.
Researchers at the University of Pennsylvania School of Medicine have identified a genetic basis for muscle endurance in animal study. The study found that mice lacking a specific gene exhibit increased endurance and fatigue resistance, similar to elite athletes.
Researchers report successful outcomes from a surgical procedure to treat chronic neck stiffness and involuntary movement. The study found that removing part of the platysma muscle significantly improved patients' overall quality of life and reduced neck tension.
Researchers have discovered that a protein in blood vessel walls plays a key role in maintaining healthy blood pressure. Malfunctioning of this protein, Kv7.4, contributes to high blood pressure and can be targeted by new treatment strategies.
A recent study published in PNAS reveals that a specific microRNA, miR-206, plays a pivotal role in normal muscle development during embryonic stages. This discovery has significant implications for understanding the maintenance and regeneration of healthy muscle tissue, particularly in diseases such as muscular dystrophy and cancer.
Research by the University of Exeter reveals that drinking beetroot juice enables competitive-level cyclists to cut down the time it takes to ride a given distance. The study found that riders who consumed beetroot juice had a higher power output and were 11 seconds quicker over a 4km distance.
Researchers discovered a key difference in how fish and mammals chew their food. Fish primarily use their tongue muscles to transport food into the mouth, whereas mammals use them to position food for optimal chewing by teeth.
Researchers found that birds flap their wings while running up steep objects to conserve energy, with power savings reaching 10%. This behavior may be essential for learning to fly and could have been a key stage in the evolution of flight.
New York Medical College scientist Stuart A. Newman suggests that the loss of a gene critical for heat generation led to the emergence of enlarged skeletal muscles in birds, enabling them to walk on two legs and adapt to flying or swimming. This theory challenges traditional views on bird evolution and extinction
A randomized, double-blind study compared the efficacy of botulinum toxin type A (onabotulinumtoxinA) and B (abobotulinumtoxinA) in reducing crow's feet wrinkles. AbobotulinumtoxinA was found to produce a greater effect when participants contracted their muscles, but no significant difference was seen at rest. The study suggests that a...
Researchers found that shorter, less strenuous warm-ups resulted in less muscle fatigue yet more peak power output compared to traditional warm-ups. This suggests that a better approach would be to aim for just enough activity to promote post-activation potentiation without creating fatigue.
Researchers have discovered a potential treatment for muscle wasting disorders using a compound found in apple peel called ursolic acid. The study found that ursolic acid promoted muscle growth and reduced muscle atrophy in mice, while also lowering body fat, blood sugar levels, cholesterol, and triglycerides.
Researchers identified a natural compound in apple peels as a promising new treatment for muscle wasting. Ursolic acid enhanced insulin signaling and corrected gene signatures linked to atrophy, promoting muscle growth and reducing blood levels of glucose and cholesterol.
Researchers have discovered a new protein, neuritin, that helps nerve fibers navigate towards muscles in zebrafish models of SMA. Artificially stimulating neuritin production improves axon branching and connection formation, leading to potential drug therapy options.
A study found that formoterol improves fat burning and protein metabolism in men, increasing metabolism by over 10% and fat oxidation by nearly 25%. The results suggest potential benefits for preventing obesity and muscle loss in humans.
Muscle cell fusion is crucial for understanding normal muscle growth and regeneration after injury or disease. Johns Hopkins researchers discovered the role of a regulatory protein called Blown Fuse in facilitating muscle cell merging by disrupting the WASP-WIP protein duo, which regulates cytoskeleton dynamics.
Researchers discovered Sox6 gene regulator that maintains fast muscle type and inhibits slow muscle development. Adult mice lacking Sox6 in fast muscles showed changes in muscle performance, including slower contraction speed and reduced fatigue.
A team of scientists flew microscopic worms into space to test the effectiveness of RNA interference (RNAi) as a treatment for muscle degradation caused by space travel. The experiment showed promising results, suggesting that RNAi could be used to prevent muscle loss in astronauts and help people suffering from similar conditions.
A new non-invasive wireless near-infrared device has been shown to be as reliable as current invasive tests in determining bladder disease. The device uses light shone through the skin to monitor changes in bladder physiology, revealing consistent patterns of normal oxygen availability and blood supply in healthy subjects during urinat...
A recent study published in the Journal of Applied Physiology found that shorter warm-ups can result in less muscle fatigue and improved peak power output. The study suggested that sprint athletes may benefit from adopting a shorter and less strenuous warm-up for better performance.
A recent study published in Nature has identified a key molecular mechanism that causes stem cells to differentiate into muscle cells in embryos. This breakthrough discovery could lead to new treatments for muscle dysfunction associated with aging and disease.
A novel gene called MLIP has been identified as affecting heart development and the aging process. The discovery opens up new avenues for understanding cardiac development and loss of cardiac function.
A study found that high doses of vitamin D supplementation on top of a standard rehabilitation program improves exercise capacity and respiratory muscle strength in patients with COPD. However, the treatment did not significantly improve health-related quality of life.
Researchers found that penguins' muscles have sufficient oxygen to sustain dives for up to 20 minutes, contrary to earlier theories. The team's discovery reveals a surprising efficiency in the birds' underwater metabolism.
Researchers identify epithelial cells as key to sponge movement, contradicting long-held assumption about muscle cell origins. The study uses 3D imaging to visualize sponges' contracted and expanded states, revealing a new understanding of the evolutionary development of musculature.
Researchers discovered losartan improves muscle regeneration and prevents wasting away from inactivity in geriatric mice. The study suggests losartan may have broader clinical applications in protecting against immobilization atrophy in older adults.
A parasitic fungus infects tropical carpenter ants, causing them to become zombie-like and die in ideal conditions for the fungus. The fungus affects the ant's muscles, nervous system, and behavior, leading to a loss of coordination and death.
A Penn State study reveals that obesity impairs skeletal muscle function in rats, leading to impaired muscle strength and locomotion. The research suggests that the muscles of obese mammals are not properly 'tuned' to their body weight.
A Texas A&M University study challenges the common perception of LDL cholesterol as 'bad' cholesterol. Research suggests that a certain amount of LDL is necessary for muscle growth and serves as a warning sign for potential health problems. The study's findings may have implications for conditions like sarcopenia, which affects million...
Researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases have identified a key player in muscle repair: the gene Ezh2. By activating this gene, satellite cells may proliferate and compensate for underlying defects, potentially increasing quality of life for individuals with degenerative diseases.
An international team of scientists used a powerful synchrotron X-ray technique to observe muscle protein changes inside intact and contracting muscle cells. The results revealed the conformation of myosin molecular motors in resting muscles and the signalling pathway between actin and myosin filaments.
Children and adolescents with inflammatory bowel disease (IBD) are less fit than their peers, with aerobic fitness levels 25% lower and muscle function 10% lower. The study suggests that active living can help reduce the risk of future health problems in IBD patients.
A new gene mutation has been identified as the cause of a rare form of muscular dystrophy, with severe cognitive impairment. Researchers created a mouse model to study the mutation and found similar muscle and brain abnormalities, offering hope for potential treatments.
A Virginia Tech researcher is working on a new device that uses electrical stimulation to help stroke patients regain their voice. The device, which is still in development, aims to improve the quality of life for patients with vocal paralysis and other neuromuscular disabilities.
Researchers identified a genetic switch, estrogen-related receptor gamma (ERR gamma), that converts fast twitch fibers into slow twitch fibers with increased blood supply. This discovery offers potential therapeutic avenues for treating critical limb ischemia and other cardiovascular diseases.
A new analysis found that fish oil supplementation can help combat cancer-related malnutrition, allowing patients to maintain their weight and muscle mass during chemotherapy. The study suggests that fish oil's omega-3 fatty acids may interfere with pathways altered in advanced cancer.
Scientists have discovered a new sauropod dinosaur, Brontomerus mcintoshi, with enormous thigh muscles and unique hip structure, suggesting it may have used its kick as defense against predators. The discovery challenges the previous idea that sauropods began to disappear in the Early Cretaceous period.
Researchers studied how children master speech by observing finger movements and neural processes. The study suggests that the beat could reveal underlying motor skills, shedding light on stuttering in children.
Researchers found that functional electrical stimulation (FES) therapy worked better than conventional occupational therapy alone to increase patients' ability to pick up and hold objects. FES therapy also improved daily activities such as dressing and eating, with significant implications for quality of life and independence.
A new gene test has identified GFPT1 as a crucial cause of Congenital Myasthenic Syndrome (CMS), a rare genetic condition affecting signal transmission between the brain and muscles. The test allows for earlier treatment with cholinesterase inhibitors, offering an effective therapy that can be taken through life.
Researchers found daily tart cherry juice consumption reduced muscle damage and improved recovery time by 5% in athletes. The study suggests antioxidant-rich anthocyanins in cherry juice may decrease oxidative damage to muscles, allowing for faster recovery.
Research on grizzly bears reveals a complex series of changes in their hearts as they hibernate, including the adaptation of a protein called myosin heavy chain. The left atrium produces more alpha protein, resulting in a weaker beat, to prevent damage from pushing against the stiffened ventricle.
Anthropologist Jane Desmond explores how Body Worlds exhibits tolerate the public display of human corpses, idealizing them as objects of scientific curiosity. The exhibitors promote the display as an advancement in anatomy studies, using de-emotional screens and depersonalization to create a universal experience.
Researchers found women with PAD lose ability to walk short distances and climb stairs sooner than men, despite having less calf muscle. Women are more likely to develop a mobility disability compared to men.
Researchers at the University of Nottingham are exploring whether chocolate and orange consumption can slow down muscle loss and frailty in older adults. The study aims to investigate the impact of cocoa and vitamin C on blood flow to leg muscles, with potential implications for improving mobility and reducing fall-related deaths.
New research from Karolinska Institutet shows that nitrate improves mitochondrial function in humans, consuming less oxygen and producing more ATP per molecule. This finding has significant implications for sports physiology and may also have positive effects on diseases involving mitochondrial dysfunction.
Researchers used accelerated evolution to engineer enzymes that can efficiently break down nerve agents, providing protection against nerve gas attacks. The developed enzymes show near-complete protection against certain types of nerve agents.
A minimally invasive procedure has shown promise in reanimating lower facial movement after paralysis, with all patients achieving improved symmetry and voluntary motion of the oral commissure. Directed physical therapy is necessary to achieve the best outcome, as spontaneous controlled smile requires intensive neuromuscular retraining.
The Muscular Dystrophy Association granted Acceleron Pharma a $1.5 million award to support the clinical studies of ACE-031 in Duchenne Muscular Dystrophy patients. The grant will enable gathering safe dosing and pharmacodynamic activity information vital to future studies.
Researchers found extensive adhesions and inelastic muscles after using amniotic membrane to prevent postoperative scarring. The use of dried amniotic membrane, rather than frozen, may be the culprit behind these complications.
A novel human protein called biglycan has been shown to significantly slow muscle damage and improve function in mice with Duchenne Muscular Dystrophy. The treatment restores utrophin presence in muscle cells, reducing muscle tissue damage by 50% compared to untreated mice.
Researchers at Vanderbilt University engineered a mouse that can run longer on a treadmill by increasing its acetylcholine supply, which could lead to new treatments for myasthenia gravis and other disorders. The study also found potential links between cholinergic signaling deficits and conditions like muscular dystrophy and ADHD.
Researchers from Michigan State University are investigating the relationship between cesarean-section deliveries and degenerative spondylolisthesis, a condition causing lower back pain and nerve damage in women. The study aims to quantify muscle function objectively and document variables in women with and without the disease.
A new mouse model of Duchenne muscular dystrophy suggests that muscle stem cells are key to understanding the disease's progression. The research found that mice with a similar mutation to humans experience severe muscle weakness and shortened life spans due to the inability of their muscle stem cells to keep up with ongoing damage.
A new $2.1 million NIH grant will help MU scientist Dongsheng Duan develop a treatment that prevents heart muscles from weakening due to Duchenne muscular dystrophy. Tests have shown that treating skeletal muscle alone can lead to complications, highlighting the need for comprehensive treatment targeting both skeletal and cardiac muscle.
Researchers identify biochemical mechanisms in Casertana and Large White pigs to produce more flavorful and leaner pork products. The study aims to develop new pig breeds with a desirable combination of leanness and flavor.
A new study found that botulinum toxin A causes muscle weakness in muscles far removed from the injection site, even after repeated use. The study also reveals muscle atrophy and loss of contractile tissue in non-injected limbs.